Qualitative and quantitative analysis of locus coeruleus neurons in Parkinson's disease.

Abstract:

:The analysis of qualitative changes in the locus coeruleus (LC) was performed on brains from 21 cases of Parkinson's disease. Eleven cases were selected for quantitative analysis of the loss of LC noradrenergic pigmented neurons. The qualitative studies revealed uneven dissemination of the noradrenergic cells loss of overall structure of the LC. Few preserved neurons showed degenerative changes. Extracellular neuromelanine granules, traces of dying neurons, were also observed. A weak astro- and microglia proliferation corresponded with neuronal loss. Lewy bodies were found in the LC in all cases. The quantitative analysis revealed that the average loss of adrenergic neurons in the LC accounts for about 70% in relation to the control group. The degenerative changes were observed in the whole LC, but they were most intensive in its caudal and next in the middle segment. The results suggest also that the degenerative process began in the middle segment and then it spread towards caudal segment of the LC as the stages of disease advanced.

journal_name

Folia Neuropathol

journal_title

Folia neuropathologica

authors

Bertrand E,Lechowicz W,Szpak GM,Dymecki J

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

80-6

issue

2

eissn

1641-4640

issn

1509-572X

journal_volume

35

pub_type

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