Abstract：
:We describe here a variety of autophagous forms encountered in the terminal stages of two models of scrapie in hamsters. We also show that the number of autophagic vacuoles increased through the incubation period in the 263K strain scrapie model. In addition, we demonstrated for the first time the presence of aggresomes in the neuronal cytoplasm in scrapie-affected hamster brains. We observed neuronal autophagic vacuoles in different stages of formation in the same specimens. However, this description is based on the subjective grading of the severity of changes, which may or may not equate to the stage of development. First, a part of the neuronal cytoplasm was sequestered by membranes (phagophores) and that part of the cytoplasm confined by membranes often exhibited increased electron density. The intracytoplasmic membranes multiplied in a labyrinth-like manner. The area taken up by autophagic vacuoles expanded and eventually a large proportion of the cytoplasm was transformed into an agglomeration mass of autophagic vacuoles. Occasionally a large but single autophagic vacuole was visible. Autophagic vacuoles developed not only in the neuronal perikarya but also in neuronal processes, eventually replacing the whole cross-section of affected neurites.Generally,there were few qualitative differences between these two models but hamsters inoculated with the 263K strain had more severe changes. In a few specimens there were round electron-dense structures that we identified as aggresomes. Aggresomes are not membrane-bound and were found in the cytoplasm of a few neurons.
journal_name
Folia Neuropatholjournal_title
Folia neuropathologicaauthors
Sikorska B,Liberski PP,Brown Psubject
Has Abstractpub_date
2007-01-01 00:00:00pages
170-8issue
4eissn
1641-4640issn
1509-572Xpii
9564journal_volume
45pub_type
杂志文章abstract：:Morphological alterations and the course of changes in motoneuron counts were studied by light microscopy (cresyl violet staining) in the L2/L3 region of the spinal cord of hemizygotic transgenic rats carrying the amyotrophic lateral sclerosis-associated mutant human gene for Cu,Zn superoxide dismutase (hSOD1G93A) and...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Globoid cell leukodystrophy (GLD, also known as Krabbe disease), whose pathophysiology is still not completely elucidated, is an inherited, metabolic, and neurodegenerative disease, caused by the deficiency of β-galactocerebrosidase (GALC) or in very rare cases by lack of active saposin A. We describe two patients, i...
journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：10.5114/fn.2012.32364
更新日期：2012-01-01 00:00:00
abstract：:Paralytic tremor (pt), a hereditary neurological disorder of rabbits, is a recessive, X-linked point mutation in exon 2 of the plp gene, responsible for substitution of 38 His by Glu in the PLP molecule. Pt genotype is expressed in a range of phenotypes, distinguished by the severity of neurological symptoms. Variable...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:We report the case of an 84-year-old male patient afflicted by cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) showing minimal symptoms of disease. The patient was diagnosed on the basis of ultrastructural and genetic examinations. Ultrastructurally, a typical vascu...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2014.47846
更新日期：2014-01-01 00:00:00
abstract：INTRODUCTION:To investigate the effects of crocin on proliferation and migration of endogenous neural stem cells and the Notch1 signalling pathway in rats after cerebral ischemia reperfusion. MATERIAL AND METHODS:SD rats were randomly divided into the sham operation group, model group and administration group (crocin)...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2020.100063
更新日期：2020-01-01 00:00:00
abstract：:The object of our report is the presentation of the morphological picture of cerebellar cortex malformation as a sequel of disturbed neuronal migration. In the disarranged tissue, cavities with a network of meningeal tissue and embedded pathological vessels were noted. The external granule cells did not form a proper ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:Inherited neurodegenerative disorders are debilitating diseases that occur across different species, such as the domestic dog (Canis lupus familiaris), and many are caused by mutations in the same genes as corresponding human conditions. In the present study, we report an inherited neurodegenerative condition, term...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2017.68580
更新日期：2017-01-01 00:00:00
abstract：:Multiple system atrophy (MSA) is a rare neurodegenerative disorder associated with parkinsonism, ataxia, and autonomic dysfunction. Its pathology is primarily subcortical comprising vacuolation, neuronal loss, gliosis, and α-synucleinimmunoreactive glial cytoplasmic inclusions (GCI). To quantify cerebellar pathology i...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2015.54420
更新日期：2015-01-01 00:00:00
abstract：:Metformin, a type 2 anti-diabetic drug and an activator of AMP-activated protein kinase (AMPK), has been shown to reduce infarct size and pathological changes affecting astroglia in animal models of ischemic stroke. In this study, we evaluated how metformin affects cell viability, apoptosis and determined the role of ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2018.80866
更新日期：2018-01-01 00:00:00
abstract：:Unmethylated CpG DNA, as a stimulatory molecule, has potent pro-inflammatory effects in the central nervous system (CNS). Dexmedetomidine (DEX) has been confirmed to exert anti-inflammatory effects in CNS. Our study was aimed to explore the effects of DEX on tumor necrosis factor-α (TNF-α) expression in unmethylated C...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2016.64817
更新日期：2016-01-01 00:00:00
abstract：:Hyponatremia is a common disorder of water-electrolyte balance characterized by the decrease of plasma sodium ions concentration below 135 mM. Although water-electrolyte balance is regulated by a kidney, symptoms of hyponatremia are related to the disturbances of intracranial homeostasis and are attributed to brain sw...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2013.37707
更新日期：2013-01-01 00:00:00
abstract：:Meningiomas are the most common primary extra-axial tumours of the central nervous system, however their metastatic spread beyond central nervous system is rare. Here we present the case of a 54-year-old male with anaplastic meningioma who, 1.5 years after initial diagnosis, developed a tumorous expansion in his left ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2019.91195
更新日期：2019-01-01 00:00:00
abstract：:Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an autosomal dominant neurodegenerative disorder caused by mutations in the MAPT gene which encodes the microtubule-associated protein tau. This hereditary tauopathy is a rare clinical syndrome, affecting approximately two hundred kindreds a...
journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：2005-01-01 00:00:00
abstract：:Chemokines play an important role in pathogenesis of multiple sclerosis (MS), mediating migration of leukocytes into the central nervous system. CCL2 (MCP-1) chemokine is expressed in astrocytes in MS lesions. The aim of the study was to evaluate the effect of a two-year treatment with IFN-beta 1a on serum CCL2 level ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:A neuropathological analysis of 172 cases of AIDS in adults was carried out, to determine the occurrence and nature of the opportunistic infections of the central nervous system (CNS). The material comprised 155 cases of men, and 17 women. Mean age of patients was 38 years. Collection under study originated from the p...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The ultrastructural pathology of cerebral cortex in human hydrocephalus is reviewed and compared with experimental hydrocephalus. Nerve cells show moderate and severe swelling. The neighboring neuropil exhibits notable enlargement of extracellular space, synaptic plasticity and degeneration, damage of myelinated axons...
journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：2010-01-01 00:00:00
abstract：:We report here the first description of florid plaques--the hallmark of variant Creutzfeldt-Jakob disease (vCJD). These plaques are composed of broad bundles of amyloid, are highly neuritic and exhibited astrocytes and microglial cells. Collectively, they are more similar to neuritic plaques of Alzheimer's disease tha...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:Human T lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic progressive myelopathy characterized by bilateral pyramidal tract involvement with sphincteric disturbances. The primary neuropathological feature of HAM/TSP is chronic myelitis characterized by perivas...
journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
abstract：:Forty human primary brain tumors: twelve protoplasmic, six gemistocytic, four fibrillary and ten anaplastic astrocytomas, eight glioblastomas were submitted for immunohistochemical and histochemical characterization of microglia in tumor tissue and in its surroundings. The following antibodies were used: GFAP, ferriti...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The pineal gland is an organ involved in regulation of homeostasis and body rhythms. It plays an important role in the growth foetuses and adaptation of newborns to new environmental conditions. The requirements of foetuses and newborns progressively change during development. The purpose of the study was to evaluate ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:The post-mortem neuropathological investigations were carried out on 20 female New Zealand rabbits. Two main types of changes were found: inflammatory, including meningeal and perivascular infiltrates, and thrombotic within the nervous tissue. The findings revealed that active process within the CNS persists at least ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:We present a case of rare orbital roof haemangioma infiltrating the medial and lateral walls of the orbit, zygomatic bone and lesser and greater wings of the sphenoid. The tumour was totally excised by the frontolateral approach, followed by craniofacial and orbital roof reconstruction. ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：:There is an increased risk of stroke in patients with HIV infection. One of the mechanisms is production of anticardiolipin (aCL) antibodies, induced by the virus. Many studies have documented a high incidence of aCL antibodies in patients with HIV infection and the increased risk of stroke, although there is no such ...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:A case of 56-year-old male with sarcomatosis of leptomeninges as well as of the brain and spinal cord coexisting with Recklinghausen's neurofibromatosis is presented. Neurological and neurophysiological symptoms of the disease resembled those of amyotrophic lateral sclerosis (ALS). Patient died 7 months after onset of...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1995-01-01 00:00:00
abstract：:The high incidence and the devastating consequences of stroke call for efficient therapies but despite extensive experimental evidence of neuroprotective improvements, most clinical treatments have failed. The poor translational success is attributed to the inappropriate selection of clinically irrelevant animal model...
journal_title：Folia neuropathologica
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
abstract：:Angiocentric glioma (AG) is a newly-classified, very rare, WHO grade I central nervous system (CNS) lesion, occurring usually in children and young adults. Only 52 patients with AG have been reported so far, making it one of the rarest neuropathological entities. Hereby we present two new cases of AG in young subjects...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：10.5114/fn.2016.58914
更新日期：2016-01-01 00:00:00
abstract：:The size frequency distributions of beta-amyloid (A beta) and prion protein (PrPsc) deposits were studied in Alzheimer's disease (AD) and the variant form of Creutzfeldt-Jakob disease (vCJD) respectively. All size distributions were unimodal and positively skewed. A beta deposits reached a greater maximum size and the...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Deficiency of dystrophin in skeletal muscles is supposed to be responsible for all the symptoms associated with Duchenne dystrophy (DMD) and Becker dystrophy (BMD). The dystrophin-deficient mdx mice, however, are clinically almost asymptomatic. Hence, other factor(s) might be responsible for the muscle pathology in DM...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
abstract：:Male Wistar rats, weighing 200-220 g, were used in the study. Quinolinic acid and racemic pentazocine were administered alone or together. Quinolinic acid was administered intraperitoneally (i.p.) in a dose of 60 mmol, racemic pentazocine intramuscularly in a dose of 2 mg/kg, once every 24 h for 8 days. The control gr...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:The aim of the study was to analyse in TEM the evolution of changes in structural elements of synaptic junctions of the cerebellar cortex in rats in valproate encephalopathy induced by chronic 12-month administration of sodium valproate - VPA (once daily intragastrically, in a dose of 200 mg/kg b.w.) and after withdra...
journal_title：Folia neuropathologica
pub_type： 杂志文章
doi：
更新日期：2002-01-01 00:00:00
