Abstract:
:Genetic variants that confer susceptibility to Parkinson's disease (PD) show unbalanced distribution among different populations; genetic predisposition to either familial or sporadic forms of PD in Mexican-mestizo population has not been comprehensively studied. The aim of the present study was to analyze genetic variants in six PARK genes in PD patients. In total 381 individuals (173 patients, 208 controls) were genotyped for p.Gly2019Ser and p.Gly2385Arg variants of LRRK2. The p.Gly2019Ser variant was present in two patients and one healthy control; the p.Gly2385Arg variant was not found. In a subgroup of early-onset PD (EOPD), MLPA analysis was done for PARKIN (PARK2), PINK1 (PARK6), DJ-1 (PARK7), LRRK2 (PARK8), SNCA (PARK1/4) and ATP13A2 (PARK9). We found a heterozygous deletion of exon 2 in PARK2 in the youngest patient of the early-onset group, who showed limited response to antiparkinsonian therapy. Although the changes Gly2019Ser and Gly2385Arg of LRRK2 are associated with PD in different populations; they may be a rare cause of PD in our population. Novel population-specific variants may underlie PD susceptibility in Mexican mestizos. Our study suggests that the heterozygous deletion of exon 2 in the PARK2 gene is a risk factor for EOPD.
journal_name
Folia Neuropatholjournal_title
Folia neuropathologicaauthors
García S,López-Hernández LB,Suarez-Cuenca JA,Solano-Rojas M,Gallegos-Arreola MP,Gama-Moreno O,Valdez-Anguiano P,Canto P,Dávila-Maldonado L,Cuevas-García CF,Coral-Vázquez RMdoi
10.5114/fn.2014.41741subject
Has Abstractpub_date
2014-01-01 00:00:00pages
22-9issue
1eissn
1641-4640issn
1509-572Xpii
22537journal_volume
52pub_type
杂志文章abstract::The 'prion-like' transfer of pathogenic proteins may play a role in the pathogenesis of frontotemporal lobar degeneration (FTLD). Propagation of such proteins along anatomical pathways may give rise to specific spatial patterns of the 'signature' neuronal cytoplasmic inclusions (NCI) characteristic of these disorders....
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2017.70482
更新日期:2017-01-01 00:00:00
abstract::Chordoid glioma is a rare benign neoplasm of uncertain histogenesis occurring in the third ventricle/ /suprasellar region. Recently, data have emerged suggesting that chordoid glioma is a variant of ependymoma related to a specialised ependyma of the subcommisural organ or the lamina terminalis area. In this study, we...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Granular osmiophilic material (GOM) is a pathognomonic feature of CADASIL that may be a consequence of pathological processes triggered by Notch3 mutations. Since knowledge of the effects of CADASIL-associated GOM deposits is important to understand the molecular pathogenesis of this disorder, we performed a thorough ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::Increased pineal calcifications and decreased pineal melatonin biosynthesis, both age related, support the notion of a pineal bio-organic timing mechanism. The role of calcification in the pathogenesis of pineal gland dysfunction remains unknown but the available data document that calcification is an organized, regul...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2010-01-01 00:00:00
abstract::We report the case of an 84-year-old male patient afflicted by cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) showing minimal symptoms of disease. The patient was diagnosed on the basis of ultrastructural and genetic examinations. Ultrastructurally, a typical vascu...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2014.47846
更新日期:2014-01-01 00:00:00
abstract::The Warburg micro syndrome (WARBM) is a genetically heterogeneous syndrome linked to at least 4 loci. At the clinical level, WARBM is characterized by microcephaly, microphthalmia, microcornea, congenital cataracts, corpus callosum hypoplasia, severe mental retardation, and hypogonadism. In some families additional cl...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2016.62537
更新日期:2016-01-01 00:00:00
abstract::The object of our report is the presentation of the morphological picture of cerebellar cortex malformation as a sequel of disturbed neuronal migration. In the disarranged tissue, cavities with a network of meningeal tissue and embedded pathological vessels were noted. The external granule cells did not form a proper ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::The endothelial vacuolar and vesicular transports in traumatic human brain oedema have been reviewed and compared with experimental brain oedema in order to establish their role in both oedema formation and oedema resolution. Normal or "non-activated" and "activated" capillaries are found. The activated capillaries sh...
journal_title:Folia neuropathologica
pub_type: 杂志文章,评审
doi:10.5114/fn.2013.35951
更新日期:2013-01-01 00:00:00
abstract::Paralytic tremor (pt), a hereditary neurological disorder of rabbits, is a recessive, X-linked point mutation in exon 2 of the plp gene, responsible for substitution of 38 His by Glu in the PLP molecule. Pt genotype is expressed in a range of phenotypes, distinguished by the severity of neurological symptoms. Variable...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::PPAX6 is an important transcription factor which plays an essential role in brain morphogenesis and eye development. It is related to migration of neuroblasts to the cerebral cortex and deep telencephalic nuclei, and the specification of cellular and regional identity. Disturbances of brain development in two sib fetu...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2009-01-01 00:00:00
abstract::In the present work, we investigated the effect of chronic haloperidol administration on the number of striatal neurons in guinea pigs. For this purpose, adult male guinea pigs were given daily injections of 1, 2 or 3 mg/kg of haloperidol for 6 weeks. After treatment, the animals were anesthetized via brief inhalation...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract::The present study examined the effect of DS exposure on median nerve development in rats during prenatal life. Pregnant female rats were divided into three groups: a control group, a saline group and a DS group. Offspring of these animals were divided into 2 subgroups: 4 weeks old and 20 weeks old. Nerve samples were ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2013.34199
更新日期:2013-01-01 00:00:00
abstract:INTRODUCTION:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary, progressive ischemic disease of small vessels of the brain characterized by migraine with aura (MA), recurrent subcortical ischemic episodes, cognitive decline and psychiatric disorders. CA...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2020.94009
更新日期:2020-01-01 00:00:00
abstract::Inherited neurodegenerative disorders are debilitating diseases that occur across different species, such as the domestic dog (Canis lupus familiaris), and many are caused by mutations in the same genes as corresponding human conditions. In the present study, we report an inherited neurodegenerative condition, term...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2017.68580
更新日期:2017-01-01 00:00:00
abstract::Electron microscopic immunocytochemical evaluation of localization and distribution of endothelins 1, 2 and 3 in the CA1 hippocampal sector in rats submitted to 10 min global cerebral ischemia was performed. The studies were done in different postischemic periods (10 min, 3, 6, 12 and 24 h) with postembedding immuno-g...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1995-01-01 00:00:00
abstract::The pineal gland is an organ involved in regulation of homeostasis and body rhythms. It plays an important role in the growth foetuses and adaptation of newborns to new environmental conditions. The requirements of foetuses and newborns progressively change during development. The purpose of the study was to evaluate ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::We describe here a variety of autophagous forms encountered in the terminal stages of two models of scrapie in hamsters. We also show that the number of autophagic vacuoles increased through the incubation period in the 263K strain scrapie model. In addition, we demonstrated for the first time the presence of aggresom...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND AND STUDY PURPOSE:due to the fact that an interrelation between metastases of lung cancer to the brain and surroundings may influence the prognosis, we made attempts to answer the following questions: 1) how is the border between the tumour and its surroundings formed? 2) are there any differences in the gli...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Male Wistar rats, weighing 200-220 g, were used in the study. Quinolinic acid and racemic pentazocine were administered alone or together. Quinolinic acid was administered intraperitoneally (i.p.) in a dose of 60 mmol, racemic pentazocine intramuscularly in a dose of 2 mg/kg, once every 24 h for 8 days. The control gr...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The analysis of qualitative changes in the locus coeruleus (LC) was performed on brains from 21 cases of Parkinson's disease. Eleven cases were selected for quantitative analysis of the loss of LC noradrenergic pigmented neurons. The qualitative studies revealed uneven dissemination of the noradrenergic cells loss of ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Telepathology is the diagnostic work of a pathologist at a distance. It includes specific application fields which require specific system solutions. These comprise: a. frozen section service; b. expert consultations; c. remote control measurements, and d. education and training. Applications but, in addition, all asp...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The efficacy of tempol and its acyl derivative tempol-C8 as retinoprotective agents was compared in a rat model of NMDA-induced retinal ganglion cell (RGC) damage. MATERIAL AND METHODS:Tempol or tempol-C8 in different doses was administered intraperitoneally to 6 weeks old (pre-adolescent) and 9-10 weeks ol...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2014.45570
更新日期:2014-01-01 00:00:00
abstract::The aim of our study was the estimation of the apoptosis process using in situ-end labelling of DNA breaks method on paraffin sections in 5 human cases of Alzheimer's disease (AD), 6 of Creutzfeldt-Jakob disease (CJD) and in 25 mice infected experimentally with the Fujisaki strain of CJD, killed sequentially at one-we...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Morphological alterations and the course of changes in motoneuron counts were studied by light microscopy (cresyl violet staining) in the L2/L3 region of the spinal cord of hemizygotic transgenic rats carrying the amyotrophic lateral sclerosis-associated mutant human gene for Cu,Zn superoxide dismutase (hSOD1G93A) and...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
abstract::Some data suggest that the central nervous system (CNS) is the main target of Staphylococcus alpha-toxin. Since this pathogen cannot penetrate the blood-brain barrier (BBB), the exact mechanism by which alpha-toxin affects the CNS remains unclear. Recent studies on the role of the innate immune system have shed light ...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The gerbils brains after 3- and 4-minute-long ischemia caused by bilateral common carotid artery occlusion and 14 days survival were investigated using lectin techniques. Chosen lectins, represented by synthetic plant glycoproteids, which are specifically bound to particular sugar residues (receptors) located on the c...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Tumours of astroglial origin, both malignant glioblastoma (GBM) and benign subependymal giant cell astrocytoma (SEGA), pose a serious medical problem. Casein kinase 2 (CK2), a member of the serine/threonine kinase family, has antiapoptotic properties and plays a vital role in glial tumour cell survival. It contributes...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2019.88452
更新日期:2019-01-01 00:00:00
abstract::A neuropathological analysis of 172 cases of AIDS in adults was carried out, to determine the occurrence and nature of the opportunistic infections of the central nervous system (CNS). The material comprised 155 cases of men, and 17 women. Mean age of patients was 38 years. Collection under study originated from the p...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::The effect of transient, global cerebral ischemia on the distribution of endothelin (ET) in blood-brain barrier (BBB) in CA1 area of hippocampus long-time after ischemia was estimated using post-embedding immunogold technique. ET-like immunoreactivity as a gold particles was localized in all compartments of the blood-...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::The visual cortex undergoes age related changes that have been studied mainly in rats Maccaca Mulata, and human beings. Despite the fact that there is no extensive neuronal loss in aged brains, a lot of important pathological changes are found in the morphology of the neurons. The present study describes the morpholog...
journal_title:Folia neuropathologica
pub_type: 杂志文章
doi:10.5114/fn.2012.30526
更新日期:2012-01-01 00:00:00