Toll-like receptors in rat brains injured by hypoxic-ischaemia or exposed to staphylococcal alpha-toxin.

abstract：:In the course of histopathological investigation of the temporal lobe sections, selected from 63 patients treated surgically for intractable epilepsy and finally presented with primary temporal tumors, we found 12 cases expressed both neoplastic process' and developmental disorders. The temporal mass lesions consistin...

journal_title：Folia neuropathologica

authors： Kroh H,Matyja E,Bidziński J

更新日期：1999-01-01 00:00:00

abstract：:Chemokines play an important role in pathogenesis of multiple sclerosis (MS), mediating migration of leukocytes into the central nervous system. CCL2 (MCP-1) chemokine is expressed in astrocytes in MS lesions. The aim of the study was to evaluate the effect of a two-year treatment with IFN-beta 1a on serum CCL2 level ...

journal_title：Folia neuropathologica

authors： Szczuciński A,Losy J

更新日期：2004-01-01 00:00:00

abstract：INTRODUCTION:Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary, progressive ischemic disease of small vessels of the brain characterized by migraine with aura (MA), recurrent subcortical ischemic episodes, cognitive decline and psychiatric disorders. CA...

journal_title：Folia neuropathologica

authors： Dorszewska J,Kowalska M,Grzegorski T,Dziewulska D,Karmelita-Katulska K,Barciszewska AM,Prendecki M,Gorczyński W,Kozubski W

更新日期：2020-01-01 00:00:00

abstract：:The investigations were based on 3 cases with Leigh, 5 cases with Krabbe's, 4 cases of Alpers, 2 cases with Sandhoff, 1 case with Alexander's disease and 1 case with metachromatic leukodystrophy. In 1 case included into the study we have diagnosed nonketotic hyperglycinemia II. All the diseases under examination are r...

journal_title：Folia neuropathologica

authors： Kałuza J,Marszał E,Jamroz E,Pietruszewski J

更新日期：1999-01-01 00:00:00

abstract：:The subcellular distribution of glutamate and GABA in synapses of Mongolian gerbils hippocampus was examined using post-embedding immunogold staining method for electron microscopy. Immunolabelling was performed with 10 nm gold-antibody complexes for glutamate and GABA. The gold particle densities gave reliable inform...

journal_title：Folia neuropathologica

authors： Gajkowska B,Gadamski R,Mossakowski M

更新日期：1995-01-01 00:00:00

abstract：:Early reviews identified over 20 risk factors associated with Alzheimer's disease (AD) including age, familial inheritance, exposure to aluminium, traumatic brain injury (TBI), and associated co-morbidities such as vascular disease and infection. In the light of recent evidence, this review reconsiders these risk fact...

journal_title：Folia neuropathologica

authors： A Armstrong R

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Transsphenoidal surgery is the treatment of choice in Cushing's disease (CD), although even late recurrences occur in some patients. Low expression of O-6-methylguanine-DNA methyltransferase (MGMT) has been linked to a high risk of relapse in pituitary tumours, but the evidence for corticotroph adenomas is...

journal_title：Folia neuropathologica

authors： Witek P,Maksymowicz M,Szamotulska K,Piaścik A,Wojciechowska-Luźniak A,Stasiewicz A,Witek J,Zieliński G

更新日期：2020-01-01 00:00:00

abstract：:Cerebellar degeneration belongs to indirect effects of malignancy on the nervous system. Although the involvement of immune system is accepted as a hypothesis of its pathology, the clinical observations of ineffective immunomodulatory therapy suggest complex pathomechanisms, which await elucidation. The aim of this st...

journal_title：Folia neuropathologica

authors： Michalak S,Wender M,Michalowska-Wender G,Kozubski W

更新日期：2010-01-01 00:00:00

abstract：:Tumours of astroglial origin, both malignant glioblastoma (GBM) and benign subependymal giant cell astrocytoma (SEGA), pose a serious medical problem. Casein kinase 2 (CK2), a member of the serine/threonine kinase family, has antiapoptotic properties and plays a vital role in glial tumour cell survival. It contributes...

journal_title：Folia neuropathologica

authors： Pucko E,Ostrowski R,Matyja E

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:Sporadic inclusion body myositis (sIBM) is one of the most common myopathies in patients above 50 years of age. Its progressive course finally leads to immobilisation, and no effective therapy exists. Its pathogenesis includes both degenerative and inflammatory processes, however, its direct causes remain ...

journal_title：Folia neuropathologica

authors： Kierdaszuk B,Berdynski M,Palczewski P,Golebiowski M,Zekanowski C,Kaminska AM

更新日期：2015-01-01 00:00:00

abstract：:A case of the 18-year-old boy suffering from epilepsy since 8 years and suspected of microangioma is presented. The craniotomy revealed left parietal parasagittal superficially located neoplasm and arteriovenous malformation beneath. Unexpected fibrillary astrocytoma associated with vascular tumor was the diagnostic p...

journal_title：Folia neuropathologica

authors： Kroh H,Bidziński J,Majchrowski A

更新日期：1994-01-01 00:00:00

abstract：:A fetal, cryopreserved ventral mesencephalic rat tissue was transplanted into striatum of healthy adult rats. A stereotactic apparatus was used for transplantation of solid tissue blocks. The survival of transplanted dopaminergic cells in rat striatum was evaluated by means of histological and immunocytochemical metho...

journal_title：Folia neuropathologica

authors： Kosno-Kruszewska E,Wierzba-Bobrowicz T,Ilnicki K,Lechowicz W,Dymecki J

更新日期：1996-01-01 00:00:00

abstract：:The post-mortem neuropathological investigations were carried out on 20 female New Zealand rabbits. Two main types of changes were found: inflammatory, including meningeal and perivascular infiltrates, and thrombotic within the nervous tissue. The findings revealed that active process within the CNS persists at least ...

journal_title：Folia neuropathologica

authors： Nowacki P,Ronin-Walknowska E,Ossowicka-Stepińska J

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Cutaneous anaesthesia in necrobiosis lipoidica (NL) has been attributed to the destruction of nerve fibres by the inflammatory process. In the 1980s, one study demonstrated a decrease in S100 positive neural fibres as proof of this. Thermalgic information is mainly dependent on small fibres, either myelinate...

journal_title：Folia neuropathologica

authors： Fernandez-Flores A

更新日期：2008-01-01 00:00:00

abstract：:A case of 56-year-old male with sarcomatosis of leptomeninges as well as of the brain and spinal cord coexisting with Recklinghausen's neurofibromatosis is presented. Neurological and neurophysiological symptoms of the disease resembled those of amyotrophic lateral sclerosis (ALS). Patient died 7 months after onset of...

journal_title：Folia neuropathologica

authors： Słowiński J,Adamek D,Krygowska-Wajs A,Rudzińska M,Kałuza J

更新日期：1995-01-01 00:00:00

abstract：:Since the earliest descriptions of the disease, senile plaques (SP) and neurofibrillary tangles (NFT) have been regarded as the pathological 'hallmarks' of Alzheimer's disease (AD). Whether or not SP and NFT are sufficient cause to explain the neurodegeneration of AD is controversial. The major molecular constituents ...

journal_title：Folia neuropathologica

authors： Armstrong RA

更新日期：2009-01-01 00:00:00

abstract：:The 'prion-like' transfer of pathogenic proteins may play a role in the pathogenesis of frontotemporal lobar degeneration (FTLD). Propagation of such proteins along anatomical pathways may give rise to specific spatial patterns of the 'signature' neuronal cytoplasmic inclusions (NCI) characteristic of these disorders....

journal_title：Folia neuropathologica

authors： A Armstrong R

更新日期：2017-01-01 00:00:00

abstract：:There is an increased risk of stroke in patients with HIV infection. One of the mechanisms is production of anticardiolipin (aCL) antibodies, induced by the virus. Many studies have documented a high incidence of aCL antibodies in patients with HIV infection and the increased risk of stroke, although there is no such ...

journal_title：Folia neuropathologica

authors： Gorczyca I,Stanek M,Podlasin B,Furmanek M,Pniewski J

更新日期：2005-01-01 00:00:00

abstract：:Forty human primary brain tumors: twelve protoplasmic, six gemistocytic, four fibrillary and ten anaplastic astrocytomas, eight glioblastomas were submitted for immunohistochemical and histochemical characterization of microglia in tumor tissue and in its surroundings. The following antibodies were used: GFAP, ferriti...

journal_title：Folia neuropathologica

authors： Wierzba-Bobrowicz T,Kuchna I,Matyja E

更新日期：1994-01-01 00:00:00

abstract：:Angiocentric glioma (AG) is a newly-classified, very rare, WHO grade I central nervous system (CNS) lesion, occurring usually in children and young adults. Only 52 patients with AG have been reported so far, making it one of the rarest neuropathological entities. Hereby we present two new cases of AG in young subjects...

journal_title：Folia neuropathologica

authors： Adamek D,Siwek GP,Chrobak AA,Herman-Sucharska I,Kwiatkowski S,Morga R,Radwańska E,Urbanowicz B

更新日期：2016-01-01 00:00:00

abstract：:Neuroacanthocytosis is a rare disease of nervous system with multisystem pathology. This review presents clinical syndromes and morphological changes of sporadic and familial forms of neuroacanthocytosis and is illustrated by the case of a 27-year-old man. Progressive extrapyramidal syndrome appeared at the age of 22....

journal_title：Folia neuropathologica

authors： Rafałowska J,Drac H,Jamrozik Z

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:Activated microglia produce neurotoxic factors, including pro-inflammatory cytokines and nitric oxide (NO), in response to neuronal destruction. Therapeutic suppression of microglial release of these factors by various approaches including hypothermia is considered to be neuroprotective after severe brain ...

journal_title：Folia neuropathologica

authors： Matsui T,Kida H,Iha T,Obara T,Nomura S,Fujimiya T,Suzuki M

更新日期：2014-01-01 00:00:00

abstract：:Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare transmissible disease caused by accumulation of pathological prion protein in the CNS. sCJD typically affects patients in their sixties. The median disease duration in sCJD (6 months) is shorter than in variant Creutzfeldt-Jakob disease (vCJD) (14 months). The clinic...

journal_title：Folia neuropathologica

authors： Krasnianski A,Meissner B,Heinemann U,Zerr I

更新日期：2004-01-01 00:00:00

abstract：:Inherited neurodegenerative disorders are debilitating diseases that occur across different species, such as the domestic dog (Canis lupus familiaris), and many are caused by mutations in the same genes as corresponding human conditions. In the present study, we report an inherited neurodegenerative condition, term...