解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Melanin is a polyanionic pigment that colors, e.g., the hair, skin and eyes. The pigment neuromelanin is closely related to melanin and is mainly produced in specific neurons of the substantia nigra. Certain drugs and chemicals bind to melanin/neuromelanin and are retained in pigment cells for long periods. This speci...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1757-0
更新日期:2016-08-01 00:00:00
abstract::Some nucleoside analogues are used to treat herpes simplex and other viral infections. They are known to impair spermatogenesis, but published data are scarce. We studied the effects of four nucleosides on SerW3 cells, a rat Sertoli cell line. Cells were cultured for 3 days in DMEM supplemented with four different con...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-016-1743-6
更新日期:2016-08-01 00:00:00
abstract::Treatment of tuberculosis (TB) has been a therapeutic challenge because of not only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also the newly acquired mutations that confer further resistance. Currently standardized regimens require patients to daily ingest up to four drugs un...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-016-1727-6
更新日期:2016-07-01 00:00:00
abstract::New strategies are needed to address the data gap between the bioactivity of chemicals in the environment versus existing hazard information. We address whether a high-throughput screening (HTS) system using a vertebrate organism (embryonic zebrafish) can characterize chemical-elicited behavioral responses at an early...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1554-1
更新日期:2016-06-01 00:00:00
abstract::Environmental carcinogens-induced lung cancer and potential mechanisms have attracted widespread attention. Currently, microRNAs (miRNAs) have been recognized as key players in development of cancer, among which guide strand of miRNA has been well documented rather than its passenger strand (miRNA*). Our previous stud...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1551-4
更新日期:2016-05-01 00:00:00
abstract::Unsaturated compounds are known to cause false-positive reactions in the local lymph node assay (LLNA) but not in the guinea pig maximization test. We have tested a panel of substances (succinic acid, undecylenic acid, 1-octyn-3-ol, fumaric acid, maleic acid, linoleic acid, oleic acid, alpha-linolenic acid, squalene, ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1527-4
更新日期:2016-04-01 00:00:00
abstract::During/after the BP/Deepwater Horizon oil spill, cleanup workers, fisherpersons, SCUBA divers, and coastal residents were exposed to crude oil and dispersants. These people experienced acute physiological and behavioral symptoms and consulted a physician. They were diagnosed with petroleum hydrocarbon poisoning and ha...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1526-5
更新日期:2016-04-01 00:00:00
abstract::The associations of four single nucleotide polymorphisms (p.Arg194Trp, p.Arg280His, p.Pro206Pro, and p.Arg399Gln) in X-ray repair cross-complementing group 1 with urinary arsenic metabolites and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were investigated in a Vietnamese population (n = 100). Individuals with genotype AA in...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1490-0
更新日期:2016-04-01 00:00:00
abstract::We analyzed adverse events in a clinical phase I trial to assess dose-dependent metabolic effects of St. John's wort co-administered with rifampicin in 12 healthy volunteers. Within 3-6 days after increasing the St. John's wort dose from 300 to 600 mg TID, five of six female participants developed ambient temperature-...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1532-7
更新日期:2016-04-01 00:00:00
abstract::Chronic arsenite exposure induces immunosuppression, but the precise mechanisms remain elusive. Our previous studies demonstrated that arsenite exposure for 24 h induces G0/G1 arrest in mouse B lymphoma A20 cells and the arrest is caused through induction of cyclin-dependent kinase inhibitor p16(INK4a) followed by acc...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1500-2
更新日期:2016-04-01 00:00:00
abstract::The acute toxicity of cyanide is determined by its peak levels reached in the body. Compared to the ingestion of free cyanide, lower peak levels may be expected after consumption of foods containing cyanogenic glycosides with the same equivalent dose of cyanide. This is due to possible delayed and/or incomplete releas...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1479-8
更新日期:2016-03-01 00:00:00
abstract::The organophosphorus (OP) pesticide malathion is a neurotoxic compound whose acute toxicity is primarily caused by the inhibition of acetylcholinesterase (AChE), leading to cholinergic syndrome-related symptoms. Some lines of evidence indicate that long-term exposure to low levels of OP may produce neuropsychiatric an...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1466-0
更新日期:2016-03-01 00:00:00
abstract::Steatosis, also known as fatty liver disease (FLD), is a disorder in which the lipid metabolism of the liver is disturbed, leading to the abnormal retention of lipids in hepatocytes. FLD can be induced by several drugs, and although it is mostly asymptomatic, it can lead to steatohepatitis, which is associated with li...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1483-z
更新日期:2016-03-01 00:00:00
abstract::The first withdrawal of certain polybrominated diphenyl ethers flame retardants from the US market occurred in 2004. Since then, use of brominated non-PBDE compounds such as bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (BEH-TEBP) and 2-ethylhexyl-2,3,4,5-tetrabromobenzoate (EH-TBB) in commercial formulations has incr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1489-6
更新日期:2016-03-01 00:00:00
abstract::The α,β-unsaturated carbonyl group is recognized as alert for mutagenicity, attributed to (1) its direct reaction with DNA, counteractable by glutathione (GSH), and (2) oxidative stress caused indirectly by GSH depletion. Accordingly, the α,β,γ,δ-unsaturated lactone patulin (PAT), a mycotoxin detected in fruits and pr...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1443-z
更新日期:2016-02-01 00:00:00
abstract::5-Hydroxymethylfurfural (HMF) and furfuryl alcohol (FFA) are moderately potent rodent carcinogens that are present in thermally processed foodstuffs. The carcinogenic effects were hypothesized to originate from sulfotransferase (SULT)-mediated bioactivation yielding DNA-reactive and mutagenic sulfate esters, a confirm...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1392-6
更新日期:2016-01-01 00:00:00
abstract::Amanita phalloides is responsible for more than 90 % of mushroom-related fatalities, and no effective antidote is available. α-Amanitin, the main toxin of A. phalloides, inhibits RNA polymerase II (RNAP II), causing hepatic and kidney failure. In silico studies included docking and molecular dynamics simulation couple...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-015-1582-x
更新日期:2015-12-01 00:00:00
abstract::Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and de...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1633-3
更新日期:2015-12-01 00:00:00
abstract::Alternative methods to detect non-genotoxic carcinogens are urgently needed, as this class of carcinogens goes undetected in the current testing strategy for carcinogenicity under REACH. A complicating factor is that non-genotoxic carcinogens act through several distinctive modes of action, which makes prediction of t...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1368-6
更新日期:2015-12-01 00:00:00
abstract:UNLABELLED:An overdose of acetaminophen (APAP) causes hepatotoxicity due to its metabolite, N-acetyl-p-benzoquinone imine. NAD(P)H:quinone oxidoreductase 1 (NQO1) is an important enzyme for detoxification, because it catabolizes endogenous/exogenous quinone to hydroquinone. Although various studies have suggested the ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1340-5
更新日期:2015-11-01 00:00:00
abstract::To reveal the molecular mechanism of deficit in learning and memory induced by chronic fluorosis, the expression of muscarinic acetylcholine receptors (mAChRs) and oxidative stress were investigated. Sixty Sprague-Dawley (SD) rats were divided randomly into two groups (30 cases in each), i.e., the control group (<0.5 ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1408-2
更新日期:2015-11-01 00:00:00
abstract::Environmental tobacco smoke (ETS) is associated with high morbidity and mortality, mainly in children. However, few studies focus on the brain development effects of ETS exposure. Myelination mainly occurs in the early years of life in humans and the first three postnatal weeks in rodents and is sensitive to xenobioti...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1343-2
更新日期:2015-11-01 00:00:00
abstract::Chronic ethanol consumption is a strong risk factor for the development of liver disease. Multiple mechanisms are involved in ethanol-mediated liver injury; oxidative stress being pointed has an important factor. However, it should be noted that moderate consumption of red wine has been associated with hepatoprotectiv...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1538-1
更新日期:2015-10-01 00:00:00
abstract::Fumonisin B1 (FB1) is a well-known inhibitor of de novo sphingolipid biosynthesis, due to its ability to inhibit ceramide synthases (CerS) activity. In mammals, this toxin triggers broad clinical symptoms with multi-organ dysfunction such as hepatotoxicity or pulmonary edema. The molecular mechanism of CerS inhibition...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1323-6
更新日期:2015-09-01 00:00:00
abstract::Perfluoroalkyl acids are widely used in numerous industrial and commercial applications due to their unique physical and chemical characteristics. Although perfluorooctanoic acid (PFOA) is associated with hepatomegaly through peroxisome proliferator-activated receptor α (PPARα) activation, liver fat accumulation and c...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1322-7
更新日期:2015-09-01 00:00:00
abstract::With the development of nanotechnology, myriad types of novel materials have been discovered at the nanoscale, among which the most interesting material is graphene. However, the toxicity data available on graphene are extremely limited. In this study, we explored toxic response of commercially available graphene nano...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1303-x
更新日期:2015-09-01 00:00:00
abstract::The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investigated the association of personal exposure to metals in respirable welding fumes during a working shift with oxi...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1319-2
更新日期:2015-08-01 00:00:00
abstract::In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly se...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1309-4
更新日期:2015-08-01 00:00:00
abstract::Increasing evidence suggests that free radical-mediated oxidation of biological substrates is a key feature of Alzheimer's disease (AD) pathogenesis. While it has long been established that biomarkers of lipid peroxidation (LPO) are elevated in AD brain as well as ventricular CSF postmortem, more recent studies have d...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1517-6
更新日期:2015-07-01 00:00:00
abstract::The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in the field of cancer research from last few decades. Aberrant activation of this transcription factor is frequently encountered in a variety of solid tumors and hematological malignancies. NF-κB family members and their regula...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-015-1470-4
更新日期:2015-05-01 00:00:00
abstract::Pregnane X receptor (PXR) is a nuclear receptor that plays a key regulatory role in xenobiotic metabolism in a ligand-dependent manner. Recently, ethanol was reported to be either an inducer or inhibitor of Cytochrome P450 (CYP) 3A expression. According to our recent microarray data, chronic ethanol upregulates the ex...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1268-9
更新日期:2015-04-01 00:00:00
abstract::Overdose of acetaminophen (APAP) causes necrosis of centrilobular cells of the liver. Accumulating evidence suggests that innate immune system may contribute to APAP-induced hepatotoxicity. Interaction between RANTES and its receptor C-C chemokine receptor (CCR) 5 is related to recruitment of macrophages to sites of i...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1253-3
更新日期:2015-02-01 00:00:00
abstract::Inhibition mechanism(s) of protein kinase B/Akt1 and its consequences on related cell signaling were investigated in human neuroblastoma SH-SY5Y cells exposed to 4-hydroxy-trans-2-nonenal (4-HNE), one of the most reactive aldehyde by-products of lipid peroxidation. In silico data indicate that 4-HNE interacts with kin...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1260-4
更新日期:2015-02-01 00:00:00
abstract::The development of non-animal methodology to evaluate the potential for a chemical to cause systemic toxicity is one of the grand challenges of modern science. The European research programme SEURAT is active in this field and will conclude its first phase, SEURAT-1, in December 2015. Drawing on the experience gained ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1421-5
更新日期:2015-01-01 00:00:00
abstract::Two Ceria nanomaterials (NM-211 and NM-212) were tested for inhalation toxicity and organ burdens in order to design a chronic and carcinogenicity inhalation study (OECD TG No. 453). Rats inhaled aerosol concentrations of 0.5, 5, and 25 mg/m(3) by whole-body exposure for 6 h/day on 5 consecutive days for 1 or 4 weeks ...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1349-9
更新日期:2014-11-01 00:00:00
abstract::Epoxide hydrolases (EH) are ubiquitously expressed in all living organisms and in almost all organs and tissues. They are mainly subdivided into microsomal and soluble EH and catalyze the hydration of epoxides, three-membered-cyclic ethers, to their corresponding dihydrodiols. Owning to the high chemical reactivity of...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-014-1371-y
更新日期:2014-11-01 00:00:00
abstract::Nephrotoxicity is a major side effect of cisplatin in chemotherapy. Pathologically, cisplatin nephrotoxicity is characterized by cell injury and death in renal tubules. The research in the past decade has gained significant understanding of the cellular and molecular mechanisms of tubular cell death, revealing a centr...
journal_title:Archives of toxicology
pub_type: 杂志文章,评审
doi:10.1007/s00204-014-1239-1
更新日期:2014-06-01 00:00:00
abstract::Brominated flame retardants (BFRs) are abundant persistent organic pollutants with well-studied toxicity. The toxicological and ecological concerns associated with BFRs argue for replacement by safe(r) alternatives. Though previous research identified the nervous system as a sensitive target organ for BFRs, the (neuro...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1187-1
更新日期:2014-04-01 00:00:00
abstract::It is estimated that only a few marketed drugs are able to directly induce liver steatosis. However, many other drugs may exacerbate or precipitate fatty liver in the presence of other risk factors or in patients prone to non-alcoholic fatty liver disease. On the other hand, current in vitro tests for drug-induced ste...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-014-1197-7
更新日期:2014-04-01 00:00:00
abstract::3-monochloropropane-1,2-diol (3-MCPD), a rat renal and testicular carcinogen, has been reported to occur in various foods and food ingredients as free or esterified forms. Since reports about toxicity of 3-MCPD esters are limited, we conducted a 13-week rat subchronic toxicity study of 3-MCPD esters (palmitate diester...
journal_title:Archives of toxicology
pub_type: 杂志文章
doi:10.1007/s00204-013-1190-6
更新日期:2014-04-01 00:00:00