abstract：:Administrative data research on maternal racial disparities supports 2 broad clinical inferences. First, failure to rescue in terms of both death and severe maternal morbidity likely accounts for a significant proportion of maternal disparities. Second, risk for adverse outcomes by race is generally differential with ...

journal_title：Clinics in perinatology

authors： Friedman A

更新日期：2020-12-01 00:00:00

abstract：:Several limitations and controversies surround the definition of hypotension; however, it remains one of the most common problems faced by neonates. Approximately 15% to 30% of neonates with hypotension fail to respond to volume and/or vasopressor or inotropes. They are considered to have refractory hypotension. Altho...

journal_title：Clinics in perinatology

authors： Kumbhat N,Noori S

更新日期：2020-09-01 00:00:00

abstract：:Gastrointestinal endoscopy permits direct observation of the alimentary tract, acquisition of mucosal tissue for histopathologic examination, and other diagnostic and therapeutic maneuvers. Endoscopes of appropriate size for many neonates and an expanding array of compatible tools and accessories have broadened what i...

journal_title：Clinics in perinatology

authors： Mezoff EA,Williams KC,Erdman SH

更新日期：2020-06-01 00:00:00

abstract：:Gastroesophageal reflux (GER) is considered physiologic and is a normal process; whereas, when aerodigestive consequences are associated, it is often interpreted as GER disease (GERD). However, the distinction between them remains a challenge in infants in the NICU. Reflux-type of symptoms are heterogeneous, and often...

journal_title：Clinics in perinatology

authors： Hasenstab KA,Jadcherla SR

更新日期：2020-06-01 00:00:00

abstract：:Severe combined immunodeficiency (SCID) encompasses a group of genetic defects. T cell development is universally affected and has alteration of B and/or NK cells. We present the case of a 5-day-old boy with combined heterozygous frame shift (c.256_257del, p.(Lys86Valfs*33)) and missense (c.1186C>T, p.(Arg396Cys)) var...

journal_title：Clinics in perinatology

authors： Tallar M,Routes J

更新日期：2020-03-01 00:00:00

abstract：:Mitochondrial disorders present in a myriad of ways, which causes them to be included in the differential diagnosis for many patients with undiagnosed disease. A subset of mitochondrial disorders are caused by intrinsic defects in the mitochondrial replication machinery, leading to loss of cellular mitochondrial conte...

journal_title：Clinics in perinatology

authors： Basel D

更新日期：2020-03-01 00:00:00

abstract：:The incidence of neonatal abstinence syndrome owing to prenatal opioid exposure has grown rapidly in recent decades and it disproportionately affects rural, non-white, and public insurance-dependent populations. Treatment consists of pharmacologic and nonpharmacologic interventions with wide variability in approaches ...

journal_title：Clinics in perinatology

authors： MacMillan KDL

更新日期：2019-12-01 00:00:00

abstract：:Diagnostic and invasive procedures in premature infants may require general anesthesia. General anesthetics interfere with the development of the immature animal brain. Accelerated apoptosis, disturbed synaptogenesis, and cytoarchitecture are among the mechanisms suspected to underlie this phenomenon. The implications...

journal_title：Clinics in perinatology

authors： Clausen NG,Hansen TG,Disma N

更新日期：2019-12-01 00:00:00

abstract：:Infants in the Neonatal Oxygenation Prospective Meta-analysis trials were randomized to SpO2 targets of 85% to 89% or 91% to 95%. Group allocation was masked. Different outcomes are likely partially attributable to differences in achieved SpO2. Infants randomized to the lower range had higher than intended readings. S...

journal_title：Clinics in perinatology

authors： Stenson BJ

更新日期：2019-09-01 00:00:00

abstract：:Oxygen therapy is an essential part of neonatal care. Targeting oxygen saturations and preventing hypoxemia and hyperoxemia is difficult, particularly in preterm infants. The mode of oxygen delivery directly affects the stability of oxygen saturations, hypoxemia, and hyperoxemia. This stability has important clinical ...

journal_title：Clinics in perinatology

authors： Travers CP,Carlo WA

更新日期：2019-09-01 00:00:00

abstract：:There is a distinct lack of age-appropriate cardiotonic drugs, and adult derived formulations continue to be administered, without evidence-based knowledge on their dosing, safety, efficacy, and long-term effects. Dopamine remains the most commonly studied and prescribed cardiotonic drug in the neonatal intensive care...

journal_title：Clinics in perinatology

authors： Dempsey E,Rabe H

更新日期：2019-06-01 00:00:00

abstract：:Necrotizing enterocolitis (NEC) is a devastating bowel necrosis that predominantly affects preterm infants and is characterized by an imbalance toward a proinflammatory state. Fish oil or omega-3 long-chain polyunsaturated fatty acids have the potential to modulate inflammation. In this article, the authors examine th...

journal_title：Clinics in perinatology

authors： Frost BL,Caplan MS

更新日期：2019-03-01 00:00:00

abstract：:Stridor, a common presenting sign of respiratory distress in a newborn, has many systemic causes. It may arise from the larynx or the tracheobronchial airway. This article presents the most common pathologic conditions in this anatomic region, with highlights on management. ...

journal_title：Clinics in perinatology

authors： Bhatt J,Prager JD

更新日期：2018-12-01 00:00:00

abstract：:Dysphagia and aspiration are commonly encountered problems in the neonatal population. It is often multifactorial in nature and management should be tailored to the individual patient. Multiple causes should be considered, including anatomic abnormalities, neurologic/developmental delay, cardiopulmonary disease/infect...

journal_title：Clinics in perinatology

authors： Raol N,Schrepfer T,Hartnick C

更新日期：2018-12-01 00:00:00

abstract：:Outcomes of neonatal intensive care unit (NICU) graduates have been categorized by rates of neurodevelopmental impairment at 2 years old. Although useful as metrics for research, these early childhood assessments may underestimate or overestimate later functional capabilities. Often overlooked are less severe but more...

journal_title：Clinics in perinatology

authors： Kilbride HW,Aylward GP,Carter B

更新日期：2018-09-01 00:00:00

abstract：:Congenital cytomegalovirus is the most common viral congenital infection, and affects up to 2% of neonates. Significant sequelae may develop after congenital cytomegalovirus, including hearing loss, cognitive defects, seizures, and death. Zika virus is an emerging virus with perinatal implications; a congenital Zika v...

journal_title：Clinics in perinatology

authors： Wood AM,Hughes BL

更新日期：2018-06-01 00:00:00

abstract：:Billions of dollars are spent yearly in perinatal medicine on studies designed to improve outcomes for mothers and their neonates. However, implementing research findings is challenging and imperfect. Strategies for implementation must be multifaceted and comprehensive. These implementation challenges extend to, and a...

journal_title：Clinics in perinatology

authors： Manuck TA,Fry RC,McFarlin BL

更新日期：2018-06-01 00:00:00

abstract：:Neonatal Cushing syndrome (CS) is most commonly caused by exogenous administration of glucocorticoids and rarely by endogenous hypercortisolemia. CS owing to adrenal lesions is the most common cause of endogenous CS in neonates and infants, and adrenocortical tumors (ACTs) represent most cases. Many ACTs develop in th...

journal_title：Clinics in perinatology

authors： Tatsi C,Stratakis CA

更新日期：2018-03-01 00:00:00

abstract：:Congenital lung lesions (CLLs) comprise a heterogeneous group of developmental and histologic entities often diagnosed on screening prenatal ultrasound. Most fetuses with CLL are asymptomatic at birth; however, the risk of malignancy and infection drives the decision to prophylactically resect these lesions. The autho...

journal_title：Clinics in perinatology

authors： Moyer J,Lee H,Vu L

更新日期：2017-12-01 00:00:00

abstract：:Each year, approximately 2.7 million babies die during the neonatal period; more than 90% of these deaths occur in developing countries, largely from preventable causes. The known, evidence-based, simple, low-cost interventions that may improve neonatal survival often have low or unknown baseline coverage rates. Gaps ...

journal_title：Clinics in perinatology

authors： Ehret DY,Patterson JK,Bose CL

更新日期：2017-09-01 00:00:00

abstract：:Emphasis has been placed on engaging parents in processes of shared decision making for delivery room management decisions of critically ill neonates whose outcomes are uncertain and unpredictable. The goal of antenatal consultation should rather be to adapt to parental needs and empower them through a personalized de...

journal_title：Clinics in perinatology

authors： Haward MF,Gaucher N,Payot A,Robson K,Janvier A

更新日期：2017-06-01 00:00:00

abstract：:Periviable birth carries a high risk of fetal and newborn death, and the potential for life-long complications in survivors. The family at risk for periviable birth should receive objective, accurate, and up to date information regarding fetal, newborn, and maternal risks and outcomes with delivery or with continued p...

journal_title：Clinics in perinatology

authors： Mercer BM

更新日期：2017-06-01 00:00:00

abstract：:The neurodevelopmental benefits of breast milk feedings for preterm infants have been controversial. However, the effect on preterm infant neurodevelopment is sustained into childhood. The effects of breast milk feeding during the neonatal period and the duration of breastfeeding display effects on cognition into adol...

journal_title：Clinics in perinatology

authors： Lechner BE,Vohr BR

更新日期：2017-03-01 00:00:00

abstract：:Cytomegalovirus (CMV) is reactivated in the lactating breast in up to 96% of CMV seropositive mothers. There is a relevant entity of postnatally acquired symptomatic CMV infection and disease of preterm infants through raw breast milk (BM). Actual data support negative influence on long-term cognitive development. Con...

journal_title：Clinics in perinatology

authors： Hamprecht K,Goelz R

更新日期：2017-03-01 00:00:00

abstract：:Although continuous positive airway pressure (CPAP) is an effective strategy to prevent invasive ventilation, failure rates are high and many babies require endotracheal intubation. Prolonged exposure to mechanical ventilation is linked with bronchopulmonary dysplasia and other morbidities. Different techniques of nas...

journal_title：Clinics in perinatology

authors： Waitz M,Mense L,Kirpalani H,Lemyre B

更新日期：2016-12-01 00:00:00

abstract：:Continuous positive airway pressure (CPAP) systems can be broadly grouped into continuous flow or variable flow devices. Bubble CPAP (bCPAP) is a continuous flow device and has physiologic properties that could facilitate gas exchange. Its efficacy has been reported to be similar to variable flow CPAP systems when use...

journal_title：Clinics in perinatology

authors： Gupta S,Donn SM

更新日期：2016-12-01 00:00:00

abstract：:Although therapies in addition to whole-body cooling are being developed to treat the neonate at risk for hypoxic-ischemic encephalopathy, we have no quickly measured serum inflammatory or neuronal biomarkers to acutely and accurately identify brain injury or to follow the efficacy of therapy. This review covers infla...

journal_title：Clinics in perinatology

authors： Chalak LF

更新日期：2016-09-01 00:00:00

abstract：:Although hyperbilirubinemia is extremely common among neonates and is usually mild and transient, it sometimes leads to bilirubin-induced neurologic damage (BIND). The auditory pathway is highly sensitive to the effects of elevated total serum/plasma bilirubin (TB) levels, with damage manifesting clinically as auditor...

journal_title：Clinics in perinatology

authors： Olds C,Oghalai JS

更新日期：2016-06-01 00:00:00

abstract：:Pulmonary hypertension in the perinatal period can present acutely (persistent pulmonary hypertension of the newborn) or chronically. Clinical and echocardiographic diagnosis of acute pulmonary hypertension is well accepted but there are no broadly validated criteria for echocardiographic diagnosis of pulmonary hypert...

journal_title：Clinics in perinatology

authors： Keller RL

更新日期：2016-03-01 00:00:00

abstract：:Cardiovascular malformations (CVMs) are the most common birth defect, occurring in 1% to 5% of all live births. Genetic, epigenetic, and environmental factors all influence the development of CVMs, and an improved understanding of the causation of CVMs is a prerequisite for prevention. Cardiac development is a complex...

journal_title：Clinics in perinatology

authors： Azhar M,Ware SM

更新日期：2016-03-01 00:00:00

abstract：:Oxygen saturation targeting is widely used in neonatal intensive care, but the optimal target range in very preterm infants has been uncertain and is the subject of recent debate and research. This review briefly discusses the technology of oxygen monitoring and the role of oxygen toxicity in preterm infants. The back...

journal_title：Clinics in perinatology

authors： Darlow BA,Morley CJ

更新日期：2015-12-01 00:00:00

abstract：:Stem cell transplantation (SCT) is an established first-line or adjunctive therapy for a variety of neonatal and adult diseases. New evidence in preclinical models as well as a few human studies show the potential utility of SCT in neuroprotection and in the modulation of inflammatory injury in at risk-neonates. This ...

journal_title：Clinics in perinatology

authors： Yoshimoto M,Koenig JM

更新日期：2015-09-01 00:00:00

abstract：:Congenital heart defects (CHDs) are structural abnormalities of the heart and great vessels that are present from birth. The presence or absence of extracardiac anomalies has historically been used to identify patients with possible monogenic, chromosomal, or teratogenic CHD causes. These distinctions remain clinicall...

journal_title：Clinics in perinatology

authors： Cowan JR,Ware SM

更新日期：2015-06-01 00:00:00

abstract：:Staphylococci are common pathogens in the neonatal period. Increased survival of premature infants leads to prolonged hospital stay with associated risk factors for developing invasive staphylococcal disease. Challenges of diagnosing coagulase-negative staphylococcal infections result in conflicting definitions and in...

journal_title：Clinics in perinatology

authors： Blanchard AC,Quach C,Autmizguine J

更新日期：2015-03-01 00:00:00

abstract：:As a standard of care for preterm/term newborns effective pain management may improve their clinical and neurodevelopmental outcomes. Neonatal pain is assessed using context-specific, validated, and objective pain methods, despite the limitations of currently available tools. Therapeutic approaches reducing invasive p...

journal_title：Clinics in perinatology

authors： Hall RW,Anand KJ

更新日期：2014-12-01 00:00:00

abstract：:Glomerular disorders in infancy can include nephrotic and nephritic syndromes. Congenital nephrotic syndrome (CNS) is most commonly caused by single gene mutations in kidney proteins, but may also be due to congenital infections or passive transfer of maternal antibodies that target kidney proteins. Prenatal findings ...

journal_title：Clinics in perinatology

authors： Rheault MN

更新日期：2014-09-01 00:00:00

abstract：:The American Academy of Pediatrics supports the feeding of human milk for all infants. Very-low-birth-weight and extremely low-birth-weight infants especially can benefit from the immune and neurodevelopmental effects of human milk. However, human milk alone is nutritionally inadequate for the rapid growth of the very...

journal_title：Clinics in perinatology

authors： Adamkin DH,Radmacher PG

更新日期：2014-06-01 00:00:00

abstract：:This article explains the mechanisms underlying choices of pharmacotherapy for hypoxic-ischemic insults of both preterm and term babies. Some preclinical data are strong enough that clinical trials are now underway. Challenges remain in deciding the best combination therapies for each age and insult. ...

journal_title：Clinics in perinatology

authors： Juul SE,Ferriero DM

更新日期：2014-03-01 00:00:00

abstract：:The increased vulnerability of late preterm infants is no longer a novel concept in neonatology, with many studies documenting excess morbidity and mortality in these infants during the birth hospitalization. Because outcomes related to gestational age constitute a continuum, it is important to analyze data from the g...

journal_title：Clinics in perinatology

authors： Kuzniewicz MW,Parker SJ,Schnake-Mahl A,Escobar GJ

更新日期：2013-12-01 00:00:00

abstract：:Moderate preterm, late preterm, and early term deliveries represent a major and growing public health concern. These deliveries are associated with significant financial burden and pose serious risks to mothers and newborns. Women who deliver at moderate and late gestational ages in one pregnancy are at increased risk...

journal_title：Clinics in perinatology

authors： Ananth CV,Friedman AM,Gyamfi-Bannerman C

更新日期：2013-12-01 00:00:00