Genetic and Developmental Basis of Cardiovascular Malformations.

Abstract:

:Cardiovascular malformations (CVMs) are the most common birth defect, occurring in 1% to 5% of all live births. Genetic, epigenetic, and environmental factors all influence the development of CVMs, and an improved understanding of the causation of CVMs is a prerequisite for prevention. Cardiac development is a complex, multistep process of morphogenesis that is under genetic regulation. Although the genetic contribution to CVMs is well recognized, the genetic causes of human CVMs are still identified infrequently. This article discusses the key genetic concepts characterizing human CVMs, their developmental basis, and the critical developmental and genetic concepts underlying their pathogenesis.

journal_name

Clin Perinatol

journal_title

Clinics in perinatology

authors

Azhar M,Ware SM

doi

10.1016/j.clp.2015.11.002

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

39-53

issue

1

eissn

0095-5108

issn

1557-9840

pii

S0095-5108(15)00123-2

journal_volume

43

pub_type

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