Abstract：
:The incidence of neonatal abstinence syndrome owing to prenatal opioid exposure has grown rapidly in recent decades and it disproportionately affects rural, non-white, and public insurance-dependent populations. Treatment consists of pharmacologic and nonpharmacologic interventions with wide variability in approaches across the United States. Standardizing clinical assessment, minimizing unnecessary interruptions, and prioritizing nonpharmacologic and family-centered care seems to improve hospital outcomes. Neonatal abstinence syndrome may have long-term developmental and biological effects, but understanding is limited owing in part confounding biosocial factors. Early intervention and longitudinal support of the infant and family promote better outcomes.
journal_name
Clin Perinatoljournal_title
Clinics in perinatologyauthors
MacMillan KDLdoi
10.1016/j.clp.2019.08.012subject
Has Abstractpub_date
2019-12-01 00:00:00pages
817-832issue
4eissn
0095-5108issn
1557-9840pii
S0095-5108(19)30100-9journal_volume
46pub_type
杂志文章,评审abstract：:The percentage of United States cesarean births increased from 20.7% in 1996 to 31.1% in 2006. Cesarean rates increased for women of all ages, race/ethnic groups, and gestational ages and in all states. Both primary and repeat cesareans have increased. Increases in primary cesareans in cases of "no indicated risk" hav...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2008.03.007
更新日期：2008-06-01 00:00:00
abstract：:Stem cell transplantation (SCT) is an established first-line or adjunctive therapy for a variety of neonatal and adult diseases. New evidence in preclinical models as well as a few human studies show the potential utility of SCT in neuroprotection and in the modulation of inflammatory injury in at risk-neonates. This ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2015.04.008
更新日期：2015-09-01 00:00:00
abstract：:Insulin resistance appears to be a causative mechanism for the development of essential hypertension. Insulin resistance syndrome consists of a cluster of abnormalities that aggravate preexisting tendencies to develop hypertension, resulting in a cascade of physiologic alterations and ultimately leading to increased r...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1998-12-01 00:00:00
abstract：:The lifespan risk of seizures is highest in the neonatal period. Current therapies have limited efficacy. Although the treatment of neonatal seizures has not changed significantly in the last several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generatio...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2009.08.001
更新日期：2009-12-01 00:00:00
abstract：:To understand medical disorders such as obstructive apnea, or pulmonary aspiration, one must understand the many functions performed by the upper airway. These functions include respiration, airway protection at the face, feeding, and regulation of thoracoabdominal pressure. The neuromuscular mechanisms that perform t...
journal_title：Clinics in perinatology
pub_type： 杂志文章
doi：
更新日期：1992-12-01 00:00:00
abstract：:Neurologically impaired infants have immature, damaged, or abnormally developed nervous systems that may cause abnormalities of sucking and swallowing, among other problems. Sucking abnormalities usually present as absence of the sucking response, weakness or incoordination of sucking and swallowing, or some combinati...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1987-03-01 00:00:00
abstract：:Expertise in neonatal resuscitation is essential for all hospital personnel involved in the care of newborn infants. The guidelines to resuscitation reviewed here have been established by the American Academy of Pediatrics and the American Heart Association and have resulted in significantly improved training and expe...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1999-09-01 00:00:00
abstract：:Correct fluid and electrolyte concentrations are essential to reduce mortality in critically ill infants. The authors list considerations in calculating the necessary maintenance volumes and emphasize the importance of continuous monitoring of data and a review and retabulation every eight hours, because requirements ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1979-03-01 00:00:00
abstract：:A scheme of regionalization is proposed in which a regional perinatal system within a defined geographic area permits access of the high risk mother-fetus and infant to the appropriate level of technology for improved perinatal outcome. ...
journal_title：Clinics in perinatology
pub_type： 杂志文章
doi：
更新日期：1976-09-01 00:00:00
abstract：:Scientific study of prenatal drug exposure and child outcome began a period of substantial growth in the 1970s with a focus on exposure to opiates. By the mid-1980s, attention shifted to cocaine. Most of this research has involved cohort studies in which groups of children are followed up longitudinally from birth. Si...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-01 00:00:00
abstract：:Oxygen saturation targeting is widely used in neonatal intensive care, but the optimal target range in very preterm infants has been uncertain and is the subject of recent debate and research. This review briefly discusses the technology of oxygen monitoring and the role of oxygen toxicity in preterm infants. The back...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2015.08.008
更新日期：2015-12-01 00:00:00
abstract：:Gastroesophageal reflux (GER) is considered physiologic and is a normal process; whereas, when aerodigestive consequences are associated, it is often interpreted as GER disease (GERD). However, the distinction between them remains a challenge in infants in the NICU. Reflux-type of symptoms are heterogeneous, and often...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2020.02.004
更新日期：2020-06-01 00:00:00
abstract：:The LBW infant with congenital heart defects is likely to be at a higher risk for postoperative death and complications than their normal-sized counterparts because of the effects of prematurity and other organ system dysfunction. Current experience, however, does not suggest that waiting to obtain an arbitrary weight...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/s0095-5108(05)70078-6
更新日期：2001-03-01 00:00:00
abstract：:For more than 100 years, three principles have guided the treatment of neonatal asphyxia: maintain body heat, free air passages of obstructions, and stimulate respiration by supplying air to the lungs for oxygenation of the blood. This article addresses the question of which gas, air or 100% oxygen, is best supplied t...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2005.11.003
更新日期：2006-03-01 00:00:00
abstract：:A regionalized system of perinatal care, which draws on the strengths of individual hospitals and corrects any weaknesses, can enhance the level of performance of the community hospital. Although the care of high risk infants takes priority in this system, concern is expressed that routine perinatal care should also r...
journal_title：Clinics in perinatology
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:We emphasize again that the prevalence of maternal infections may vary in different populations, and others might arrive at different estimates about the percentage of infants colonized and, concerning those infants colonized, about the percentage with adverse outcomes. Additionally, many women are colonized or infect...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1997-03-01 00:00:00
abstract：:It is now recognized that pregnancy is associated with significant changes in maternal thyroid function that are largely mediated by the placenta. The author summarizes the understanding of these changes during pregnancy and follows with a discussion of fetal thyroid system ontogenesis. ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1983-10-01 00:00:00
abstract：:Beta-sympathomimetic agents are used extensively in obstetrics to inhibit premature labor. Knowledge of the pharmacology, mode of action on smooth muscle, and cardiovascular and metabolic side effects of these agents is essential for the obstetrician and perinatologist. This review article draws extensively on recent ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1987-12-01 00:00:00
abstract：:Congenital diaphragmatic hernia (CDH) is a common birth anomaly. Absence or presence of liver herniation and determination of lung-to-head ratio are the most accurate predictors of prognosis for fetuses with CDH. Though open fetal CDH repair has been abandoned, fetal endoscopic balloon tracheal occlusion promotes lung...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2012.04.005
更新日期：2012-06-01 00:00:00
abstract：:Familial hypothyroidism results from both thyroidal and extrathyroidal dysfunction. Specific intrathyroidal abnormalities in thyroid hormone synthesis causing goitrous hypothyroidism are iodide trap defect, organification defect, "coupling" defect, iodoprotein defect, and dehalogenase defect. The diagnostic studies fo...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1976-03-01 00:00:00
abstract：:Prematurity is the leading cause of perinatal morbidity and mortality in the industrial world, occurring in 4% to 9% of all deliveries, a rate that has remained unchanged during the past decades. Despite the relative minority of obstetric patients affected by this problem, prematurity is responsible for approximately ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1998-09-01 00:00:00
abstract：:Congenital hemiplegia is the most common form of cerebral palsy in children born at term, and stroke is the number one cause. Neonatal ischemic stroke includes perinatal arterial ischemic stroke, presumed pre- or perinatal stroke, and cerebral sinovenous thrombosis, all of which have emerged as important contributors ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2006.03.008
更新日期：2006-06-01 00:00:00
abstract：:Neutropenia, a below normal concentration of neutrophils in the circulating blood, can be the kinetic result of diminished neutrophil production, excessive neutrophil margination, or accelerated neutrophil utilization and destruction. The significance of neutropenia to the well-being of the subject is dependent, in pa...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1995-09-01 00:00:00
abstract：:Congenital heart disease (CHD) is an attractive target for fetal therapy. With the development of successful neonatal repair for many types of CHD over the last 20 years, fetal therapy has become the next frontier. Concurrent advances in interventional catheterization and fetal imaging provided a foundation for the no...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2009.03.015
更新日期：2009-06-01 00:00:00
abstract：:This article reviews key recent findings in the field of human cortical development. This development is divided into three major time-dependent phases: neural proliferation of inhibitory and excitatory neurons in spatially distinct regions, migration through multiple cellular boundaries, and maturation through morpho...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2009.06.008
更新日期：2009-09-01 00:00:00
abstract：:Emphasis has been placed on engaging parents in processes of shared decision making for delivery room management decisions of critically ill neonates whose outcomes are uncertain and unpredictable. The goal of antenatal consultation should rather be to adapt to parental needs and empower them through a personalized de...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2017.01.006
更新日期：2017-06-01 00:00:00
abstract：:It is clear that prostaglandins and related compounds are important in the physiology and pathophysiology of the perinatal pulmonary circulation. This article focuses on what is known about prostaglandin-related compounds (PRC) in the pulmonary circulation of the developing and newly born mammal. Also included is a di...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1984-10-01 00:00:00
abstract：:Late preterm neonates have unique susceptibilities to infection. The closed setting of the neonatal ICU (NICU) and the immunologic immaturity of premature infants set the state for the development of nosocomial infections. This article discusses infections that might be seen in this population and gives options for di...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2006.09.005
更新日期：2006-12-01 00:00:00
abstract：:Inherited organic acidemias are a group of metabolic disorders currently being described and investigated as gas-liquid chromatography is applied to unexplained diseases of infancy and childhood. Common clinical presentations include attacks of ketoacidosis, unexplained metabolic acidosis, failure of normal developmen...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：
更新日期：1976-03-01 00:00:00
abstract：:Cesarean delivery as a result of maternal request is increasingly popular, leading to important ethical questions. One of the challenging issues is balancing respect for the autonomy of a pregnant woman with concerns of beneficence and nonmaleficence for her and the fetus. The perceived benefit of cesarean section is ...
journal_title：Clinics in perinatology
pub_type： 杂志文章,评审
doi：10.1016/j.clp.2008.03.011
更新日期：2008-06-01 00:00:00
