Prostaglandins, related compounds, and the perinatal pulmonary circulation.

abstract：:The development of the flow-directed pulmonary artery catheter in the early 1970s moved invasive monitoring from the laboratory to the patient's bedside. Its current use in obstetrics is directed toward definition of certain pathophysiologic states unique to pregnancy and toward diagnosis and management of critically ...

journal_title：Clinics in perinatology

authors： Hankins GD

更新日期：1986-12-01 00:00:00

abstract：:Glomerular disorders in infancy can include nephrotic and nephritic syndromes. Congenital nephrotic syndrome (CNS) is most commonly caused by single gene mutations in kidney proteins, but may also be due to congenital infections or passive transfer of maternal antibodies that target kidney proteins. Prenatal findings ...

journal_title：Clinics in perinatology

authors： Rheault MN

更新日期：2014-09-01 00:00:00

abstract：:This article reviews key recent findings in the field of human cortical development. This development is divided into three major time-dependent phases: neural proliferation of inhibitory and excitatory neurons in spatially distinct regions, migration through multiple cellular boundaries, and maturation through morpho...

journal_title：Clinics in perinatology

authors： Diaz AL,Gleeson JG

更新日期：2009-09-01 00:00:00

abstract：:Babies of extremely low birthweight and elderly adults both require expensive and scarce resources, and both have a relatively poor prognosis for survival if they require intensive care. Thus, proposals for rationing often target one or both of these groups. We suspected that although mortality rates might be higher i...

journal_title：Clinics in perinatology

authors： Meadow W,Lantos JD,Mokalla M,Reimshisel T

更新日期：1996-09-01 00:00:00

abstract：:Most allegations in obstetric lawsuits against obstetrician-gynecologists relate in some manner to the management of labor and delivery; few solely involve perceived flaws in prenatal or postpartum care. Although many of these cases accuse the defendant of not having properly monitored the fetus during labor for signs...

journal_title：Clinics in perinatology

authors： Cohen WR,Schifrin BS

更新日期：2007-06-01 00:00:00

abstract：:Neonatology has optimized medical outcomes for high-risk newborns yet neurodevelopmental outcomes continue to be a concern. Basic science, clinical research, and environmental design perspectives have shown the impact of the caregiving environment on the developing brain and the role of professional caregivers in prov...

journal_title：Clinics in perinatology

authors： Browne JV

更新日期：2011-12-01 00:00:00

abstract：:Antimicrobial-resistant pathogens are of increasing concern in the neonatal intensive care unit population. A myriad of resistance mechanisms exist in microorganisms, and management can be complex because broad-spectrum antibiotics are increasingly needed. Control and prevention of antibiotic-resistant organisms (AROs...

journal_title：Clinics in perinatology

authors： Patel SJ,Saiman L

更新日期：2010-09-01 00:00:00

abstract：:This article provides a roadmap for your quality measurement journey. It begins with a discussion of 3 approaches to measurement (improvement, accountability and research) and challenges readers to be clear about why they are measuring. Key milestones along the quality measurement journey are then presented and a fram...

journal_title：Clinics in perinatology

authors： Lloyd RC

更新日期：2010-03-01 00:00:00

abstract：:Despite advances in neonatal medicine, the mortality rate for congenital diaphragmatic hernia remains high. The results of work in animal models suggest that this anomaly may be amenable to in utero surgical correction. In this article, the natural history of congenital diaphragmatic hernia in humans is reviewed, and ...

journal_title：Clinics in perinatology

authors： Neerhof MG,MacGregor SN,Kilner JF

更新日期：1996-09-01 00:00:00

abstract：:Neonatal sepsis continues to take a devastating toll globally. Although adequate to protect against invasive infection in most newborns, the distinct function of neonatal innate host defense coupled with impairments in adaptive immune responses increases the likelihood of acquiring infection early in life, with subseq...

journal_title：Clinics in perinatology

authors： Wynn JL,Levy O

更新日期：2010-06-01 00:00:00

abstract：:The care of extremely premature infants involves a number of complex clinical and ethical issues. The ethical and scientific quality of decisions made in the care of these infants has profound long-term consequences for these infants and their families. In circumstances when it is unclear whether intensive care should...

journal_title：Clinics in perinatology

authors： Tyson JE,Stoll BJ

更新日期：2003-06-01 00:00:00

abstract：:The educational programs that have been developed in newborn special care facilities have two purposes: first, they teach personnel the manual skills that are necessary to manage the sick newborn infant; second, they provide personnel with a better understanding of neonatal pathophysiology so that they can begin to re...

journal_title：Clinics in perinatology

authors： Coen RW

更新日期：1976-09-01 00:00:00

abstract：:Although therapies in addition to whole-body cooling are being developed to treat the neonate at risk for hypoxic-ischemic encephalopathy, we have no quickly measured serum inflammatory or neuronal biomarkers to acutely and accurately identify brain injury or to follow the efficacy of therapy. This review covers infla...

journal_title：Clinics in perinatology

authors： Chalak LF

更新日期：2016-09-01 00:00:00

abstract：:Multiple pregnancies represent a state of magnified nutritional requirements, resulting in a greater nutrient drain on maternal resources and an accelerated depletion of nutritional reserves. Maternal weight gain to 20 weeks and between 20 and 28 weeks has the greatest effect on birthweight in twin and triplet pregnan...

journal_title：Clinics in perinatology

authors： Luke B

更新日期：2005-06-01 00:00:00

abstract：:The incidence of neonatal abstinence syndrome owing to prenatal opioid exposure has grown rapidly in recent decades and it disproportionately affects rural, non-white, and public insurance-dependent populations. Treatment consists of pharmacologic and nonpharmacologic interventions with wide variability in approaches ...

journal_title：Clinics in perinatology

authors： MacMillan KDL

更新日期：2019-12-01 00:00:00

abstract：:Human milk provided by healthy and well-nourished mothers is believed to cover the infant's nutrient requirements during the first half year of life. It is composed of a mixture of nutritive components as well as other bioactive factors with relevant physiologic effects in the neonate infant. Human milk composition ha...

journal_title：Clinics in perinatology

authors： Kunz C,Rodriguez-Palmero M,Koletzko B,Jensen R

更新日期：1999-06-01 00:00:00

abstract：:Medical liability coverage has become increasingly expensive and scarce since 2001, especially for obstetrics and other high-risk specialties. Physicians, whose own fees are constrained, see this as a crisis needing tort reform to cap payouts. Plaintiffs' lawyers fight caps; they blame insurance trends and call for st...

journal_title：Clinics in perinatology

authors： Bovbjerg RR

更新日期：2005-03-01 00:00:00

abstract：:This article discusses the background, methodology, previous clinical studies, and the clinical role and limitations of the noninvasive Doppler technique in the assessment of the cerebral circulation of the newborn infant. ...

journal_title：Clinics in perinatology

authors： Perlman JM

更新日期：1985-02-01 00:00:00

abstract：:Prevention of harm from medication errors has become a national priority. Medication errors in the neonatal intensive care unit are common, and most can be avoided. This article reviews the prevalence and types of medication errors affecting the care of the neonate and summarizes approaches that have been used to redu...

journal_title：Clinics in perinatology

authors： Stavroudis TA,Miller MR,Lehmann CU

更新日期：2008-03-01 00:00:00

abstract：:This article examines the role of biologic and environmental factors in determining the long-term outcomes of extremely low-birth weight infants. Research focusing on follow-up to at least 4 years of age is reviewed. Methodologic issues related to sampling, the use of control groups, and diagnostic criteria are also d...

journal_title：Clinics in perinatology

authors： Lester BM,Miller-Loncar CL

更新日期：2000-06-01 00:00:00

abstract：:The increased vulnerability of late preterm infants is no longer a novel concept in neonatology, with many studies documenting excess morbidity and mortality in these infants during the birth hospitalization. Because outcomes related to gestational age constitute a continuum, it is important to analyze data from the g...

journal_title：Clinics in perinatology

authors： Kuzniewicz MW,Parker SJ,Schnake-Mahl A,Escobar GJ

更新日期：2013-12-01 00:00:00

abstract：:Although it has been customary to treat neonatal jaundice at lower serum bilirubin levels in low-birth weight infants than in term infants, the threshold bilirubin levels and long-term benefits for early treatment of preterm infants have not been validated. This article summarizes and evaluates existing evidence and s...

journal_title：Clinics in perinatology

authors： Cashore WJ

更新日期：2000-03-01 00:00:00

abstract：:When cystic hygroma is detected antenatally, the prognosis is usually poor, and intrauterine or neonatal death are common. This seems especially true for Turner syndrome (the largest etiologic group associated with cystic hygroma) and the lethal multiple pterygium syndromes. However, some fetuses with Turner syndrome,...

journal_title：Clinics in perinatology

authors： Edwards MJ,Graham JM Jr

更新日期：1990-09-01 00:00:00

abstract：:The management of PPHN entered a new era with the development of inhaled NO therapy for the relief of pulmonary hypertension. The wider application of INO therapy and improved ventilation strategies led to a decrease in the need for invasive life-sustaining therapies such as ECMO. The remarkable advances in the unders...

journal_title：Clinics in perinatology

authors： Konduri GG

更新日期：2004-09-01 00:00:00

abstract：:This article summarizes new information on the natural history of maternal varicella and maternal parvovirus B19. Controversies in the therapy of respiratory syncytial virus are presented. Prophylactic and therapeutic immunotherapy of neonatal enteroviral disease are reviewed. ...

journal_title：Clinics in perinatology

authors： Keyserling HL

更新日期：1997-03-01 00:00:00

abstract：:Ischemic perinatal stroke (IPS) occurs in 1 of 2300 to 5000 live births. It is an under-recognized cause of significant long-term disabilities, including hemiplegic cerebral palsy, epilepsy, cognitive delays, and behavioral impairments. The pathophysiology is complex and multifactorial, involving maternal, fetal, plac...

journal_title：Clinics in perinatology

authors： Barnette AR,Inder TE

更新日期：2009-03-01 00:00:00

abstract：:There is a distinct lack of age-appropriate cardiotonic drugs, and adult derived formulations continue to be administered, without evidence-based knowledge on their dosing, safety, efficacy, and long-term effects. Dopamine remains the most commonly studied and prescribed cardiotonic drug in the neonatal intensive care...

journal_title：Clinics in perinatology

authors： Dempsey E,Rabe H

更新日期：2019-06-01 00:00:00

abstract：:Pulmonary hypertension in the perinatal period can present acutely (persistent pulmonary hypertension of the newborn) or chronically. Clinical and echocardiographic diagnosis of acute pulmonary hypertension is well accepted but there are no broadly validated criteria for echocardiographic diagnosis of pulmonary hypert...

journal_title：Clinics in perinatology

authors： Keller RL

更新日期：2016-03-01 00:00:00

abstract：:Using the pregnant woman as a means to medicate her fetus represents a new and exciting therapeutic approach in clinical pharmacology. In years to come, we will see an increase in the use of the currently accepted fetal therapies and an increase in the number of therapies available to the caregiver or clinician aimed ...

journal_title：Clinics in perinatology

authors： Simone C,Derewlany LO,Koren G

更新日期：1994-09-01 00:00:00

abstract：:Normal pregnancy produces profound metabolic alterations that occur, in large part, by the conclusion of the first trimester. Although necessary to support the metabolic needs of the conceptus, the metabolic and cardiovascular changes of pregnancy are well established weeks before the metabolic needs of the fetus and ...

journal_title：Clinics in perinatology

authors： Carpenter MW

更新日期：1993-09-01 00:00:00