解剖学和形态学
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行为科学
心脏和心血管系统
细胞和组织工程学
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牙科,口腔外科和医学
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病毒学
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abstract::This review brings together the past and current methods for synthesizing the classical cucurbit[n]uril (Q[n]), structural variants, and derivatives. Here we refer to the first family of Q[n] as " classical," where the cavity is spheroidal and carry no substituents at any of the equatorial methine carbons or the methy...
journal_title:Chirality
pub_type: 杂志文章,评审
doi:10.1002/chir.22363
更新日期:2014-11-01 00:00:00
abstract::Chirality of amyloid fibrils-linear beta-sheet-rich aggregates of misfolded protein chains-often manifests in morphological traits such as helical twist visible in atomic force microscopy and in chiroptical properties accessible to vibrational circular dichroism (VCD). According to recent studies the relationship betw...
journal_title:Chirality
pub_type: 杂志文章,评审
doi:10.1002/chir.22335
更新日期:2014-09-01 00:00:00
abstract::The effects of temperature on the chiral recognition of cyclic β-amino acid enantiomers on zwitterionic [Chiralpak ZWIX(+) and ZWIX(-)] chiral stationary phases were investigated. Experiments were performed at different mobile phase compositions and under 10°C column temperature increments in the temperature range 10-...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22333
更新日期:2014-08-01 00:00:00
abstract::8-Prenylnaringenin (8PN) is a naturally occurring bioactive chiral prenylflavonoid found most commonly in the female flowers of hops (Humulus lupulus L.). A stereospecific method of analysis for 8PN in biological fluids is necessary to study the pharmacokinetic disposition of each enantiomer. A novel and simple liquid...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22343
更新日期:2014-08-01 00:00:00
abstract::A series of representative optically active derivatives of 4-hydroxy-5-alkylcyclopent-2-en-1-one were prepared from the respective 2-furyl methyl carbinols via the Piancatelli rearrangement followed by the enzymatic kinetic resolution of racemates. Applicability of chiroptical methods (experimental and calculated elec...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22322
更新日期:2014-06-01 00:00:00
abstract::Solid phase extraction (SPE)-chiral separation of the important drugs pheniramine, oxybutynin, cetirizine, and brinzolamide was achieved on the C18 cartridge and AmyCoat (150 x 46 mm) and Chiralpak AD (25 cm x 0.46 cm id) chiral columns in human plasma. Pheniramine, oxybutynin, cetirizine, and brinzolamide were resolv...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22276
更新日期:2014-03-01 00:00:00
abstract::The resolution methods applying (-)-(4R,5R)-4,5-bis(diphenylhydroxymethyl)-2,2-dimethyldioxolane ("TADDOL"), (-)-(2R,3R)-α,α,α',α'-tetraphenyl-1,4-dioxaspiro[4.5]decan-2,3-dimethanol ("spiro-TADDOL"), as well as the acidic and neutral Ca(2+) salts of (-)-O,O'-dibenzoyl- and (-)-O,O'-di-p-toluoyl-(2R,3R)-tartaric acid ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22293
更新日期:2014-03-01 00:00:00
abstract::The enantiomerization and enantioselective bioaccumulation of metalaxyl by a single dose of exposure to Tenebrio molitor larvae under laboratory condition were studied by high-performance liquid chromatography tandem mass spectroscopy (HPLC-MS/MS) based on a ChiralcelOD-3R [cellulosetris-tris-(3, 5-dichlorophenyl-carb...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22269
更新日期:2014-02-01 00:00:00
abstract::The electronic circular dichroism (ECD) spectra of two sesquiterpenoids (1 and 2) related to oplopanone, obtained from a methanolic extract of the plant Serphidium stenocephalum (Artemisia stenocephala), were measured and reproduced by means of time-dependent density functional theory (TDDFT) calculations, establishin...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22263
更新日期:2014-01-01 00:00:00
abstract::Bis(diamido)-bridged basket resorcin[4]arene (all-S)-1 and its (all-R)-1 enantiomer proved able to interact with 2'-deoxycytidine (2) and pyrimidine nucleoside analogs in dimethyl sulfoxide (DMSO) solution. In such a solvent, the resorcinarene hosts adopt a preferential 1,3-alternate-like conformation, with a larger c...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22224
更新日期:2013-12-01 00:00:00
abstract::The chiral fungicide furametpyr is widely used in the rice field to control rice sheath blight; however, furametpyr enantiomers are treated as just one compound in traditional achiral analysis, which gives only partial information. An effective chiral analytical method was developed for the resolution and determinatio...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22232
更新日期:2013-12-01 00:00:00
abstract::The present study describes the development of two approaches for the determination of the enantiopurity of both enantiomers of indatraline. Initially, a method was developed using different chiral solvating agents (CSAs) for diastereomeric discrimination regarding signal separation in (1)H nuclear magnetic resonance ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22235
更新日期:2013-12-01 00:00:00
abstract::Chiral sulfoxides/N-oxides (R)-1 and (R,R)-2 are effective chiral promoters in the enantioselective allylation of α-keto ester N-benzoylhydrazone derivatives 3a-g to generate the corresponding N-benzoylhydrazine derivatives 4a-g, with enantiomeric excesses as high as 98%. Representative hydrazine derivatives 4a-b were...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22159
更新日期:2013-09-01 00:00:00
abstract::Growing attention in developing new N-heterocyclic carbene (NHC)-mediated reactions involving homoenolate intermediates has prompted our interest in exploring the mechanistic details of the related reactions. In this work, we carried out a detailed theoretical study for the NHC-catalyzed annulation reaction of cinnama...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22157
更新日期:2013-09-01 00:00:00
abstract::The UV absorption and electronic circular dichroism (ECD) spectra of (R)- and (S)-nicotine and (S)-nornicotine in aqueous solution were measured to a significantly lower wavelength range than previously reported, allowing the identification of four previously unobserved electronic transitions. The ECD spectra of the t...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22141
更新日期:2013-05-01 00:00:00
abstract::The versatility of a previously developed method for the synthesis of chiral carbene-based palladacycles is demonstrated through the synthesis of two new chiral pyridine-functionalized N-heterocyclic carbene palladacycles with different wingtip groups. The efficiency in their resolution with different counter anions a...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22116
更新日期:2013-03-01 00:00:00
abstract::Metoprolol is available for clinical use as a racemic mixture. The S-(-)-metoprolol enantiomer is the one expressing higher activity in the blockade of the β(1)-adrenergic receptor. The α-hydroxymetoprolol metabolite also has activity in the blockade of the β(1)-adrenergic receptor. The present study describes the dev...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22102
更新日期:2013-01-01 00:00:00
abstract::Symmetry breaking by photons, electrons, and molecular interactions lies at the heart of many important problems as varied as the origin of homochiral life to enantioselective drug production. Herein we report a system in which symmetry breaking can be induced and measured in situ at the single-molecule level using sc...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22096
更新日期:2012-12-01 00:00:00
abstract::The hemicryptophane racemate (±)-1 was optically resolved by semipreparative HPLC on Chiralpak IC column. The absolute configuration of each isolated enantiomer was established from the analysis of their electronic circular dichroism spectra. Enantiodifferentiation of the chiral cationic cage (±)-1 was evidenced in so...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22100
更新日期:2012-12-01 00:00:00
abstract::Immobilized Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding by SBA-15 was applied to asymmetric Henry reaction, and good enantioselectivities were obtained (up to 83% ee) between 2-methoxybenzaldehyde and CH(3)NO(2) in isopropyl alcohol (iPrOH). The catalyst could be reused seven times without any obvious loss in enan...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22104
更新日期:2012-12-01 00:00:00
abstract::(R)-(+) and (S)-(-)-1-phenylethylamine have been shown to promote highly diastereoselective and complementary enantioselective formal [3 + 2]carbocyclization reactions between 2,3-butanedione and conjugated nitroalkenes with formation of enantiomerically rich 2-hydroxy-3-nitrocyclopentanone derivatives. The reactions ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22088
更新日期:2012-12-01 00:00:00
abstract::A selection of my work on chirality is sketched in two distinct parts of this lecture. Symmetry and Chirality explains how the discrete symmetries of parity P, time reversal T, and charge conjugation C may be used to characterize the properties of chiral systems. The concepts of true chirality (time-invariant enantiom...
journal_title:Chirality
pub_type: 杂志文章,评审
doi:10.1002/chir.22017
更新日期:2012-11-01 00:00:00
abstract::Mirror symmetry breaking is ubiquitous in our visible universe taking place in elementary particles, atoms, and molecules. Molecular chirality is not biogenic in itself, although its detection is often considered a biosignature, a conjecture inferred from the fact that we do not know life devoid of homochirality. The ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22028
更新日期:2012-11-01 00:00:00
abstract::Isophthalic and terephthalic acid monoesters of cyclic nigerosyl-(1→6)-nigerose (CNN), a cyclic tetrasaccharide composed of four d-glucopyranosyl residues connected by alternating α-1,3- and α-1,6-linkages, were synthesized as novel chiral supramolecular sensitizers for enantiodifferentiating photoisomerization of (Z)...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22014
更新日期:2012-11-01 00:00:00
abstract::The impact of crystalline forces on the solid-state circular dichroism (CD) spectrum of hypothemycin (), a biologically active molecule extracted from natural sources, has been analyzed by means of time-dependent density functional theory CD calculations. Input structures were extracted from the X-ray geometry of and ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22008
更新日期:2012-09-01 00:00:00
abstract::A sensitive and stereospecific liquid chromatography-tandem mass spectrometry method for the quantitative determination of TWo8 enantiomers ((2RS)-1-(7-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)-propan-2-ol) was developed and validated in rat serum and some tissues. Racemic TWo8 is a new chemical ent...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22011
更新日期:2012-08-01 00:00:00
abstract::Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the effect of hyperlipidemic (HL) serum on the metabolism of HF enantiomers by primary rat hepatocyt...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22054
更新日期:2012-07-01 00:00:00
abstract::Two "click" binaphthyl chiral stationary phases were synthesized and evaluated by liquid chromatography. Their structures incorporate S-(-)-1,1'-binaphthyl moiety as the chiral selector and 1,2,3-triazole ring as the spacer. These chiral stationary phases (CSPs) allowed the efficient resolution for a wide range of rac...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22039
更新日期:2012-05-01 00:00:00
abstract::A simple high-yield three-steps route to optically active 4-hydroxymethyl-3-(1H-indolyl)oxazolidin-2-ones from (S)-glycidol is described. The key intermediates (R)-oxiran-2-ylmethyl 1H-indol-4/-5-ylcarbamates are obtained in high yields from (S)-glycidol. These are readily transformed to oxazolidin-2-ones, very intere...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.22003
更新日期:2012-04-01 00:00:00
abstract::Environmental enantioselectivity information is important to fate assessment of chiral contaminants. Warfarin, a rodenticide and prescription medicine, is a chiral chemical but used in racemic form. Little is known about its enantioselective behavior in the environment. In this study, enantioselective degradation of w...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.21023
更新日期:2012-01-01 00:00:00
abstract::[3β,5β,7α,12α]-3-(4-t-Butylbenzoilamine)-7,12-dihydroxycholan-24-oic acid was synthesized and recrystallized from chlorobenzene and acetone. Orthorhombic P2(1)2(1)2(1) and monoclinic P2(1) crystals were obtained, respectively, and both crystals include solvent and water molecules with a 1:1:1 stoichiometry. In the sec...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.21020
更新日期:2011-11-01 00:00:00
abstract::Homoprolinol analogs, a class of optically active γ-amino alcohols, were examined systematically in the enantioselective addition reactions of diethylzinc to aldehydes. By comparison of the results catalyzed by these γ-amino alcohols with those by the β-amino alcohols based on pyrrolidine architecture reported in the ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.21017
更新日期:2011-11-01 00:00:00
abstract::The measurement of optical rotation (OR) and optical rotatory dispersion has been finding renewed interest for some years, because of advancement in computational methods and in the performance of new experiments. Here, we shortly review the traditional and most-used experimental methods. We define and discuss the two...
journal_title:Chirality
pub_type: 杂志文章,评审
doi:10.1002/chir.20981
更新日期:2011-10-01 00:00:00
abstract::Fourier transform infrared vibrational circular dichroism (FTIR-VCD) measurements have gone through major advances in the last decade. A major thrust in these advances was to find ways that can minimize the VCD spectral artifacts and obtain the VCD signals at enhanced signal quality. However, all these advances are no...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20999
更新日期:2011-10-01 00:00:00
abstract::Massarigenin A (1) and papyracillic acids A (2) and B (3) were isolated from the endophytic fungus Microsphaeropsis sp. Their structures were elucidated by multidimensional nuclear magnetic resonance spectroscopy; the structure of massarigenin A (1) was also confirmed by X-ray crystallography. The absolute configurati...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20985
更新日期:2011-09-01 00:00:00
abstract::The first direct asymmetric synthetic preparation of trifluoro-1-(indol-3-yl)ethanols (TFIEs) is described by an enantioselective organocatalytic method from indoles and inexpensive trifluoroacetaldehyde methyl hemiacetal. The reaction is catalyzed by hydroquinine to produce TFIEs in an almost quantitative yield and w...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20982
更新日期:2011-09-01 00:00:00
abstract::The direct separation of the enantiomers of 1-(α-aminoarylmethyl)-2-naphthol, 1-(α-aminoalkyl)-2-naphthol, 2-(α-aminoarylmethyl)-1-naphthol analogs, and 2-(1-amino-2-methylpropyl)-1-naphthol) was performed on a newly developed chiral stationary phase containing isopropyl carbamate-cyclofructan6 as chiral selector, wit...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20968
更新日期:2011-08-01 00:00:00
abstract::(S)-(-)-2-(α-hydroxyethyl)-benzimidazole and (S)-(+)-2-(α-hydroxybenzyl)-benzimidazole work as chiral Brønsted bases (BBs) in Diels-Alder reaction between anthrone and maleimides under mild reaction condition. These chiral BBs cause asymmetric induction. ...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20942
更新日期:2011-05-01 00:00:00
abstract::A detailed experimental investigation of an aza-Michael reaction of aniline and chalcone is presented. A series of Cinchona alkaloid-derived organocatalysts with different functional groups were prepared and used in the aza-Michael and retro-aza-Michael reaction. There was an interesting finding that a complete revers...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20940
更新日期:2011-05-01 00:00:00
abstract::In modern chromatography, chiral stationary phase (CSP) and enantiomer self-disproportionation (ESD) are new inventions of packing material offer a guarantee for a successful enantiomeric separation. All CSPs were synthesized by chemical bonding of the relevant organic moieties onto a porous parent silica material for...
journal_title:Chirality
pub_type: 杂志文章
doi:10.1002/chir.20917
更新日期:2011-04-01 00:00:00