解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Functional MRI (fMRI) studies have traditionally relied on intersubject normalization based on global brain morphology, which cannot establish proper functional correspondence between subjects due to substantial intersubject variability in functional organization. Here, we reliably identified a set of discrete, homolo...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2007032
更新日期:2019-03-25 00:00:00
abstract::Every instant of perception depends on a cascade of brain processes calibrated to the history of sensory and decisional events. In the present work, we show that human visual perception is constantly shaped by two contrasting forces exerted by sensory adaptation and past decisions. In a series of experiments, we used ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000144
更新日期:2019-03-05 00:00:00
abstract::Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca2+)-activated nonselective cationic current (ICAN) to generate robust neural bursts. Hypothesized to be rhythmogenic, reducing ICAN is predicted to slow down or stop breathing; its contributions to motor patt...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006094
更新日期:2019-02-21 00:00:00
abstract::Seasonal influenza virus infections can cause significant morbidity and mortality, but the threat from the emergence of a new pandemic influenza strain might have potentially even more devastating consequences. As such, there is intense interest in isolating and characterizing potent neutralizing antibodies that targe...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000139
更新日期:2019-02-04 00:00:00
abstract::Although the developmental principles of sensory and cognitive processing have been extensively investigated, their synergy has been largely neglected. During early life, most sensory systems are still largely immature. As a notable exception, the olfactory system is functional at birth, controlling mother-offspring i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006994
更新日期:2019-01-31 00:00:00
abstract::Over the past decade, biology has undergone a data revolution in how researchers collect data and the amount of data being collected. An emerging challenge that has received limited attention in biology is managing, working with, and providing access to data under continual active collection. Regularly updated data pr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000125
更新日期:2019-01-29 00:00:00
abstract::In fungi, mating between partners depends on the molecular recognition of two peptidyl mating pheromones by their respective receptors. The fission yeast Schizosaccharomyces pombe (Sp) has two mating types, Plus (P) and Minus (M). The mating pheromones P-factor and M-factor, secreted by P and M cells, are recognized b...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000101
更新日期:2019-01-22 00:00:00
abstract::PolD is an archaeal replicative DNA polymerase (DNAP) made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2). Recently, we reported the individual crystal structures of the DP1 and DP2 catalytic cores, thereby revealing that PolD is an atypical DNAP that has all functional pro...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000122
更新日期:2019-01-18 00:00:00
abstract::During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer undergoes a sequence of conformational changes triggered by both CD4 and coreceptor engagement. Resolving the conformation of these transient entry intermediates has proven challenging. Here, we fine-mapped the...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000114
更新日期:2019-01-16 00:00:00
abstract::Metastatic dissemination employs both the blood and lymphatic vascular systems. Solid tumors dynamically remodel and generate both vessel types during cancer progression. Lymphatic vessel invasion and cancer cells in the tumor-draining lymph nodes (LNs) are prognostic markers for breast cancer metastasis and patient o...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005907
更新日期:2018-12-28 00:00:00
abstract::The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process vulnerable to aberrations, which may lead to neurodevelopmental d...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006838
更新日期:2018-12-26 00:00:00
abstract::Infants' cognitive development and learning rely profoundly on their interactions with other people. In the first year, infants become increasingly sensitive to others' gaze and use it to focus their own attention on relevant visual input. However, infants are not passive observers in early social interactions, and th...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.3000055
更新日期:2018-12-13 00:00:00
abstract::Genome editing occurs in the context of chromatin, which is heterogeneous in structure and function across the genome. Chromatin heterogeneity is thought to affect genome editing efficiency, but this has been challenging to quantify due to the presence of confounding variables. Here, we develop a method that exploits ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005595
更新日期:2018-12-12 00:00:00
abstract::In this Formal Comment, the authors of the recent publication "Large-scale investigation of the reasons why potentially important genes are ignored" maintain that it can be read as an opportunity to explore the unknown. ...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.3000075
更新日期:2018-12-11 00:00:00
abstract::In this paper, we describe why and how to build a local community of practice in scientific programming for life scientists who use computers and programming in their research. A community of practice is a small group of scientists who meet regularly to help each other and promote good practices in scientific programm...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005561
更新日期:2018-11-28 00:00:00
abstract::The endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2, which connect ER Ca2+ depletion with extracellular Ca2+ influx, are crucial for the maintenance of Ca2+ homeostasis in mammalian cells. Despite the recent progress in unraveling the role of STIM2 in Ca2+ signaling, the mechan...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006898
更新日期:2018-11-16 00:00:00
abstract::A developing plant organ exhibits complex spatiotemporal patterns of growth, cell division, cell size, cell shape, and organ shape. Explaining these patterns presents a challenge because of their dynamics and cross-correlations, which can make it difficult to disentangle causes from effects. To address these problems,...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005952
更新日期:2018-11-01 00:00:00
abstract::A ubiquitous feature of the nervous system is the processing of simultaneously arriving sensory inputs from different modalities. Yet, because of the difficulties of monitoring large populations of neurons with the single resolution required to determine their sensory responses, the cellular mechanisms of how populati...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004527
更新日期:2018-10-15 00:00:00
abstract::Global warming is significantly altering arctic marine ecosystems. Specifically, the precipitous loss of sea ice is creating a dichotomy between ice-dependent polar bears and pinnipeds that are losing habitat and some cetaceans that are gaining habitat. While final outcomes are hard to predict for the many and varied ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006708
更新日期:2018-10-09 00:00:00
abstract::In this Open Highlight, Senior Editor Lauren Richardson features exciting new Open Access research into how species evolve their characteristic traits. ...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.3000020
更新日期:2018-10-04 00:00:00
abstract::Many efforts are making science more open and accessible; they are mostly concentrated on issues that appear before and after experiments are performed: open access journals, open databases, and many other tools to increase reproducibility of science and access to information. However, these initiatives do not promote...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000014
更新日期:2018-09-27 00:00:00
abstract::Head and neck squamous cell carcinomas (HNSCCs) are characterized by outstanding molecular heterogeneity that results in severe therapy resistance and poor clinical outcome. Inter- and intratumoral heterogeneity in epithelial-mesenchymal transition (EMT) was recently revealed as a major parameter of poor clinical outc...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006624
更新日期:2018-09-27 00:00:00
abstract::In this Formal Comment the authors respond to objections to their previous Essay, reiterating that comparative linguistics is not an easy undertaking. ...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.3000019
更新日期:2018-09-24 00:00:00
abstract::Copper (Cu) has emerged as an important modifier of body lipid metabolism. However, how Cu contributes to the physiology of fat cells remains largely unknown. We found that adipocytes require Cu to establish a balance between main metabolic fuels. Differentiating adipocytes increase their Cu uptake along with the ATP7...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006519
更新日期:2018-09-10 00:00:00
abstract::Temporarily holding information in mind is an important part of many cognitive processes, such as reasoning and language. The amount of information that can be actively held "in mind" at any time is greatly limited-research suggests that we can only actively hold three or four pieces of information at once. A central ...
journal_title:PLoS biology
pub_type: 评论,杂志文章
doi:10.1371/journal.pbio.3000012
更新日期:2018-08-29 00:00:00
abstract::PubMed is a free search engine for biomedical literature accessed by millions of users from around the world each day. With the rapid growth of biomedical literature-about two articles are added every minute on average-finding and retrieving the most relevant papers for a given query is increasingly challenging. We pr...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005343
更新日期:2018-08-28 00:00:00
abstract::Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent af...
journal_title:PLoS biology
pub_type: 杂志文章,评审
doi:10.1371/journal.pbio.2006592
更新日期:2018-08-24 00:00:00
abstract::There is currently a demand for new highly efficient and specific drugs to treat osteoporosis, a chronic bone disease affecting millions of people worldwide. We have developed a combinatorial strategy for engineering bispecific inhibitors that simultaneously target the unique combination of c-FMS and αvβ3 integrin, wh...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2002979
更新日期:2018-08-24 00:00:00
abstract::A key component of working memory is the ability to remember multiple items simultaneously. To understand how the human brain maintains multiple items in memory, we examined direct brain recordings of neural oscillations from neurosurgical patients as they performed a working memory task. We analyzed the data to ident...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003805
更新日期:2018-08-15 00:00:00
abstract::HAPLESS2 (HAP2) is a broadly conserved, gamete-expressed transmembrane protein that was shown recently to be structurally homologous to viral class II fusion proteins, which initiate fusion with host cells via insertion of fusion loops into the host membrane. However, the functional conformation of the HAP2 fusion loo...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006357
更新日期:2018-08-13 00:00:00
abstract::Animals employ various types of taste receptors to identify and discriminate between different nutritious food chemicals. These macronutrients are thought to fall into 3 major groups: carbohydrates/sugars, proteins/amino acids, and fats. Here, we report that Drosophila larvae exhibit a novel appetitive feeding behavio...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005570
更新日期:2018-08-07 00:00:00
abstract::Cell motility is essential for protozoan and metazoan organisms and typically relies on the dynamic turnover of actin filaments. In metazoans, monomeric actin polymerises into usually long and stable filaments, while some protozoans form only short and highly dynamic actin filaments. These different dynamics are partl...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005345
更新日期:2018-07-16 00:00:00
abstract::Animals live together with diverse bacteria that can impact their biology. In Drosophila melanogaster, gut-associated bacterial communities are relatively simple in composition but also have a strong impact on host development and physiology. It is generally assumed that gut bacteria in D. melanogaster are transient a...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005710
更新日期:2018-07-05 00:00:00
abstract::CellProfiler has enabled the scientific research community to create flexible, modular image analysis pipelines since its release in 2005. Here, we describe CellProfiler 3.0, a new version of the software supporting both whole-volume and plane-wise analysis of three-dimensional (3D) image stacks, increasingly common i...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005970
更新日期:2018-07-03 00:00:00
abstract::Our current understanding of biology is heavily based on a small number of genetically tractable model organisms. Most eukaryotic phyla lack such experimental models, and this limits our ability to explore the molecular mechanisms that ultimately define their biology, ecology, and diversity. In particular, marine prot...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006333
更新日期:2018-07-02 00:00:00
abstract::Catch-up growth after insults to growing organs is paramount to achieving robust body proportions. In fly larvae, injury to individual tissues is followed by local and systemic compensatory mechanisms that allow the damaged tissue to regain normal proportions with other tissues. In vertebrates, local catch-up growth h...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2005086
更新日期:2018-06-26 00:00:00
abstract::We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves mitochondrial memb...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004408
更新日期:2018-06-21 00:00:00
abstract::Zinc is an essential mineral, but our understanding of its uses in the body is limited. Capitalizing on approaches available in the model system Caenorhabditis elegans, Zhao and colleagues show that zinc transduces a signal that induces sperm to become motile. This is an enigmatic process because sperm in all sexually...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2006204
更新日期:2018-06-07 00:00:00
abstract::Primates sample their visual environment actively through saccades and microsaccades (MSs). Saccadic eye movements not only modulate neural spike rates but might also affect temporal correlations (synchrony) among neurons. Neural synchrony plays a role in neural coding and modulates information transfer between cortic...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2004132
更新日期:2018-05-31 00:00:00
abstract::Sleep science is entering a new era, thanks to new data-driven analysis approaches that, combined with mouse gene-editing technologies, show a promise in functional genomics and translational research. However, the investigation of sleep is time consuming and not suitable for large-scale phenotypic datasets, mainly du...
journal_title:PLoS biology
pub_type: 杂志文章
doi:10.1371/journal.pbio.2003663
更新日期:2018-05-29 00:00:00