解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic systemic inflammation. Oxidative stress may play a role in the pathogenesis of SLE. An increase in free radicals or an impaired antioxidant defense system in SLE causes oxidative stress. Therefore, oxidative damage plays an important role in the ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315593170
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE). METHODS:A series of meta-analyses were conducted to test for association between the CD40 ...
journal_title:Lupus
pub_type: 杂志文章,meta分析
doi:10.1177/0961203315583543
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Patients with systemic lupus erythematosus (SLE) are at a high risk for cardiovascular disease (CVD) due to increased prevalence of traditional and nontraditional CVD risks factors. OBJECTIVE:To evaluate the effect of patient-centered nutrition counseling methods on changes in select nutrient, anthropometri...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315582284
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:Health-related quality of life (HRQoL) has not been fully explored in antiphospholipid syndrome (APS); therefore, we compared HRQoL between APS patients and the general population and assessed the impact of thromboembolic history. METHODS:HRQoL was measured in a multicentre cohort study by the Medical Outco...
journal_title:Lupus
pub_type: 杂志文章,多中心研究
doi:10.1177/0961203315580871
更新日期:2015-10-01 00:00:00
abstract:INTRODUCTION:The use of hydroxychloroquine (HCQ) in patients with systemic lupus erythematosus (SLE) offers a wide range of benefits. However, there are evidence in favour of cardiotoxicity, including heart conduction disturbances and congestive heart failure. OBJECTIVE:To determine the effects of HCQ in the resting h...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315580870
更新日期:2015-10-01 00:00:00
abstract:INTRODUCTION:Anti-RNP autoantibodies occur either in mixed connective tissue disease (MCTD) (with a frequently favorable prognosis), or in systemic lupus erythematosus (SLE) cases with aggressive major organ disease. It is uncertain how to assess for the risk of severe disease in anti-RNP + patients. METHODS:Following...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315575586
更新日期:2015-09-01 00:00:00
abstract::A 24 year old female with hereditary spastic paraplegia presented with intermittent headache for one year. She also had lower abdominal pain and vomiting for two months. She was pale, had icterus and mild splenomegaly. On diagnostic evaluation she was found to have hemolytic anemia, thrombocytopenia and bilateral adre...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315573853
更新日期:2015-09-01 00:00:00
abstract::The aim of this study was to use transthoracic Doppler echocardiographic (TTE) imaging methods to identify cardiac dysfunction, an indicator of subclinical atherosclerosis in asymptomatic systemic lupus erythematosus (SLE) patients in terms of cardiac effects. This study involved 80 patients: a study group (n = 50) an...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570164
更新日期:2015-09-01 00:00:00
abstract::In 1964, Miyoshi reported a series of patients with diverse symptoms after receiving treatment with silicone or paraffin fillers. Miyoshi named this condition 'human adjuvant disease'. Since then, the literature has been flooded with case reports and case series of granulomatous and systemic autoimmune disorders relat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315579092
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to evaluate the correlation and agreement of spot urine protein/creatinine (P/C) ratio with 24 h proteinuria in patients with lupus nephritis (LN) under different scores of activity index (AI). METHODS:In total, 90 pairs of 24 h urine and spot urine samples from 90 patients with bi...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570688
更新日期:2015-08-01 00:00:00
abstract:BACKGROUND:In a previous study performed 9 ± 3.6 years ago, 74 asymptomatic patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS) underwent lung function testing. A significantly low diffusion capacity (DLCO) ranging from 45% to 70% was recorded in 28 of the 74 (37.8%) patients who wer...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314566633
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. Recently, a specific highly activated T helper cell subset, follicular helper T (Tfh) cell, has emerged as a key immunoregulator of germinal center (GC) formation and high-affinity antibody productio...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314567750
更新日期:2015-08-01 00:00:00
abstract:INTRODUCTION:Children with systemic lupus erythematosus (SLE) have an increased prevalence of kidney disease compared to their adult counterparts. Our goal was to identify potential clinical and laboratory predictors of renal disease. METHODS:We performed a cohort study of incident and prevalent patients with SLE aged...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315570162
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:Environmental factors appear to play a role in the pathogenesis of lupus erythematosus (LE). OBJECTIVE:To determine the association between cigarette smoking and various types of cutaneous LE. DESIGN:Retrospective descriptive study at a dermatology clinic of a tertiary referral hospital. METHODS:All patie...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314559630
更新日期:2015-06-01 00:00:00
abstract::Lupus anticoagulant-hypoprothrombinemia syndrome (LA-HPS) is a rare acquired disorder caused by prothrombin antibodies. The disease is most common in the pediatric age group (<16 years), and more prevalent in women. There are well-established clinical diseases associated with LA-HPS, most notably systemic lupus erythe...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314558859
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:We aimed to determine 1) ultrasound (US) abnormalities in patients with systemic lupus erythematosus (SLE) with and without hand arthralgia at the day of examination compared with clinical evaluation and healthy controls, and 2) inter-observer reliability of the US abnormalities. METHODS:Thirty-three female...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314561666
更新日期:2015-06-01 00:00:00
abstract::We investigated obstetric outcomes and comorbidities during pregnancy in females with preexisting lupus nephritis (LN) and identified predictors for renal flare. In cases of renal flare during pregnancy, we assessed the long-term post-delivery renal outcome. We performed a retrospective analysis of 183 systemic lupus ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203315572715
更新日期:2015-06-01 00:00:00
abstract::Mycobacterial infections can cause a variety of different manifestations. The increasing incidence of these infections worldwide brought another medical dilemma: immunological manifestations characterized by the presence of many autoantibodies and concomitant presence of autoimmune diseases. The burden of tuberculosis...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314559634
更新日期:2015-04-01 00:00:00
abstract::Patients with chronic hepatitis C virus (HCV) infection frequently present with extrahepatic manifestations covering a large spectrum, involving different organ systems leading to the concept of systemic HCV infection. These manifestations include autoimmune phenomena and frank autoimmune and/or rheumatic diseases and...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314556140
更新日期:2015-04-01 00:00:00
abstract::We report clinical and histopathological features, treatment and outcome of 37 Croatian children with biopsy-proven lupus nephritis seen over a 30-year period. The mean age at lupus nephritis presentation was 12.11 ± 2.59 years (range 4.66-17.0). The most frequent histopathological finding was class IV (37.8%), follow...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314563133
更新日期:2015-03-01 00:00:00
abstract::Neonatal antiphospholipid syndrome (neonatal APS) seems to be exceedingly rare, as the antiphospholipid antibodies (aPL) related thrombosis in the neonatal period. The pathogenesis of perinatal aPL related thrombosis may be explained both by the transplacental passage of the maternal antibodies and by the production o...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314560207
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND:Although the survival rate has considerably improved, many patients with systemic lupus erythematosus (SLE) develop irreversible organ damage. OBJECTIVES:The objectives of this paper are to characterize cumulative damage in SLE patients and identify variables associated with its presence and severity. METH...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314555172
更新日期:2015-03-01 00:00:00
abstract::The objective of this study was to identify risk factors associated with flare during pregnancy in women with systemic lupus erythematosus (SLE). We performed a retrospective analysis of pregnant women with SLE in a referral hospital. Flare was considered according to predetermined definitions. We analyzed 15 clinical...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314552116
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVES:The objectives of this paper are to prospectively determine the incidence of paediatric systemic lupus erythematosus (pSLE) in Australia as well as describe the demographics, clinical presentation and one-year outcome. STUDY DESIGN:Newly diagnosed cases of pSLE were ascertained prospectively from October 20...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314552118
更新日期:2015-01-01 00:00:00
abstract::The current study was to investigate the features of hospitalized patients with systemic lupus erythematosus (SLE) at different altitudes. The correlation between SLE activity and altitudinal variations was also explored. Medical records of 1029 patients were retrospectively reviewed. Activity of SLE in each organ sys...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314544186
更新日期:2014-12-01 00:00:00
abstract::Multiple sources were used to identify 325 systemic lupus erythematosus (SLE) patients within the city of Oslo during 1999-2009 who met ≥ 4 of the American College of Rheumatology (ACR) criteria. The survival, standard mortality rate (SMR), years of potential life loss before 60 years of age (YPLL60) and causes of dea...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314551083
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVES:The objective of this paper is to perform the cross-cultural validation of the French version of the LupusPRO, a disease-targeted patient-reported outcome measure, among systemic lupus erythematosus (SLE) patients in Canada. METHODS:The French version of the LupusPRO and the MOS SF-36 were administered; dem...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543921
更新日期:2014-12-01 00:00:00
abstract:INTRODUCTION:Creatine supplementation has emerged as a promising non-pharmacological therapeutic strategy to counteract muscle dysfunction and low lean mass in a variety of conditions, including in pediatric and rheumatic diseases. The objective of this study was to examine the efficacy and safety of creatine supplemen...
journal_title:Lupus
pub_type: 杂志文章,随机对照试验
doi:10.1177/0961203314546017
更新日期:2014-12-01 00:00:00
abstract::Herein, we investigated the risk of juvenile-onset systemic lupus erythematosus (JSLE) in children with atopic dermatitis (AD). From 2000 to 2007, 192,357 children with newly diagnosed AD and 769,428 matched non-AD controls were identified. By the end of 2008, incidences and hazard ratios (HRs) of JSLE were measured. ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543920
更新日期:2014-12-01 00:00:00
abstract::Lupus nephritis during pregnancy increases morbidity and mortality for mother and baby. Flares are difficult to treat as many therapeutic options are teratogenic or fetotoxic. Steroids alone may be unable to control disease activity and are associated with higher rates of preterm delivery, sepsis and gestational diabe...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314540353
更新日期:2014-10-01 00:00:00
abstract::Children born to women with systemic lupus erythematosus seem to have a potentially increased risk of neurodevelopmental disorders compared to children born to healthy women. Recent experimental data suggest in utero exposure to maternal antibodies and cytokines as important risk factors for neurodevelopmental disorde...
journal_title:Lupus
pub_type: 杂志文章,评审
doi:10.1177/0961203314541691
更新日期:2014-10-01 00:00:00
abstract::Heart valve disease (HVD) is the most common cardiac manifestation in the antiphospholipid syndrome (APS). Valve lesions should be described according to the established definition. HVD is progressive despite anticoagulant/antiplatelet treatments. Around 4-6% of patients with HVD in APS will require valve replacement ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314534307
更新日期:2014-10-01 00:00:00
abstract::Diagnostic strategy studies commonly focus on the accuracy of tests in diagnosing, and grading this body of evidence is a challenge in itself because (1) standard tools for grading evidence were designed for questions about treatment rather than diagnostic testing; and (2) the clinical usefulness of a diagnostic strat...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314543922
更新日期:2014-10-01 00:00:00
abstract::Antiphospholipid syndrome (APS), as a primary disease or a secondary syndrome in systemic lupus erythematosus (SLE), is characterized by the presence of antiphospholipid antibodies (aPL) and a clinical event. It is likely that both genetic and environmental factors lead to the development of aPL and progression to dis...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314548248
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:YB current affiliation: Department of Pediatrics, Hadassah-Hebrew University Medical Center, Mount Scopus, Israel YB and MJS contributed equally to the study and should be regarded as joint first authors on this manuscript. Antiphospholipid syndrome (APS) may present with thrombosis and persistently elevated ...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314531842
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To examine the immune cell profile in the bone marrow of systemic lupus erythematosus (SLE) patients and to assess its clinical relevance. METHODS:Sixteen bone marrow samples from 14 SLE patients were compared with seven healthy control samples. The numbers of immune cells and apoptotic cells in the bone ma...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314531634
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVES:To estimate the prevalence of pulmonary arterial hypertension (PAH) and risk factors for PAH in patients registered in the Chinese SLE Treatment and Research group (CSTAR) database, the first online registry of Chinese patients with systemic lupus erythematosus (SLE). METHODS:A prospective cross-sectional s...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314527366
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:The objective of this paper is to investigate the incidence of both non-vertebral and vertebral fracture in female patients with systemic lupus erythematosus (SLE) and to identify risk factors for incident fracture. METHODS:In a five-year prospective study of 127 female Chinese SLE patients with an average a...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314528555
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:The main vitamin D source is exposure to ultraviolet radiation, which aggravates cutaneous lupus erythematosus (CLE). OBJECTIVES:The aims of this study were to identify variables associated with lower serum 25-hydroxyvitamin D [25(OH)D] levels in CLE patients and assess the effect of vitamin D restoration o...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314522338
更新日期:2014-06-01 00:00:00
abstract::Belimumab is a monoclonal antibody against soluble B-lymphocyte stimulator, an essential growth factor for B-cell maturation and activation, which was approved by the US FDA in 2011 for patients with active autoantibody-positive systemic lupus erythematosus (SLE) who have failed standard treatment. Here we present the...
journal_title:Lupus
pub_type: 杂志文章
doi:10.1177/0961203314524292
更新日期:2014-06-01 00:00:00