解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Studies investigating the effects of microRNA (miR)-155 on the behavior of tumor cells have concentrated primarily on proliferation and apoptosis. The aim of the present study was to investigate the effect of miR-155 inhibitor on the metastatic and invasive ability of gastric carcinoma cells and whether this effect is...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9152
更新日期:2018-10-01 00:00:00
abstract::Integrin signaling may modulate several different functions involved in cell migration, invasion, proliferation and motility, and is a potential candidate biomarker for oral cancer. In the present study, a total of four integrin genes were evaluated as potential biomarkers of oral squamous cell carcinoma (OSCC). Gene ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9168
更新日期:2018-10-01 00:00:00
abstract::Acute myeloid leukemia associated with t(8;21)(q22;q22)/runt related transcription factor (RUNX)1-RUNX1 translocation partner 1 has been reported to exhibit a favorable outcome. The quantitative polymerase chain reaction is a reliable method for assessing minimal residual disease persistence, and peripheral blood (PB)...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9228
更新日期:2018-10-01 00:00:00
abstract::Peroxiredoxin (Prx) II is an imperative member of the superfamily of peroxidases. It serves an essential role in scavenging organic hydroperoxide and H2O2. It is involved in the development of various malignant tumors. In order to investigate the significance of Prx II expressions level in gastric cancer (GC), downreg...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9208
更新日期:2018-10-01 00:00:00
abstract::Gastric cancer is an intractable disease with a poor prognosis and limited treatment options. Its treatment remains a major clinical challenge worldwide. Ephrin-B2 is upregulated and involved in tumor growth in various types of cancer. However, the association between ephrin-B2 and prognosis of gastric cancer, and the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9202
更新日期:2018-10-01 00:00:00
abstract::Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9195
更新日期:2018-10-01 00:00:00
abstract::Papillary thyroid cancer (PTC) is the most common type of thyroid malignancy, and it is often observed to overexpress epidermal growth factor receptor (EGFR). Previous research has indicated that EH domain-containing 1 (EHD1) is associated with EGFR-mediated endocytotic recycling in multiple tumor types. The objective...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9200
更新日期:2018-10-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in different types of cancer, including gastric cancer. Although altered lncRNAs profiles have been observed in or around gastric cancer tissues, the diagnostic value of circulating lncRNAs in gastric cancer remains unclear. In the present study, a n...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9199
更新日期:2018-10-01 00:00:00
abstract::The traditional Chinese medicine Jinfukang (JFK) has been shown as a valuable drug to treat non-small cell lung cancer (NSCLC). Previously, it was reported that JFK-induced epigenetic alteration is involved in anti-lung cancer activity. In the present study, the effect of JFK on lung cancer cell lines was examined wit...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9149
更新日期:2018-10-01 00:00:00
abstract::Poly(ADP-Ribose) polymerase family member 9 (PARP9) promotes the proliferation, survival and chemotherapy resistance in lymphoma and prostate cancer. The expression and function of PARP9 in human breast cancer remains unknown. In the present study, it was demonstrated that PARP9 is frequently overexpressed in human br...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9124
更新日期:2018-09-01 00:00:00
abstract::Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microarray analysis was u...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9128
更新日期:2018-09-01 00:00:00
abstract::Triptolide exhibits immunosuppressive, anti-inflammatory, antifertility and antineoplastic functions. However, the anticancer effect of triptolide on cervical cancer and the underlying mechanism remains to be fully understood. The present study assessed the mechanisms underlying the effect of triptolide on the viabili...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9074
更新日期:2018-09-01 00:00:00
abstract::Bufalin, one of the active ingredients of the Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, the role of bufalin in renal cell carcinoma (RCC) remains unclear. In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cyc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9111
更新日期:2018-09-01 00:00:00
abstract::The expression of human transfer ribonucleic acid (tRNA) methyltransferase 9-like (KIAA1456) protein in lung cancer tissue and its effects on certain genes involved in the proliferation, migration and invasion of lung cancer cells were investigated. Immunohistochemistry was applied to stain lung cancer tissue and adja...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9119
更新日期:2018-09-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the most common types of human tumors, which is characterized by high morbidity and mortality rates. AKT1 transcriptional activity is implicated in HCC initiation and development. In the present study, the effects of rs2494752 single nucleotide polymorphism (SNP) on AKT1 transc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9060
更新日期:2018-09-01 00:00:00
abstract::The aim of the present study was to use imaging to retrospectively analyze the recurrent sites and patterns of spread of early cervical cancer following radical surgery. A total of 86 patients with cervical cancer (stage IB or IIA) showed postoperative pelvic recurrences and distant metastases. Based on positron emiss...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9070
更新日期:2018-09-01 00:00:00
abstract::Homoisoflavanone-1 is a natural compound that may be extracted from the Chinese medicinal herb Polygonatum odoratum, which has pronounced antioxidant activities. The present study reports that homoisoflavanone-1 significantly inhibited tumor cell growth and induced apoptosis in A549 non-small cell lung cancer (NSCLC) ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9085
更新日期:2018-09-01 00:00:00
abstract::V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel negative immune checkpoint that belongs to the B7 family. VISTA is primarily expressed on hematopoietic cells and inhibits T cell proliferation and cytokine production. The blockade of VISTA has demonstrated promising results in certain murine ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9059
更新日期:2018-09-01 00:00:00
abstract::Breast tissue is very sensitive to ionizing radiation due to the presence of reproductive hormones, including estrogen. In the present pilot study, the efficiency of mammography X-rays to induce DNA double strand breaks (DSB) in mammary epithelial cells was investigated. For this, freshly resected healthy breast tissu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9024
更新日期:2018-09-01 00:00:00
abstract::microRNAs (miRNA/miRs) are a class of small non-coding RNAs; they serve important biological roles in tumorigenesis through the regulation of oncogene expression, and they may be used for the diagnosis and treatment of human cancer. miR-375 was identified to exhibit abnormal expression levels in a number of types of t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9011
更新日期:2018-09-01 00:00:00
abstract::The present study aimed to identify the probable anti-Condyloma acuminata (CA) mechanism of microRNA-375 (miRNA-375) in human papillomavirus (HPV). Firstly, the overexpression of miRNA-375 significantly suppressed cell proliferation, increased lactate dehydrogenase activity and induced apoptosis in HPV-18(+) cervical ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8983
更新日期:2018-09-01 00:00:00
abstract::Salidroside has a wide range of pharmacological activities, including antitumor, anti-inflammatory, analgesic, antibacterial, antiviral and anti-fertility abilities. In the present study, the effects of salidroside on the viability and apoptosis of bladder cancer cells, and the potential underlying mechanisms, were ex...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8982
更新日期:2018-09-01 00:00:00
abstract::Bladder cancer (BC) is one of the most common urogenital malignancies. However, present studies of its multiple gene interaction and cellular pathways remain unable to accurately verify the genesis and the development of BC. The aim of the present study was to investigate the genetic signatures of BC and identify its ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9002
更新日期:2018-09-01 00:00:00
abstract::There is increasing evidence that microRNAs (miRNAs) play important roles in tumor progression and development by targeting different genes, including gastric cancer (GC). However, the role of miR-16 in GC is so far unclear. Herein, we examined the function and potential mechanism of miR-16 in GC. Reverse transcriptio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8997
更新日期:2018-09-01 00:00:00
abstract::The present study was performed to determine the molecular mechanism of calcium gluconate (CG) in alleviating the toxic effect of hydrofluoric (HF) acid on human dermal fibroblasts (HDFs). HDF morphology was observed by optical microscopy and the vimentin immunofluorescence assay. Cell viability and apoptosis were eva...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8975
更新日期:2018-09-01 00:00:00
abstract::Radiofrequency ablation has become an increasingly common therapeutic technique for patients with hepatocellular carcinoma or metastatic liver tumors. However, reports on the effect of percutaneous radiofrequency ablation (PRFA) on circulating tumor cells (CTCs) are limited. The present study aimed to further investig...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9019
更新日期:2018-09-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Rever...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8969
更新日期:2018-08-01 00:00:00
abstract::The incidence of breast cancer is increasing throughout the world. Although significant progress has been made in diagnostic techniques and targeted therapies, the prognosis of breast cancer remains poor. Regulator of differentiation 1 (ROD1) may inhibit the development of several types of cancer. However, the role of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8917
更新日期:2018-08-01 00:00:00
abstract::Lichen sclerosus is a chronic and inflammatory disease. Extensive studies have focused on the epidermis, with the dermis or epidermis-dermis receiving less attention. To investigate the role of galectin-7, a keratinocyte protein, in vulvar lichen sclerosus (VLS) and its potential effects on dermal fibroblasts, immunoh...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8897
更新日期:2018-08-01 00:00:00
abstract::Regulatory ability of micro-ribose nucleic acid-130a (miRNA-130a) in the proliferation and invasive growth of human brain glioma cells and its mechanism were investigated. RT-qPCR was used to analyze expression of miRNA-130a in U-87MG glioma specimens; lipidosome was used to mediate miRNA-130a mimic transfecting gliom...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8878
更新日期:2018-08-01 00:00:00
abstract::Abnormalities in proto-oncogene B-Raf (BRAF) are typical in several subgroups of gliomas, including pilocytic astrocytomas, optic nerve gliomas, pleomorphic xanthoastrocytomas (PXA), anaplastic PXAs and gangliogliomas. However, they are rarely reported in adult gliomas. BRAF alterations are frequent in a distinct vari...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8919
更新日期:2018-08-01 00:00:00
abstract::Resistance to oxaliplatin (L-OHP) is a major obstacle to successful chemotherapy in colorectal cancer (CRC). In the present study, the ability of gambogic acid (GA) to reverse L-OHP resistance in CRC LoVo cells was investigated. L-OHP-resistant LoVo/L-OHP cells were established by exposing them to increasing concentra...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8916
更新日期:2018-08-01 00:00:00
abstract::The present study aimed to examine whether monoclonal immunoglobulin heavy chain (IGH) or T-cell receptor (TCR) gene rearrangement in cell-free DNA (cfDNA) may be used for minimal residual disease (MRD) monitoring in patients with acute myeloid leukemia (AML). Monoclonal IGH and TCR rearrangement in cfDNA were monitor...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8966
更新日期:2018-08-01 00:00:00
abstract::MicroRNAs (miRs) are an emerging class of non-coding, endogenous and small RNA molecules that serve important functions in tumorigenesis and development. The present study investigated the expression, functions and molecular mechanism underlying miR-205 in hepatocellular carcinoma. miR-205 was downregulated in hepatoc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8933
更新日期:2018-08-01 00:00:00
abstract::Histone methylation is closely associated with the occurrence of cancer. Histone H3 trimethylation at lysine 4 (H3K4me3) has been reported to modulate the expression of tumor-associated expression and be altered during the progression of several human cancers. WD Repeat Domain 82 (Wdr82), a key epigenetics-associated ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8902
更新日期:2018-08-01 00:00:00
abstract::Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8863
更新日期:2018-08-01 00:00:00
abstract::AR-42 is a member of a novelly discovered class of phenylbutyrate-derived histone deacetylase inhibitors, and has a number of antitumor effects in a variety of tumor types; however, the role of AR-42 and its possible mechanisms have not been reported in the treatment of breast cancer. The aim of the present study was ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8854
更新日期:2018-08-01 00:00:00
abstract::Notch-regulated ankyrin-repeat protein (NRARP) has recently been reported to be involved in a number of malignant cancers; however, its role in non-small lung cancer (NSCLC) remains unclear. The present study aimed to identify whether NRARP could be applied as a novel prognostic marker for NSCLC. A total of 108 NSCLC ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8826
更新日期:2018-08-01 00:00:00
abstract::In the present study, the function and mechanism of cytokine-induced killer cells (CIK) combined with dendritic cells (DC-CIK) were examined in Lewis lung cancer (LLC) cells. Co-culture of CIK dendritic cells (DC) in vitro was used to investigate their proliferation and the antitumor effects on LLC cells. DC and CIK c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8834
更新日期:2018-08-01 00:00:00
abstract::Pleural effusion (PE) is a common manifestation associated with certain chest diseases. However, there is no effective diagnostic marker with high sensitivity and specificity. The aim of the present study was to evaluate the diagnostic performance of several biomarkers in the use of detecting malignant pleural disorde...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8871
更新日期:2018-08-01 00:00:00