Expression of V-domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer.

abstract：:Krüppel-like factor 5 (KLF5) is frequently deleted and inactivated in prostate cancer, and exerts tumor-suppressing function in prostate cancer cells. However, the function of KLF5 in the apoptosis of prostate cancer cells remains unclear. In the present study, the effect of KLF5 on phorbol 12-myristate 13-acetate (PM...

journal_title：Oncology letters

authors： Shi Q,Jia J,Hui K,Gao Y,Xu S,Guan B,Tang X,Wang X,He D,Guo P

更新日期：2017-08-01 00:00:00

abstract：:Gemcitabine (GCB), which functions via the inhibition of DNA synthesis, is commonly used in the treatment of bladder cancer; however, its response rate is not satisfactory due to the development of drug resistance. The potential for phytochemicals to reverse drug resistance in bladder cancer tumor cells was evaluated....

journal_title：Oncology letters

authors： Cho CJ,Yang CW,Wu CL,Ho JY,Yu CP,Wu ST,Yu DS

更新日期：2019-12-01 00:00:00

abstract：:Pancreatic cancer has a low survival rate globally. Anillin (ANLN) is involved in the pathogenesis of pancreatic cancer (PC). The present study used databases and reverse transcription-quantitative PCR to investigate the association between ANLN expression, clinical variables and the survival rate of patients with pan...

journal_title：Oncology letters

authors： Nie Y,Zhao Z,Chen M,Ma F,Fan Y,Kang Y,Kang B,Wang C

更新日期：2021-02-01 00:00:00

abstract：:Autophagy is an intracellular protein transport process leading to the degradation of organelles and long-lived proteins in eukaryotes. The down-regulation of autophagy observed in cancer cells has been associated with tumor progression. This study investigated autophagy induced by resveratrol, a natural compound, in ...

journal_title：Oncology letters

authors： Yamamoto M,Suzuki SO,Himeno M

更新日期：2010-05-01 00:00:00

abstract：:Increasing evidence has indicated that the abnormal expression of microRNAs contributes to tumorigenesis and tumor development. Understanding the roles of microRNAs in non-small cell lung cancer (NSCLC) might provide valuable information for therapeutic strategies in the therapy for patients with NSCLC. In the present...

journal_title：Oncology letters

authors： Wu Z,Li Y,Zhang G

更新日期：2017-11-01 00:00:00

abstract：:Cervical cancer (CC) is one of the leading causes of cancer-associated mortalities in women from developing countries. Similar to other types of cancer, CC is considered to be a multifactorial disease, involving socioeconomic, cultural, immunological and epigenetic factors, as well as persistent human papilloma virus ...

journal_title：Oncology letters

authors： Mendoza-Almanza G,Ortíz-Sánchez E,Rocha-Zavaleta L,Rivas-Santiago C,Esparza-Ibarra E,Olmos J

更新日期：2019-10-01 00:00:00

abstract：:Toll-like receptor-9 (TLR9) is a member of the innate immune system and recognizes bacterial and vertebrate DNA in cells. In addition to being expressed in cells of the immune system, it is widely expressed in various types of human cancer, including prostate cancer. We have previously demonstrated that synthetic TLR9...

journal_title：Oncology letters

authors： Väisänen MR,Jukkola-Vuorinen A,Vuopala KS,Selander KS,Vaarala MH

更新日期：2013-05-01 00:00:00

abstract：:We investigated the possible association between DLKI gene promoter region methylation and the increased invasion capacity of non-small cell lung cancer (NSCLC). Lung cancer cell line H1299, as well as the gene transfection and RNA interference technology were used to build DLK gene overexpression and knockdown cells....

journal_title：Oncology letters

authors： Zhong Z,Ye Y,Guo W,He Y,Hu W

更新日期：2017-06-01 00:00:00

abstract：:Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker and as a potential target for cancer therapy. In this study, F§FJ-5, a characterized naphthoquinone modifier of mollugin, was synthesized in order to investigate its anticancer activity and the potential mechanisms. It was observed...

journal_title：Oncology letters

authors： Wei X,Li M,Ma M,Jia H,Zhang Y,Kang W,Wang T,Shi X

更新日期：2017-02-01 00:00:00

abstract：:Actinomycosis is a chronic disease characterized by slow progression, abscess formation, tissue fibrosis and draining sinuses. Occurrence originating from the nasopharynx is extremely low. The present study described the case of a 46-year-old otherwise healthy female, with no remarkable history of mucosal injury or te...

journal_title：Oncology letters

authors： Lin YH,Hu C,Chuang HW,Lin MY

更新日期：2015-07-01 00:00:00

abstract：:Polymorphisms of the vitamin D receptor (VDR) gene may be a risk factor for pancreatic cancer (PC). We investigated the association of two single-nucleotide polymorphisms (SNPs) of the VDR gene with PC in age- and gender-matched patients and controls. PC (n=91) and healthy control (n=80) samples were genotyped for the...

journal_title：Oncology letters

authors： Li L,Wu B,Yang L,Yin G,Wei W,Sui S,Liu J

更新日期：2013-05-01 00:00:00

abstract：:The ATP-binding cassette subfamily B member 1 (ABCB1) is a transporter that mediates multidrug resistance (MDR) against chemotherapy, which leads to decreased patient survival. To inhibit ABCB1 activity in MDR cancer cells, the authors previously designed and synthesized a derivative from 20(S)-protopanaxadiol (PPD) P...

journal_title：Oncology letters

authors： Wei S,Chen W,Hu L,Pan J,Wang X

更新日期：2018-11-01 00:00:00

abstract：:Extra-adrenal pheochromocytomas are rare tumors that originate from the chromaffin tissue of the sympathetic nervous system. Ovarian extra-adrenal pheochromocytoma is even more rare. The present study reports a rare case of an extra-adrenal pheochromocytoma that was localized to the right ovary, but was gynecologicall...

journal_title：Oncology letters

authors： Liu H,Li WZ,Wang XY,Pei YG,Long XY,Chen CY,Hu YB

更新日期：2015-02-01 00:00:00

abstract：:Abnormalities in proto-oncogene B-Raf (BRAF) are typical in several subgroups of gliomas, including pilocytic astrocytomas, optic nerve gliomas, pleomorphic xanthoastrocytomas (PXA), anaplastic PXAs and gangliogliomas. However, they are rarely reported in adult gliomas. BRAF alterations are frequent in a distinct vari...

journal_title：Oncology letters

authors： Tosuner Z,Geçer MÖ,Hatiboğlu MA,Abdallah A,Turna S

更新日期：2018-08-01 00:00:00

abstract：:Breast cancer is a highly heterogeneous disease at the molecular level and >90% of mortalities are due to metastasis and its associated complications. The present study determined the impact of molecular subtypes on metastatic behavior and overall survival (OS) of patients with metastatic breast cancer. The influence ...

journal_title：Oncology letters

authors： Yang H,Wang R,Zeng F,Zhao J,Peng S,Ma Y,Chen S,Ding S,Zhong L,Guo W,Wang W

更新日期：2020-10-01 00:00:00

abstract：:Effects of different levels of PM2.5 on invasion and proliferation of HeLa cells and the expression levels of inflammatory cytokines IL-1 and IL-6 under 10 µg/ml PM2.5 were investigated. Different groups of HeLa cells were treated with PM2.5 at 0, 10, 25, 50, 100 and 200 µg/ml for 36 h, respectively. Cell proliferatio...

journal_title：Oncology letters

authors： Huang K,Li W,Chen Y,Zhu J

更新日期：2018-12-01 00:00:00

abstract：:Physical activity offers a paradoxical hormetic effect and a health benefit to cancer survivors; however, the biochemical mechanisms have not been entirely elucidated. Despite the well-documented evidence implicating oxidative stress in breast cancer, the association between health benefits and redox status has not be...

journal_title：Oncology letters

authors： Tomasello B,Malfa GA,Strazzanti A,Gangi S,Di Giacomo C,Basile F,Renis M

更新日期：2017-01-01 00:00:00

abstract：:Malignant mesothelioma in the mediastinum is rare and the majority of known cases have been reported as 'localized mesothelioma'. The present study reports a case of an upper mediastinal tumor, which was diagnosed through thoracoscopic surgery and surgical biopsies of the mass. A computed tomography scan revealed a gi...

journal_title：Oncology letters

authors： Zhang S,Song P,Zhang B

更新日期：2013-07-01 00:00:00

abstract：:Clear cell renal cell carcinoma (ccRCC) exhibits the highest mortality among all urological malignancies. The investigation of the potential disease progression markers can improve ccRCC diagnosis and treatment. Gene associated with retinoid-interferon-induced mortality-19 (GRIM-19) is involved in carcinogenesis and c...

journal_title：Oncology letters

authors： Yan N,Feng X,Jiang S,Sun W,Sun MZ,Liu S

更新日期：2020-06-01 00:00:00

abstract：:The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...

journal_title：Oncology letters

authors： Li Z,Gu X,Fang Y,Xiang J,Chen Z

更新日期：2012-02-01 00:00:00

abstract：:An individual with a twin who has developed leukemia or non-Hodgkin lymphoma (NHL) has an increased risk of developing the same disease, particularly with monozygotic twins. The few reported pairs of twins who developed NHL had similar primary sites and pathological subtypes. Here, we present the first reported cases ...

journal_title：Oncology letters

authors： Ishibashi N,Sugaya S,Takahashi H,Nishimaki H,Nakanishi Y,Chinen Y,Maebayashi T

更新日期：2019-01-01 00:00:00

abstract：:Tumor-induced osteomalacia (TIO) is a rare acquired form of hypophosphatemia commonly associated with phosphaturic mesenchymal tumors (PMTs) located in the bone or soft tissue. Resection of the tumor can cure osteomalacia. Fibroblast growth factor 23 has been identified as a major pathophysiological factor responsible...

journal_title：Oncology letters

authors： Morimoto T,Takenaka S,Hashimoto N,Araki N,Myoui A,Yoshikawa H

更新日期：2014-07-01 00:00:00

abstract：:The frequency of deficient mismatch repair (dMMR) or microsatellite instability-high colorectal cancer (CRC) is estimated to be ~15% of all patients with CRC; however, the patients reported are limited to surgical cases, and the frequency of patients exhibiting stage 0 disease is not considered, despite the currently ...

journal_title：Oncology letters

authors： Sugiyama T,Iwaizumi M,Kaneko M,Tani S,Yamade M,Hamaya Y,Furuta T,Miyajima H,Osawa S,Baba S,Maekawa M,Sugimoto K

更新日期：2020-09-01 00:00:00

abstract：:The association between inflammation and cancer has been established in certain forms of human malignancies; however, its role in prostate cancer remains unclear. The present study investigates a possible association between chronic inflammation and the development of epithelial neoplasia in the prostate. Needle biops...

journal_title：Oncology letters

authors： Glover M,Soni S,Ren Q,Maclennan GT,Fu P,Gupta S

更新日期：2017-10-01 00:00:00

abstract：:Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atl...

journal_title：Oncology letters

authors： Zhang ZH,Luan ZY,Han F,Chen HQ,Liu WB,Liu JY,Cao J

更新日期：2019-11-01 00:00:00

abstract：:Cytokine-induced killer (CIK) cells are a group of heterogeneous immune cells which can be isolated from human peripheral blood mononuclear cells and have demonstrated therapeutic benefit both in hematologic malignancies and solid tumors, including colorectal cancer. However, poor tumor-targeted migration has limited ...

journal_title：Oncology letters

authors： Zou Y,Liang J,Li D,Fang J,Wang L,Wang J,Zhang J,Guo Q,Yan X,Tang H

更新日期：2020-07-01 00:00:00

abstract：:Radiofrequency ablation has become an increasingly common therapeutic technique for patients with hepatocellular carcinoma or metastatic liver tumors. However, reports on the effect of percutaneous radiofrequency ablation (PRFA) on circulating tumor cells (CTCs) are limited. The present study aimed to further investig...

journal_title：Oncology letters

authors： Li Y,Huang N,Wang C,Ma H,Zhou M,Lin L,Huang Z,Sun L,Shi M,Liao W

更新日期：2018-09-01 00:00:00

abstract：:The t(3;21)(q26.2;q22) translocation is a rare chromosomal abnormality exhibited almost exclusively in therapy-related myelodysplastic syndrome/acute myeloid leukemia (t-MDS/AML) or in the blastic crisis phase of chronic myelogenous leukemia, which results in the fusion of the runt related transcription factor 1 (RUNX...

journal_title：Oncology letters

authors： Tanaka K,Oshikawa G,Akiyama H,Ishida S,Nagao T,Yamamoto M,Miura O

更新日期：2017-07-01 00:00:00

abstract：:Multiple myeloma is defined as a malignant proliferation of a single clone of plasma cells resulting in monoclonal immunoglobulin production. Due to the number of plasma cell morphological variants, difficulty is often faced during morphological diagnosis. The current study describes the case of a 49-year-old woman pr...

journal_title：Oncology letters

authors： Jiang P,Xia W,Sun X,Dai X,Li L

更新日期：2016-03-01 00:00:00

abstract：:The present study aimed to examine the associations between the protein and mRNA expression levels of ovarian cancer gene 1 (OVCA1), cyclin D1 and p16 and high-risk human papillomavirus (HR-HPV) infection in cervical lesions. The protein expression levels of OVCA1, cyclin D1 and p16 in 66 cases of cervical cancer, 64 ...

journal_title：Oncology letters

authors： Tong R,Yang Q,Wang C,Bi F,Jiang B

更新日期：2017-05-01 00:00:00