Screening and identification of key biomarkers in bladder carcinoma: Evidence from bioinformatics analysis.

abstract：:Hypoxia-inducible factor-1α (HIF-1α) and toll-like receptor 4 (TLR4) are involved in numerous mechanisms of cancer biology, including cell proliferation and survival; however the interaction of the two factors under hypoxic conditions remains unclear. The present study investigated the in vitro mechanism that results ...

journal_title：Oncology letters

authors： Zhang X,Li S,Li M,Huang H,Li J,Zhou C

更新日期：2016-08-01 00:00:00

abstract：:Special AT-rich sequence binding protein 1 (SATB1) has regulatory effects on gene expression and appears to play an important role in tumor progression. The present study screened the promoter region of the SATB1 gene for polymorphisms, evaluated the corresponding haplotypes regarding alterations in promoter activity ...

journal_title：Oncology letters

authors： Heubner M,Kimmig R,Aktas B,Siffert W,Frey UH

更新日期：2014-06-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most common cause of cancer-associated mortality worldwide. Prostaglandin E2 (PGE2) regulates various biological processes, including invasion, proliferation and apoptosis. E-prostanoid 3 (Ep3) is a PGE2 receptor, and the functional role of Ep3 in the progression of NSCLC rema...

journal_title：Oncology letters

authors： Li L,Lv Y,Yan D

更新日期：2018-11-01 00:00:00

abstract：:Gefitinib is a selective inhibitor of the tyrosine kinase epidermal growth factor receptor, which inhibits tumor pathogenesis, metastasis and angiogenesis, as well as promoting apoptosis. Therefore, gefitinib presents an effective drug for the targeted therapy of lung cancer. However, the underlying mechanisms by whic...

journal_title：Oncology letters

authors： Zhao ZQ,Yu ZY,Li J,Ouyang XN

更新日期：2016-07-01 00:00:00

abstract：:Acanthus ebracteatus Vahl. is commonly consumed with the aim of curing cancer, inflammatory conditions and skin diseases in traditional Thai medicine. It is known to contain various phytochemicals; however, very little is known about the effects of A. ebracteatus protein hydrolysate on cancer cells, including its mole...

journal_title：Oncology letters

authors： Khamwut A,Jevapatarakul D,Reamtong O,T-Thienprasert NP

更新日期：2019-09-01 00:00:00

abstract：:In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer. The present study aimed to investigate the effects of RHL on H460 and A549 non-sma...

journal_title：Oncology letters

authors： Zhen YZ,Hu G,Zhao YF,Yan F,Li R,Gao JL,Lin YJ

更新日期：2013-08-01 00:00:00

abstract：:The present study aimed to investigate the effect of fisetin on proliferation and apoptosis of gastric cancer cells, as well as the underlying mechanism. Proliferation in SGC7901 cancer and GES-1 normal cells was analyzed using a CCK-8 assay. Apoptosis was analyzed using an Annexin V/Propidium Iodide apoptosis kit and...

journal_title：Oncology letters

authors： Yan W,Chen S,Zhao Y,Ye X

更新日期：2018-06-01 00:00:00

abstract：:A number of available studies have focused on the role of mastocytes and their angiogenic factors, such as tryptase expression, in cancer growth as a major research objective. Cardiac myxoma is a rare neoplasia and is the most common primary tumor of the heart. The cellular elements of cardiac myxoma have an endotheli...

journal_title：Oncology letters

authors： Donato G,Conforti F,Camastra C,Ammendola M,Donato A,Renzulli A

更新日期：2014-07-01 00:00:00

abstract：:The present study reports the rare case of a patient with quintuple primary cancer that underwent systematic treatment, including surgical intervention. A 63-year-old male patient was initially diagnosed with primary esophageal cancer and hypopharyngeal cancer. The patient underwent total pharyngolaryngoesophagectomy ...

journal_title：Oncology letters

authors： Otowa Y,Nakamura T,Takiguchi G,Urakawa N,Ishida R,Imanishi T,Suzuki S,Tanaka K,Kuroda D,Kakeji Y

更新日期：2015-06-01 00:00:00

abstract：:Cancer and embryo expression protein 65 (CEP65) is a centrosomal protein that is expressed at relatively high levels in embryonic tissue and different cancerous tissues, but its role in tumorigenesis remains unknown. In the present study, CEP65 was stably expressed in AGS gastric cancer cells. CEP65 was found to promo...

journal_title：Oncology letters

authors： Jin G,Peng L,Zhang J,Qu L,Shou C

更新日期：2015-04-01 00:00:00

abstract：:5,7-dihydroxy-3',4',6-trimethoxyflavone, commonly known as eupatilin, is a traditional Asian medicinal plant, which is mainly used for the treatment of gastritis, as well as its use as an anti-inflammatory agent. Eupatilin is a bioactive compound; however, its effects on osteosarcoma (OS) have remained to be elucidate...

journal_title：Oncology letters

authors： Li YY,Wu H,Dong YG,Lin BO,Xu G,Ma YB

更新日期：2015-10-01 00:00:00

abstract：:Lung cancer, a malignant tumor, is the most frequently fatal cancer, with poor survival rates in the advanced stages. In order to improve the understanding of this disease, and to improve the outcomes of patients, additional studies are required. In the present study, differentially expressed genes (DEGs) in patients ...

journal_title：Oncology letters

authors： Xu X,Cao L,Zhang Y,Yin Y,Hu X,Cui Y

更新日期：2018-01-01 00:00:00

abstract：:Malignant melanoma can be successfully treated when it is identified in its early stages, but the disease is associated with a poor prognosis when it is detected in an advanced stage. Papillary thyroid carcinoma is a thyroid cancer that has a good prognosis. The present study reports a rare case of malignant melanoma ...

journal_title：Oncology letters

authors： Ozgun A,Tuncel T,Emirzeoglu L,Celik S,Bilgi O,Haholu A,Urhan M,Karagoz B

更新日期：2015-01-01 00:00:00

abstract：:The present study aimed to investigate the clinical characteristics, diagnosis and treatment of accessory breast cancer, and contribute valuable information regarding this rare tumour to the current literature, ultimately facilitating the development of improved treatment strategies. The present study reported the cas...

journal_title：Oncology letters

authors： Zhang S,Yu YH,Qu W,Zhang Y,Li J

更新日期：2015-09-01 00:00:00

abstract：:The current case-control study was conducted to assess the value of activated fibroblasts with high α-smooth muscle actin (α-SMA) expression as an indicator of survival in hepatocellular carcinoma (HCC) patients. In total, 47 patients diagnosed with HCC who underwent a liver biopsy at the Veterans Affairs Medical Cent...

journal_title：Oncology letters

authors： Parikh JG,Kulkarni A,Johns C

更新日期：2014-02-01 00:00:00

abstract：:Certain patients with lymphoma may harbor mutations in perforin 1 (PRF1), unc-13 homolog D (UNC13D), syntaxin 11 (STX11), STXBP2 (syntaxin binding protein 2) or SH2 domain containing 1A (SH2D1A), which causes functional defects of cytotoxic lymphocytes. Data regarding the association between genetic defects and the de...

journal_title：Oncology letters

authors： Chen X,Zhang Y,Wang F,Wang M,Teng W,Lin Y,Han X,Jin F,Xu Y,Cao P,Fang J,Zhu P,Tong C,Liu H

更新日期：2017-11-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and malignant type of glioma, with a poor prognosis for patients. The survival time of patients varies greatly due to the complexity of the human genome, which harbors diverse oncogenic drivers. In order to identify the specific driving factors, 325 glioma samples from ...

journal_title：Oncology letters

authors： Zeng F,Wang K,Huang R,Liu Y,Zhang Y,Hu H

更新日期：2019-07-01 00:00:00

abstract：:The present study sought to characterize the role of macrophage inflammatory protein-3α (MIP-3α) in non-small cell lung cancer (NSCLC) patients with early recurrence or metastasis after primary pulmonary resection. Follow-up examinations were conducted for 203 NSCLC patients with primary pulmonary resection for two ye...

journal_title：Oncology letters

authors： Zhang X,Meng A,Wang H,Yan X

更新日期：2014-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-associated death worldwide. Glioma-associated oncogene homolog 1 (Gli1) is a key component and functions as a reliable marker of Hedgehog signaling pathway activation. Previous studies have demonstrated that Gli1 serves important roles in the pro...

journal_title：Oncology letters

authors： Hu Z,Xie F,Hu A,Xu M,Liu Y,Zhang J,Xiao J,Song Y,Zhong J,Chen B

更新日期：2020-11-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a type of cancer that is characterized by increased invasiveness, metastatic potential and tumor recurrence. Camptothecin has been demonstrated to exhibit anticancer activity. However, the potential underlying molecular mechanisms mediated by camptothecin in NPC cells remain elusive. ...

journal_title：Oncology letters

authors： Li BS,Huang JY,Guan J,Chen LH

更新日期：2018-07-01 00:00:00

abstract：:The current study presents a case of primary T-cell lymphoma (PTBL), unspecified, in a 27-year-old female. The patient received chemotherapy [cyclophosphamide, epirubicin, vindesine and prednisolone (CHOP) and VP-16 plus CHOP (ECHOP)] and autologous peripheral blood stem cell transplantation, however, relapse occurred...

journal_title：Oncology letters

authors： Gao Q,Zhang X,Xiang H,Ren G,Zheng Y

更新日期：2014-01-01 00:00:00

abstract：:The present study aimed to investigate the effect of microRNA-150 (miRNA/miR-150) in osteosarcoma (OS) cell invasion and metastasis by the regulation of Ezrin. To compare the differences in the expression of miR-150 and Ezrin, cell models of OS metastasis were established by exogenous transfection of miR-150 on the ba...

journal_title：Oncology letters

authors： Zhan C,Li C,Zhang H,Tang H,Ji F,Qiao SC,Xu WD,Wang ZW

更新日期：2016-11-01 00:00:00

abstract：:The risk factors for the development of hepatocellular carcinoma (HCC) in patients who have achieved a long-term sustained viral response (SVR) to interferon (IFN) are not fully understood. This study aimed to investigate the characteristics of patients who developed HCC after 10 years of achieving SVR. We retrospecti...

journal_title：Oncology letters

authors： Nojiri K,Sugimoto K,Shiraki K,Kusagawa S,Tanaka J,Beppu T,Yamamoto N,Takei Y,Hashimoto A,Shimizu A,Omori S,Tameda M,Takase K

更新日期：2010-05-01 00:00:00

abstract：:DNA hypomethylation is associated with carcinogenesis due to its involvement in cancer initiation and progression. In this study we analyzed the hypomethylation status of candidate genes in clear cell renal cell carcinoma (CCRCC) using a large-scale, high-throughput DNA methylation profiling technique. Results reveale...

journal_title：Oncology letters

authors： Yoo KH,Park YK,Chang SG

更新日期：2013-01-01 00:00:00

abstract：:The optimal administration of 5-fluorouracil (5-FU)/leucovorin (LV) for colorectal cancer (CRC) has yet to be fully defined although evidence of the combination has already been established. In a multicentre phase II study, pharmacokinetic modulating chemotherapy (PMC), which is based on the concept that continuous in...

journal_title：Oncology letters

authors： Inoue Y,Tanaka K,Hiro J,Toiyama Y,Miki C,Kusunoki M

更新日期：2010-01-01 00:00:00

abstract：:We report a case of tumor lysis syndrome (TLS) in a patient with gallbladder carcinoma. TLS has not been reported in association with this type of tumor. TLS typically occurs in cases of highly proliferative hematological malignancies and small cell carcinoma. Two factors that may have contributed to TLS in this case ...

journal_title：Oncology letters

authors： Duff DJ,Haddadin S,Freter C,Papageorgiou C

更新日期：2013-04-01 00:00:00

abstract：:Osteosarcoma (OS) mortality rate is increasing. Various microRNAs (miRNAs) have been investigated in the pathological process of OS except for miR-744. Hence, this research was designed to explore miR-744 function in OS. RT-qPCR and western blot analysis were used to quantify miR-744 and large tumor suppressor kinase ...

journal_title：Oncology letters

authors： Sun L,Liu M,Luan S,Shi Y,Wang Q

更新日期：2019-09-01 00:00:00

abstract：:The autosomal dominant hereditary disorder von Hippel-Lindau (VHL) disease is caused by a germline mutation in the VHL gene. The symptoms of VHL include hemangioblastoma of the central nervous system, retinal angiomas, visceral tumors and multiple visceral cysts. However, advanced renal cell carcinoma (RCC) occurs in ...

journal_title：Oncology letters

authors： Zhang L,Xu B,Wang Y,Liu C,Lu K,Huang Y,Liu N,Zhang X,Chen S,Chen M

更新日期：2015-08-01 00:00:00

abstract：:The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound in combination with hematoporphyrin monomethyl ether (HMME). The optimum frequency of ultrasound was determined by 3-(4,5-dimethythiazol-2-yl)...

journal_title：Oncology letters

authors： Dai S,Xu C,Tian Y,Cheng W,Li B

更新日期：2014-10-01 00:00:00

abstract：:Extraventricular choroid plexus papillomas (CPPs) are rare. In this study, we reveal the imaging findings of CPPs located in extraventricular sites. The imaging findings of 11 masses [10 masses on magnetic resonance imaging (MRI) and one mass on computed tomography (CT)] of extraventricular CPP in 10 patients were ret...

journal_title：Oncology letters

authors： Shi Y,Li X,Chen X,Xu Y,Bo G,Zhou H,Liu Y,Zhou G,Wang Z

更新日期：2017-03-01 00:00:00