Abstract:
:Special AT-rich sequence binding protein 1 (SATB1) has regulatory effects on gene expression and appears to play an important role in tumor progression. The present study screened the promoter region of the SATB1 gene for polymorphisms, evaluated the corresponding haplotypes regarding alterations in promoter activity in vitro and analyzed the impact of these haplotypes on the clinical course of breast cancer patients. A cohort of 241 female Caucasian breast cancer patients who had been treated was enrolled in this retrospective analysis. The median follow-up time was 93 months (range, 4-155 months). PCR products from DNA of 10 healthy, unrelated volunteers were analyzed to identify new polymorphisms within the promoter region. Genotyping was conducted using restriction fragment length polymorphism and pyrosequencing. PCR constructs with the respective alleles from the four most frequent haplotypes were cloned into the vector pGEM®-T Easy and then transferred into the luc2-containing reporter vector pGl 4.10® for transfection of HEK293 cells. The pGl 4.73® vector, containing hRluc, was used for normalizing the transfection rates. Sequencing the region -3807 to -2828 bp upstream of ATG from ten healthy blood donors, three single nucleotide polymorphisms consisting of base exchanges were identified: -3600T>C, -3363A>G and -2984C>T. The SATB1 -3600T/-3363A/-2984C haplotype had lower promoter activity than all other constructs in vitro and exhibited a significant association with nodal status (P<0.05). Kaplan-Meier survival analysis revealed significantly improved overall survival for homozygous SATB1 -3600T/-3363A/-2984C haplotype carriers compared with heterozygous carriers or the other haplotypes (P=0.033). The SATB1 -3600T/-3363A/-2984C haplotype is associated with lower promoter activity and appears to impact upon survival in breast cancer patients.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Heubner M,Kimmig R,Aktas B,Siffert W,Frey UHdoi
10.3892/ol.2014.1983subject
Has Abstractpub_date
2014-06-01 00:00:00pages
2007-2012issue
6eissn
1792-1074issn
1792-1082pii
ol-07-06-2007journal_volume
7pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The role of mitogen-activated protein kinase (MAPK) signaling pathways in cell growth and differentiation has been well established. The present study aimed to investigate the anti-proliferative effect of stevioside on human colon cancer HT-29 cells. Additionally, the effect of stevioside on cell cycle arrest and MAPK...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5744
更新日期:2017-04-01 00:00:00
abstract::The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11310
更新日期:2020-03-01 00:00:00
abstract::Forkhead box protein A1 (FOXA1) is essential for the growth and differentiation of breast epithelium, and has a favorable outcome in breast cancer (BC). Elevated FOXA1 expression in BC also facilitates hormone responsiveness in estrogen receptor (ESR)-positive BC. However, the interaction between these two pathways is...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6329
更新日期:2017-08-01 00:00:00
abstract::The expression of macrophage inhibitory cytokine-1 (MIC-1) of early gastric cancer treated using endoscopic mucosal resection (EMR) and its correlation with prognosis were investigated. One hundred and forty-seven patients with early gastric cancer (less than 20 mm in diameter) were recruited and assigned into an obse...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6376
更新日期:2017-08-01 00:00:00
abstract::Virosecurinine, a primary alkaloid from Securinega suffruticosa plant is known as a potent differentiation-inducing agent in acute leukemia cells. The present study aimed to investigate the effects and underlying mechanisms of virosecurinine on human leukemia THP-1 cells in vitro. The effects of virosecurinine on cell...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7437
更新日期:2018-01-01 00:00:00
abstract::Anesthetic effect of propofol combined with remifentanil or sevoflurane intravenous anesthesia on patients undergoing radical gastrectomy was evaluated. The clinical data of 516 cancer patients who received radical gastrectomy in the First Bethune Hospital of Jilin University between January 2011 and December 2017 wer...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10238
更新日期:2019-06-01 00:00:00
abstract::The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL). The viability of T24 cells was estimated using a sulforhodamine B assay. Cell morphological changes were examin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6159
更新日期:2017-07-01 00:00:00
abstract::The aim of the present study was to identify monitoring and prevention measures as well as predictive factors for early detection of renal toxicity associated with long-term administration of adefovir dipivoxil in order to avoid progression to Fanconi syndrome. Clinical data of 28 patients with Fanconi syndrome caused...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5393
更新日期:2017-01-01 00:00:00
abstract::The aim of the present study was to investigate the expression of activin A in esophageal carcinoma and its association with tumor differentiation and metastasis. A total of 57 esophageal carcinoma patients and 36 controls were included in the current study. The mRNA and protein expression levels of activin A in esoph...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3248
更新日期:2015-07-01 00:00:00
abstract::The present study aimed to address the pharmacogenetic role of BAG1 in platinum-based chemotherapy in advanced non-small-cell lung cancer (NSCLC) and in cultured human lung adenocarcinoma A549 cells. A total of 108 NSCLC patients (stages I-IIIA) were treated with a standard chemotherapy regimen of cisplatin plus vinor...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4003
更新日期:2016-02-01 00:00:00
abstract::Tumor development is associated with the methylation of cytosine-guanine (CpG) islands. The occurrence of methylation requires several factors, such as DNA methylation systems and polycomb group (PcG) proteins. At present, novel drugs are needed for the treatment of chronic myeloid leukaemia (CML), particularly consid...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6050
更新日期:2017-06-01 00:00:00
abstract::Gastric cancer is an intractable disease with a poor prognosis and limited treatment options. Its treatment remains a major clinical challenge worldwide. Ephrin-B2 is upregulated and involved in tumor growth in various types of cancer. However, the association between ephrin-B2 and prognosis of gastric cancer, and the...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9202
更新日期:2018-10-01 00:00:00
abstract::The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000157
更新日期:2010-09-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2019.10030.]. ...
journal_title:Oncology letters
pub_type: 已发布勘误
doi:10.3892/ol.2020.11409
更新日期:2020-04-01 00:00:00
abstract::The tumor suppressor protein p53 (TP53) gene is associated with various types of cancer; however, little is known about TP53 expression in patients with childhood acute lymphoblastic leukemia (ALL). The aim of the present study was to investigate the prognostic value of TP53 expression in childhood ALL. To achieve thi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11064
更新日期:2020-01-01 00:00:00
abstract::Telomeres are located at the ends of chromosomes and protect them from degradation. Suppressing the activity of telomerase, a telomere-synthesizing enzyme, and maintaining short telomeres is a protective mechanism against cancer in humans. In most human somatic cells, the expression of telomerase reverse transcriptase...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11659
更新日期:2020-08-01 00:00:00
abstract::The present study aimed to investigate the role of homeobox B4 (HOXB4) in breast cancer. Analysis of The Cancer Genome Atlas data revealed that HOXB4 expression was positively associated with expression of the StAR-related lipid transfer domain protein 13 (STARD13), and the overall survival of patients with breast can...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6825
更新日期:2017-10-01 00:00:00
abstract::Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site-specific treatment that utilizes a photo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9322
更新日期:2018-10-01 00:00:00
abstract::The incidence of synchronous multiple primary lung cancer (MPLC) is increasing. However, present diagnostic methods are unable to satisfy the individualized treatment requirements of patients with MPLC. The present study aimed to establish a quantitative mathematical model and analyze its diagnostic value for distingu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2880
更新日期:2015-03-01 00:00:00
abstract::Central diabetes insipidus (DI) is a rare complication in patients with acute myeloid leukemia (AML), typically occurring in patients with abnormalities of chromosomes 3 or 7. The association between AML with monosomy 7 and DI has been described in a number of studies; however, DI has been rarely reported in cases of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3139
更新日期:2015-06-01 00:00:00
abstract::Glutathione transferase Mu 1 (GSTM1) induces cancer drug resistance by hydrolyzing cancer chemotherapeutics or activating the anti-apoptosis pathway. However, the chemoresistance-inducing mechanism of GSTM1 in hepatocellular carcinoma (HCC) remains unknown. In the present study, the expression of GSTM1 was examined in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8667
更新日期:2018-07-01 00:00:00
abstract::Being biomarkers that reflect host nutritional and immune status, prognostic nutritional index (PNI) and neutrophil/lymphocyte ratio (NLR) have been identified to be independent prognostic factors in various malignancies. The aim of the present study was to determine the predictive value of these parameters for the pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9870
更新日期:2019-02-01 00:00:00
abstract::The present study aimed to investigate the expression and roles of deleted in pancreatic carcinoma locus 4 (DPC4) and vascular endothelial growth factor (VEGF) in the development of cervical carcinoma. A total of 115 patients aged between 25 and 60 years were involved, including 19 cervical inflammation, 35 cervical i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7580
更新日期:2018-02-01 00:00:00
abstract::The evaluation of minimal residual disease (MRD) in acute leukemia (AL) is currently recognized as a potential critical tool to assess the response and relapse rate of treatments. The present study investigated serum peptides from patients with AL to identify biomarkers that would be useful in providing clinical evalu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1574
更新日期:2013-11-01 00:00:00
abstract::To investigate the prospective roles and the clinicopathological application of microRNA-21-5p (miR-21-5p) in hepatocellular carcinoma (HCC), the present review is based on 24 studies and bioinformatics investigation. Firstly, HCC-associated miR-21-5p data were aggregated from literature databases and two public genom...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9627
更新日期:2019-01-01 00:00:00
abstract::Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3184
更新日期:2015-07-01 00:00:00
abstract::Although it is the most widely used biomarker for prostate cancer, the use of prostate specific antigen (PSA) is controversial due to its limitations in specificity and sensitivity. The proteasome is a complex associated with cell proliferation and apoptosis, and the abnormity of these processes may lead to tumor occu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7936
更新日期:2018-04-01 00:00:00
abstract::Extra-adrenal pheochromocytomas are rare tumors that originate from the chromaffin tissue of the sympathetic nervous system. Ovarian extra-adrenal pheochromocytoma is even more rare. The present study reports a rare case of an extra-adrenal pheochromocytoma that was localized to the right ovary, but was gynecologicall...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2718
更新日期:2015-02-01 00:00:00
abstract::The S100 protein family is widely involved in the pathological process of various types of cancer. However, the prognostic value of the S100 protein family member S100A12 in hepatocellular carcinoma (HCC) remains unknown. A total of 139 patients undergoing curative surgical resection for HCC from December 2005 to June...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9270
更新日期:2018-10-01 00:00:00
abstract::Knowledge of potential tumor markers may improve chemotherapeutic efficacy. Interleukin-6 (IL-6) expression in local tumor tissues is associated with cancer progression and poor prognosis in variety of cancer types. The aim of the present study was to investigate the role and potential application of IL-6 in determini...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3990
更新日期:2016-02-01 00:00:00