Network analysis of DEGs and verification experiments reveal the notable roles of PTTG1 and MMP9 in lung cancer.

abstract：:Ovarian cancer (OC) is the most common and lethal gynecologic malignancy. The pathophysiology of OC tumor development is complex and involves numerous biological pathways. Previous studies suggest that circular (circ)RNAs serve important roles in OC tumor pathology. In the present study, a re-annotation strategy was p...

journal_title：Oncology letters

authors： Guo Q,He Y,Sun L,Kong C,Cheng Y,Zhang G

更新日期：2019-04-01 00:00:00

abstract：:The safety and immunological responsiveness of a peptide vaccine of ring finger protein 43 and 34-kDa translocase of the outer mitochondrial membrane combined with uracil-tegafur/leucovorin (UFT/LV) was previously demonstrated in metastatic colorectal cancer (CRC) in a phase I clinical trial. To clarify the survival b...

journal_title：Oncology letters

authors： Kawamura J,Sugiura F,Sukegawa Y,Yoshioka Y,Hida JI,Hazama S,Okuno K

更新日期：2018-04-01 00:00:00

abstract：:Primary hemangioendotheliomas (HEs) of the spleen are rare, low-grade borderline-malignant vascular tumors. To date, only a few splenic HE cases have been reported in adults. In infants, one 9-year-old male patient has previously been reported, and the patient succumbed to the disease shortly following surgery. Curren...

journal_title：Oncology letters

authors： Wang Z,Zhang L,Zhang B,Mu D,Cui K,Li S

更新日期：2015-01-01 00:00:00

abstract：:Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previo...

journal_title：Oncology letters

authors： Chen Q,Zhou Z,Shan L,Zeng H,Hua Y,Cai Z

更新日期：2015-07-01 00:00:00

abstract：:Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a specific E1-like ubiquitin-activating enzyme involved in interferon-stimulated gene 15 (ISG15) conjugation. UBA7 expression has been reported to be notably decreased in lung cancer. The present study aimed to investigate the changes in UBA7 expression in breast c...

journal_title：Oncology letters

authors： Lin M,Li Y,Qin S,Jiao Y,Hua F

更新日期：2020-04-01 00:00:00

abstract：:Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, ca...

journal_title：Oncology letters

authors： Yang L,Wang Y,Wang H

更新日期：2019-12-01 00:00:00

abstract：:The present study aimed to investigate the feasibility of using ecto-mesenchymal stem cell (EMSC)-derived dendritic cells (DCs) for glioma immunotherapy following infection by a recombinant adenovirus containing the melanoma-associated antigen D4a (MAGE-D4a) gene. The ex vivo cultured EMSCs were infected by the adenov...

journal_title：Oncology letters

authors： Hu S,Li B,Shen X,Zhang R,Gao D,Guo Q,Jin Y,Fei Z

更新日期：2016-04-01 00:00:00

abstract：:The present study aimed to retrospectively review the contribution of 18F-fluorodeoxygluose-positron emission tomography/computed tomography (18F-FDG PET/CT) in the assessment of biochemical recurrence in patients with a diagnosis of local-stage prostate cancer (PCa) who underwent radical prostatectomy (RP) or receive...

journal_title：Oncology letters

authors： Öztürk H,Karapolat I

更新日期：2016-01-01 00:00:00

abstract：:The aim of this study was to objectively evaluate the benefits of laparoscopically assisted vaginal radical hysterectomy and lymphadenectomy for early-stage cervical cancer. Clinical data were prospectively collected from patients with IA-IIB cervical cancer who underwent laparoscopically assisted vaginal radical hyst...

journal_title：Oncology letters

authors： Hou CY,Li XL,Jiang F,Gong RJ,Guo XY,Yao YQ

更新日期：2011-07-01 00:00:00

abstract：:Pulmonary tumor thrombotic microangiopathy (PTTM) is an uncommon cancer-related complication characterized by intimal proliferation in pulmonary small arteries and arterioles with or without tumor emboli. In the majority of cases, the causative lesion is gastric poorly differentiated adenocarcinoma. In the present stu...

journal_title：Oncology letters

authors： Hotta M,Ishida M,Kojima F,Iwai Y,Okabe H

更新日期：2011-05-01 00:00:00

abstract：:Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with ...

journal_title：Oncology letters

authors： Li M,Zhao Y,Liu X,Zhang S,Jiang Y,Yang Z

更新日期：2020-04-01 00:00:00

abstract：:Although previous studies have demonstrated that dysregulation of microRNA (miR)-126 is associated with the progression of several types of cancer, including lung cancer, the relationship between miR-126 and lung cancer metastasis remains unclear. SPC-A1 lung cancer cells were transfected with miR-126 mimic and negati...

journal_title：Oncology letters

authors： Jia Z,Zhang Y,Xu Q,Guo W,Guo A

更新日期：2018-05-01 00:00:00

abstract：:AR-42 is a member of a novelly discovered class of phenylbutyrate-derived histone deacetylase inhibitors, and has a number of antitumor effects in a variety of tumor types; however, the role of AR-42 and its possible mechanisms have not been reported in the treatment of breast cancer. The aim of the present study was ...

journal_title：Oncology letters

authors： Zhou R,Wu J,Tang X,Wei X,Ju C,Zhang F,Sun J,Shuai D,Zhang Z,Liu Q,Lv XB

更新日期：2018-08-01 00:00:00

abstract：:Extranodal natural killer/T-cell lymphoma (ENKL) is marked by a profound cellular immune deficiency that may influence the capacity of T cells to extract an efficient antitumor immune response. It has been confirmed that the B7-CD28 pathway may promote tumor immune evasion by providing a negative regulatory signal. Th...

journal_title：Oncology letters

authors： Han L,Liu F,Li R,Li Z,Chen X,Zhou Z,Zhang X,Hu T,Zhang Y,Young K,Sun S,Wen J,Zhang M

更新日期：2014-10-01 00:00:00

abstract：:Imiquimod is an imidazoquinoline immune response modifier that is used in antiviral and antiallergic creams. Combination therapy using transcutaneous imiquimod and oral sorafenib was previously demonstrated to reduce the tumor burden of renal cell carcinoma growing cutaneously in a mouse model. In the present study, a...

journal_title：Oncology letters

authors： Karashima T,Udaka K,Niimura M,Suzuki K,Osakabe H,Shimamoto T,Fukata S,Inoue K,Kuroda N,Seiki M,Shuin T

更新日期：2017-07-01 00:00:00

abstract：:Ovarian remnant syndrome (ORS) is a rare, but well-known gynecological complication, most often induced by difficult bilateral salpingo-oophorectomy (BSO) procedures that leave residual ovarian tissue on the pelvic wall. The most common preexisting conditions for this complication include endometriosis, pelvic inflamm...

journal_title：Oncology letters

authors： Imai A,Matsunami K,Takagi H,Ichigo S

更新日期：2014-07-01 00:00:00

abstract：:Choroidal melanoma is the most common primary intraocular tumor in adults. Cepharanthine (CEP), a natural alkaloid extracted from the roots of Stephania cepharantha Hayata, has been demonstrated to inhibit the proliferation of various cancer cells. However, its potential anticancer effect in choroidal melanoma has not...

journal_title：Oncology letters

authors： Zhu Q,Guo B,Chen L,Ji Q,Liang H,Wen N,Zhang L

更新日期：2017-05-01 00:00:00

abstract：:C-X-C motif chemokine ligand 5 (CXCL5) is a CXC-type chemokine that is a crucial inflammatory mediator and a powerful attractant for granulocytic immune cells. Increasing evidence has indicated that CXCL5 is involved in the tumorigenesis of various malignancies. The present investigation demonstrated that CXCL5 was ex...

journal_title：Oncology letters

authors： Yang Y,Hou J,Shao M,Zhang W,Qi Y,E S,Wang S,Sui H,Meng D,Wang B,Wang M,Han Y,Cao Y,Huang X,Li Y,Zhang P,Wang W

更新日期：2017-12-01 00:00:00

abstract：:The incidence of gastric cancer is high, especially in China. The present study aims to provide a novel therapeutic target for gastric cancer. Peripheral blood, cancerous and paracancerous tissues were collected from patients with gastric cancer. T-cell immunoglobulin mucin domain-3 (Tim-3) expression in T-cells was m...

journal_title：Oncology letters

authors： Yu J,Zhang H,Sun S,Sun S,Li L

更新日期：2019-02-01 00:00:00

abstract：:The alteration of microRNA (miR)-130b expression has been associated with promoting or suppressing numerous types of human cancer. A previous study evaluated the expression level of miR-130b in osteosarcoma tissues, and subsequently investigated the effects of miR-130b on the regulation of osteosarcoma cells malignant...

journal_title：Oncology letters

authors： Wu Y,Sun W,Kong Y,Liu B,Zeng M,Wang W

更新日期：2018-07-01 00:00:00

abstract：:The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL). The viability of T24 cells was estimated using a sulforhodamine B assay. Cell morphological changes were examin...

journal_title：Oncology letters

authors： Si L,Yang X,Yan X,Wang Y,Zheng Q

更新日期：2017-07-01 00:00:00

abstract：:This study investigated energy metabolism and its association with inflammatory cytokines and appetite- regulating hormones in patients with gastrointestinal cancer. Subjects were inpatients scheduled to undergo therapeutic intervention for diagnosed gastrointestinal cancer. Nutritional status on admission was assesse...

journal_title：Oncology letters

authors： Shinsyu A,Bamba S,Kurihara M,Matsumoto H,Sonoda A,Inatomi O,Andoh A,Takebayashi K,Kojima M,Iida H,Tani M,Sasaki M

更新日期：2020-08-01 00:00:00

abstract：:Mitotically-associated long non-coding RNA (MANCR) is involved in malignant breast cancer. The present study analyzed the role of MANCR in hepatocellular carcinoma (HCC). MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR...

journal_title：Oncology letters

authors： Zhang X,Li H,Mao M,Wang X,Zheng J,Yang S

更新日期：2019-12-01 00:00:00

abstract：:Partial hydatidiform mole and coexisting fetus (PHMCF) is a rare condition that presents a dilemma for physicians and the parents of the fetus, particularly when PHMCF is detected during the second trimester of pregnancy. The present study reports a case of PHMCF terminated by induction of labor via administration of ...

journal_title：Oncology letters

authors： Wang Y,Qian H,Wang J

更新日期：2015-12-01 00:00:00

abstract：:MicroRNA-181 (miR-181) has been recently demonstrated to participate in the differentiation and development of immune cells, including natural killer cells and B and T lymphocytes, and myeloid linages, including erythroid and megakaryocytic cells. The aberrant expression of miR-181, particularly low expression levels,...

journal_title：Oncology letters

authors： Wang G,Zhao R,Zhao X,Chen XI,Wang D,Jin Y,Liu XI,Zhao CI,Zhu Y,Ren C,Li M,Jin X,Zhang F,Zhong Z,Wang T,Li X

更新日期：2015-11-01 00:00:00

abstract：:The liver kinase B1 (LKB1)/5'-adenosine monophosphate-activated protein kinase pathway has been reported to facilitate glioma cell growth by improving growth conditions. To investigate the clinical significance of LKB1 in human gliomas western blot analysis and quantitative polymerase chain reaction experiments were p...

journal_title：Oncology letters

authors： Huang J,Chen H,Wei Q,Zhang Z,Zhong Z,Xu Y

更新日期：2017-03-01 00:00:00

abstract：:Studies have shown that homeobox D10 (HOXD10) is the target gene of microRNA-10b (miR-10b) and is closely associated with the inhibition of cell migration and invasion. Ras homolog family member C (RhoC) has been reported to promote tumor metastasis in various types of cancer. The effect of miR-10b on colorectal cance...

journal_title：Oncology letters

authors： Wang Y,Li Z,Zhao X,Zuo X,Peng Z

更新日期：2016-07-01 00:00:00

abstract：:The aim of the present study was to identify and characterize side population (SP) cells in primary cervical cancer. A primary culture was successfully established, and the SP cells were isolated via fluorescence-activated cell sorting. Subsequently, in vitro analysis of clonogenic capacity by soft agar assay and in v...

journal_title：Oncology letters

authors： Wei ZT,Yu XW,He JX,Liu Y,Zhang SL

更新日期：2017-09-01 00:00:00

abstract：:Pleomorphic adenomas (PAs) of salivary glands are the most frequent entity of solid parotid tumors. Nonetheless, their genetics is not yet well understood. Thus, the current study characterized 14 PAs using a unique combination of cytogenetic, molecular cytogenetic and/or molecular karyotyping based approaches. The cu...

journal_title：Oncology letters

authors： Thielker J,Weise A,Othman MAK,Carreria IM,Melo JB,Von Eggeling F,Guntinas-Lichius O,Ziegler M,Liehr T

更新日期：2020-02-01 00:00:00

abstract：:Integrin signaling may modulate several different functions involved in cell migration, invasion, proliferation and motility, and is a potential candidate biomarker for oral cancer. In the present study, a total of four integrin genes were evaluated as potential biomarkers of oral squamous cell carcinoma (OSCC). Gene ...

journal_title：Oncology letters

authors： Chang HW,Yen CY,Chen CH,Tsai JH,Tang JY,Chang YT,Kao YH,Wang YY,Yuan SF,Lee SY

更新日期：2018-10-01 00:00:00