Application of eupatilin in the treatment of osteosarcoma.

abstract：:Corosolic acid (CRA), a pentacyclic triterpene isolated from medicinal herbs, has been reported to exhibit anticancer properties in several cancers. However, the anticancer activity of CRA in osteosarcoma cells is still unclear. In the present study, the inhibitory effect of CRA in osteosarcoma MG-63 cells was investi...

journal_title：Oncology letters

authors： Jia Y,Yuan H,Shan S,Xu G,Yu J,Zhao C,Mou X

更新日期：2016-11-01 00:00:00

abstract：:The phosphoinositide-3 kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) pathway is a cellular pathway involved in cell growth, tumorigenesis and cell invasion which is frequently activated in various types of cancer. The downstream effector of the pathway is mTOR which is important in cellular growth and homeost...

journal_title：Oncology letters

authors： Li M,Sun H,Song L,Gao X,Chang W,Qin X

更新日期：2012-12-01 00:00:00

abstract：:A tissue-specific promoter can control downstream gene expression in tissues or organs. The human involucrin (hINV) promoter (pINV) that contains 2474 bp of hINV upstream sequence is able to regulate tissue-specific gene expression. This tissue specificity may be important for the prevention and treatment of human pap...

journal_title：Oncology letters

authors： Gao H,Huang Z,Shi C,Li H

更新日期：2015-02-01 00:00:00

abstract：:The predominant characteristic of malignant glioma is the presence of invading tumor cells in the peritumoral zone. Distinguishing between tumor cells and normal cells in a peritumoral lesion is challenging. Therefore, the aim of the present study was to investigate the cell-cycle phase measurements of fixed paraffin-...

journal_title：Oncology letters

authors： Nakajima S,Morii K,Takahashi H,Fujii Y,Yamanaka R

更新日期：2016-03-01 00:00:00

abstract：:Breast tissue is very sensitive to ionizing radiation due to the presence of reproductive hormones, including estrogen. In the present pilot study, the efficiency of mammography X-rays to induce DNA double strand breaks (DSB) in mammary epithelial cells was investigated. For this, freshly resected healthy breast tissu...

journal_title：Oncology letters

authors： Depuydt J,Viaene T,Blondeel P,Roche N,Van den Broecke R,Thierens H,Vral A

更新日期：2018-09-01 00:00:00

abstract：:Esophageal adenocarcinoma has shown a significant increase in incidence in recent years. It is thought that the development of gastroesophageal reflux disease (GERD), followed by columnar-lined esophagus and the development of dysplasia, leads to invasive adenocarcinoma. The exact pathogenesis of this process, the dia...

journal_title：Oncology letters

authors： Jaœkiewicz K,Iżycka-Œwieszewska E,Janiak M,Lysiak-Szydłowska W,Adrych K,Reinartz J,Jankun J,Skrzypczak-Jankun E

更新日期：2010-09-01 00:00:00

abstract：:Poly(ADP-Ribose) polymerase family member 9 (PARP9) promotes the proliferation, survival and chemotherapy resistance in lymphoma and prostate cancer. The expression and function of PARP9 in human breast cancer remains unknown. In the present study, it was demonstrated that PARP9 is frequently overexpressed in human br...

journal_title：Oncology letters

authors： Tang X,Zhang H,Long Y,Hua H,Jiang Y,Jing J

更新日期：2018-09-01 00:00:00

abstract：:Ku80, a subunit of the heterodymeric Ku protein, is clearly implicated in nonhomologous end joining DNA repair, chemoresistance and radioresistance in malignant tumors. In the present study, the clinicopathological significance of Ku80 in esophageal squamous cell carcinoma (ESCC) was investigated. The expression level...

journal_title：Oncology letters

authors： Wang S,Wang Z,Yang YU,Shi MO,Sun Z

更新日期：2015-11-01 00:00:00

abstract：:A disintegrin and metalloproteinase 9 (ADAM9) is a member of the transmembrane ADAM family. It is expressed in different types of solid cancer and promotes tumor invasiveness. To the best of our knowledge, the present study was the first to examine ADAM9 expression in vestibular schwannomas (VS) from patients with and...

journal_title：Oncology letters

authors： Breun M,Schwerdtfeger A,Martellotta DD,Kessler AF,Monoranu CM,Matthies C,Löhr M,Hagemann C

更新日期：2020-03-01 00:00:00

abstract：:The integrality of low molecular weight protein (LMP)2/LMP7 function plays an important role in the processing of GC cell antigens. The purpose of the present hospital-based case-control study was to estimate the effect of polymorphisms in the LMP2 and LMP7 genes on the risk of GC. Polymerase chain reaction-restrictio...

journal_title：Oncology letters

authors： Ma X,Yang C,Tang R,Xu Z,Zhang Z,Wang Y,Zhang J,Yang LI

更新日期：2015-07-01 00:00:00

abstract：:Actinomycosis is a chronic disease characterized by slow progression, abscess formation, tissue fibrosis and draining sinuses. Occurrence originating from the nasopharynx is extremely low. The present study described the case of a 46-year-old otherwise healthy female, with no remarkable history of mucosal injury or te...

journal_title：Oncology letters

authors： Lin YH,Hu C,Chuang HW,Lin MY

更新日期：2015-07-01 00:00:00

abstract：:Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. However, the expression and mechanisms underlying the function of ACY1 in colorectal cancer remain unclear. In order to investigate the expression and function of ACY1 in colorectal cancer, tumor tissue and blood samples w...

journal_title：Oncology letters

authors： Yu B,Liu X,Cao X,Zhang M,Chang H

更新日期：2017-04-01 00:00:00

abstract：:Prognosis and treatment differences between initial and second primary chondrosarcoma (pCS) remain unknown. In the present study, patients with chondrosarcoma diagnosed between January 2004 and December 2015 were identified using the Surveillance Epidemiology and End Results database. Kaplan-Meier curves and log-rank ...

journal_title：Oncology letters

authors： Mao W,Kong M,Yu H,Wang D,Huang X,Yao X,Fan J,Geng J

更新日期：2019-07-01 00:00:00

abstract：:The objective of the present study was to investigate and analyze the epithelial-cadherin (E-cadherin) expression in invasive ductal carcinoma of the breast, and to analyze the associations between the expression and clinicopathological characteristics of lymph node metastasis and the prognosis of breast cancer. The i...

journal_title：Oncology letters

authors： Yang L,Wang XW,Zhu LP,Wang HL,Wang B,Zhao Q,Wang XY

更新日期：2018-08-01 00:00:00

abstract：:Macrophages are a heterogeneous group of phagocytes that play critical roles in inflammation, infection and tumor growth. Macrophages respond to different environmental factors and are thereby polarized into specialized functional subsets. Although hypoxia is an important environmental factor, its impact on human macr...

journal_title：Oncology letters

authors： Ke X,Chen C,Song Y,Cai Q,Li J,Tang Y,Han X,Qu W,Chen A,Wang H,Xu G,Liu D

更新日期：2019-12-01 00:00:00

abstract：:Breast cancer is a common malignant tumor among females, with triple-negative breast cancer being an important type accounting for 15-20% of all breast cancer cases. Triple-negative breast cancer is one of the most aggressive types of cancer without standard adjuvant chemotherapy. Ganoderic acid A (GA-A) is one of the...

journal_title：Oncology letters

authors： Yang Y,Zhou H,Liu W,Wu J,Yue X,Wang J,Quan L,Liu H,Guo L,Wang Z,Lian X,Zhang Q

更新日期：2018-11-01 00:00:00

abstract：:The present study evaluated androgen deprivation methods to determine the approach that most improves the progression-free survival (PFS) of patients with metastatic prostate cancer. Patients had received continuous maximal androgen blockade (MAB) or monotherapy [luteinizing-hormone releasing hormone (LHRH) agonist or...

journal_title：Oncology letters

authors： Min GE,Ahn H

更新日期：2017-06-01 00:00:00

abstract：:With the growing requirement for novel prognostic biomarkers for pancreatic cancer, many studies have focused on clinical and/or genomic variables. Although many studies have been performed, carbohydrate antigen 19-9 is the only biomarker in clinical use. Therefore, the present study examined whether γ-secretase genes...

journal_title：Oncology letters

authors： Jeon YH,Ha M,Kim SW,Kim MJ,Lee CS,Oh CK,Han ME,Oh SO,Kim YH

更新日期：2019-05-01 00:00:00

abstract：:The incidence rate of tonsillar cancer is increasing worldwide. The current study identifies a parallel increase in the incidence of tonsillar cancer, human papilloma virus (HPV) and p16 expression among a population from northern Sweden, a sparsely populated area, confirming the strong association between p16 and HPV...

journal_title：Oncology letters

authors： Loizou C,Laurell G,Lindquist D,Öfverman C,Stefansson K,Nylander K,Olofsson K

更新日期：2015-12-01 00:00:00

abstract：:The expression of T-box transcription factor 5 (TBX5) has previously been observed in human cancer. The aim of the present study was to investigate TBX5 expression and its potential clinical significance in gastric cancer (GC). Using reverse transcription-quantitative polymerase chain reaction, the TBX5 mRNA expressio...

journal_title：Oncology letters

authors： Zheng Y,Li YF,Wang W,Chen YM,Wang DD,Zhao JJ,Pan QZ,Jiang SS,Zhang XF,Yuan SQ,Qiu HB,Huang CY,Zhao BW,Zhou ZW,Xia JC

更新日期：2015-10-01 00:00:00

abstract：:Effects of miR-135a-5p and miR-141 on the biological function of colorectal cancer SW620 cells were investigated. Fifty-four specimens of cancer tissues and 54 specimens of corresponding adjacent tissues in colon cancer patients who were treated in The Central Hospital of Wuhan from March 2014 to March 2015 were colle...

journal_title：Oncology letters

authors： Wang J,Yang J,Zhang H,Liao Y,Xu D,Ma S

更新日期：2020-07-01 00:00:00

abstract：:Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...

journal_title：Oncology letters

authors： Ieni A,Giuffrè G,Lanzafame S,Nuciforo G,Curduman M,Villari L,Roz E,Certo G,Cabibi D,Salomone E,Labate A,Messina D,Franco V,Adamo V,Tuccari G

更新日期：2012-01-01 00:00:00

abstract：:The evaluation of minimal residual disease (MRD) in acute leukemia (AL) is currently recognized as a potential critical tool to assess the response and relapse rate of treatments. The present study investigated serum peptides from patients with AL to identify biomarkers that would be useful in providing clinical evalu...

journal_title：Oncology letters

authors： Song W,Wang N,Li W,Wang G,Hu J,He K,Li Y,Meng Y,Chen N,Wang S,Hu L,Xu B,Wang J,Li A,Cui J

更新日期：2013-11-01 00:00:00

abstract：:Knowledge of potential tumor markers may improve chemotherapeutic efficacy. Interleukin-6 (IL-6) expression in local tumor tissues is associated with cancer progression and poor prognosis in variety of cancer types. The aim of the present study was to investigate the role and potential application of IL-6 in determini...

journal_title：Oncology letters

authors： Zhao ZF,Li JX,Ye R,Wu X,Gao LL,Niu BL

更新日期：2016-02-01 00:00:00

abstract：:Chemotherapy is widely administered to patients with advanced lung cancer; however, data regarding chemotherapeutic sensitivity are limited. The present study aimed to investigate the predictive value of inflammatory indexes for chemotherapeutic efficacy in advanced lung cancer. Patients with stage III and IV unresect...

journal_title：Oncology letters

authors： Sun H,Hu P,Du J,Wang X

更新日期：2018-03-01 00:00:00

abstract：:Effect of microRNA-27b (miR-27b) on cisplatin chemotherapy sensitivity of oral squamous cell carcinoma (OSCC) was investigated to provide a reference for clinical prevention of OSCC cell resistance. The clinical tissues of 34 patients with OSCC-resistant cancer and 28 patients with cisplatin-sensitive OSCC in Nanjing ...

journal_title：Oncology letters

authors： Liu B,Cao G,Dong Z,Guo T

更新日期：2019-07-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) expression is a poor prognostic factor in various types of cancer. Expression levels of HGF have been reported to be regulated by shorter poly(dA) sequences in the promoter region. In the present study, the poly(dA) mononucleotide tract in various types of human cancer cell lines was exa...

journal_title：Oncology letters

authors： Sakai K,Takeda M,Okamoto I,Nakagawa K,Nishio K

更新日期：2015-01-01 00:00:00

abstract：:Impairment of microRNA (miRNA) biogenesis may be involved in clear cell renal cell carcinoma (ccRCC). The objective of the present study was to investigate the mRNA levels of important miRNA machinery components, DICER1, DROSHA, DiGeroge syndrome critical region gene 8 (DGCR8), and Argonaute 2 (AGO2), and their correl...

journal_title：Oncology letters

authors： Lee SS,Min H,Ha JY,Kim BH,Choi MS,Kim S

更新日期：2019-10-01 00:00:00

abstract：:Although cisplatin (DDP) has been reported to be a promising antitumor therapy for non-small cell lung cancer (NSCLC), the effectiveness of the treatment remains limited due to an inherent tumor resistance to DDP. Genistein (GEN) is an abundant, naturally occurring isoflavonoid found in soy products that has been demo...

journal_title：Oncology letters

authors： Liu D,Yan L,Wang L,Tai W,Wang W,Yang C

更新日期：2014-12-01 00:00:00

abstract：:Cisplatin resistance has been a major factor limiting its clinical use as a chemotherapy drug. The present study aimed to investigate whether SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase closely associated with tumors can affect the sensitivity of tumors to cisplatin chemotherapy. Real...

journal_title：Oncology letters

authors： Wang L,Xu ML,Wang C,Dong QQ,Miao Z,Chen XY,Wang N,He HP,Zhang TC,Luo XG

更新日期：2020-05-01 00:00:00