Evaluation of the prognostic significances of γ-secretase genes in pancreatic cancer.

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death. Due to rapid progression and metastasis, the long-term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that chond...

journal_title：Oncology letters

authors： Huang Z,Zhang N,Li W,Cao J,Zhang L,Chen Y

更新日期：2017-02-01 00:00:00

abstract：:Personalized chemotherapy with the use of biomarkers helps to maximize clinical efficiency. Therefore, the present study aimed to identify a potential method for identifying biomarkers in esophageal cancer. A total of 49 freshly resected tumor tissues and 72 paraffin-embedded specimens from patients with esophageal ca...

journal_title：Oncology letters

authors： Wei B,Wang J,Zhang X,Qian Z,Wu J,Sun Y,Han Q,Wan L,Zhu J,Gao Y,Chen X

更新日期：2017-12-01 00:00:00

abstract：:The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesion...

journal_title：Oncology letters

authors： Yan Z,Liu G,Liang M,Xu Y

更新日期：2019-02-01 00:00:00

abstract：:Multiple myeloma (MM) is a hematological malignancy that lacks a cure. However, novel combination therapy is a current anti-MM strategy. Doxorubicin (DOX) is a type of anthracycline which is a first-line chemotherapeutic for treating MM and induces senescence in many types of cancer. Dinaciclib is a potent, small mole...

journal_title：Oncology letters

authors： Tang H,Xu L,Liang X,Gao G

更新日期：2018-11-01 00:00:00

abstract：:Hepatic epithelioid angiomyolipoma (EAML) is a rare type of hepatic tumor. Due to a lack of adequate understanding about this tumor, hepatic EAML is often misdiagnosed as other diseases with similar clinical characteristics such as hepatic cancer. In the present study, 3 cases of hepatic EAML are reported, and the mai...

journal_title：Oncology letters

authors： Liu W,Meng Z,Liu H,Li W,Wu Q,Zhang X,E C

更新日期：2016-06-01 00:00:00

abstract：:The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is a master scaffold protein involved in Wnt signaling. Axin2 negatively regulates Wnt signaling and acts as a tumor suppressor protein. The present study evaluated the association between the Axin2 single...

journal_title：Oncology letters

authors： Ma C,Liu C,Huang P,Kaku H,Chen J,Guo K,Ueki H,Sakai A,Nasu Y,Kumon H,Shimizu K,Watanabe M

更新日期：2014-08-01 00:00:00

abstract：:The talin proteins are a key component of the extracellular matrix-integrin-cytoskeleton system, and our previous study suggested that talin2 contributes to the tumor invasion and metastasis processes regulated by the tumor microenvironment. In the present study, the specific effects of talin2 on the invasive ability ...

journal_title：Oncology letters

authors： Wen Z,Liang Y,Deng S,Zou L,Xie X,Yang J,Wu Y

更新日期：2019-06-01 00:00:00

abstract：:The 78-kDa glucose-regulated protein (GRP78) is a stress induced heat shock protein which, under limiting conditions, functions as a cell surface signaling receptor. Tumor cells are considered to be subjected to a physiologically stressful microenvironment due to their excessive growth. The role of GRP78 in tumor surv...

journal_title：Oncology letters

authors： Yerushalmi R,Raiter A,Nalbandyan K,Hardy B

更新日期：2015-10-01 00:00:00

abstract：:Interleukin (IL)-32 is a newly identified cytokine in humans and primates. It has been established that IL-32 may antagonize cancer growth. However, to the best of our knowledge, the direct effect of IL-32 on breast cancer cell growth has not yet been investigated. In addition, rodents lack the expression of IL-32; he...

journal_title：Oncology letters

authors： Wang S,Chen F,Tang L

更新日期：2015-01-01 00:00:00

abstract：:Glioblastoma multiforme (GBM) was one of the first cancer types systematically studied at a genomic and transcriptomic level due to its high incidence and aggressivity; however, the detailed mechanism remains unclear, even though it is known that numerous cytokines are involved in the occurrence and development of GBM...

journal_title：Oncology letters

authors： He K,Shi L,Jiang T,Li Q,Chen Y,Meng C

更新日期：2016-10-01 00:00:00

abstract：:Ovarian cancer (OVAC) remains the most lethal gynecological malignancy; it is ranked fifth among the most common types of cancer that affect women worldwide. Several aspects of the disease, including molecular pathogenesis, epidemiology, histological subtypes, poor prognosis at early stages due to the absence of speci...

journal_title：Oncology letters

authors： Sun W,Fu S

更新日期：2019-09-01 00:00:00

abstract：:A malignant peripheral nerve sheath tumor (MPNST) is defined as any malignant tumor that develops or differentiates from cells in the peripheral nerve sheath. This tumor is commonly associated with neurofibromatosis type 1 (NF1) and previous radiotherapy treatment. Primary intraosseous MPNSTs are extremely rare and a ...

journal_title：Oncology letters

authors： Suzuki K,Yasuda T,Hori T,Watanabe K,Kanamori M,Kimura T

更新日期：2014-06-01 00:00:00

abstract：:Collecting duct carcinoma (CDC) is a rare type of renal neoplasm. Early diagnosis is possibly the only factor leading to a prolonged survival for patients with CDC. The purpose of the present study was to characterize the imaging features of CDC and improve its diagnosis. Radiological data of six patients were retrosp...

journal_title：Oncology letters

authors： Hu Y,Lu GM,Li K,Zhang LJ,Zhu H

更新日期：2014-02-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a disease of the clonal hematopoietic stem cells caused by a balanced translocation between the long arms of chromosomes 9 and 22. Overall, 90-95% of CML patients present with a Philadelphia (Ph) chromosome t(9;22)(q34;q11) translocation and in addition, variant complex translocations...

journal_title：Oncology letters

authors： Asif M,Hussain A,Malik A,Rasool M

更新日期：2015-09-01 00:00:00

abstract：:The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...

journal_title：Oncology letters

authors： Li Z,Gu X,Fang Y,Xiang J,Chen Z

更新日期：2012-02-01 00:00:00

abstract：:Tumor development and progression are multistep processes that involve local tumor growth and invasion, followed by metastasis. The aggressiveness of the tumor is the major determinant of the mortality of oral cancer patients. The present study investigates whether the expression levels of cyclooxygenase-2 (COX-2), nu...

journal_title：Oncology letters

authors： Lee EY,Kang JY,Kim KW

更新日期：2015-11-01 00:00:00

abstract：:Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen...

journal_title：Oncology letters

authors： Li W,Wang Z,Chen Y,Wang K,Lu T,Ying F,Fan M,Li Z,Wu J

更新日期：2017-04-01 00:00:00

abstract：:The present study aimed to investigate the effect of fisetin on proliferation and apoptosis of gastric cancer cells, as well as the underlying mechanism. Proliferation in SGC7901 cancer and GES-1 normal cells was analyzed using a CCK-8 assay. Apoptosis was analyzed using an Annexin V/Propidium Iodide apoptosis kit and...

journal_title：Oncology letters

authors： Yan W,Chen S,Zhao Y,Ye X

更新日期：2018-06-01 00:00:00

abstract：:The evaluation of minimal residual disease (MRD) in acute leukemia (AL) is currently recognized as a potential critical tool to assess the response and relapse rate of treatments. The present study investigated serum peptides from patients with AL to identify biomarkers that would be useful in providing clinical evalu...

journal_title：Oncology letters

authors： Song W,Wang N,Li W,Wang G,Hu J,He K,Li Y,Meng Y,Chen N,Wang S,Hu L,Xu B,Wang J,Li A,Cui J

更新日期：2013-11-01 00:00:00

abstract：:This study was designed to explore the expression of phosphoinositide-dependent protein kinase 1 (PDK-1), deleted in malignant brain tumors (DMBT1) in the thyroid carcinoma. A total of 87 fresh samples of thyroid carcinoma from surgical resection in The Second People's Hospital of Lianyungang from June 2016 to March 2...

journal_title：Oncology letters

authors： Sun Z,Xu L

更新日期：2019-09-01 00:00:00

abstract：:The present study aimed to investigate the clinical significance of paired-box 8 (PAX8) in primary epithelial ovarian cancer (PEOC). Using immunohistochemical (IHC) staining, the expression of PAX8 in 60 patients with PEOC, 20 patients with ovarian benign lesions and 10 patients with metastatic ovarian cancer (MOC), w...

journal_title：Oncology letters

authors： Chai HJ,Ren Q,Fan Q,Ye L,Du GY,Du HW,Xu W,Li Y,Zhang L,Cheng ZP

更新日期：2017-11-01 00:00:00

abstract：:Keloids are a type of benign hyperplasia that cause dermatologic dysfunction and esthetic deformity by invading adjacent normal tissues. Little is known about their etiology, therefore, they are a challenge to treat using plastic surgery. In a previous study, it was demonstrated that the expression of the long non-cod...

journal_title：Oncology letters

authors： Li Y,Liang X,Wang P,Long X,Wang X,Meng Z

更新日期：2018-07-01 00:00:00

abstract：:Solitary fibrous tumors (SFTs) are uncommon, with the pleura as a site of predilection. Central nervous system SFTs, particularly intracranial SFTs, are extremely rare. The lesions are generally benign and localized, and surgery is the main therapeutic solution. The current study reports the cases of a patient who pre...

journal_title：Oncology letters

authors： Wang ZY,Qiu K,Ma YH,Wang XT,Bao JJ,Zhang ZF,Liu XZ

更新日期：2016-02-01 00:00:00

abstract：:The extremely delicate shift from an inflammatory process to tumorigenesis is a field of major scientific interest. While the inflammation induced by environmental agents has well known underlying mechanisms, less is known concerning the oncogenic changes that follow an inflammatory chronic status in the tissue microe...

journal_title：Oncology letters

authors： Neagu M,Constantin C,Caruntu C,Dumitru C,Surcel M,Zurac S

更新日期：2019-05-01 00:00:00

abstract：:Retroperitoneal liposarcoma is a rare tumor with an incidence of 2.5 per million individuals. Early diagnosis is difficult as there is an absence of specific clinical presentations. The present case study reports a patient diagnosed with retroperitoneal liposarcoma who was treated by complete surgical resection and re...

journal_title：Oncology letters

authors： Zhang WD,Liu DR,Que RS,Zhou CB,Zhan CN,Zhao JG,Chen LI

更新日期：2015-07-01 00:00:00

abstract：:Src is a tyrosine kinase that is of significance in tumor biology. The present review focuses on Src, its molecular structure, and role in cancer, in addition to its expression and function in sarcoma. In addition, the feasibility of Src as a potential drug target for the treatment of sarcoma is also discussed. Previo...

journal_title：Oncology letters

authors： Chen Q,Zhou Z,Shan L,Zeng H,Hua Y,Cai Z

更新日期：2015-07-01 00:00:00

abstract：:Cancer cachexia is a syndrome that impairs the quality of life and overall survival of patients, and thus the effectiveness of anticancer agents. There are no effective therapies for cancer cachexia due to the complexity of the syndrome, and insufficient knowledge of its pathogenesis results in difficulty establishing...

journal_title：Oncology letters

authors： Morimoto M,Aikawa K,Hara T,Yamaoka M

更新日期：2017-12-01 00:00:00

abstract：:The medicinal mushroom Ganoderma lucidum (G. lucidum) has been used for the treatment of various diseases, and is known for the immune-enhancing activity of its polysaccharide. However, little is known about another of its major constituents, triterpene. This study investigated the anticancer mechanism of a triterpene...

journal_title：Oncology letters

authors： Ji Z,Tang Q,Hao R,Zhang J,Pan Y

更新日期：2011-05-01 00:00:00

abstract：:Hepatocyte growth factor (HGF) expression is a poor prognostic factor in various types of cancer. Expression levels of HGF have been reported to be regulated by shorter poly(dA) sequences in the promoter region. In the present study, the poly(dA) mononucleotide tract in various types of human cancer cell lines was exa...

journal_title：Oncology letters

authors： Sakai K,Takeda M,Okamoto I,Nakagawa K,Nishio K

更新日期：2015-01-01 00:00:00

abstract：:Activation of brown adipose tissue (BAT) is an effective strategy for treating obesity. Hepatocellular carcinoma (HCC) is a life-threatening hepatic malignancy with a high mortality rate. Considering that obesity is a risk factor for HCC, the aim of the present study was to investigate the association between HCC and ...

journal_title：Oncology letters

authors： Liu D,Li Y,Shang Y,Wang W,Chen SZ

更新日期：2019-03-01 00:00:00