解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Acute myeloid leukemia (AML) is a highly heterogeneous disease that remains untreatable. MicroRNAs (miRNAs or miRs) play important roles in the pathogenesis of leukemia. miR-21 is highly expressed in multiple types of human cancer and displays oncogenic activities; however, the clinical significance of miR-21 in AML r...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12380
更新日期:2021-02-01 00:00:00
abstract::Pancreatic cancer has a low survival rate globally. Anillin (ANLN) is involved in the pathogenesis of pancreatic cancer (PC). The present study used databases and reverse transcription-quantitative PCR to investigate the association between ANLN expression, clinical variables and the survival rate of patients with pan...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12368
更新日期:2021-02-01 00:00:00
abstract::Lin28 is involved in the progression of several types of tumors. Data collected from clinical trials have suggested that Lin28 expression is correlated with poor prognosis in thyroid carcinoma. The present study was conducted to investigate the association between Lin28 expression and the clinicopathological parameter...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12358
更新日期:2021-02-01 00:00:00
abstract::Long non-coding RNAs (lncRNAs) have been reported to participate in multiple biological processes, including tumorigenesis. In the current study, the function of a novel lncRNA LINC00887 was investigated in lung carcinoma. For this purpose, LINC00887 expression was assessed by reverse-transcription quantitative PCR. C...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12348
更新日期:2021-02-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2017.6360.]. ...
journal_title:Oncology letters
pub_type: 已发布勘误
doi:10.3892/ol.2020.12344
更新日期:2021-02-01 00:00:00
abstract::Skin cancer is the deadliest type of malignant disease and causes primary mortality worldwide. Dioscin, which exists in medicinal plants, has potent anticancer effects. However, its effects on skin cancer remain unknown. In the present study, the activity and mechanism of dioscin on the human skin cancer A431 cell lin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12321
更新日期:2021-01-01 00:00:00
abstract::Gastric cancer is a common malignancy in China, with the second highest mortality rate worldwide. Advanced gastric cancer usually exhibits a poor prognosis with a low 5-year survival rate. Therefore, developing novel drugs for the treatment of this cancer will be beneficial for patients. Demethylzeylasteral, an extrac...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12310
更新日期:2021-01-01 00:00:00
abstract::Stromal cell-derived factor 1α (SDF1α) and its receptor C-X-C chemokine receptor type 4 (CXCR4) have been reported to form an important chemokine signaling pathway. Our previous study reported that SDF1α from tumor stromal cells may stimulate the proliferation of gastric cancer (GC) cells through the CXCR4 axis in a h...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12299
更新日期:2021-01-01 00:00:00
abstract::The incidence and mortality rates of gastric cancer rank among the highest five of all cancer types worldwide. The chemotherapeutic agent 5-fluorouracil (5-FU) is the gold standard for treating gastric cancer, but its efficacy is limited due to high rates of resistance. To improve the therapeutic efficacy of 5-FU and ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12285
更新日期:2021-01-01 00:00:00
abstract::Interleukins (ILs) are involved in the occurrence and development of numerous types of cancer, and serve a critical role in the development of effective cancer therapeutics. The aim of the present study was to investigate the effect of IL-27 on chemotherapy resistance in lung cancer cells, and analyze its potential mo...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12275
更新日期:2021-01-01 00:00:00
abstract::The global incidence of prostate cancer (PCa) has been increasing in recent years. Meanwhile, some studies have indicated the association between malignancies, such as lung and gastric cancer and PCa, and microRNAs (miRNAs). The present study was designed to assess the prognostic value of miR-92b-3p in patients with P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12265
更新日期:2021-01-01 00:00:00
abstract::Herpesvirus entry mediator (HVEM) displays dual signals in T-cell activation according to the ligands and intracytoplasmic effectors it interacts with. High HVEM expression may play an immunosuppressive role in several malignancies. The present study investigated the clinical impact of HVEM on intrahepatic cholangioca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12330
更新日期:2021-01-01 00:00:00
abstract::Research on the immunosuppression of cancer cells has attracted much attention in recent years. The present study sought to provide a new strategy for tumor immunotherapy targeting mast cells by studying the mechanisms underlying mast cell function in cancer immunosuppression. Between January 2015 and December 2017, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12224
更新日期:2020-12-01 00:00:00
abstract::The aim of the present study was to investigate the role of edema surrounding breast cancer masses in the prognostic prediction of magnetic resonance imaging (MRI) T2-weighted fat suppression sequence. For this purpose, 80 patients with mass-type breast cancer underwent conventional plain breast MRI, dynamic contrast-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12177
更新日期:2020-12-01 00:00:00
abstract::Hepatocellular carcinoma is a serious public health problem in China. The mortality rate associated with the majority of cancer types has decreased as a result of targeted therapy. However, the mortality rates associated with hepatocellular carcinoma have not improved; therefore, the identification of new molecular ta...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12245
更新日期:2020-12-01 00:00:00
abstract::Sex determining region Y-box 2 (SOX2) is a transcription factor that serves a role in numerous different types of malignant cancer. Altered expression of chloride channel proteins has been described in a variety of malignancies. However, the association between SOX2 and chloride channel proteins is not yet fully under...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12235
更新日期:2020-12-01 00:00:00
abstract::Platycodin D (PD) is a triterpenoid saponin that exists in the roots of Platycodonis. It exhibits evident growth inhibitory effects and potent cytotoxicity against multiple types of cancer. Gallbladder cancer (GBC) is the most common malignant disease of the biliary tract system. Patients with GBC usually have limited...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12174
更新日期:2020-12-01 00:00:00
abstract::Endocrine-disrupting chemicals (EDCs) are exogenous chemical compounds ubiquitously found in everyday life of the modern world. EDCs enter the human body where they act similarly to endogenous hormones, altering the functions of the endocrine system and causing adverse effects on human health. Bisphenol A (BPA), the p...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.12145
更新日期:2020-12-01 00:00:00
abstract::The present study aimed to explore the clinical efficacy and safety of hydromorphone combined with sufentanil in patient-controlled intravenous analgesia (PCIA) for patients with hepatocellular carcinoma (HCC) and its effect on serum immune factors in serum. Data from 385 patients with HCC, admitted to the Hunan Provi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12159
更新日期:2020-12-01 00:00:00
abstract::The development of upper tract urothelial carcinoma (UTUC) has been associated with the ingestion of aristolochic acid (AA) in Chinese herbs. The tumors are more malignant and patients have a worse prognosis in China compared with that in Western countries. Recently, whole-genome and exome sequencing of AA-associated ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12212
更新日期:2020-12-01 00:00:00
abstract::The IL-6R/JAK2/STAT3 pathway mediated by interleukin-6 (IL-6) plays an important role in the occurrence and development of multiple myeloma (MM), which is associated with decreased microRNA-451a. However, the biological function of microRNA-451a in MM remains unclear. The bone marrow (BM) of patients with MM was sampl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12202
更新日期:2020-12-01 00:00:00
abstract::The transcription factor AP-2 β (TFAP2B) serves an important role in kidney development. MicroRNAs (miRNAs) regulate carcinogenic pathways and have gained increasing attention owing to their association with human clear cell renal cell carcinoma (ccRCC) tumorigenesis. However, whether miRNAs could affect renal cell tu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12187
更新日期:2020-12-01 00:00:00
abstract::Despite advances in the diagnosis and treatment in recent years, lung cancer is still one of the primary causes of cancer-associated morbidity and mortality in globally. Abnormally expressed microRNAs (miRNAs/miRs) in tumor tissues serve vital roles in the pathological mechanism of tumors and have become prospective b...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12253
更新日期:2020-12-01 00:00:00
abstract::The underlying causes of esophageal cancer (EC) are unknown. To explore the molecular mechanisms that lead to EC, gene expression profiles of large cohorts of patients with EC were obtained from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases (GSE5364, GSE20347 and GSE23400). The present study ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12077
更新日期:2020-11-01 00:00:00
abstract::Ovarian carcinoma (OV) is one of the most lethal gynecological malignancies globally, and the overall 5-year survival rate of OV was 47% in 2018 according to American data. To increase the survival rate of patients with OV, many researchers have sought to identify biomarkers that act as both prognosis-predictive marke...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12067
更新日期:2020-11-01 00:00:00
abstract::The development of drug resistance to chemotherapeutic agents has consistently presented a challenge in terms of the treatment of patients with triple-negative breast cancer (TNBC). In the present study, gemcitabine (dFdC)-resistant TNBC cells were established, and the effects of lentivirus-deoxyribonucleoside kinase ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12109
更新日期:2020-11-01 00:00:00
abstract::Immunotherapy based on the tumor microenvironment is a feasible method for treating cancer; therefore, it is necessary to investigate the immune microenvironment of pancreatic cancer and the influencing factors of the immune microenvironment. Chemokines are an important factor affecting the tumor immune microenvironme...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12120
更新日期:2020-11-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2018.8006.]. ...
journal_title:Oncology letters
pub_type: 已发布勘误
doi:10.3892/ol.2020.12110
更新日期:2020-11-01 00:00:00
abstract::The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12044
更新日期:2020-11-01 00:00:00
abstract::Osteosarcoma is a malignant tumor derived from the skeletal system, often occurring in bone tissues, and it is the most common malignant tumor in the skeletal system, with more than 90% of cases being highly malignant. The present study was designed to explore the regulatory effects of microRNA (miR)-19a on the prolif...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12033
更新日期:2020-11-01 00:00:00
abstract::Sirtuin 3 (Sirt3) is an important member of the sirtuin protein family. It is a deacetylase that was previously reported to modulate the level of reactive oxygen species (ROS) production and limit the extent of oxidative damage in cellular components. As an important member of the class III type of histone deacetylase...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.12023
更新日期:2020-11-01 00:00:00
abstract::The expression levels of α-enolase, also known as enolase 1 (ENO1), in liver cancer tissues and the autoantibody levels of ENO1 in the sera of patients with liver cancer were detected to investigate the function of ENO1 in the invasion and metastasis of liver cancer, as well as its clinical diagnostic value. Small int...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12003
更新日期:2020-11-01 00:00:00
abstract::The present study aimed to investigate the expression levels and clinical value of miR-365 and miR-25 in serum of patients with non-small cell lung cancer (NSCLC). Patients (180) diagnosed with NSCLC at the Affiliated Hospital of Guangdong Medical University from July 2011 to December 2013 were used as the experimenta...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12053
更新日期:2020-11-01 00:00:00
abstract::Cervical carcinoma expressed PCNA regulatory long non-coding (lnc)RNA (CCEPR) has recently been reported to play oncogenic roles in some common types of human cancer. However, the clinical significance of CCEPR mRNA expression levels in esophageal squamous cell carcinoma (ESCC) and the exact function of CCEPR in regul...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12006
更新日期:2020-11-01 00:00:00
abstract::Protein tyrosine phosphatase receptor type A (PTPRA), one of the classic protein tyrosine phosphatases, is crucial for modulating tumorigenesis and metastasis in breast cancer; however, its functional mechanism has not fully elucidated. The present study assessed PTPRA expression and estimated its clinical impact on s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11992
更新日期:2020-11-01 00:00:00
abstract::Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors, and has high incidence and mortality rates, worldwide. Myelodysplastic syndrome (MDS), a disorder of hematopoietic stem or progenitor cells, results in marrow failure, which increases the risk of acute myeloid leukemia (AML). Few stu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12129
更新日期:2020-11-01 00:00:00
abstract::[This retracts the article DOI: 10.3892/ol.2016.5302.]. ...
journal_title:Oncology letters
pub_type: 撤回出版物
doi:10.3892/ol.2020.12101
更新日期:2020-11-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-associated death worldwide. Glioma-associated oncogene homolog 1 (Gli1) is a key component and functions as a reliable marker of Hedgehog signaling pathway activation. Previous studies have demonstrated that Gli1 serves important roles in the pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12091
更新日期:2020-11-01 00:00:00
abstract::Although tumor thrombus (TT) infringement of the inferior vena cava (IVC) and right atrium (RA) is rarely observed in hepatocellular carcinoma (HCC), the prognosis for this condition is extremely poor, with a median survival time of several months, given that the condition is often diagnosed at an advanced tumor stage...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11962
更新日期:2020-10-01 00:00:00
abstract::Pyropia yezoensis Sookwawon 104 is a newly cultivated strain of red marine algae. The present study aimed to investigate the in vitro antiproliferative activity of sulfated polysaccharide extracted from P. yezoensis Sookwawon 104 (PYSP), as well as that of its low molecular weight (Mw) derivatives. PYSP is a heterogen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11952
更新日期:2020-10-01 00:00:00