Fisetin inhibits the proliferation of gastric cancer cells and induces apoptosis through suppression of ERK 1/2 activation.

abstract：:A disintegrin and metalloproteinase 9 (ADAM9) is a member of the transmembrane ADAM family. It is expressed in different types of solid cancer and promotes tumor invasiveness. To the best of our knowledge, the present study was the first to examine ADAM9 expression in vestibular schwannomas (VS) from patients with and...

journal_title：Oncology letters

authors： Breun M,Schwerdtfeger A,Martellotta DD,Kessler AF,Monoranu CM,Matthies C,Löhr M,Hagemann C

更新日期：2020-03-01 00:00:00

abstract：:The aim of the present study was to examine the interrelations between MEG-A3 gene and incidence of breast cancer. The expression of MEG-A3 gene in the tissue samples of patients with breast cancer and normal controls at RNA and protein levels was determined. Subsequently, the relative expression of RNA for the same p...

journal_title：Oncology letters

authors： Hou X,Guo F,Sun Q

更新日期：2016-12-01 00:00:00

abstract：:Icotinib is an epidermal growth factor receptor tyrosine kinase inhibitor, which has been revealed to inhibit proliferation in tumor cells. However, the effect of icotinib on cancer cell metastasis remains to be explained. This study examines the effect of icotinib on the migration and invasion of squamous cells of to...

journal_title：Oncology letters

authors： Yang C,Yan J,Yuan G,Zhang Y,Lu D,Ren M,Cui W

更新日期：2014-09-01 00:00:00

abstract：:Nanoparticle albumin-bound (nab)-paclitaxel appears to exhibit better response rates in patients with metastatic urothelial cancer of the bladder whom are pretreated with nab-paclitaxel compared with conventional paclitaxel. Paclitaxel may induce multidrug resistance in patients with cancer, while the mechanisms of re...

journal_title：Oncology letters

authors： Vallo S,Köpp R,Michaelis M,Rothweiler F,Bartsch G,Brandt MP,Gust KM,Wezel F,Blaheta RA,Haferkamp A,Cinatl J Jr

更新日期：2017-06-01 00:00:00

abstract：:Sclerosing stromal tumor (SST) of the ovary, which was first described by Chalvardjian and Scully in 1973, is a rare ovarian neoplasm, occurring predominantly in young women. The most common clinical symptom in patients with SST is menstrual irregularities. Microscopically, the tumor is characterized by the presence o...

journal_title：Oncology letters

authors： Tian T,Zhu Q,Chen W,Wang S,Sui W,Wu J

更新日期：2016-06-01 00:00:00

abstract：:Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder. It is characterized by the presence of the Philadelphia (Ph) chromosome, t(9;22)(q34.1;q11.2), which carries the BCR-ABL1 fusion gene. Tyrosine kinase inhibitors (TKIs) have markedly changed the treatment approach of CML and have become the f...

journal_title：Oncology letters

authors： Al-Khallaf H,Alali H,Alkhatti A

更新日期：2018-11-01 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) process has increasingly been examined due to its role in the progression of human tumors. Renal cell carcinoma (RCC) is one of the most common urological tumors that results in patient mortality. Previous studies have demonstrated that the EMT process is closely associated ...

journal_title：Oncology letters

authors： Zhou N,Lu F,Liu C,Xu K,Huang J,Yu D,Bi L

更新日期：2016-09-01 00:00:00

abstract：:The 78-kDa glucose-regulated protein (GRP78) is a stress induced heat shock protein which, under limiting conditions, functions as a cell surface signaling receptor. Tumor cells are considered to be subjected to a physiologically stressful microenvironment due to their excessive growth. The role of GRP78 in tumor surv...

journal_title：Oncology letters

authors： Yerushalmi R,Raiter A,Nalbandyan K,Hardy B

更新日期：2015-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) metastases in the mediastinum are rare, particularly under the arch of the aorta. The present study describes the case of a 30-year-old male patient who presented with back pain and hoarseness for 2 months due to lymph node metastasis of HCC. The patient had undergone right hepatic lobec...

journal_title：Oncology letters

authors： Xu L,Xue F,Wang B,Yan D,Ding W,Yin J,Yi C,Wang W

更新日期：2016-08-01 00:00:00

abstract：:Melatonin, which is synthesized by the pineal gland and released into the blood, exhibits antitumor properties. However, the mechanisms underlying these effects, particularly in stomach cancer, remain unknown. In the present study, the effect of melatonin on the nuclear factor (NF)-κB signaling pathway and the mitogen...

journal_title：Oncology letters

authors： Li W,Wang Z,Chen Y,Wang K,Lu T,Ying F,Fan M,Li Z,Wu J

更新日期：2017-04-01 00:00:00

abstract：:Lung is one of the most common sites for bladder cancer to metastasize. Although the involvement of the epithelial-to-mesenchymal transition (EMT) in bladder cancer progression has been established, the mechanism of EMT induction remains unclear. In order to investigate this, T24-parental (P) and T24-lung (L) bladder ...

journal_title：Oncology letters

authors： Zhu J,Huang Z,Zhang M,Wang W,Liang H,Zeng J,Wu K,Wang X,Hsieh JT,Guo P,Fan J

更新日期：2018-03-01 00:00:00

abstract：:The association between endometriosis and malignant transformation has often been described in the medical literature. A search was conducted between 1966 and 2010 through the English language literature (online Medline PubMed database) using the keywords endometriosis combined with malignant transformation. The searc...

journal_title：Oncology letters

authors： Higashiura Y,Kajihara H,Shigetomi H,Kobayashi H

更新日期：2012-07-01 00:00:00

abstract：:Osteosarcoma (OS) is the third most frequent type of cancer in adolescents and represents >56% of all bone tumors. In addition, metastatic OS frequently demonstrates resistance to conventional chemotherapy; thus, the development of novel therapeutic agents for the treatment of patients with metastatic OS is warranted....

journal_title：Oncology letters

authors： Li X,Yan ML,Yu Q

更新日期：2017-06-01 00:00:00

abstract：:Effects of different levels of PM2.5 on invasion and proliferation of HeLa cells and the expression levels of inflammatory cytokines IL-1 and IL-6 under 10 µg/ml PM2.5 were investigated. Different groups of HeLa cells were treated with PM2.5 at 0, 10, 25, 50, 100 and 200 µg/ml for 36 h, respectively. Cell proliferatio...

journal_title：Oncology letters

authors： Huang K,Li W,Chen Y,Zhu J

更新日期：2018-12-01 00:00:00

abstract：:The present study aimed to evaluate the effects of amentoflavone on sorafenib-induced apoptosis in sorafenib-resistant hepatocellular carcinoma (HCC) cells. The sorafenib-resistant SK-Hep1 (SK-Hep1R) cell line was established for the present study. Initially, the differences in sorafenib-induced cytotoxicity and apopt...

journal_title：Oncology letters

authors： Chen WL,Hsieh CL,Chen JH,Huang CS,Chen WT,Kuo YC,Chen CY,Hsu FT

更新日期：2017-09-01 00:00:00

abstract：:The present study aimed to evaluate the expression of p53, Ki-67, epidermal growth factor receptor (EGFR) and O6-methylguanine-DNA methyltransferase (MGMT), and to analyze the correlation between their expression and the histological grade of the tumors in 152 patients with gliomas. The tumors were classified accordin...

journal_title：Oncology letters

authors： Hu X,Miao W,Zou Y,Zhang W,Zhang Y,Liu H

更新日期：2013-07-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) are recently identified regulators in tumorigenesis and tumour progression. BRAF-activated lncRNA (BANCR) is overexpressed in melanoma and has a potential functional role in melanoma cell migration. However, little is known concerning the role of BANCR in the development of colorectal ca...

journal_title：Oncology letters

authors： Guo Q,Zhao Y,Chen J,Hu J,Wang S,Zhang D,Sun Y

更新日期：2014-08-01 00:00:00

abstract：:In the present study, the functions and mechanisms of rotundic acid (RA) underlying its induction of apoptosis in caspase-3-transfected MCF-7 human breast cancer cells (Cas3-MCF-7 cells) were investigated. RA induced apoptosis in Cas3-MCF-7 cells more efficiently compared with that in MCF-7 cells transfected with cont...

journal_title：Oncology letters

authors： Nan ML,Wang X,Li HJ,Yu DH,Sun WY,Xu HM,He YF,Zhao QC

更新日期：2019-01-01 00:00:00

abstract：:Determining the resectable region and volume of the liver prior to anatomical resection is important. The synapse Vincent (SV) system is the current method for surgical liver resection that relies on the surgeon's individual experience and skill. Additionally, in cases involving abnormal liver function, the resectable...

journal_title：Oncology letters

authors： Shimoda M,Hariyama M,Oshiro Y,Suzuki S

更新日期：2019-12-01 00:00:00

abstract：:Metaplastic carcinoma of the breast refers to a heterogenous group of mammary carcinomas that contain a mixture of various cell types, including squamous cells, spindle cells and/or a mesenchymal component, such as bone or cartilage. To the best of our knowledge, the clinical course of a tumour that has undergone a tr...

journal_title：Oncology letters

authors： Chuthapisith S,Warnnissorn M,Amornpinyokiat N,Pradniwat K,Angsusinha T

更新日期：2013-09-01 00:00:00

abstract：:Carbohydrate sulfotransferase 15 (CHST15) synthesizes matrix proteoglycan that regulates various pathogenic mediators and contributes to tissue remodeling and fibrosis during injury. CHST15 has been reported to promote tumor growth and invasion in various types of cancer. Our previous study reported the safety and eff...

journal_title：Oncology letters

authors： Matsuda Y,Fujii Y,Matsukawa M,Ishiwata T,Nishimura M,Arai T

更新日期：2019-10-01 00:00:00

abstract：:Intramuscular myxoma (IM) is a benign intramuscular neoplasm composed of fibroblasts and abundant myxoid stroma. IMs most commonly affect larger skeletal muscles, while those affecting the oral and maxillofacial regions are rare, with a small number of documented cases in the available literature. The aim of the prese...

journal_title：Oncology letters

authors： Li G,Jiang W,Li W,Li J

更新日期：2014-05-01 00:00:00

abstract：:The traditional Chinese medicine Jinfukang (JFK) has been shown as a valuable drug to treat non-small cell lung cancer (NSCLC). Previously, it was reported that JFK-induced epigenetic alteration is involved in anti-lung cancer activity. In the present study, the effect of JFK on lung cancer cell lines was examined wit...

journal_title：Oncology letters

authors： Lu J,Chen J,Kang Y,Wu J,Shi H,Fu Y,Jiao L,Dong C,Li X,Jin Y,Zhao W,Xu L,Zhao X

更新日期：2018-10-01 00:00:00

abstract：:Microglia, once assimilated to peripheral macrophages, in gliomas has long been discussed and currently it is hypothesized to play a pro-tumor role in tumor progression. Uncertain between M1 and M2 polarization, it exchanges signals with glioma cells to create an immunosuppressive microenvironment and stimulates cell ...

journal_title：Oncology letters

authors： Annovazzi L,Mellai M,Bovio E,Mazzetti S,Pollo B,Schiffer D

更新日期：2018-01-01 00:00:00

abstract：:1,6-Bis[4-(4-amino-3-hydroxyphenoxy)phenyl] diamantane (DPD), a diamantane derivative, was previously noted as an anticancer compound through anticancer drug screening with NCI-60 human tumor cells. Irinotecan (CPT-11), a semisynthetic derivative of camptothecin, is clinically active in the treatment of colorectal can...

journal_title：Oncology letters

authors： Yang PS,Wang JJ,Wang YH,Jan WC,Cheng SP,Hsu YC

更新日期：2016-05-01 00:00:00

abstract：:Skeletal muscle is rich in lymphatic vessels, with an abundant blood supply, and it is an infrequent site of cancer metastasis. Previous studies have demonstrated that enhanced secretion of MyoD may occur when skeletal muscle is injured or becomes cancerous. It was hypothesized that MyoD may act as an endogenous cytok...

journal_title：Oncology letters

authors： Cai C,Qin X,Wu Z,Shen Q,Yang W,Zhang S,Duan J,Liang F,Liu C

更新日期：2016-06-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the leading causes of mortality among men and women. Chemo-resistance, adverse effects and disease recurrence are major challenges in the development of effective cancer therapeutics. Substantial literature on this subject highlights that populations consuming diets rich in fibers, fr...

journal_title：Oncology letters

authors： Ahmed K,Zaidi SF,Cui ZG,Zhou D,Saeed SA,Inadera H

更新日期：2019-07-01 00:00:00

abstract：:A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...

journal_title：Oncology letters

authors： Dong Y,Li Y,Liu R,Li Y,Zhang H,Liu H,Chen J

更新日期：2020-03-01 00:00:00

abstract：:MicroRNA-1470 (miR-1470) is overexpressed in esophageal squamous cell carcinoma (ESCC); however, its role and underlying molecular mechanism remain unknown. The aim of the present study was to explore the tumorigenic role and mechanism of miR-1470 overexpression in ESCC. The expression of miR-1470 in ESCC tissues and ...

journal_title：Oncology letters

authors： Mei LL,Qiu YT,Wang WJ,Bai J,Shi ZZ

更新日期：2017-12-01 00:00:00

abstract：:The multidrug resistance of glioma impedes chemo-radiotherapy and leads to adverse outcomes. In the present study, the doxorubicin (DOX)-resistant glioma SHG44/DOX cell line was established to investigate the effects and mechanisms of Salvia miltiorrhiza ligustrazine (SML), a traditional Chinese medicine, on the rever...

journal_title：Oncology letters

authors： Wang F,Huang N,Yang Q,Liu J,Chen J

更新日期：2017-10-01 00:00:00