Abstract:
:Tumor development and progression are multistep processes that involve local tumor growth and invasion, followed by metastasis. The aggressiveness of the tumor is the major determinant of the mortality of oral cancer patients. The present study investigates whether the expression levels of cyclooxygenase-2 (COX-2), nuclear factor-κB (NF-κB), peroxiredoxin 1 (PRDX1) and PRDX6 are associated with the development, proliferation, differentiation and recurrence of oral squamous cell carcinoma (OSCC). The mRNA expression levels of COX-2, NF-κB, PRDX1 and PRDX6 were examined in 50 OSCC specimens and 19 normal oral mucosae by quantitative polymerase chain reaction (qPCR). qPCR analysis showed that the mRNA levels of COX-2 in OSCC were significantly higher than those in the normal oral mucosae (P=0.021). The expression levels of PRDX1 in high-stage tumors (T3 and T4) were significantly elevated compared with those in low-stage tumors (T1) (P=0.047). Additionally, the expression levels of NF-κB in the high-grade tumor were significantly elevated compared with those in the low-grade tumors (P=0.030). Overall, it was indicated that the expression of COX-2 is strongly associated with the development of OSCC. Moreover, the enhanced expression of PRDX1 and NF-κB may function in the progression of OSCC, which serves as a useful marker for prognosis in patients with oral cancer.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Lee EY,Kang JY,Kim KWdoi
10.3892/ol.2015.3705subject
Has Abstractpub_date
2015-11-01 00:00:00pages
3129-3136issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-3705journal_volume
10pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Although tumor thrombus (TT) infringement of the inferior vena cava (IVC) and right atrium (RA) is rarely observed in hepatocellular carcinoma (HCC), the prognosis for this condition is extremely poor, with a median survival time of several months, given that the condition is often diagnosed at an advanced tumor stage...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11962
更新日期:2020-10-01 00:00:00
abstract::Poly(ADP-Ribose) polymerase family member 9 (PARP9) promotes the proliferation, survival and chemotherapy resistance in lymphoma and prostate cancer. The expression and function of PARP9 in human breast cancer remains unknown. In the present study, it was demonstrated that PARP9 is frequently overexpressed in human br...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9124
更新日期:2018-09-01 00:00:00
abstract::Inactivating mutations of the multiple endocrine neoplasia 1 (MEN1) gene cause MEN1 syndrome, characterized by primary hyperparathyroidism (pHPT), and parathyroid and gastro-entero-pancreatic pituitary tumors. At present, only 14 cases of malignant parathyroid tumor have been associated with the syndrome, with 6 cases...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6162
更新日期:2017-07-01 00:00:00
abstract::The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesion...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9788
更新日期:2019-02-01 00:00:00
abstract::Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a specific E1-like ubiquitin-activating enzyme involved in interferon-stimulated gene 15 (ISG15) conjugation. UBA7 expression has been reported to be notably decreased in lung cancer. The present study aimed to investigate the changes in UBA7 expression in breast c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11406
更新日期:2020-04-01 00:00:00
abstract::Extra-adrenal pheochromocytomas are rare tumors that originate from the chromaffin tissue of the sympathetic nervous system. Ovarian extra-adrenal pheochromocytoma is even more rare. The present study reports a rare case of an extra-adrenal pheochromocytoma that was localized to the right ovary, but was gynecologicall...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2718
更新日期:2015-02-01 00:00:00
abstract::In order to examine the role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression for the prognostic evaluation of non-small cell lung carcinoma (NSCLC), a total of 186 breast cancer patients, with adjacent non-tumor lung tissues, were selected for immunohistochemical staining of IMP3 protein. The...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2910
更新日期:2015-04-01 00:00:00
abstract::Leptomeningeal metastasis (LM) is increasingly common in patients with non-small cell lung cancer (NSCLC) due to improved treatment, and ultimately, prolonged patient survival. The current study is a pooled analysis that evaluated intrathecal chemotherapy (ITC) as a treatment for NSCLC patients with LM. The PUBMED, OV...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4783
更新日期:2016-08-01 00:00:00
abstract::Pendred syndrome is a rare genetic disease that causes a disturbance in thyroid hormone synthesis, which results in thyroid dysfunction and the development of goiter and sensorineural deafness. The present report describes the case of a young euthyroid male, who developed a large goiter and hearing impairment, despite...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2461
更新日期:2014-11-01 00:00:00
abstract::Special AT-rich sequence binding protein 1 (SATB1) has regulatory effects on gene expression and appears to play an important role in tumor progression. The present study screened the promoter region of the SATB1 gene for polymorphisms, evaluated the corresponding haplotypes regarding alterations in promoter activity ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1983
更新日期:2014-06-01 00:00:00
abstract::Aquaporin 5 (AQP5), a water channel protein, is highly expressed in non-small cell lung cancer (NSCLC) tissues compared with adjacent normal tissues. AQP5 expression in lung cancer tissues is associated with a poor prognosis. The present study aimed to analyze the expression of AQP5 and investigate its role in primary...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3108
更新日期:2015-06-01 00:00:00
abstract::Bufalin, one of the active ingredients of the Chinese drug Chan su, exhibits significant antitumor activity against various cancer types. However, the role of bufalin in renal cell carcinoma (RCC) remains unclear. In the present study, it was demonstrated that bufalin inhibited cell proliferation, blocked the cell cyc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9111
更新日期:2018-09-01 00:00:00
abstract::Thyroid carcinoma is the most prevalent endocrine neoplasm globally. In the majority of thyroid carcinoma cases, a positive prognosis is predicted following administration of the appropriate treatment. A wide range of genetic alterations present in thyroid carcinoma exert their oncogenic actions partially through the ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4298
更新日期:2016-04-01 00:00:00
abstract::The present study aimed to investigate the anti-cancer activity of imidazo[1,2-a]pyridine 5-7 in the A375 and WM115 melanoma and HeLa cervical cancer cell lines. The viability of cancer cells was analyzed by the MTT assay. Apoptosis was quantified by flow cytometry following staining of the cells with AnnexinV/propidi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10341
更新日期:2019-07-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is a common type of cancer worldwide. Long non-coding RNAs (lncRNAs) have been demonstrated to be associated with the development of multiple types of human cancer. The present study aimed to identify the potential role of lncRNA colon cancer associated transcript 1 (CCAT1) in NPC. Rever...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8969
更新日期:2018-08-01 00:00:00
abstract::Cross-talk between competing endogenous RNAs (ceRNAs) play key roles in tumor development. In this study, we performed exon-level expression profiling on 26 glioblastomas (GBMs) and 6 controls to identify long non-coding RNAs (lncRNAs) of GBM initiation and progression using lncRNA-mediated ceRNA network (LMCN). The m...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10114
更新日期:2019-05-01 00:00:00
abstract::The underlying causes of esophageal cancer (EC) are unknown. To explore the molecular mechanisms that lead to EC, gene expression profiles of large cohorts of patients with EC were obtained from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases (GSE5364, GSE20347 and GSE23400). The present study ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12077
更新日期:2020-11-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-associated death worldwide. Glioma-associated oncogene homolog 1 (Gli1) is a key component and functions as a reliable marker of Hedgehog signaling pathway activation. Previous studies have demonstrated that Gli1 serves important roles in the pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12091
更新日期:2020-11-01 00:00:00
abstract::The present study aimed to investigate the feasibility of using ecto-mesenchymal stem cell (EMSC)-derived dendritic cells (DCs) for glioma immunotherapy following infection by a recombinant adenovirus containing the melanoma-associated antigen D4a (MAGE-D4a) gene. The ex vivo cultured EMSCs were infected by the adenov...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4306
更新日期:2016-04-01 00:00:00
abstract::Despite improvements in diagnosis and treatment, the survival of patients with advanced stages of esophageal squamous cell carcinoma (ESCC) remains poor. Therefore, novel biomarkers that can assist with early detection of ESCC are required. In the present study, three paired ESCC and normal esophageal tissue samples f...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9904
更新日期:2019-03-01 00:00:00
abstract::microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies have reported that miR-223 may serve as a tumor suppressor in a number of cancer types, however, knowledge of its targets in non-small cell lung cancer (NSCLC) remains li...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1375
更新日期:2013-08-01 00:00:00
abstract::Multifocal epithelial hyperplasia (MEH), also known as Heck's disease, manifests as a papulonodular lesion in the oral mucosa and has been associated with the human papillomavirus, a virus related to various precancerous diseases in the oral cavity. It has a predisposition for the female gender and for children. Altho...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.465
更新日期:2012-02-01 00:00:00
abstract::Septin 2 (SEPT2) is a tumor-related gene belonging to the SEPT family that affects the cellular processes of hepatoma carcinoma cells, glioblastoma cells and mesangial cells and is highly expressed in breast cancer, biliary tract cancer and acute myeloid leukemia. Colorectal cancer (CRC) is the third most common type ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10528
更新日期:2019-09-01 00:00:00
abstract::Melanoma is the most severe type of skin cancer and its incidence has increased in the last decades. In the United States, it is the 6th most common cancer in both men and women. Prognosis for patients with melanoma depends on the stage of the disease at the time of diagnosis and it can be influenced by the immunologi...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.9940
更新日期:2019-05-01 00:00:00
abstract::This study investigated the expression of special AT-rich sequence-binding protein 1 (SATB1) and toll-like receptor 4 (TLR4) protein in breast cancer and its clinical significance. We collected breast cancer tissues from 120 patients and adjacent non-cancerous tissue from 53 patients. SATB1 was expressed in 89 cases o...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6571
更新日期:2017-09-01 00:00:00
abstract::Previously, the preoperative neutrophil-to-lymphocyte ratio (NLR) has been demonstrated to be a beneficial prognostic marker in patients with upper tract urothelial carcinoma (UTUC). However, to the best of our knowledge, the postoperative NLR has rarely been investigated. Therefore, the present study evaluated the pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10178
更新日期:2019-06-01 00:00:00
abstract::Ovarian endometrioid borderline tumors (EBTs) are extremely rare, and are thought to be precursors of endometrioid carcinoma, beginning as adenofibroma or endometriosis and progressing in a slow, stepwise manner. In endometrioid carcinomas, a high frequency of activating mutations in phosphatase and tensin homolog (PT...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8626
更新日期:2018-07-01 00:00:00
abstract::There are multiple bioinformatics tools available for the detection of coding driver mutations in cancers. However, the prioritization of pathogenic non-coding variants remains a challenging and demanding task. The present study was performed to discriminate non-coding disease-causing mutations and prioritize potentia...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5135
更新日期:2016-11-01 00:00:00
abstract::Lung cancer is one of the most common cancers, which is the leading cause of cancer-related death among various cancers worldwide. Flavokawain A (FKA), a chalcone found in the kava plant, exerts potent anticancer activity. However, the activity and mechanisms of FKA in inhibiting the viability of paclitaxel (PTX)-resi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11069
更新日期:2020-01-01 00:00:00
abstract::Ovarian carcinoma (OV) is one of the most lethal gynecological malignancies globally, and the overall 5-year survival rate of OV was 47% in 2018 according to American data. To increase the survival rate of patients with OV, many researchers have sought to identify biomarkers that act as both prognosis-predictive marke...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12067
更新日期:2020-11-01 00:00:00