Genetic analysis and phosphoinositide 3-kinase/protein kinase B signaling pathway status in ovarian endometrioid borderline tumor samples.

abstract：:Metaplastic carcinoma of the breast (MBC) is a rare and heterogeneous type of neoplasm. Knowledge about its clinical characteristics, prognostic significance and optimal treatment modalities is fragmentary and controversial. The present retrospective study aimed to investigate the prognostic value of the clinicopathol...

journal_title：Oncology letters

authors： Xiao M,Yang Z,Tang X,Mu L,Cao X,Wang X

更新日期：2017-08-01 00:00:00

abstract：:Leiomyosarcomas account for ~24% of all adult sarcomas, and develop predominantly either in the uterus [uterine leiomyosarcoma (ULMS)] or in deep soft tissue or the retroperitoneum [non-uterine leiomyosarcoma (NULMS)]. Leiomyosarcomas are relatively chemoresistant tumors, and the prognosis of patients with leiomyosarc...

journal_title：Oncology letters

authors： Iura K,Kohashi K,Yasutake N,Ishii T,Maekawa A,Bekki H,Otsuka H,Yamada Y,Yamamoto H,Ohishi Y,Matsumoto Y,Iwamoto Y,Oda Y

更新日期：2018-01-01 00:00:00

abstract：:The present study aimed to investigate the clinical significance of paired-box 8 (PAX8) in primary epithelial ovarian cancer (PEOC). Using immunohistochemical (IHC) staining, the expression of PAX8 in 60 patients with PEOC, 20 patients with ovarian benign lesions and 10 patients with metastatic ovarian cancer (MOC), w...

journal_title：Oncology letters

authors： Chai HJ,Ren Q,Fan Q,Ye L,Du GY,Du HW,Xu W,Li Y,Zhang L,Cheng ZP

更新日期：2017-11-01 00:00:00

abstract：:The aim of the present study was to evaluate whether downregulation of extracellular signal-regulated kinase 1/2 (ERK1/2) is involved in conventional reversal methods and whether the inhibitors of the ERK signaling pathway reverse multidrug resistance (MDR) in hepatocellular carcinoma (HCC) cells. The sensitivities of...

journal_title：Oncology letters

authors： Chen S,Wang Y,Ruan W,Wang X,Pan C

更新日期：2014-11-01 00:00:00

abstract：:Renal collecting duct carcinoma (CDC) is a rare and highly aggressive subtype of kidney cancer with poor prognosis. We report a case of one patient, who was successfully treated with gemcitabine-platin based chemotherapy for polymetastatic renal CDC, and experienced a late and prolonged complete remission. In June 201...

journal_title：Oncology letters

authors： Dano D,Delteil C,Boissier R,Delaporte V,Habert P,Salas S,Duffaud F,Deville JL

更新日期：2019-03-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC), one of the most common malignant tumors, endangers human health. Recently, the incidence of HNSCC has kept increasing: However, its prognosis has not significantly improved. Understanding the molecular mechanism underlying HNSCC development will therefore provide new stra...

journal_title：Oncology letters

authors： Zou B,Guan X,Zhang W,Wang D,Xu K,Yuan DY,Meng Z,Zhang B

更新日期：2019-12-01 00:00:00

abstract：:The aim of this study was to clarify the association between expression of human leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival ...

journal_title：Oncology letters

authors： Ichinokawa K,Nakanishi Y,Hida Y,Tsuchikawa T,Kato T,Itoh T,Kaji M,Kaga K,Hirano S

更新日期：2019-07-01 00:00:00

abstract：:A number of studies have revealed the usefulness of multimodal imaging in gliomas. Although the results have been heavily affected by the method used for region of interest (ROI) design, the most discriminatory method for setting the ROI remains unclear. The aim of the present study was to determine the most suitable ...

journal_title：Oncology letters

authors： Takano K,Kinoshita M,Arita H,Okita Y,Chiba Y,Kagawa N,Watanabe Y,Shimosegawa E,Hatazawa J,Hashimoto N,Fujimoto Y,Kishima H

更新日期：2018-05-01 00:00:00

abstract：:Endocrine-disrupting chemicals (EDCs) are exogenous chemical compounds ubiquitously found in everyday life of the modern world. EDCs enter the human body where they act similarly to endogenous hormones, altering the functions of the endocrine system and causing adverse effects on human health. Bisphenol A (BPA), the p...

journal_title：Oncology letters

authors： Dumitrascu MC,Mares C,Petca RC,Sandru F,Popescu RI,Mehedintu C,Petca A

更新日期：2020-12-01 00:00:00

abstract：:The clinical significance of the proteasome inhibitor MG132 has been examined in numerous human cancer types; however, its influence on the metastasis and progression of pancreatic cancer is yet to be determined. In the present study, the effect of MG132 treatment on pancreatic ductal adenocarcinoma (PDAC) cell lines ...

journal_title：Oncology letters

authors： Jin F,Xiao D,Zhao T,Yu M

更新日期：2020-01-01 00:00:00

abstract：:A promising nutraceutical, apigenin, was recently revealed to exhibit biological activity in inhibiting several types of cancer. The effects of apigenin on the growth inhibition and apoptosis of the cholangiocarcinoma HuCCA-1 cell line were investigated. Protein alterations subsequent to apigenin treatment were studie...

journal_title：Oncology letters

authors： Subhasitanont P,Chokchaichamnankit D,Chiablaem K,Keeratichamroen S,Ngiwsara L,Paricharttanakul NM,Lirdprapamongkol K,Weeraphan C,Svasti J,Srisomsap C

更新日期：2017-10-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between cyclin A expression and efficacy of paclitaxel-based chemotherapy in patients with esophageal squamous cell carcinoma (ESCC). The expression of cyclin A was examined in 48 newly diagnosed ESCC patients prior to treatment using the MaxVision immunohistoch...

journal_title：Oncology letters

authors： Huang JX,Shen SL,Lin M,Xiao W,Chen WC,Lin MS,Yu H,Chen P,Qian RY

更新日期：2012-10-01 00:00:00

abstract：:Gene therapy with adenoviral early region gene (E1A) may enhance the susceptibility of neoplastic cells to chemotherapy-induced cell death. Our previous study developed a urothelium-specific oncolytic serotype 5 adenovirus (Ad5) with the uroplakin II (UPII) promoter controlling E1A expression. The present study invest...

journal_title：Oncology letters

authors： Li S,Wang F,Zhai Z,Fu S,Lu J,Zhang H,Guo H,Hu X,Li R,Wang Z,Rodriguez R

更新日期：2017-08-01 00:00:00

abstract：:Previous studies have demonstrated that C-X-C chemokine receptor type 7 (CXCR7) regulates papillary thyroid carcinoma (PTC) growth and metastasis; however, the molecular mechanisms underlying this regulation remain unclear. In the present study, the protein expression profiles of the PTC cell line GLAG-66 and GLAG-66 ...

journal_title：Oncology letters

authors： Zhang H,Yang L,Liu Z,Liu C,Teng X,Zhang L,Yin B,Liu Z

更新日期：2017-09-01 00:00:00

abstract：:Solamargine (SM), a steroidal alkaloid glycoside purified from the Chinese traditional herb Solanum incanum, is known to possess various biological activities. However, only a few previous studies have reported the anti-metastatic activity of SM. In the present study, the inhibitory effects of SM on metastatic action ...

journal_title：Oncology letters

authors： Xie X,Zhu H,Zhang J,Wang M,Zhu L,Guo Z,Shen W,Wang D

更新日期：2017-07-01 00:00:00

abstract：:The aim of the present study was to investigate the expression of activin A in esophageal carcinoma and its association with tumor differentiation and metastasis. A total of 57 esophageal carcinoma patients and 36 controls were included in the current study. The mRNA and protein expression levels of activin A in esoph...

journal_title：Oncology letters

authors： Wang Z,Zhang N,Song R,Fan R,Yang L,Wu L

更新日期：2015-07-01 00:00:00

abstract：:The clinicopathological value and exploration of the potential molecular mechanism of microRNA-183-5p (miR-183-5p) have been investigated in various cancers; however, to the best of the author's knowledge, no similar research has been reported for bladder cancer. In the present study, it was revealed that the expressi...

journal_title：Oncology letters

authors： Gao JM,Huang LZ,Huang ZG,He RQ

更新日期：2018-04-01 00:00:00

abstract：:Congenital leukemia is rare disease with an incidence of one to five cases per million births. Transient abnormal myelopoiesis (TAM), also called transient myeloproliferative disorder, is a pre-leukemia disorder that may occur in Down syndrome (DS) or non-DS infants. TAM may enter spontaneous remission; however, conti...

journal_title：Oncology letters

authors： Salvatori G,Foligno S,Sirleto P,Genovese S,Russo S,Coletti V,Dotta A,Luciani M

更新日期：2017-01-01 00:00:00

abstract：:A malignant peripheral nerve sheath tumor (MPNST) is defined as any malignant tumor that develops or differentiates from cells in the peripheral nerve sheath. This tumor is commonly associated with neurofibromatosis type 1 (NF1) and previous radiotherapy treatment. Primary intraosseous MPNSTs are extremely rare and a ...

journal_title：Oncology letters

authors： Suzuki K,Yasuda T,Hori T,Watanabe K,Kanamori M,Kimura T

更新日期：2014-06-01 00:00:00

abstract：:Exophthalmos, myxedema and osteoarthropathy (EMO) comprise the triad known as EMO syndrome, which is rarely observed in patients with autoimmune thyroid disease. The present study reports the case of a patient with EMO, including the response of this rare combination to radiotherapy. A 48-year-old patient with EMO syn...

journal_title：Oncology letters

authors： Elsayad K,Kriz J,Bauch J,Scobioala S,Haverkamp U,Sunderkötter C,Eich HT

更新日期：2015-05-01 00:00:00

abstract：:Current endocrine therapies for females with estrogen receptor-positive breast cancer have facilitated substantial improvements in outcomes. The effectiveness of endocrine therapy is limited by either initial de novo resistance or acquired endocrine resistance. Multiple mechanisms responsible for endocrine resistance ...

journal_title：Oncology letters

authors： Zhou J,Teng R,Wang Q,Xu C,Guo J,Yuan C,Shen J,Hu W,Wang L,Xie S

更新日期：2013-08-01 00:00:00

abstract：:Tuberous sclerosis complex (TSC) is an autosomal dominant disease involving multiple organs, but there are a limited number of reports on family TSC. In the present report, a case of a 52-year-old female with a familial genetic TSC, associated with bilateral giant renal angiomyolipoma, was described. The mother, secon...

journal_title：Oncology letters

authors： Wang L,Ni D,Zhong L,Wang J

更新日期：2017-12-01 00:00:00

abstract：:Bovine lactoferricin P13 (LfcinB-P13) is a peptide derived from LfcinB. In the present study, the effect of LfcinB-P13 on the human liver cancer cell line SMMC7721 was investigated in vitro and in vivo. The results of the present study indicate that LfcinB-P13 significantly decreased SMMC7721 cell viability in vitro (...

journal_title：Oncology letters

authors： Meng L,Xu G,Li J,Liu W,Jia W,Ma J,Wei D

更新日期：2017-01-01 00:00:00

abstract：:Peritumoral edema (PTE), one of the main characteristics of malignant glioma, is a significant contributor to the morbidity and mortality from glioma, however, a recent systematic review suggested that controversy remains with regard to its prognostic value. To further determine whether PTE was a potential prognostic ...

journal_title：Oncology letters

authors： Wu CX,Lin GS,Lin ZX,Zhang JD,Chen L,Liu SY,Tang WL,Qiu XX,Zhou CF

更新日期：2015-11-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/ol.2017.5668.]. ...

journal_title：Oncology letters

authors： Lee J,Kim DS,Lee HS,Choi SI,Cho YG

更新日期：2017-11-01 00:00:00

abstract：:This study aims to comparatively analyze the impact of laparoscopic myomectomy (LM) and transcervical resection of myoma (TCRM) on ovarian function, immune function and quality of sexual life of patients with hysteromyoma. Two hundred and forty patients with hysteromyoma admitted into the Second Affiliated Hospital of...

journal_title：Oncology letters

authors： Zhang Y,Gu X,Meng Y,Guo H,Du J,Xing W

更新日期：2018-03-01 00:00:00

abstract：:The present study aimed to identify the regulatory mechanisms associated with the metastasis of prostate cancer (PC). The microRNA (miRNA/miR) microarray dataset GSE21036 and gene transcript dataset GSE21034 were downloaded from the Gene Expression Omnibus database. Following pre-processing, differentially expressed m...

journal_title：Oncology letters

authors： Guo K,Liang Z,Li F,Wang H

更新日期：2017-11-01 00:00:00

abstract：:The development of drug resistance to chemotherapeutic agents has consistently presented a challenge in terms of the treatment of patients with triple-negative breast cancer (TNBC). In the present study, gemcitabine (dFdC)-resistant TNBC cells were established, and the effects of lentivirus-deoxyribonucleoside kinase ...

journal_title：Oncology letters

authors： Zhao Y,Jiang H,Gu M,Zu C,Zheng X

更新日期：2020-11-01 00:00:00

abstract：:Microcystic adnexal carcinoma (MAC) is extremely rare among Asians, with the majority of cases presenting in Caucasian individuals. The current study describes the case of a 38-year-old Chinese woman who presented with a 10 year history of a mass in the upper lip. A biopsy resulted in a diagnosis of MAC. The patient u...

journal_title：Oncology letters

authors： Chen J,Yang S,Chen J,Liao T,Deng W,Li W

更新日期：2016-04-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is upregulated in numerous types of cancer, and is implicated in various cellular processes associated with cancer progression. However, the underlying molecular mechanisms by which MALAT1 regulates metastasis remain unclear. ...

journal_title：Oncology letters

authors： Zhang Y,Guan X,Wang H,Wang Y,Yue D,Chen R

更新日期：2020-10-01 00:00:00