Rechallenge of carboplatin-gemcitabine based chemotherapy for rapidly progressing metastatic collecting duct carcinoma of the kidney leading to a delayed and durable complete response: A case report.

abstract：:Homoisoflavanone-1 is a natural compound that may be extracted from the Chinese medicinal herb Polygonatum odoratum, which has pronounced antioxidant activities. The present study reports that homoisoflavanone-1 significantly inhibited tumor cell growth and induced apoptosis in A549 non-small cell lung cancer (NSCLC) ...

journal_title：Oncology letters

authors： Ning D,Jin M,Xv T,Sun J,Li M

更新日期：2018-09-01 00:00:00

abstract：:Patients with renal medullary carcinoma (RMC) have a poor prognosis, usually due to late diagnosis. Computed tomography (CT) analysis may aid the differentiation between RMC and other types of renal cell carcinoma, in order to establish an accurate early diagnosis. There is a limited number of reports in the literatur...

journal_title：Oncology letters

authors： Shi Z,Zhuang Q,You R,Li Y,Li J,Cao D

更新日期：2016-01-01 00:00:00

abstract：:Bladder cancer is one of the most common forms of malignancies involving the urinary system and multiple risk factors have been associated with its etiology. The most common of which include cigarette smoking and various occupational or chemical exposures. It is usually diagnosed in older individuals with an average a...

journal_title：Oncology letters

authors： Khan R,Ibrahim H,Tulpule S,Iroka N

更新日期：2016-05-01 00:00:00

abstract：:Expression level of messenger RNA (mRNA) of cold shock domain protein A intronless pseudogene (CSDAP1) in lung cancer tissues was studied. Fresh pathological specimens collected from 317 patients with primary lung cancer through surgical resection from January 2007 to January 2012 were selected. Reverse transcription-...

journal_title：Oncology letters

authors： Xu T,Li D,He Y,Zhang F,Qiao M,Chen Y

更新日期：2018-10-01 00:00:00

abstract：:The present study aimed to ascertain whether suppression of midkine (MK) expression in pancreatic cancer cells inhibits metastasis to the liver. Human pancreatic cancer AsPC-1 cells were transfected with small interfering RNA (siRNA) targeting MK. siRNA against MK was observed to reduce the expression of MK mRNA and p...

journal_title：Oncology letters

authors： Yu L,Fan Y,Chen B,Hu Y,Gao Y,Wei D

更新日期：2013-11-01 00:00:00

abstract：:Breast cancer is one of the most prevalent types of cancer in women and contributes to 32% of all female cancer cases. Cathepsins, a family of proteins, are known to have a critical role in human cancers. However, previous studies on the systematic analysis of the role of cathepsin family members in breast cancer are ...

journal_title：Oncology letters

authors： Sun T,Jiang D,Zhang L,Su Q,Mao W,Jiang C

更新日期：2016-01-01 00:00:00

abstract：:The epidemiology and clinical outcome of gastrointestinal mucinous adenocarcinoma (MA) are not well illustrated. The present study aimed to explore the evolving epidemiology and prognostic factors that affect the survival of patients with MA in the gastrointestinal tract. A retrospective and population-based study was...

journal_title：Oncology letters

authors： Zong Z,Luo Y,Ying H,Wang A,Li H,Yi C

更新日期：2018-11-01 00:00:00

abstract：:The present study investigated the correlations of the Tspan-1 gene expression with the clinical characteristics and survival prognoses of patients with advanced gastric cancer. A total of 150 patients with advanced gastric cancer were enrolled in the present study, of whom 84 were at stage II and 66 were at stage III...

journal_title：Oncology letters

authors： Cai Y,Zheng M,Zhao Z,Huang H,Fu W,Xu X

更新日期：2017-09-01 00:00:00

abstract：:The predominant characteristic of malignant glioma is the presence of invading tumor cells in the peritumoral zone. Distinguishing between tumor cells and normal cells in a peritumoral lesion is challenging. Therefore, the aim of the present study was to investigate the cell-cycle phase measurements of fixed paraffin-...

journal_title：Oncology letters

authors： Nakajima S,Morii K,Takahashi H,Fujii Y,Yamanaka R

更新日期：2016-03-01 00:00:00

abstract：:Esophageal cancer is one of the most common types of malignant tumors located within the digestive system, with >50% of esophageal cancer cases worldwide occurring in China. Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are frequently dysregulated in cancer; however, few lncRNAs have been charac...

journal_title：Oncology letters

authors： Chen R,Xia W,Wang X,Qiu M,Yin R,Wang S,Xi X,Wang J,Xu Y,Dong G,Xu L,De W

更新日期：2018-04-01 00:00:00

abstract：:Autophagy is a lysosomal degradation process which is key for the regulation of the turnover of long-lived or damaged proteins and organelles and which promotes cell survival during nutrient deprivation or other microenvironmental stresses. Current evidence supports the hypothesis that autophagy suppresses tumorigenes...

journal_title：Oncology letters

authors： Xu Y,Xia X,Pan H

更新日期：2013-02-01 00:00:00

abstract：:Urothelial carcinoma (UC) is the most common type of cancer of the bladder and upper urinary tract, and is characterized by a high risk of recurrence and progression. Urine fluorescence in situ hybridization (FISH) is a technique that detects genetic aberrations in exfoliated cells in the urine, with specific probes f...

journal_title：Oncology letters

authors： Lin T,Liu Z,Liu L,Yang L,Han P,Zhang P,Wei Q

更新日期：2017-05-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) promotes invasive and migratory activities by upregulating Forkhead box protein M1 (FoxM1) expression. The present study investigated whether modulation of MnSOD and FoxM1 expression was responsible for the antitumor effects of genistein on cancer stem-like cells (CSLCs) derived ...

journal_title：Oncology letters

authors： Fu Z,Cao X,Liu L,Cao X,Cui Y,Li X,Quan M,Ren K,Chen A,Xu C,Qiu Y,Chen X,Wang Z,Cao J

更新日期：2020-09-01 00:00:00

abstract：:Preeclampsia (PE) is characterized by gestational hypertension and proteinuria, and is a leading cause of maternal death and perinatal morbidity globally. Although the exact cause of PE remains unclear, several studies have suggested a role for abnormal expression of multiple genes. The aim of the present study was to...

journal_title：Oncology letters

authors： Xu Z,Wu C,Liu Y,Wang N,Gao S,Qiu S,Wang Z,Ding J,Zhang L,Wang H,Wu W,Wan B,Yu J,Fang J,Yang P,Shao Q

更新日期：2020-08-01 00:00:00

abstract：:Pristimerin is an active compound isolated from the traditional Chinese herbs Celastraceae and Hippocrateaceae. It has been reported to exert antitumor effects under experimental and clinical conditions; however, the antitumor effects and underlying mechanisms of pristimerin in oral cancer cells have not yet been iden...

journal_title：Oncology letters

authors： Wu H,Li L,Ai Z,Yin J,Chen L

更新日期：2019-03-01 00:00:00

abstract：:The present study evaluated the expression of p53, pRb, hMLH1 and MDM2 prior to preoperative chemoradiotherapy (CRT) in patients with rectal cancer, and attempted to determine any correlation with treatment outcome. Forty-five patients with available pretreatment biopsy tissues and who received preoperative CRT were e...

journal_title：Oncology letters

authors： Nam TK,Lee JS,Kim HR,Ahn SJ,Song JY,Yoon MS

更新日期：2010-01-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising therapeutic options for patients with advanced cancer. The aim of the present study was to investigate the prognostic value of somatic mutations in mismatch repair (MMR) genes in metastatic cancers after ICI treatment, as well as their assoc...

journal_title：Oncology letters

authors： Liu Y,Chen L,Zhang S,Shu Y,Qi Q,Zhu M,Peng Y,Ling Y

更新日期：2020-10-01 00:00:00

abstract：:Effect of microRNA-27b (miR-27b) on cisplatin chemotherapy sensitivity of oral squamous cell carcinoma (OSCC) was investigated to provide a reference for clinical prevention of OSCC cell resistance. The clinical tissues of 34 patients with OSCC-resistant cancer and 28 patients with cisplatin-sensitive OSCC in Nanjing ...

journal_title：Oncology letters

authors： Liu B,Cao G,Dong Z,Guo T

更新日期：2019-07-01 00:00:00

abstract：:Although it is the most widely used biomarker for prostate cancer, the use of prostate specific antigen (PSA) is controversial due to its limitations in specificity and sensitivity. The proteasome is a complex associated with cell proliferation and apoptosis, and the abnormity of these processes may lead to tumor occu...

journal_title：Oncology letters

authors： Wei X,Zeng W,Xie K,Diao P,Tang P

更新日期：2018-04-01 00:00:00

abstract：:The chemokine system has been reported to be utilized and manipulated by tumor cells in order to promote local tumor growth and distant dissemination. The present study aimed to investigate the expression of three chemokine ligand-receptor axes in lung carcinoma tissues. Tumor and healthy normal tissue samples were ob...

journal_title：Oncology letters

authors： Liu Y,Wu BQ,Geng H,Xu ML,Zhong HH

更新日期：2015-09-01 00:00:00

abstract：:The current study presents the case of a 68-year-old female patient who received biological intensity-modulated radiotherapy (BIMRT) and neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer. The International Federation of Gynecology and Obstetrics disease stage was IIIc. In addition, the pati...

journal_title：Oncology letters

authors： Huang S,Dang Y,Li F,Wei W,Ma Y,Qiao S,Wang Q

更新日期：2015-03-01 00:00:00

abstract：:While erlotinib is primarily administered to patients with non-small cell lung cancer with sensitizing epidermal growth factor receptor (EGFR) mutations, it is also prescribed to patients with wild type (wt) EGFR in higher lines of treatment. However, there is no predictive marker for erlotinib efficacy in patients wi...

journal_title：Oncology letters

authors： Svaton M,Fiala O,Krakorova G,Blazek J,Hurdalkova K,Barinova M,Mukensnabl P,Pesek M

更新日期：2020-08-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/ol.2018.8006.]. ...

journal_title：Oncology letters

authors： Xu F,Zhu Y,Lu Y,Yu Z,Zhong J,Li Y,Pan J

更新日期：2020-11-01 00:00:00

abstract：:Diagnostic assays for human epidermal growth factor receptor 2 (HER2) expression have a high predictive value because patients with HER2-positive tumors could benefit from HER2-targeted therapy. The aim of the present study is to analyze the incidence of HER2 gene amplification in selected tumors with adverse features...

journal_title：Oncology letters

authors： Petroni S,Caldarola L,Scamarcio R,Giotta F,Latorre A,Mangia A,Simone G

更新日期：2016-11-01 00:00:00

abstract：:It is well-known that tumor angiogenesis is important in cancer development, and studies on blocking angiogenesis to treat tumors have become one of the most promising and active fields in anticancer research. The present study investigated the effect of siRNA targeting the tyrosine kinase receptor 2 (Tie2) gene in co...

journal_title：Oncology letters

authors： Guo F,Xun Q,Zhou H

更新日期：2013-06-01 00:00:00

abstract：:Local adjuvant treatment of giant cell tumours (GCTs) of the bone with phenol has led to a significant reduction in recurrence rates. In the current study, the optimal phenol concentration and duration of intralesional exposure were evaluated. Specimens of GCTs were exposed to various concentrations of phenol solution...

journal_title：Oncology letters

authors： Mittag F,Leichtle C,Kieckbusch I,Wolburg H,Rudert M,Kluba T,Leichtle U

更新日期：2013-05-01 00:00:00

abstract：:Portal vein tumor thrombus (PVTT) promotes distant metastasis of hepatocellular carcinoma (HCC), which increases the mortality of patients with HCC and PVTT. The aim of the present study was to develop an early risk warning system for distant metastasis of hepatitis B virus (HBV)-associated primary HCC (HBV-HCC) with ...

journal_title：Oncology letters

authors： Li M,Zhao Y,Liu X,Zhang S,Jiang Y,Yang Z

更新日期：2020-04-01 00:00:00

abstract：:The aim of the present study was to investigate whether ultrasound combined with microbubbles was able to enhance liposome-mediated transfection of genes into human prostate cancer cells, and to examine the association between autophagy and tumor protein P53 (P53). An MTT assay was used to evaluate cell viability, whi...

journal_title：Oncology letters

authors： Wang YU,Chen YN,Zhang W,Yang YU,Bai WK,Shen E,Hu B

更新日期：2016-01-01 00:00:00

abstract：:The global incidence of prostate cancer (PCa) has been increasing in recent years. Meanwhile, some studies have indicated the association between malignancies, such as lung and gastric cancer and PCa, and microRNAs (miRNAs). The present study was designed to assess the prognostic value of miR-92b-3p in patients with P...

journal_title：Oncology letters

authors： Wang G,Cheng B,Jia R,Tan B,Liu W

更新日期：2021-01-01 00:00:00

abstract：:Preoperative radiotherapy improves local disease control and disease-free survival in patients with advanced rectal cancer; however, a reliable predictive biomarker for the effectiveness of irradiation has yet to be elucidated. Phosphorylation of H2A histone family member X (H2AX) to γ-H2AX is induced by DNA double-st...

journal_title：Oncology letters

authors： Kawashima S,Kawaguchi N,Taniguchi K,Tashiro K,Komura K,Tanaka T,Inomata Y,Imai Y,Tanaka R,Yamamoto M,Inoue Y,Lee SW,Kawai M,Tanaka K,Okuda J,Uchiyama K

更新日期：2020-09-01 00:00:00