Abstract:
:Local adjuvant treatment of giant cell tumours (GCTs) of the bone with phenol has led to a significant reduction in recurrence rates. In the current study, the optimal phenol concentration and duration of intralesional exposure were evaluated. Specimens of GCTs were exposed to various concentrations of phenol solution (6, 60 and 80%) for either 1 or 3 min. Following embedding in glutaraldehyde, the tumour cell layers were examined by transmission electron microscopy. Destroyed cell organelles indicated the penetration depth as a sign of denaturation. Incubation of GCT specimens with 6% phenol solution for 3 min resulted in the most tissue damage and the deepest tissue penetration of ∼200 μm. Incubation with 60 and 80% phenol solution reached a penetration depth of only ∼100 μm. Phenol instillation may be used for the treatment of small scattered cellular debris following intralesional curettage; however, it is not suitable for treatment of remaining solid tumour tissue of GCT. The use of high phenol concentrations has no benefit and increases the risk of local or systemic intoxication.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Mittag F,Leichtle C,Kieckbusch I,Wolburg H,Rudert M,Kluba T,Leichtle Udoi
10.3892/ol.2013.1244subject
Has Abstractpub_date
2013-05-01 00:00:00pages
1595-1598issue
5eissn
1792-1074issn
1792-1082pii
ol-05-05-1595journal_volume
5pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor, which may affect various organs. The preferential site for IMT in the genitourinary system is the urinary bladder, while the presence of IMT in the kidney, and particularly in the renal pelvis, is rare. In the present report, the case of a 4...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3767
更新日期:2015-12-01 00:00:00
abstract::Personalized chemotherapy with the use of biomarkers helps to maximize clinical efficiency. Therefore, the present study aimed to identify a potential method for identifying biomarkers in esophageal cancer. A total of 49 freshly resected tumor tissues and 72 paraffin-embedded specimens from patients with esophageal ca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7069
更新日期:2017-12-01 00:00:00
abstract::Our previous study demonstrated that the 2-benzyloxybenzaldehyde analog CCY-1a-E2 is a potent compound against HL-60 human leukemia cell lines. To investigate the potential therapeutic application of CCY-1a-E2 for leukemia, we analyzed the antileukemic effects and safety of CCY-1a-E2 in the BALB/c mouse WEHI-3 allogra...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1079
更新日期:2013-03-01 00:00:00
abstract::The aim of the present study was to investigate the treatment options for patients with tuberous sclerosis complex (TSC)-associated renal angiomyolipomas (AMLs). A total of 17 patients who were consecutively diagnosed with TSC-associated renal AMLs at the Department of Urology of Zhongshan Hospital between 1998 and 20...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4766
更新日期:2016-08-01 00:00:00
abstract::An individual with a twin who has developed leukemia or non-Hodgkin lymphoma (NHL) has an increased risk of developing the same disease, particularly with monozygotic twins. The few reported pairs of twins who developed NHL had similar primary sites and pathological subtypes. Here, we present the first reported cases ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9723
更新日期:2019-01-01 00:00:00
abstract::Reactive nodular fibrous pseudotumor (RNFP) is a tumor-like lesion that is characterized by reactive fibroblast/myofibroblast proliferation within collagenic hyalinized stroma, due to its association with injury or inflammation. The current study describes the case of a 60-year-old female with a history of abdominal s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2882
更新日期:2015-03-01 00:00:00
abstract::Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.425
更新日期:2012-01-01 00:00:00
abstract::Inhibition of nuclear factor-κB (NF-κB) results in antitumor activity in leukemia cells, and may be a potential therapeutic strategy for the treatment of leukemia. However, a significant limitation of NF-κB inhibition in the treatment of leukemia is the low efficiency of this technique. NF-κB inhibitor treatment induc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3786
更新日期:2015-12-01 00:00:00
abstract::Inactivating mutations of the multiple endocrine neoplasia 1 (MEN1) gene cause MEN1 syndrome, characterized by primary hyperparathyroidism (pHPT), and parathyroid and gastro-entero-pancreatic pituitary tumors. At present, only 14 cases of malignant parathyroid tumor have been associated with the syndrome, with 6 cases...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6162
更新日期:2017-07-01 00:00:00
abstract::Pneumocystis jiroveci pneumonia (PCP) has long been recognized as a cause of mortality in immuno-compromised populations, including those with advanced lung cancer. Although Pneumocystis colonization has only recently been described due to the development of more sensitive molecular techniques, including polymerase ch...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1052
更新日期:2013-02-01 00:00:00
abstract::Deoxypodophyllotoxin (DPPT) is extracted and separated from citrus-related plants, including Podophyllum (P.) peltatum, P. pleianthum, P. emodi (also called P. hexandrum) and Diphylleia grayi. DPPT has significant antitumor and antiviral activity. However, due to its strong toxicity and side effects, its use is limite...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4943
更新日期:2016-10-01 00:00:00
abstract::Terrein is a bioactive fungal metabolite isolated from Aspergillus terreus. Besides being a melanogenesis inhibitor, previous studies have revealed that terrein has antiproliferative effects on a number of types of cancer tumors. In the present study, the inhibitory effect of terrein on esophageal cancer was evaluated...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5758
更新日期:2017-04-01 00:00:00
abstract::Expression of long non-coding RNA SNHG7 (lncRNA-SNHG7) and its clinical significance in hepatocellular carcinoma (HCC) were explored. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of lncRNA-SNHG7 in cancer tissues. Kaplan-Meier curves and multivariate Cox proportion...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11490
更新日期:2020-06-01 00:00:00
abstract::Central nervous system-based cancers have a much higher mortality rate with the 2016 estimates at 6.4 for incidence and 4.3 for deaths per 100,000 individuals. Grade IV astrocytomas, known as glioblastomas are highly aggressive and show a high proliferation index, diffused infiltration, angiogenesis, microvascular pro...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4952
更新日期:2016-10-01 00:00:00
abstract::Breast cancer (BC) is the most frequently diagnosed malignant tumor in women worldwide, and the development of new molecules associated with BC is essential for the management of this disease. RAS and EF-hand domain-containing (RASEF) encodes the GTPase enzyme that belongs to the Rab family. Although the effects of th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9542
更新日期:2018-12-01 00:00:00
abstract::The prognosis of patients with metastatic or recurrent breast cancer (MBC) is improving as novel treatments are developed. The present study compared the clinical characteristics of patients with MBC with or without a complete clinical response (cCR) and identified the survival-associated factors. This was a retrospec...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8145
更新日期:2018-05-01 00:00:00
abstract::The major aim of the present study was to develop an integrin receptor-targeted liposomal paclitaxel (PTX) to enhance the targeting specificity and therapeutic effect of PTX on hepatocellular carcinoma (HCC) cells. The specific Arg-Gly-Asp (RGD) ligand was conjugated to 1,2-distearoylphosphatidylethanolamine-polyethyl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3242
更新日期:2015-07-01 00:00:00
abstract::Ductal adenocarcinoma of the prostate (DAP) is a rare variant of prostate cancer, and has poorly-identified clinical characteristics. Few cases have been previously reported in Chinese males and DAP is more commonly reported in Caucasian males over 70-years of age. In the present study, a 55-year-old Chinese male pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4098
更新日期:2016-02-01 00:00:00
abstract::The present study reports a case of hemorrhage from branches of the right obturator artery following laparoscopic radical prostatectomy. On post-operative day 9, the patient complained of lower abdominal pain, and the hemoglobin and hematocrit levels had decreased. Emergency computed tomography angiography showed a la...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3381
更新日期:2015-09-01 00:00:00
abstract::Retroperitoneal liposarcoma is a rare tumor with an incidence of 2.5 per million individuals. Early diagnosis is difficult as there is an absence of specific clinical presentations. The present case study reports a patient diagnosed with retroperitoneal liposarcoma who was treated by complete surgical resection and re...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3193
更新日期:2015-07-01 00:00:00
abstract::The risk factors for the development of hepatocellular carcinoma (HCC) in patients who have achieved a long-term sustained viral response (SVR) to interferon (IFN) are not fully understood. This study aimed to investigate the characteristics of patients who developed HCC after 10 years of achieving SVR. We retrospecti...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000075
更新日期:2010-05-01 00:00:00
abstract::The present study aimed to clarify the association between kinesin family member 11 (KIF11) and human breast cancer, and the effect of KIF11 on breast cancer cell progression. Western blot analysis, reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis, retroviral infection, immunohistochemis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7053
更新日期:2017-12-01 00:00:00
abstract::Pendred syndrome is a rare genetic disease that causes a disturbance in thyroid hormone synthesis, which results in thyroid dysfunction and the development of goiter and sensorineural deafness. The present report describes the case of a young euthyroid male, who developed a large goiter and hearing impairment, despite...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2461
更新日期:2014-11-01 00:00:00
abstract::The present study aimed to explore the clinical efficacy and safety of hydromorphone combined with sufentanil in patient-controlled intravenous analgesia (PCIA) for patients with hepatocellular carcinoma (HCC) and its effect on serum immune factors in serum. Data from 385 patients with HCC, admitted to the Hunan Provi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12159
更新日期:2020-12-01 00:00:00
abstract::Natural products are a promising source for the development of novel cancer therapies, due to their potential effectiveness and low toxicity profiles. As a main component of Herba oxytropis, 2',4'-dihydroxychalcone (TFC) is known to demonstrate anti-tumor activity in vitro. In the present study, TFC was found to potent...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3795
更新日期:2015-12-01 00:00:00
abstract::Immunotherapy based on the tumor microenvironment is a feasible method for treating cancer; therefore, it is necessary to investigate the immune microenvironment of pancreatic cancer and the influencing factors of the immune microenvironment. Chemokines are an important factor affecting the tumor immune microenvironme...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12120
更新日期:2020-11-01 00:00:00
abstract::It has been widely reported that patient-derived tumor xenografts (PDXs) are more similar to tumor tissues than conventional cancer cell lines. Kinetochore-associated protein 2 (KNTC2) is known to be upregulated specifically in tumor tissues of cancer patients and is recognized as a potential target for cancer therapy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7890
更新日期:2018-04-01 00:00:00
abstract::Osteosarcoma (OS) is identified as the most commonly diagnosed malignant cancer of bone, and has approximately three million new cases annually. miR-26a plays an important role in the development of various types of cancer. We investigated whether miR-26a can regulate the migration and invasion of OS by targeting high...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8359
更新日期:2018-06-01 00:00:00
abstract::As a member of the tripartite motif family, tripartite motif-containing protein 59 (TRIM59) serves as an E3 ubiquitin ligase in various cellular processes, including intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy and carcinogenesis. The present study aimed to inves...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11199
更新日期:2020-02-01 00:00:00
abstract::Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) is a diterpenoid isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine. It was demonstrated in our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5099
更新日期:2016-11-01 00:00:00