Abstract:
:Our previous study demonstrated that the 2-benzyloxybenzaldehyde analog CCY-1a-E2 is a potent compound against HL-60 human leukemia cell lines. To investigate the potential therapeutic application of CCY-1a-E2 for leukemia, we analyzed the antileukemic effects and safety of CCY-1a-E2 in the BALB/c mouse WEHI-3 allograft model. Our results showed that CCY-1a-E2 decreased the percentage of viable cells in a concentration-dependent manner. The IC(50) of CCY-1a-E2 was 5 μM for the 24-h treatment of WEHI-3 cells. We examined the antileukemic activity of CCY-1a-E2 in the BALB/c mouse WEHI-3 allograft model. The CCY-1a-E2 (100 mg/kg) group was not found to have significantly decreased body weight compared with the control group, while the leukemia group was found to have significantly decreased body weight compared with the control mice. The CCY-1a-E2 (100 mg/kg) group showed no difference in spleen and liver weight, but significantly decreased levels of CD11b and CD45 compared with the leukemia group. In safety evaluation analysis, CCY-1a-E2 had no adverse effects on renal, hepatic and hematological parameters. Based on these observations, CCY-1a-E2 has efficacious antileukemic activity in the BALB/c mouse WEHI-3 allograft model.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Lin C,Yang JS,Tsai SC,Lin CF,Lee MRdoi
10.3892/ol.2012.1079subject
Has Abstractpub_date
2013-03-01 00:00:00pages
777-782issue
3eissn
1792-1074issn
1792-1082pii
ol-05-03-0777journal_volume
5pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12044
更新日期:2020-11-01 00:00:00
abstract::The detection and characterisation of tumour-derived circulating epithelial tumor cells (CETCs) or circulating tumor cells (CTCs) have been a main focus of basic oncological research over previous years. Numerous studies in the past decade have shown that CTCs are a promising tool for the estimation of the risk for me...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4878
更新日期:2016-09-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignant disease that is resistant to various chemotherapeutic agents and commonly relapses. Efficient elimination of metastasized PDA is critical for a positive post-surgical treatment outcome. The present study analyzed the effect of the B-cell lymphoma-2 (Bcl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6211
更新日期:2017-07-01 00:00:00
abstract::[This retracts the article DOI: 10.3892/ol.2016.5302.]. ...
journal_title:Oncology letters
pub_type: 撤回出版物
doi:10.3892/ol.2020.12101
更新日期:2020-11-01 00:00:00
abstract::A 77-year-old female, with proptosis, reduced eye motility and diplopia which had developed over two to three months and a 69-year-old female with proptosis, oedema of the eyelid, reduced motility and ptosis, which had developed over three weeks, are presented in the present study. Computed tomography scans revealed i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3282
更新日期:2015-08-01 00:00:00
abstract::Integrin signaling may modulate several different functions involved in cell migration, invasion, proliferation and motility, and is a potential candidate biomarker for oral cancer. In the present study, a total of four integrin genes were evaluated as potential biomarkers of oral squamous cell carcinoma (OSCC). Gene ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9168
更新日期:2018-10-01 00:00:00
abstract::The present study aimed to measure the expression of WNT1 in ameloblastoma (AB). Immunohistochemistry was used to observe changes in WNT1 expression in 80 AB samples, 10 keratocystic odontogenic tumor (KCOT) samples and 10 normal oral mucosa (NOM) samples. Western blotting and reverse transcription-quantitative polyme...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8820
更新日期:2018-08-01 00:00:00
abstract::The aim of the study was to determine whether interleukin-8 (IL-8) affects human SKOV3 ovarian cancer cell migration and invasion by targeting silencing of IL-8 expression. Silencing small-interfering RNA (siRNA) targeting IL-8 gene was constructed to infect SKOV3 cells by lentiviral vector. The expression of IL-8 and...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5511
更新日期:2017-02-01 00:00:00
abstract::The aim of the present study was to investigate the role of edema surrounding breast cancer masses in the prognostic prediction of magnetic resonance imaging (MRI) T2-weighted fat suppression sequence. For this purpose, 80 patients with mass-type breast cancer underwent conventional plain breast MRI, dynamic contrast-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12177
更新日期:2020-12-01 00:00:00
abstract::The present study aimed to reveal the key long non-coding RNAs (lncRNAs) and the potential molecular mechanisms of XAV939 treatment in non-small cell lung cancer (NSCLC). The NSCLC cell line, NCI-H1299, was cultured with 10 µM XAV939 for 12 h, and NCI-H1299 cells without XAV939 treatment were used as controls. Followi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10191
更新日期:2019-06-01 00:00:00
abstract::The present study aimed to identify polypeptides that specifically bond to breast cancer stem cells from a phage display random 12 peptide library, in addition to the affinity and specificity of polypeptides. A phage display random 12 peptide library was screened using breast cancer stem cells as targets isolated from...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5248
更新日期:2016-12-01 00:00:00
abstract::The aim of the present study was to investigate the ability of Nimotuzumab to increase radiosensitivity at different delivery times in the mixed cancer cell line Eca109, to determine the optimal delivery time. Cultured Eca109 cells were classified into five groups: Control with no treatment (O group); irradiation with...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9897
更新日期:2019-03-01 00:00:00
abstract::Cyclin-dependent kinase inhibitor 2A (p16INK4a) protein is a surrogate immunohistochemical marker of human papillomavirus infection in oropharynx squamous cell carcinoma (OPSCC). However, the effects of p16INK4a in non-OPSCC require additional analysis. In addition, major gaps remain in the literature, including small...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9353
更新日期:2018-11-01 00:00:00
abstract::Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are an approved first-line therapy against unresectable or advanced non-small cell lung cancer (NSCLC) harboring EGFR gene activating mutations. However, the majority of tumors develop acquired resistance against EGFR-TKIs and some tumors exhibi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11524
更新日期:2020-06-01 00:00:00
abstract::In this study, we report the cytogenetic analysis of a 31-year-old male with a rare translocation between chromosomes 1 and 16 and inversion of chromosome 5 in CD99-positive soft tissue sarcoma of the thigh, which metastasized to the lung. Histologically, the tumor showed ovoid or short-spindle atypical cells with pos...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.641
更新日期:2012-06-01 00:00:00
abstract::TACC3, a member of the transforming acidic coiled-coil protein (TACC) family, is a multifunctional protein that is involved in various biological functions, including proliferation and differentiation of tumor cells, cancer progression and metastasis. The aims of the present study were to examine whether TACC3 express...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8262
更新日期:2018-05-01 00:00:00
abstract::The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks after intervention. P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1407
更新日期:2013-08-01 00:00:00
abstract::Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8007
更新日期:2018-04-01 00:00:00
abstract::Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. However, the expression and mechanisms underlying the function of ACY1 in colorectal cancer remain unclear. In order to investigate the expression and function of ACY1 in colorectal cancer, tumor tissue and blood samples w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5702
更新日期:2017-04-01 00:00:00
abstract::Despite all efforts at management, prognosis of advanced lung cancer is extremely poor, with a median survival time of ~1 year. The number of cancer patients aged >70 years is significantly increased among the cancer patient population. The aim of this study was to investigate the clinical importance of age in lung ca...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1566
更新日期:2013-11-01 00:00:00
abstract::Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Skeletal metastases from carcinoid tumors are considered to be extremely rare. In this study, we present two cases of carcinoid tumors that metastasized to the bone. Furthermore, we review 50 published case reports and reveal the featur...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.622
更新日期:2012-05-01 00:00:00
abstract::A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platele...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4760
更新日期:2016-08-01 00:00:00
abstract::The present study aimed to elucidate the role of cluster of differentiation (CD)8+, CD4+, natural killer (NK), and myeloid (CD11b+) cells in the course of the growth and rejection of experimental major histocompatibility complex (MHC) class I-deficient, HPV16 E6/E7-associated TC-1/A9 tumors in mice. Stable mouse lines...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7763
更新日期:2018-03-01 00:00:00
abstract::MicroRNAs (miRs) are an emerging class of non-coding, endogenous and small RNA molecules that serve important functions in tumorigenesis and development. The present study investigated the expression, functions and molecular mechanism underlying miR-205 in hepatocellular carcinoma. miR-205 was downregulated in hepatoc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8933
更新日期:2018-08-01 00:00:00
abstract::High mobility group box 1 (HMGB1) functions as a chromatin-associated nuclear protein and an extracellular signaling molecule. The concentration of HMGB1 protein and the expression of HMGB1 mRNA were analyzed by ELISA and polymerase chain reaction (PCR), respectively. The present study reports high plasma HMGB1 levels...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1851
更新日期:2014-04-01 00:00:00
abstract::Prostate cancer is the most common form of cancer in men, with increased incidence rates observed in older individuals. Prostate cancer is primarily driven via activation of the androgen receptor (AR), the principal transcriptional factor governing prostate cancer cellular programming and its associated metabolism. On...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9677
更新日期:2019-01-01 00:00:00
abstract::The aim of the present study was to analyze potential therapy targets for prostate cancer using integrated analysis of two gene expression profiles. First, gene expression profiles GSE38241 and GSE3933 were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) between prostate can...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6879
更新日期:2017-11-01 00:00:00
abstract::The recent successful use of the immune checkpoint inhibitors (CPIs) anti-programmed death receptor-1 (PD-1)/PD-1 ligand 1 in clinical trials indicates their crucial role in obtaining an effective cancer immune therapy. These CPIs have been identified to have an effective therapeutic response, particularly in tumors w...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10166
更新日期:2019-06-01 00:00:00
abstract::It is estimated that breast cancer will be the second leading cause of cancer-associated mortality in women in 2018. Previous research has demonstrated that the atypical protein kinase C-ζ (PKC-ζ) is a component of numerous dysregulated pathways in breast cancer, including cellular proliferation, survival, and cell cy...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9792
更新日期:2019-02-01 00:00:00
abstract::Lung cancer is a major cause of death worldwide, and non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The aim of this study was to investigate whether miR-96 mediated the invasion and metastasis of NSCLC by targeting glypican-3 (GPC3). Reverse transcription-quantitative PCR (RT-qPCR) was empl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8507
更新日期:2018-06-01 00:00:00