Abstract:
:Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are an approved first-line therapy against unresectable or advanced non-small cell lung cancer (NSCLC) harboring EGFR gene activating mutations. However, the majority of tumors develop acquired resistance against EGFR-TKIs and some tumors exhibit natural resistance. A number of resistance mechanisms against the latest third-generation EGFR-TKIs have been reported, including tertiary EGFR C797S mutation and several gene alterations activating EGFR or other signaling pathways. The current study aimed to identify the frequency of natural EGFR-TKI resistance in pretreatment NSCLC and to predict the therapeutic effect of EGFR-TKIs. A total of 246 EGFR-TKI-naïve NSCLC patients harboring known EGFR gene mutations were identified. The presence of EGFR C797S and T790M mutations were determined using the peptide nucleic acid-locked nucleic acid PCR clamp method. ERBB2, MET, EGFR, ALK, BRAF, FGFR1, MYC, RET, CCND1, CCND2, CDK4, CDK6, MDM2 and MDM4 gene amplification, which can lead to resistance against any generation EGFR-TKIs, was determined using the multiplex ligation-dependent probe amplification assay. No concurrent C797S mutation with known EGFR mutations were identified. T790M mutation was identified in 12 patients (4.9%). ERBB2 or MET gene amplification was found in some patients (0.0-0.4%). MDM2 gene amplification was associated with tumor recurrence and shorter progression-free survival (PFS) for first- or second-generation EGFR-TKIs. De novo EGFR C797S mutation was not identified. Other resistance mechanisms against EGFR-TKIs were indicated in some patients with EGFR-TKI-naïve NSCLC. MDM2 gene amplification, which can lead to altered cell cycle, was associated with tumor recurrence and shorter PFS in EGFR-TKI therapy.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Yamaura T,Muto S,Mine H,Takagi H,Watanabe M,Ozaki Y,Inoue T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki Hdoi
10.3892/ol.2020.11524subject
Has Abstractpub_date
2020-06-01 00:00:00pages
4169-4176issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-11524journal_volume
19pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Diagnostic value of magnetic resonance imaging (MRI) and multi-slice spiral CT (MSCT) for different pathological stages of prostate cancer was compared. A total of 112 patients with prostate cancer who underwent surgical pathology in The Affiliated Yantai Yuhuangding Hospital of Qingdao University from February 2014 t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10272
更新日期:2019-06-01 00:00:00
abstract::Expression level of miR-181c in neuroblastoma children and its effect on proliferation of neuroblastoma M17 cells were investigated. Fifty-seven neuroblastoma patients admitted to Weifang People's Hospital from January 2013 to December 2017 were selected and their cancer tissues and normal adjacent tissues were obtain...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10602
更新日期:2019-09-01 00:00:00
abstract::Delisheng is a widely used antineoplastic agent in China. Although previous studies revealed that Delisheng exhibits numerous pharmacological effects including the inhibition of cancer cell differentiation and enhancement of immune function with the lowest toxicity, the precise anticancer mechanisms of Delisheng in hu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7074
更新日期:2017-12-01 00:00:00
abstract::Melanoma is the most common primary intraocular malignancy and metastasis of melanoma to other organs often results in a poor prognosis. ADP-ribosyltransferase 3 (ART3) is involved in cell division and DNA repair. However, its biological function in melanoma remains unclear. In the present study, it was identified tha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8252
更新日期:2018-05-01 00:00:00
abstract::The present case study reported of amelanotic malignant melanoma of the esophagus. A 68-year-old man underwent laparoscopic distal gastrectomy for early gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a protruded lesion lying adjacent to the melanosis area of the esophagus. Histology of th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8479
更新日期:2018-06-01 00:00:00
abstract::The expression level and roles of microRNA-497 (miR-497) have been frequently reported in previous studies on cancer. However, its expression, function and associated molecular mechanisms in retinoblastoma remain unknown. In the present study, miR-497 expression levels in human retinoblastoma tissues, normal retinal t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6083
更新日期:2017-06-01 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignant disease that is resistant to various chemotherapeutic agents and commonly relapses. Efficient elimination of metastasized PDA is critical for a positive post-surgical treatment outcome. The present study analyzed the effect of the B-cell lymphoma-2 (Bcl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6211
更新日期:2017-07-01 00:00:00
abstract::Sarcomas arise from primitive mesenchymal cells, which are classified, into two main groups: Bone and soft tissue sarcomas. We have searched all-important electronic databases including Google scholar and PubMed for the collection of latest literature pertaining to pediatric sarcomas. Latest literature confirmed that ...
journal_title:Oncology letters
pub_type: 杂志文章,收录出版
doi:10.3892/ol.2017.7467
更新日期:2018-02-01 00:00:00
abstract::Osteosarcoma (OS) is the most common tumor of the musculoskeletal system. Recently, cold atmospheric plasma (CAP) has been regarded as a promising anti-oncogenic therapy. Previous experimental studies have demonstrated that CAP treatment results in significant growth inhibition of human sarcoma and is able to induce a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11115
更新日期:2020-01-01 00:00:00
abstract::Euchromatic histone-lysine N-methyltransferase (G9A), the primary histone methyltransferase for histone H3 Lys9, has been identified to be upregulated in numerous types of cancer. The aim of the present study was to analyze the clinical significance of G9A, and preliminarily explore its function in hepatocellular carc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8572
更新日期:2018-06-01 00:00:00
abstract::The elbow is an uncommon site for malignant bone tumors. Surgical options for the reconstruction of the elbow joint are limited and technically challenging. In this study, we describe a patient with osteosarcoma of the proximal ulna treated by wide resection and reconstruction with a combined use of free vascularised ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000024
更新日期:2010-01-01 00:00:00
abstract::Deoxypodophyllotoxin (DPPT) is extracted and separated from citrus-related plants, including Podophyllum (P.) peltatum, P. pleianthum, P. emodi (also called P. hexandrum) and Diphylleia grayi. DPPT has significant antitumor and antiviral activity. However, due to its strong toxicity and side effects, its use is limite...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4943
更新日期:2016-10-01 00:00:00
abstract::DNA hypomethylation is associated with carcinogenesis due to its involvement in cancer initiation and progression. In this study we analyzed the hypomethylation status of candidate genes in clear cell renal cell carcinoma (CCRCC) using a large-scale, high-throughput DNA methylation profiling technique. Results reveale...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.992
更新日期:2013-01-01 00:00:00
abstract::Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11938
更新日期:2020-10-01 00:00:00
abstract::No standard therapy for pulmonary epithelioid hemangioendothelioma (PEH) has yet been established due to the rarity of the disease, the lack of clear standards for treatment and the partial-to-complete spontaneous regression. This report describes three cases of PHE manifested as bilateral intrapulmonary masses with a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1217
更新日期:2013-05-01 00:00:00
abstract::Extra-abdominal desmoid tumour is a rare type of tumour which is conventionally treated with wide local excision. However, wide local excision usually causes irreparable damage to the limbs. Nevertheless, few patients have been subjected to wide local excision and reconstructive surgery in a single procedure. A 52-yea...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.766
更新日期:2012-09-01 00:00:00
abstract::Ewing sarcoma (ES) is a highly malignant pediatric tumor with a low survival rate and a high rate of metastasis. However, there have been limited reports on the exploration of new biomarkers of ES. Therefore, the aim of the present study was to identify the potential hub genes associated with overall vital survival (O...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10681
更新日期:2019-10-01 00:00:00
abstract::The aim of the present study was to investigate the association between the clinicopathological and demographic factors, and the survival time of patients with triple-negative breast cancer (TNBC) in China. The patients had received adjuvant chemotherapy consisting of 5-fluorouracil, epirubicin and cyclophosphamide (F...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4176
更新日期:2016-03-01 00:00:00
abstract::MicroRNA (miRNA or miR)-298 has been reported to be downregulated and to modify the expression of the polycomb protein enhancer of zeste 2 (EZH2) in recurrent epithelial ovarian cancer (EOC). To date, no functional evidence of a miR-298-EZH2 axis in EOC has been documented. The present study aimed to investigate the a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5204
更新日期:2016-11-01 00:00:00
abstract::MicroRNA-101 (miR-101) is evidently downregulated in several types of cancer, including non-small cell lung cancer (NSCLC), and is crucial in sensitizing cells to chemotherapy drugs. The aim of the present study was to investigate the correlation between miR-101 and chemosensitivity in the A549 NSCLC cell line. Here, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1725
更新日期:2014-02-01 00:00:00
abstract::Cisplatin resistance has been a major factor limiting its clinical use as a chemotherapy drug. The present study aimed to investigate whether SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase closely associated with tumors can affect the sensitivity of tumors to cisplatin chemotherapy. Real...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11465
更新日期:2020-05-01 00:00:00
abstract::Primary mediastinal extraskeletal Ewing's sarcoma (EES) is quite rare. To the best of our knowledge, only five cases have been reported. Given the paucity of data, there is consequently no optimal treatment strategy available. The current study presents the case of a 51-year-old female with unresectable EES of the pos...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2788
更新日期:2015-02-01 00:00:00
abstract::As an important chemotherapeutic agent for the treatment of osteosarcoma, the effectiveness of cisplatin is considered to be due to its unique properties, which allow it to penetrate the cell membrane and form various DNA-platinum adducts, resulting in genetic alterations or DNA damage. However, chemoresistance to cis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7432
更新日期:2018-01-01 00:00:00
abstract::Radiofrequency ablation (RFA) and cryoablation are alternative forms of therapy used widely in various pathological states, including treatment of carcinogenesis. The reason is that ablation techniques have ability of modulating the immune system. Furthermore, recent studies have applied this form of therapy on tumor ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4997
更新日期:2016-10-01 00:00:00
abstract::The present study was conducted to evaluate the methanolic extract of Piper betle leaves (MPBL) and its organic fractions with regard to antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice and to confirm their antioxidant activities. At 24 h post-intraperitoneal inoculation of tumor cells i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2738
更新日期:2015-02-01 00:00:00
abstract::MicroRNAs (miRNAs/miRs) are small, noncoding RNA molecules that are closely associated with the occurrence and development of tumors. miR-20b is overexpressed in hepatocellular carcinoma cell lines and tissues. However, it is not clear whether miR-20b can promote the proliferation of hepatocellular carcinoma cells. In...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9925
更新日期:2019-03-01 00:00:00
abstract::The Ganoderma lucidum (G. lucidum) mushroom is one of the most extensively studied functional foods, known for its numerous health benefits, including the inhibition of tumor cell growth. The present study assessed the anti-proliferative and pro-apoptotic activity of a novel G. lucidum polysaccharide peptide (GL-PP) i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7823
更新日期:2018-04-01 00:00:00
abstract::The aim of the present study was to determine the usefulness of the positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) in the detection of recurrence or metastasization of differentiated thyroid carcinoma (DTC) in patients with abnormal thyroglobulin levels and negative finding...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4229
更新日期:2016-04-01 00:00:00
abstract::Targeted therapy of non-small cell lung cancer (NSCLC) patients with mutations in the epidermal growth factor receptor (EGFR) gene has been associated with improved prognosis. However, there is a shortage on data from real-world clinical practice in management of EGFR-positive NSCLC patients in Poland. The present stu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6907
更新日期:2017-11-01 00:00:00
abstract::The present study aimed to investigate the effects of the WW domain-containing oxidoreductase (WWOX) gene on the stem cell properties of human ovarian cancer stem cells. A eukaryotic expression vector containing the WWOX gene was transfected into human ovarian cancer stem cells and Western blotting was used to assess ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2971
更新日期:2015-04-01 00:00:00