Targeted silencing of the ADP-ribosyltransferase 3 gene inhibits the migration ability of melanoma cells.

abstract：:Prostate cancer is the most common form of cancer in men, with increased incidence rates observed in older individuals. Prostate cancer is primarily driven via activation of the androgen receptor (AR), the principal transcriptional factor governing prostate cancer cellular programming and its associated metabolism. On...

journal_title：Oncology letters

authors： Dan C,Zhang H,Zeng W,Huang L,Gong X,Li H,Yang E,Wang L,Yao Q

更新日期：2019-01-01 00:00:00

abstract：:DNA hypomethylation is associated with carcinogenesis due to its involvement in cancer initiation and progression. In this study we analyzed the hypomethylation status of candidate genes in clear cell renal cell carcinoma (CCRCC) using a large-scale, high-throughput DNA methylation profiling technique. Results reveale...

journal_title：Oncology letters

authors： Yoo KH,Park YK,Chang SG

更新日期：2013-01-01 00:00:00

abstract：:In the present study, we investigated the correlation between the presence of occult neoplastic cells (ONCs) in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer in 164 patients who underwent radical curative resection. We calculated the five-year relapse-free survival rate (5Y-RFS) and five-...

journal_title：Oncology letters

authors： Sekido Y,Mukai M,Yamazaki M,Tajima T,Yamamoto S,Hasegawa S,Kishima K,Tajiri T,Nakamura N

更新日期：2014-01-01 00:00:00

abstract：:Cluster of differentiation 44 (CD44), a marker for cancer stem cells, has been reported to be associated with poor prognosis in non-small cell lung cancer (NSCLC), but its involvement in tumor growth has not fully been elucidated. The present study explored the associations between CD44 expression and clinicopathologi...

journal_title：Oncology letters

authors： Hu B,Ma Y,Yang Y,Zhang L,Han H,Chen J

更新日期：2018-04-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is upregulated in numerous types of cancer, and is implicated in various cellular processes associated with cancer progression. However, the underlying molecular mechanisms by which MALAT1 regulates metastasis remain unclear. ...

journal_title：Oncology letters

authors： Zhang Y,Guan X,Wang H,Wang Y,Yue D,Chen R

更新日期：2020-10-01 00:00:00

abstract：:The present study reports a case of a 59-year-old male suffering from oligodendroglioma that metastasized to the bone marrow (BM). The metastasis was detected 5 years after craniotomy was performed for the resection of the primary tumor; however, it manifested as multiple myeloma (MM)-like bone lesions, a small M comp...

journal_title：Oncology letters

authors： Jian Y,Gao W,Wu Y,Li Y,Zhang Y,Yang G,Chen W

更新日期：2016-07-01 00:00:00

abstract：:The aim of the present study was to investigate the association between methylation of cyclin-dependent kinase inhibitor 2B (CDKN2B) CpG islands and telomerase activity in children with acute lymphoblastic leukemia (ALL). A total of 72 children with ALL and 12 children with immune thrombocytopenia (ITP) were subjected...

journal_title：Oncology letters

authors： Hu Q,Chen X,Liu S,Wen R,Yuan X,Xu D,Liu G,Wen F

更新日期：2017-04-01 00:00:00

abstract：:Krüppel-like factor 5 (KLF5) is frequently deleted and inactivated in prostate cancer, and exerts tumor-suppressing function in prostate cancer cells. However, the function of KLF5 in the apoptosis of prostate cancer cells remains unclear. In the present study, the effect of KLF5 on phorbol 12-myristate 13-acetate (PM...

journal_title：Oncology letters

authors： Shi Q,Jia J,Hui K,Gao Y,Xu S,Guan B,Tang X,Wang X,He D,Guo P

更新日期：2017-08-01 00:00:00

abstract：:Golgi protein 73 (GP73) is a resident Golgi type II transmembrane protein that has been reported to markedly increase in chronic liver disease, particularly in hepatocellular carcinoma (HCC). However, it remains unclear as to whether serum GP73 represents a reliable serum marker for the diagnosis of HCC. The aim of th...

journal_title：Oncology letters

authors： Hou SC,Xiao MB,Ni RZ,Ni WK,Jiang F,Li XY,Lu CH,Chen BY

更新日期：2013-10-01 00:00:00

abstract：:Sarcomas arise from primitive mesenchymal cells, which are classified, into two main groups: Bone and soft tissue sarcomas. We have searched all-important electronic databases including Google scholar and PubMed for the collection of latest literature pertaining to pediatric sarcomas. Latest literature confirmed that ...

journal_title：Oncology letters

authors： Cao J,An Q,Wang L

更新日期：2018-02-01 00:00:00

abstract：:Leptomeningeal metastasis (LM) is an uncommon presentation of relapse in breast cancer, which is associated with poor clinical outcomes and poor prognosis. Notably, LM most commonly occurs in breast cancer. The aim of the present review was to investigate the occurrence of LM as the primary presentation of relapse fol...

journal_title：Oncology letters

authors： Sacco K,Muhammad A,Saleem W,Alshaker H,Monzon L,Islam MR,Pchejetski D

更新日期：2016-08-01 00:00:00

abstract：:[-2]pro-prostate-specific antigen (2pPSA), a proform of PSA, is a new marker in patients at risk of prostate cancer. We explored the potential role of 2pPSA in the identification of patients with metastatic progression following radical prostatectomy for prostate cancer. Seventy-six patients with biochemical (PSA) rec...

journal_title：Oncology letters

authors： Sottile A,Ortega C,Berruti A,Mangioni M,Saponaro S,Polo A,Prati V,Muto G,Aglietta M,Montemurro F

更新日期：2012-04-01 00:00:00

abstract：:Hypericum ascyron L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. The aim of the present study was to clarify the anticancer a...

journal_title：Oncology letters

authors： Li XM,Luo XG,He JF,Wang N,Zhou H,Yang PL,Zhang TC

更新日期：2018-03-01 00:00:00

abstract：:Colorectal carcinoma (CRC) is a common tumor of the digestive system with poor prognosis. Studies have shown that aberrant microRNA (miRNA) expression can affect CRC progression by regulating target genes. In the present study, we investigated the functional roles and potential mechanisms of miR-331-3p in CRC. The exp...

journal_title：Oncology letters

authors： Zhang H,Wang R,Wang M

更新日期：2019-12-01 00:00:00

abstract：:Metastasis-associated in colon cancer-1 (MACC1) is a gene that has been newly identified by a genome-wide search for differentially expressed genes in human colon cancer tissues, metastases and normal tissues. MACC1 exerts an important role in colon cancer metastasis through upregulation of the c-Met proto-oncogene. T...

journal_title：Oncology letters

authors： Li H,Zhang H,Zhao S,Shi Y,Yao J,Zhang Y,Guo H,Liu X

更新日期：2015-05-01 00:00:00

abstract：:The present study aimed to address the pharmacogenetic role of BAG1 in platinum-based chemotherapy in advanced non-small-cell lung cancer (NSCLC) and in cultured human lung adenocarcinoma A549 cells. A total of 108 NSCLC patients (stages I-IIIA) were treated with a standard chemotherapy regimen of cisplatin plus vinor...

journal_title：Oncology letters

authors： Wang Y,Ha M,Liu J,Li P,Zhang W,Zhang X

更新日期：2016-02-01 00:00:00

abstract：:The aim of this study was to evaluate the efficacy of multi-detector row helical computed tomography (MDCT) angiography in the detection of feeding arteries prior to multi-arterial infusion for lung cancer. A total of 59 consecutive patients (44 males and 15 females; age range, 27-86 years; median age, 62 years) with ...

journal_title：Oncology letters

authors： Ye XD,Yuan Z,Ye JD,Xiao XS

更新日期：2013-01-01 00:00:00

abstract：:We report a case of tumor lysis syndrome (TLS) in a patient with gallbladder carcinoma. TLS has not been reported in association with this type of tumor. TLS typically occurs in cases of highly proliferative hematological malignancies and small cell carcinoma. Two factors that may have contributed to TLS in this case ...

journal_title：Oncology letters

authors： Duff DJ,Haddadin S,Freter C,Papageorgiou C

更新日期：2013-04-01 00:00:00

abstract：:Hedgehog (HH) and Wnt pathway activation have been implicated in poor prognosis of breast cancer. Crosstalk between these two pathways has been demonstrated to be important in breast cancer progression, however the association between these two pathways and breast cancer survival rate is unknown. The present study com...

journal_title：Oncology letters

authors： Arnold KM,Pohlig RT,Sims-Mourtada J

更新日期：2017-11-01 00:00:00

abstract：:Recommendations concerning the intake of vitamin D and/or sunlight exposure in the handling of patients with vitamin D deficiency remain a matter of debate. The present study of the German network of dermato-oncologists (Onkoderm e.V.) refers to an inquiry conducted among general practitioners on this and related issu...

journal_title：Oncology letters

authors： Reinhold U,Dirschka T,Hartgens K,Kirchesch H,Ostendorf R,Petering H,Prieur H,Krähn-Senftleben G,Malaisse WJ

更新日期：2012-12-01 00:00:00

abstract：:Interleukin (IL)-37, a new IL-1 family member, has received increasing attention in recent years. In the past decade, it has been determined that IL-37 is expressed in various normal cells and tissues and is regulated by inflammatory stimuli and pro-cytokines via different signal transduction pathways. Recently, it ha...

journal_title：Oncology letters

authors： Wang L,Quan Y,Yue Y,Heng X,Che F

更新日期：2018-04-01 00:00:00

abstract：:The transcription factor forkhead box O1 (FOXO1) can be inactivated via its phosphorylation, resulting in suppression of apoptosis. Using immunohistochemistry, the expression of a phosphorylated form of FOXO1 was assessed in upper urinary tract urothelial carcinoma (UUTUC) specimens. Overall, phospho-FOXO1 (p-FOXO1) w...

journal_title：Oncology letters

authors： Ide H,Jiang G,Mizushima T,Fujita K,Inoue S,Yamaguchi S,Fushimi H,Nonomura N,Miyamoto H

更新日期：2019-01-01 00:00:00

abstract：:Effects of Rapamycin on the proliferation and apoptosis of retinoblastoma cells through the phosphatidylinositol 3-hydroxy kinase (PI3K)/protein kinase B (AKT) signaling pathway were studied. The retinoblastoma Y79 cells were selected and divided into negative control group (NC group), 0.2 µM Rapamycin group and 0.4 µ...

journal_title：Oncology letters

authors： Yao J,Xu M,Liu Z

更新日期：2020-04-01 00:00:00

abstract：:Icotinib is an epidermal growth factor receptor tyrosine kinase inhibitor, which has been revealed to inhibit proliferation in tumor cells. However, the effect of icotinib on cancer cell metastasis remains to be explained. This study examines the effect of icotinib on the migration and invasion of squamous cells of to...

journal_title：Oncology letters

authors： Yang C,Yan J,Yuan G,Zhang Y,Lu D,Ren M,Cui W

更新日期：2014-09-01 00:00:00

abstract：:The present study investigated the effects of N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine, on the growth of gliomas. To analyze the effects of ketamine treatment, rat C6 glioma cells arising from astrocytes, and RNB cells representing non-malignant astrocytes, were examined. In ketamine-treated C6 cells,...

journal_title：Oncology letters

authors： Niwa H,Furukawa KI,Seya K,Hirota K

更新日期：2017-10-01 00:00:00

abstract：:Gastric cancer is one of leading causes of cancer-related mortality worldwide and is a notable disease due to its heterogeneity. Recently, numerous studies have investigated the molecular basis of gastric cancer, involving the alteration of pathogenesis, and invasion and metastasis. With the development of modern tech...

journal_title：Oncology letters

authors： Jin Z,Jiang W,Wang L

更新日期：2015-04-01 00:00:00

abstract：:Esophageal adenocarcinoma has shown a significant increase in incidence in recent years. It is thought that the development of gastroesophageal reflux disease (GERD), followed by columnar-lined esophagus and the development of dysplasia, leads to invasive adenocarcinoma. The exact pathogenesis of this process, the dia...

journal_title：Oncology letters

authors： Jaœkiewicz K,Iżycka-Œwieszewska E,Janiak M,Lysiak-Szydłowska W,Adrych K,Reinartz J,Jankun J,Skrzypczak-Jankun E

更新日期：2010-09-01 00:00:00

abstract：:In colorectal cancer (CRC), KRAS and BRAF mutations in primary tumors are associated with resistance to anti-epidermal growth factor receptor (anti-EGFR)-based therapies. However, the correlation between KRAS/BRAF mutation in primary tumors and serum has not been well studied. To evaluate the degree of concordance of ...

journal_title：Oncology letters

authors： Pu X,Pan Z,Huang Y,Tian Y,Guo H,Wu L,He X,Chen X,Zhang S,Lin T

更新日期：2013-01-01 00:00:00

abstract：:We previously reported that the dissected pancreatic tissue margin (DPM) and the preoperative serum level of carbohydrate antigen 19-9 (preCA19-9) were independent prognostic factors in pancreatic ductal adenocarcinoma (PDAC). In the current study, the prognostic relevance of these factors, including their molecular a...

journal_title：Oncology letters

authors： Nishizawa N,Kumamoto Y,Katoh H,Ushiku H,Yokoi K,Tanaka T,Ishii S,Igarashi K,Tajima H,Kaizu T,Yoshida T,Saegusa M,Watanabe M,Yamashita K

更新日期：2019-02-01 00:00:00

abstract：:Mangiferin, a flavonoid extracted from the mango tree, possesses anti-inflammatory, antibacterial, anti-herpes simplex and antitumor activity, and is able to affect immune function. The present study investigated the anticancer effects of mangiferin treatment on PC3 human prostate cancer cells, and the potential under...

journal_title：Oncology letters

authors： Li M,Ma H,Yang L,Li P

更新日期：2016-01-01 00:00:00