Interleukin-37: A crucial cytokine with multiple roles in disease and potentially clinical therapy.

abstract：:V-domain immunoglobulin suppressor of T cell activation (VISTA) is a novel negative immune checkpoint that belongs to the B7 family. VISTA is primarily expressed on hematopoietic cells and inhibits T cell proliferation and cytokine production. The blockade of VISTA has demonstrated promising results in certain murine ...

journal_title：Oncology letters

authors： Liao H,Zhu H,Liu S,Wang H

更新日期：2018-09-01 00:00:00

abstract：:Ovarian carcinoma (OV) is one of the most lethal gynecological malignancies globally, and the overall 5-year survival rate of OV was 47% in 2018 according to American data. To increase the survival rate of patients with OV, many researchers have sought to identify biomarkers that act as both prognosis-predictive marke...

journal_title：Oncology letters

authors： Lin H,Wang J,Wen X,Wen Q,Huang S,Mai Z,Lu L,Liang X,Pan H,Li S,He Y,Ma H

更新日期：2020-11-01 00:00:00

abstract：:Extraskeletal myxoid chondrosarcoma (EMC) is a relatively rare but well-defined neoplasm. This report describes two patients, one with EMC of the buttock and one with EMC of the knee. The two cases presented with large lobed masses and long T1 and T2 signaling identified by magnetic resonance imaging (MRI). An enhance...

journal_title：Oncology letters

authors： Zhang GW,Wang AJ,Zhang GH,Zhao SN,Qu JL

更新日期：2014-04-01 00:00:00

abstract：:T-box 3 (Tbx3), a member of the T-box transcription factor family, serves a crucial role in embryonic development and cancer progression. Previous studies have demonstrated the clinical significance of Tbx3 in numerous types of cancer. However, the expression level and pathological function of Tbx3 in non-small cell l...

journal_title：Oncology letters

authors： Wu Y,Feng J,Hu W,Zhang Y

更新日期：2017-05-01 00:00:00

abstract：:Pancreatic cancer is one of the most lethal cancers. Transmembrane 4 superfamily member 5 protein (TM4SF5) is one of the candidate molecular targets used for the prevention and treatment of TM4SF5-expressing cancers, including hepatocellular carcinoma, colon cancer and pancreatic cancer. Recently, a previous study rep...

journal_title：Oncology letters

authors： Park S,Kim D,Park JA,Kwon HJ,Lee Y

更新日期：2020-01-01 00:00:00

abstract：:Lymph node metastasis is the primary site of metastasis for patients with gallbladder cancer (GBC). Vascular endothelial growth factor-C (VEGF-C) has been implicated in the control of lymphangiogenesis and lymph node metastasis in various malignant tumors. However, the function of circulating VEGF-C is unclear and it ...

journal_title：Oncology letters

authors： Jiang L,Liu M,Cai X,Xie L,She F,Chen Y

更新日期：2018-11-01 00:00:00

abstract：:Programmed cell death 4 (PDCD4) is known to suppress neoplastic transformation, cell proliferation and metastasis, and to be downregulated by microRNA-21 (miR-21) in renal cell carcinoma (RCC) cell lines and tissues. The aim of the present study was to investigate the roles of and association between PDCD4 and miR-21 ...

journal_title：Oncology letters

authors： Yuan H,Xin S,Huang Y,Bao Y,Jiang H,Zhou L,Ren X,Li L,Wang Q,Zhang J

更新日期：2017-09-01 00:00:00

abstract：:DNA topoisomerase II-α (Topo II-α) is essential for numerous cell processes, including DNA replication, transcription, recombination, and chromosome separation and condensation. Altered Topo II-α expression may lead to carcinogenesis and cancer progression. The aim of the present study was to investigate the associati...

journal_title：Oncology letters

authors： Feng Y,Zhang H,Gao W,Wen S,Huangfu H,Sun R,Bai W,Wang B

更新日期：2014-10-01 00:00:00

abstract：:The present study aimed to explore the clinical efficacy and safety of hydromorphone combined with sufentanil in patient-controlled intravenous analgesia (PCIA) for patients with hepatocellular carcinoma (HCC) and its effect on serum immune factors in serum. Data from 385 patients with HCC, admitted to the Hunan Provi...

journal_title：Oncology letters

authors： Liu J,Wang Y,Tang Y,Luo J,Long Y,Tan S

更新日期：2020-12-01 00:00:00

abstract：:In the present study, we investigated the correlation between the presence of occult neoplastic cells (ONCs) in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer in 164 patients who underwent radical curative resection. We calculated the five-year relapse-free survival rate (5Y-RFS) and five-...

journal_title：Oncology letters

authors： Sekido Y,Mukai M,Yamazaki M,Tajima T,Yamamoto S,Hasegawa S,Kishima K,Tajiri T,Nakamura N

更新日期：2014-01-01 00:00:00

abstract：:Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNA that have gained attention from researchers for their involvement in multiple biological processes. circRNAs are ubiquitously expressed in eukaryotic cells and regulate gene expression at the transcriptional or post-transcriptional level by interac...

journal_title：Oncology letters

authors： Ren X,Du Y,You L,Zhao Y

更新日期：2017-12-01 00:00:00

abstract：:The present study aimed to analyze the characteristics of polyethylene glycol (PEG)ylated carboplatin liposomes (PL-CBPs), including size, stability, their release, entrapping and loading efficiencies, and their antitumor and antimetastatic effects on the lymph nodes. The PL-CBPs were prepared using PEG-2000 with the ...

journal_title：Oncology letters

authors： Zhang J,Huang C,Huang H

更新日期：2014-11-01 00:00:00

abstract：:The aim of the present study was to determine the usefulness of the positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) in the detection of recurrence or metastasization of differentiated thyroid carcinoma (DTC) in patients with abnormal thyroglobulin levels and negative finding...

journal_title：Oncology letters

authors： Lu CZ,Cao SS,Wang W,Liu J,Fu N,Lu F

更新日期：2016-04-01 00:00:00

abstract：:The existence of cancer stem cells (CSCs) is central to the pathogenesis and therapeutic target of human hepatocellular carcinoma. The aim of this study was to investigate the effects of casticin on epithelial-mesenchymal transition (EMT) of liver cancer stem cells (LCSCs) derived from the SMMC-7721 cell line. Our res...

journal_title：Oncology letters

authors： He M,Cao XC,He GC,Sheng XF,Ai XH,Wu YH

更新日期：2014-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) metastases in the mediastinum are rare, particularly under the arch of the aorta. The present study describes the case of a 30-year-old male patient who presented with back pain and hoarseness for 2 months due to lymph node metastasis of HCC. The patient had undergone right hepatic lobec...

journal_title：Oncology letters

authors： Xu L,Xue F,Wang B,Yan D,Ding W,Yin J,Yi C,Wang W

更新日期：2016-08-01 00:00:00

abstract：:Acanthus ebracteatus Vahl. is commonly consumed with the aim of curing cancer, inflammatory conditions and skin diseases in traditional Thai medicine. It is known to contain various phytochemicals; however, very little is known about the effects of A. ebracteatus protein hydrolysate on cancer cells, including its mole...

journal_title：Oncology letters

authors： Khamwut A,Jevapatarakul D,Reamtong O,T-Thienprasert NP

更新日期：2019-09-01 00:00:00

abstract：:The aim of the present study was to investigate the association between methylation of cyclin-dependent kinase inhibitor 2B (CDKN2B) CpG islands and telomerase activity in children with acute lymphoblastic leukemia (ALL). A total of 72 children with ALL and 12 children with immune thrombocytopenia (ITP) were subjected...

journal_title：Oncology letters

authors： Hu Q,Chen X,Liu S,Wen R,Yuan X,Xu D,Liu G,Wen F

更新日期：2017-04-01 00:00:00

abstract：:Clinical evidence indicates that drug resistance is a major obstacle in the treatment of breast cancer (BC). Drug resistance results in the disease being uncontrollable, and leads to high mortality rates. The aim of the present study was to investigate the chemosensitizing effect of microRNA (miR)-16 on Adriamycin (AD...

journal_title：Oncology letters

authors： Gao X,Wang M,Zhang Y,Xu Z,Ding J,Tang J

更新日期：2019-09-01 00:00:00

abstract：:Collecting duct carcinoma (CDC) is a rare type of renal neoplasm. Early diagnosis is possibly the only factor leading to a prolonged survival for patients with CDC. The purpose of the present study was to characterize the imaging features of CDC and improve its diagnosis. Radiological data of six patients were retrosp...

journal_title：Oncology letters

authors： Hu Y,Lu GM,Li K,Zhang LJ,Zhu H

更新日期：2014-02-01 00:00:00

abstract：:DJ-1 and HSP90α play a significant role in the progression of various types of cancer and are known to be associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), PI3K-p110α and pAkt, the signaling molecule proteins from the phosphatidylinositol 3-kinase (PI3K) pathway. However, the expression o...

journal_title：Oncology letters

authors： Lee H,Choi SK,Ro JY

更新日期：2012-03-01 00:00:00

abstract：:The aim of the present study was to investigate the significance and values of 3.0T diffusion weighted imaging (DWI) to differentially diagnose benign and malignant space-occupying liver lesions. A total of 91 patients with liver space-occupying lesions (145 lesions) were admitted into Zhongnan Hospital of Wuhan Unive...

journal_title：Oncology letters

authors： Li R,Wu G,Wang R

更新日期：2018-02-01 00:00:00

abstract：:Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study a...

journal_title：Oncology letters

authors： Tan KT,Chen PW,Li S,Ke TM,Lin SH,Yang CC

更新日期：2019-08-01 00:00:00

abstract：:Lung cancer negatively impacts global health, and the incidence of non-small cell lung cancer (NSCLC) is highest among all forms of lung cancer. Chemotherapy failure mainly occurs due to drug resistance; however, the associated molecular mechanism remains unclear. Casein kinase II (CK2), which plays important roles in...

journal_title：Oncology letters

authors： Jin C,Song P,Pang J

更新日期：2019-10-01 00:00:00

abstract：:The expression levels of cyclooxygenase (COX)-2 and the prostaglandin E2 (PGE2) content have been associated with poor prognosis in patients with colorectal cancer (CRC). There is a strong correlation between COX-2 expression and PGE2 production in tissues from CRC patients, suggesting an important role for COX-2 on t...

journal_title：Oncology letters

authors： Cervantes-Madrid DL,Nagi S,Asting Gustafsson A

更新日期：2017-03-01 00:00:00

abstract：:Special AT-rich sequence binding protein 1 (SATB1) is a nuclear factor that functions as a global chromatin organizer to regulate gene expression. Recent studies have suggested an oncogenic role of SATB1 in breast cancer. However, the role of SATB1 in gastric cancer, especially in regulating the malignant phenotypes, ...

journal_title：Oncology letters

authors： Sun F,Lu X,Li H,Peng Z,Wu K,Wang G,Tong Q

更新日期：2012-07-01 00:00:00

abstract：:The present study aimed to ascertain whether suppression of midkine (MK) expression in pancreatic cancer cells inhibits metastasis to the liver. Human pancreatic cancer AsPC-1 cells were transfected with small interfering RNA (siRNA) targeting MK. siRNA against MK was observed to reduce the expression of MK mRNA and p...

journal_title：Oncology letters

authors： Yu L,Fan Y,Chen B,Hu Y,Gao Y,Wei D

更新日期：2013-11-01 00:00:00

abstract：:The transient receptor potential melastatin member 8 (TRPM8) is a newly characterized oncoprotein involved in various malignant tumors. However, its expression pattern and biological function in osteosarcoma remain unclear. The present study aimed to explore the expression and prognostic significance of TRPM8 in osteo...

journal_title：Oncology letters

authors： Zhao W,Xu H

更新日期：2016-08-01 00:00:00

abstract：:Carbon dioxide (CO2) laser ablation in combination with photodynamic therapy (PDT) has previously been successfully used to treat superficial basal cell carcinoma (BCC). However, the efficacy of this treatment modality is limited in the treatment of deeper lesions and the more aggressive subtypes of BCC. In order to i...

journal_title：Oncology letters

authors： Kim SA,Lee KS,Cho JW

更新日期：2013-10-01 00:00:00

abstract：:Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ...

journal_title：Oncology letters

authors： Guo E,Wei H,Liao X,Xu Y,Li S,Zeng X

更新日期：2018-04-01 00:00:00

abstract：:Lung cancer is a major cause of death worldwide, and non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The aim of this study was to investigate whether miR-96 mediated the invasion and metastasis of NSCLC by targeting glypican-3 (GPC3). Reverse transcription-quantitative PCR (RT-qPCR) was empl...

journal_title：Oncology letters

authors： Fei X,Zhang J,Zhao Y,Sun M,Zhao H,Li S

更新日期：2018-06-01 00:00:00