Abstract:
:Golgi protein 73 (GP73) is a resident Golgi type II transmembrane protein that has been reported to markedly increase in chronic liver disease, particularly in hepatocellular carcinoma (HCC). However, it remains unclear as to whether serum GP73 represents a reliable serum marker for the diagnosis of HCC. The aim of the present study was to evaluate the diagnostic value of serum GP73 in patients with HCC and to determine the diagnostic accuracy of measuring serum GP73 in combination with α-fetoprotein (AFP) and γ-glutamyl transferase isoenzyme II (GGT-II) in HCC. Serum GP73 was detected using a time-resolved fluorescence immunological assay (TRFIA) and enzyme-linked immunosorbent assay (ELISA) in 79 HCC cases, including 16 liver cirrhosis, 30 chronic hepatitis and 28 healthy individuals. The correlation between serum GP73 and tumor size and HCC grading was analyzed and the complementary diagnostic value of serum GP73, AFP and GGT-II was evaluated. TRFIA was established for the detection of serum GP73 and was sensitive and reproducible. The expression levels of serum GP73 were markedly higher in the patients with HCC when compared with those of the individuals with liver cirrhosis and chronic hepatitis or the healthy individuals. According to the receiver operating characteristic (ROC) curve, diagnostic sensitivity and specificity for HCC with a cut-off value of 78.1 ng/l were 73.4 and 79.0%, respectively. However, no correlation was identified among serum GP73 and tumor size or grading, and no correlations were identified among serum GP73, AFP and GGT-II. The diagnostic sensitivities for HCC, as detected by TRFIA of GP73, AFP and GGT-II, were 73.4, 55.6 and 68.4%, respectively, and the specificities were 80.0, 86.7 and 97.1%, respectively. The combined determination of these markers increased the diagnostic sensitivity to 96.3% for HCC. TRFIA functions as a sensitive and replicable assay for the detection of serum GP73. The levels of serum GP73 were significantly higher in the HCC group when compared with the individuals with benign liver diseases. Serum GP73 may serve as a potential independent diagnostic candidate for HCC and the combined determination of serum GP73, AFP and GGT-II may increase the diagnostic efficiency of HCC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Hou SC,Xiao MB,Ni RZ,Ni WK,Jiang F,Li XY,Lu CH,Chen BYdoi
10.3892/ol.2013.1522subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1152-1158issue
4eissn
1792-1074issn
1792-1082pii
ol-06-04-1152journal_volume
6pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Evidence-based guidelines for the prevention of surgical site infection (SSI) have been published by the U.S. Centers for Disease Control and Prevention (CDC). According to these guidelines, a wound should usually be covered with a sterile dressing for 24 to 48 h when a surgical incision is closed primarily. However, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.687
更新日期:2012-07-01 00:00:00
abstract::Low-grade cribriform cystadenocarcinoma (LGCCC) is a malignant salivary gland tumor. LGCCC occurs rarely, with the parotid gland being the most commonly afflicted site. Few cases arise in other sites. The present study reports a case of LGCCC that occurred at the palatal gland of the hard palate. A 56-year-old female ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3528
更新日期:2015-10-01 00:00:00
abstract::Myelolipoma is a rare, benign neoplasm composed of mature adipocytes and hematopoietic tissue, mainly occurring in the adrenal glands. The majority of extra-adrenal myelolipomas have been identified in the presacral region and primary mediastinal myelolipoma is very rare. Computed tomography (CT) and magnetic resonanc...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.1085
更新日期:2013-03-01 00:00:00
abstract::The aim of the present study was to investigate the association between methylation of cyclin-dependent kinase inhibitor 2B (CDKN2B) CpG islands and telomerase activity in children with acute lymphoblastic leukemia (ALL). A total of 72 children with ALL and 12 children with immune thrombocytopenia (ITP) were subjected...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5710
更新日期:2017-04-01 00:00:00
abstract::The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound in combination with hematoporphyrin monomethyl ether (HMME). The optimum frequency of ultrasound was determined by 3-(4,5-dimethythiazol-2-yl)...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2419
更新日期:2014-10-01 00:00:00
abstract::Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and r...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4168
更新日期:2016-03-01 00:00:00
abstract::This study aimed to investigate the clinicopathological characteristics, differential diagnosis and prognosis of pulmonary epithelioid hemangioendothelioma (PEH). PEH is a rare low-grade malignant vascular tumor. The cause of PEH remains unclear. Patient prognosis is unpredictable, with life expectancy ranging from 1 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2566
更新日期:2014-12-01 00:00:00
abstract::Patients with the luminal B subtype of breast cancer exhibit a poor prognosis, high metastatic risk and high incidence of chemotherapy resistance. Luminal B breast cancer is sub-classified into B1 and B2. The pathophysiological mechanism of luminal B2 breast cancer (LB2BC) progression has yet to be characterized. Ther...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7256
更新日期:2017-12-01 00:00:00
abstract::Pulmonary sequestration (PS) is an uncommon lung disease. Carcinoid tumorlets in pulmonary sequestration are extremely rare. This case report presents a rare clinical case of carcinoid tumorlet in pulmonary sequestration with bronchiectasis after breast cancer. A 64-year-old female was diagnosed with infiltrating duct...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1210
更新日期:2013-05-01 00:00:00
abstract::Hypoxia-inducible factor-1α (HIF-1α) and toll-like receptor 4 (TLR4) are involved in numerous mechanisms of cancer biology, including cell proliferation and survival; however the interaction of the two factors under hypoxic conditions remains unclear. The present study investigated the in vitro mechanism that results ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4705
更新日期:2016-08-01 00:00:00
abstract::The present study reports the clinical data of two patients with renal pelvis carcinoma and one patient with renal carcinoma who developed port-site metastasis following retroperitoneal laparoscopic surgery. The current study aimed to identify the cause and prognosis of the occurrence of port-site metastasis subsequen...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4541
更新日期:2016-06-01 00:00:00
abstract::Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10905
更新日期:2019-11-01 00:00:00
abstract::Dopamine receptor 2 (DR2) may be a biomarker for various types of cancer. Ovarian cancer cells overexpress DR2; therefore, blocking DR2 may be a novel treatment strategy for ovarian cancer. Thioridazine, a DR2 blocker, has antineoplastic activity in a variety of cancer cells. In view of the requirement for novel thera...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7184
更新日期:2017-12-01 00:00:00
abstract::microRNAs (miRNA/miRs) are a class of small non-coding RNAs; they serve important biological roles in tumorigenesis through the regulation of oncogene expression, and they may be used for the diagnosis and treatment of human cancer. miR-375 was identified to exhibit abnormal expression levels in a number of types of t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9011
更新日期:2018-09-01 00:00:00
abstract::Cisplatin resistance has been a major factor limiting its clinical use as a chemotherapy drug. The present study aimed to investigate whether SET and MYND domain-containing protein 3 (SMYD3), a histone methyltransferase closely associated with tumors can affect the sensitivity of tumors to cisplatin chemotherapy. Real...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11465
更新日期:2020-05-01 00:00:00
abstract::The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesion...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9788
更新日期:2019-02-01 00:00:00
abstract::Metastases to the gingival soft tissues are rare in hepatocellular carcinoma (HCC). To the best of our knowledge, only 13 cases have been reported in English literature to date. The present study described the case of a 43-year-old Chinese man who was admitted to Tangdu Hospital (Xi'an, China) due to the presence of a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3422
更新日期:2015-09-01 00:00:00
abstract::Extragastrointestinal stromal tumors (EGISTs) are relatively rare soft tissue neoplasms arising from the extra gastrointestinal tract. The current study presents a case of primary EGIST of the prostate observed in a 55-year-old male. Imaging studies showed a 10×10.5×9.5-cm prostate mass. On histological observation, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1968
更新日期:2014-06-01 00:00:00
abstract::The underlying causes of esophageal cancer (EC) are unknown. To explore the molecular mechanisms that lead to EC, gene expression profiles of large cohorts of patients with EC were obtained from The Cancer Genome Atlas and the Gene Expression Omnibus (GEO) databases (GSE5364, GSE20347 and GSE23400). The present study ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12077
更新日期:2020-11-01 00:00:00
abstract::Voltage-dependent anion channels (VDACs) are situated in the outer membrane of the mitochondria and serve as gatekeepers that control metabolite and ion exchange between the cytosol and mitochondria. VDAC1 is one of the most studied members of the VDAC protein family and is overexpressed in multiple types of cancer. H...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10534
更新日期:2019-09-01 00:00:00
abstract::The present study aimed to investigate the clinical outcomes of percutaneous transhepatic biliary drainage in patients with obstructive jaundice and identify potential predictors of patient survival. Clinical data from 102 patients (66 males and 36 females; median age, 63.50 years; range, 29-84 years) with a mean (± s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1860
更新日期:2014-04-01 00:00:00
abstract::Observational and experimental studies have produced inconsistent evidence about the association of serum levels of B-type natriuretic peptide (BNP) with anthracycline-induced cardiotoxicity (AIC). Therefore, the current meta-analysis examined the association between serum BNP levels and AIC by using data from high qu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4424
更新日期:2016-05-01 00:00:00
abstract::Peroxiredoxin (Prx) II is an imperative member of the superfamily of peroxidases. It serves an essential role in scavenging organic hydroperoxide and H2O2. It is involved in the development of various malignant tumors. In order to investigate the significance of Prx II expressions level in gastric cancer (GC), downreg...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9208
更新日期:2018-10-01 00:00:00
abstract::Anti-CD19 chimeric antigen receptor T cell (CAR-T) therapy has changed the typical outcomes of relapsed/refractory B-cell leukemia and lymphoma. However, treatment effectiveness for patients with relapsed/refractory B-cell non-Hodgkin lymphoma has been less satisfactory compared with patients with B-cell acute lymphob...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10783
更新日期:2019-11-01 00:00:00
abstract::Pancreatic cancer is one of the most lethal cancers. Transmembrane 4 superfamily member 5 protein (TM4SF5) is one of the candidate molecular targets used for the prevention and treatment of TM4SF5-expressing cancers, including hepatocellular carcinoma, colon cancer and pancreatic cancer. Recently, a previous study rep...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11134
更新日期:2020-01-01 00:00:00
abstract::Alcohol consumption is a risk factor for the development of hepatocellular carcinoma (HCC); however, the association between alcohol and HCC remains unknown. The present study aimed to identify key genes related to alcohol-associated HCC to improve the current understanding of the pathology of this disease. Alcohol-as...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9757
更新日期:2019-02-01 00:00:00
abstract::Diagnostic value of magnetic resonance imaging (MRI) and multi-slice spiral CT (MSCT) for different pathological stages of prostate cancer was compared. A total of 112 patients with prostate cancer who underwent surgical pathology in The Affiliated Yantai Yuhuangding Hospital of Qingdao University from February 2014 t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10272
更新日期:2019-06-01 00:00:00
abstract::Chromodomain helicase DNA-binding 5 (CHD5), which is a member of the CHD family, has been identified as a tumor suppressor gene in a variety of malignancies. The aim of the current study was to clarify the clinical significance of CHD5 expression in gastric cancer. CHD5 expression was evaluated using immunohistochemis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11138
更新日期:2020-01-01 00:00:00
abstract::There is increasing evidence that microRNAs (miRNAs) play important roles in tumor progression and development by targeting different genes, including gastric cancer (GC). However, the role of miR-16 in GC is so far unclear. Herein, we examined the function and potential mechanism of miR-16 in GC. Reverse transcriptio...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8997
更新日期:2018-09-01 00:00:00
abstract::Gastric cancer is a pathological process of an accumulation of multigene and multistage mutations. A new gene segment, MDSCBC11, has been previously obtained using a gene chip and is negatively associated with gastric cancer. The present study aimed to clone the full cDNA sequence of the MDSCBC11 segment and to detect...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1595
更新日期:2013-12-01 00:00:00