Targeting TM4SF5 with anti-TM4SF5 monoclonal antibody suppresses the growth and motility of human pancreatic cancer cells.

abstract：:Emerging evidence has revealed that mitochondrial DNA (mtDNA) is encapsulated in plasma extracellular vesicles (EVs). However, the characteristics of mtDNA in EVs from patients with cancer remain largely unexplored, which greatly limits its clinical application. Whole genome and capture-based sequencing found that EV ...

journal_title：Oncology letters

authors： Li Y,Guo X,Guo S,Wang Y,Chen L,Liu Y,Jia M,An J,Tao K,Xing J

更新日期：2020-09-01 00:00:00

abstract：:To aim of the present study was to investigate the association between special AT-rich DNA-binding protein-1 (SATB1) expression and liver cancer metastasis. SATB1 mRNA and protein expression in hepatocellular carcinoma tissues was analyzed by immunohistochemistry, and in two hepatocellular cancer cell lines, MHCC-97H ...

journal_title：Oncology letters

authors： Wu D,Zeng L,Liu F,Zhong Q,Zhang D,Cai C,Zhang W,Wu L,Chen H

更新日期：2016-12-01 00:00:00

abstract：:The present case report describes the infrequent coexistence of squamous cell transformation and the epidermal growth factor receptor (EGFR) T790M mutation as resistance mechanisms to first line treatment with tyrosine kinase inhibitors. The patient was a 44-year-old female, diagnosed with a primitive advanced lung ad...

journal_title：Oncology letters

authors： Bruno R,Proietti A,Alì G,Puppo G,Ribechini A,Chella A,Fontanini G

更新日期：2017-11-01 00:00:00

abstract：:DNA hypomethylation is associated with carcinogenesis due to its involvement in cancer initiation and progression. In this study we analyzed the hypomethylation status of candidate genes in clear cell renal cell carcinoma (CCRCC) using a large-scale, high-throughput DNA methylation profiling technique. Results reveale...

journal_title：Oncology letters

authors： Yoo KH,Park YK,Chang SG

更新日期：2013-01-01 00:00:00

abstract：:Controversy exists regarding a possible association between prostatitis and prostate cancer. To further evaluate the incidence of prostate cancer following prostatitis, a study of prostate cancer incidence in a cohort of Finnish men was performed. The original survey evaluating self-reported prostatitis was conducted ...

journal_title：Oncology letters

authors： Vaarala MH,Mehik A,Ohtonen P,Hellström PA

更新日期：2016-08-01 00:00:00

abstract：:Death associated protein kinase 1 (DAPK1) is a notable serine/threonine kinase involved in the regulation of multiple cellular pathways, including apoptosis and autophagy. Although DAPK1 is usually considered to be a tumor suppressor, it was previously reported to promote the viability of p53 mutant cancer cell lines ...

journal_title：Oncology letters

authors： Huang Y,Lin M,Chen X,Huang C,Zhang X,Chen L,Wu K,Chen Y,Zhu Y,Lin Y

更新日期：2018-06-01 00:00:00

abstract：:The pharmacological actions of Ophiopogonin D include resistance to cardiovascular and cerebrovascular diseases, anti-aging effects, improvement in learning deficit and dysmnesia, anti-tumor, anti-radiation and anti-inflammatory effects, immunoregulation, and the relief of cough and hepatopulmonary pathological lesion...

journal_title：Oncology letters

authors： Yan Z,Liu G,Liang M,Xu Y

更新日期：2019-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the fourth most common cause of cancer-associated death worldwide. Glioma-associated oncogene homolog 1 (Gli1) is a key component and functions as a reliable marker of Hedgehog signaling pathway activation. Previous studies have demonstrated that Gli1 serves important roles in the pro...

journal_title：Oncology letters

authors： Hu Z,Xie F,Hu A,Xu M,Liu Y,Zhang J,Xiao J,Song Y,Zhong J,Chen B

更新日期：2020-11-01 00:00:00

abstract：:Inactivating mutations of the multiple endocrine neoplasia 1 (MEN1) gene cause MEN1 syndrome, characterized by primary hyperparathyroidism (pHPT), and parathyroid and gastro-entero-pancreatic pituitary tumors. At present, only 14 cases of malignant parathyroid tumor have been associated with the syndrome, with 6 cases...

journal_title：Oncology letters

authors： Cinque L,Sparaneo A,Cetani F,Coco M,Clemente C,Chetta M,Balsamo T,Battista C,Sanpaolo E,Pardi E,D'Agruma L,Marcocci C,Maiello E,Hendy GN,Cole DEC,Scillitani A,Guarnieri V

更新日期：2017-07-01 00:00:00

abstract：:Gastric cancer is one of the most common malignancies with high cancer-associated mortality rate globally. Hepcidin is the peptide hormone, which is critically important in the regulation of systemic iron homeostasis. Cumulating evidence has reported that the disturbed local expression of hepcidin may serve as a predi...

journal_title：Oncology letters

authors： Zuo E,Lu Y,Yan M,Pan X,Cheng X

更新日期：2018-02-01 00:00:00

abstract：:The adaptive response of the genome protection mechanism occurs in cells when exposed to genotoxic stress due to the overproduction of free radicals via inflammation and infection. In such circumstances, cells attempt to maintain health via several genome protection mechanisms. However, evidence is increasing that thi...

journal_title：Oncology letters

authors： Loilome W,Kadsanit S,Muisook K,Yongvanit P,Namwat N,Techasen A,Puapairoj A,Khuntikeo N,Phonjit P

更新日期：2017-02-01 00:00:00

abstract：:The aim of the present retrospective study was to ascertain the significance of pathological complete response (pCR) on overall survival (OS) and disease-free survival (DFS) in each disease subtype of operable breast cancer. Using a single-institution database, 90 patients were identified, who received neoadjuvant che...

journal_title：Oncology letters

authors： Kawajiri H,Takashima T,Aomatsu N,Kashiwagi S,Noda S,Onoda N,Ishikawa T,Hirakawa K

更新日期：2014-03-01 00:00:00

abstract：:Metastasis negatively affects the prognosis of hepatocellular carcinoma (HCC). In the present study, niclosamide, which is known to suppress the proliferation of HCC cells, was investigated for possible suppressant effects on the migration of HCC cells. HLF and PLC/PRF/5 HCC cells were cultured in the presence of nicl...

journal_title：Oncology letters

authors： Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Ishige N

更新日期：2015-12-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) govern gene expression by competitively binding to microRNA response elements (MREs). Although they were initially considered as transcriptional noise, lncRNAs have attracted increased attention in oncology. Dysregulation of lncRNAs occurs in various types of human tumor, including esoph...

journal_title：Oncology letters

authors： Yu Y,Chen X,Cang S

更新日期：2019-11-01 00:00:00

abstract：:erbB-2 is amplified or overexpressed in approximately 30% of human breast cancers, and has been associated with poor prognosis and therapeutic resistance. Previous studies have suggested that erbB-2 overexpression in transgenic mice induces genomic instability; however, the patterns of genetic lesions vary with indivi...

journal_title：Oncology letters

authors： Kim YM,Ma Z,Lee S,Lee J,Li S,Yang X

更新日期：2011-11-01 00:00:00

abstract：:Cancer stem cells (CSCs) are proposed to be closely correlated with the development and progression of tumors, as well as with chemo- and radioresistance. Targeting CSCs may therefore be a promising potential strategy for the treatment of cancer. Currently, natural products have received great interest due to their th...

journal_title：Oncology letters

authors： Sun G,Wei L,Feng J,Lin J,Peng J

更新日期：2016-06-01 00:00:00

abstract：:Normal and cancerous cells are suggested to have differential utilization of fatty acids and ketone bodies, which could be exploited in cancer therapy. The present study examined the effect of 3-hydroxybutyric acid (3-HBA), which is a ketone body generating acetyl-CoA, and lauric acid (LAA, C12:0), which is a medium-c...

journal_title：Oncology letters

authors： Kadochi Y,Mori S,Fujiwara-Tani R,Luo Y,Nishiguchi Y,Kishi S,Fujii K,Ohmori H,Kuniyasu H

更新日期：2017-07-01 00:00:00

abstract：:Elongator protein 3 (ELP3), the catalytic subunit of the elongator complex of RNA polymerase II, is involved in various functions, including transcriptional elongation, chromatin modification and cytoskeletal regulation. In this study, ELP3 expression was immunohistochemically examined in normal uterus tissue and uter...

journal_title：Oncology letters

authors： Wang Y,Ikeda JI,Rahadiani N,Mamat S,Ueda Y,Tian T,Enomoto T,Kimura T,Aozasa K,Morii E

更新日期：2012-01-01 00:00:00

abstract：:Based on our previous analysis of neutral glycolipids in the human endometrium, the present authors already reported that the concentrations of glucosylceramide, lactosylceramide and globotriaosylceramide (Gb3Cer), in which both fatty acids and sphingosines in the ceramides are hydroxylated, exhibit a marked increase ...

journal_title：Oncology letters

authors： Tajima T,Miyazawa M,Hayashi M,Asai S,Ikeda M,Shida M,Hirasawa T,Iwamori M,Mikami M

更新日期：2017-01-01 00:00:00

abstract：:Lung cancer is one of the most lethal types of cancer, and its poor prognosis is primarily due to drug resistance and cancer recurrence. As it is associated with a low five-year survival rate, lung cancer stem cells (LCSCs) have been the subject of numerous recent studies. For these studies of LCSCs, lung cancer cell ...

journal_title：Oncology letters

authors： Wang Y,Jiang M,Du C,Yu Y,Liu Y,Li M,Luo F

更新日期：2018-05-01 00:00:00

abstract：:T-box 3 (Tbx3), a member of the T-box transcription factor family, serves a crucial role in embryonic development and cancer progression. Previous studies have demonstrated the clinical significance of Tbx3 in numerous types of cancer. However, the expression level and pathological function of Tbx3 in non-small cell l...

journal_title：Oncology letters

authors： Wu Y,Feng J,Hu W,Zhang Y

更新日期：2017-05-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and remains the third leading cause of cancer-associated mortality. The present study aimed to fully elucidate the pathogenesis of CRC and identify associated genes in tumor development. Microarray GSE44076, GSE41328 and GSE44861 datasets were...

journal_title：Oncology letters

authors： Shen X,Yue M,Meng F,Zhu J,Zhu X,Jiang Y

更新日期：2016-11-01 00:00:00

abstract：:Although a combination of platinum- and taxane-based chemotherapy is recommended for at least 70% patients with ovarian cancer as treatment subsequent to surgery, the initial response to the chemotherapy is not durable and tumors become resistant. Histone deacetylase and proteasome inhibitors are novel therapeutic age...

journal_title：Oncology letters

authors： Jin X,Fang Y,Hu Y,Chen J,Liu W,Chen G,Gong M,Wu P,Zhu T,Wang S,Zhou J,Wang H,Ma D,Li K

更新日期：2017-06-01 00:00:00

abstract：:The present study aimed to evaluate regional liver function impairment following transcatheter arterial chemoembolization (TACE), assessed by magnetic resonance imaging (MRI) enhanced by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Additionally, this study evaluated the associations betwe...

journal_title：Oncology letters

authors： Xiao YD,Paudel R,Liu H,Zhang B,Ma C,Zhou SK

更新日期：2015-03-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDA) is an aggressive malignant disease that is resistant to various chemotherapeutic agents and commonly relapses. Efficient elimination of metastasized PDA is critical for a positive post-surgical treatment outcome. The present study analyzed the effect of the B-cell lymphoma-2 (Bcl...

journal_title：Oncology letters

authors： Kasai S,Sasaki T,Watanabe A,Nishiya M,Yasuhira S,Shibazaki M,Maesawa C

更新日期：2017-07-01 00:00:00

abstract：:The present study reports a case of a 59-year-old male suffering from oligodendroglioma that metastasized to the bone marrow (BM). The metastasis was detected 5 years after craniotomy was performed for the resection of the primary tumor; however, it manifested as multiple myeloma (MM)-like bone lesions, a small M comp...

journal_title：Oncology letters

authors： Jian Y,Gao W,Wu Y,Li Y,Zhang Y,Yang G,Chen W

更新日期：2016-07-01 00:00:00

abstract：:The clinicopathological value and exploration of the potential molecular mechanism of microRNA-183-5p (miR-183-5p) have been investigated in various cancers; however, to the best of the author's knowledge, no similar research has been reported for bladder cancer. In the present study, it was revealed that the expressi...

journal_title：Oncology letters

authors： Gao JM,Huang LZ,Huang ZG,He RQ

更新日期：2018-04-01 00:00:00

abstract：:Clinical application value was investigated of transvaginal color Doppler ultrasound (TV-CDS) combined with serum tumor markers carbohydrate antigen 125 (CA125), vascular endothelial growth factor (VEGF) and osteopontin (OPN) in the diagnosis of ovarian cancer (OC). One hundred and six patients with OC [malignant tumo...

journal_title：Oncology letters

authors： Yu C,Dou T,Liu Y,Liu R

更新日期：2020-08-01 00:00:00

abstract：:A malignant peripheral nerve sheath tumor (MPNST) is defined as any malignant tumor that develops or differentiates from cells in the peripheral nerve sheath. This tumor is commonly associated with neurofibromatosis type 1 (NF1) and previous radiotherapy treatment. Primary intraosseous MPNSTs are extremely rare and a ...

journal_title：Oncology letters

authors： Suzuki K,Yasuda T,Hori T,Watanabe K,Kanamori M,Kimura T

更新日期：2014-06-01 00:00:00

abstract：:The aim of the present study was to determine the usefulness of the positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) in the detection of recurrence or metastasization of differentiated thyroid carcinoma (DTC) in patients with abnormal thyroglobulin levels and negative finding...

journal_title：Oncology letters

authors： Lu CZ,Cao SS,Wang W,Liu J,Fu N,Lu F

更新日期：2016-04-01 00:00:00