Next generation sequencing-based analysis of mitochondrial DNA characteristics in plasma extracellular vesicles of patients with hepatocellular carcinoma.

abstract：:This study aimed to determine the relationship between human papillomavirus (HPV) and nuclear factor-κB (NF-κB) in cervical cancer using 62 tissues of cervical cancer, and to compare the findings to penile cancer. HPV-DNA integration is a crucial factor for malignant transformation in cervical cancer and can be identi...

journal_title：Oncology letters

authors： Senba M,Buziba N,Mori N,Fujita S,Morimoto K,Wada A,Toriyama K

更新日期：2011-01-01 00:00:00

abstract：:Serine/threonine kinase 39 (STK39) is associated with hypertension, autism, Parkinson's disease and various types of cancer in recent years. This study investigated STK39 expression and possible roles in osteosarcoma using qPCR and western blot analysis. Compared to normal bone tissues, the mRNA and protein expression...

journal_title：Oncology letters

authors： Huang T,Zhou Y,Cao Y,Tao J,Zhou ZH,Hang DH

更新日期：2017-10-01 00:00:00

abstract：:Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and ...

journal_title：Oncology letters

authors： Shintani M,Tashiro A,Sangawa A,Yamao N,Kamoshida S

更新日期：2016-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death. Due to rapid progression and metastasis, the long-term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that chond...

journal_title：Oncology letters

authors： Huang Z,Zhang N,Li W,Cao J,Zhang L,Chen Y

更新日期：2017-02-01 00:00:00

abstract：:Despite advancements in treatment regimens, the mortality rate of patients with oral tongue squamous cell carcinoma (OTSCC) is high. In addition, the signaling pathways and oncoproteins involved in OTSCC progression remain largely unknown. Therefore, the aim of the present study was to identify specific prognostic mar...

journal_title：Oncology letters

authors： Zhong P,Liu L,Shen A,Chen Z,Hu X,Cai Y,Lin J,Wang B,Li J,Chen Y,Peng J

更新日期：2019-12-01 00:00:00

abstract：:Microcystic adnexal carcinoma (MAC) is extremely rare among Asians, with the majority of cases presenting in Caucasian individuals. The current study describes the case of a 38-year-old Chinese woman who presented with a 10 year history of a mass in the upper lip. A biopsy resulted in a diagnosis of MAC. The patient u...

journal_title：Oncology letters

authors： Chen J,Yang S,Chen J,Liao T,Deng W,Li W

更新日期：2016-04-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as locally advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in Western patients, however comprehensive genomic features of CCA in Chinese patients have not been well understood. To explore the specific genom...

journal_title：Oncology letters

authors： Tian W,Hu W,Shi X,Liu P,Ma X,Zhao W,Qu L,Zhang S,Shi W,Liu A,Cao J

更新日期：2020-04-01 00:00:00

abstract：:The present study reports a case of a 59-year-old male suffering from oligodendroglioma that metastasized to the bone marrow (BM). The metastasis was detected 5 years after craniotomy was performed for the resection of the primary tumor; however, it manifested as multiple myeloma (MM)-like bone lesions, a small M comp...

journal_title：Oncology letters

authors： Jian Y,Gao W,Wu Y,Li Y,Zhang Y,Yang G,Chen W

更新日期：2016-07-01 00:00:00

abstract：:The global incidence of prostate cancer (PCa) has been increasing in recent years. Meanwhile, some studies have indicated the association between malignancies, such as lung and gastric cancer and PCa, and microRNAs (miRNAs). The present study was designed to assess the prognostic value of miR-92b-3p in patients with P...

journal_title：Oncology letters

authors： Wang G,Cheng B,Jia R,Tan B,Liu W

更新日期：2021-01-01 00:00:00

abstract：:Expression of long non-coding RNA SNHG7 (lncRNA-SNHG7) and its clinical significance in hepatocellular carcinoma (HCC) were explored. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of lncRNA-SNHG7 in cancer tissues. Kaplan-Meier curves and multivariate Cox proportion...

journal_title：Oncology letters

authors： Shen A,Ma J,Hu X,Cui X

更新日期：2020-06-01 00:00:00

abstract：:The expression levels of cyclooxygenase (COX)-2 and the prostaglandin E2 (PGE2) content have been associated with poor prognosis in patients with colorectal cancer (CRC). There is a strong correlation between COX-2 expression and PGE2 production in tissues from CRC patients, suggesting an important role for COX-2 on t...

journal_title：Oncology letters

authors： Cervantes-Madrid DL,Nagi S,Asting Gustafsson A

更新日期：2017-03-01 00:00:00

abstract：:We investigated the possible association between DLKI gene promoter region methylation and the increased invasion capacity of non-small cell lung cancer (NSCLC). Lung cancer cell line H1299, as well as the gene transfection and RNA interference technology were used to build DLK gene overexpression and knockdown cells....

journal_title：Oncology letters

authors： Zhong Z,Ye Y,Guo W,He Y,Hu W

更新日期：2017-06-01 00:00:00

abstract：:The collagen gel droplet embedded culture-drug sensitivity test (CD-DST) is an anticancer drug sensitivity test developed about 10 years ago. This study reports the application of this test in the choice of neoadjuvant chemotherapy for the treatment of one patient with a large synovial sarcoma in the right shank. A 28...

journal_title：Oncology letters

authors： Gu F,Ma Y,Fan Y,Lang R,Ding T,Hao X,Gong Y,Kobayahsi H,Fang Z,Fu L

更新日期：2010-09-01 00:00:00

abstract：:MicroRNA-181 (miR-181) has been recently demonstrated to participate in the differentiation and development of immune cells, including natural killer cells and B and T lymphocytes, and myeloid linages, including erythroid and megakaryocytic cells. The aberrant expression of miR-181, particularly low expression levels,...

journal_title：Oncology letters

authors： Wang G,Zhao R,Zhao X,Chen XI,Wang D,Jin Y,Liu XI,Zhao CI,Zhu Y,Ren C,Li M,Jin X,Zhang F,Zhong Z,Wang T,Li X

更新日期：2015-11-01 00:00:00

abstract：:The clinical efficiency of bone transport distraction osteogenesis in the reconstruction of large tibial defects following resection of osteosarcoma remains unclear. The current study presents two cases of large tibial defects treated with bone transport distraction using an Orthofix external fixator. Case 1 was a 29-...

journal_title：Oncology letters

authors： Yang Z,Jin L,Tao H,Yang D

更新日期：2016-08-01 00:00:00

abstract：:First-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have markedly improved the treatment of non-small cell lung cancer (non-SCLC) with EGFR-sensitive mutations. However, acquired resistance to these drugs was inevitable. The transformation of lung adenocarcinoma to SCLC following ...

journal_title：Oncology letters

authors： Fang L,He J,Xia J,Dong L,Zhang X,Chai Y,Li Y,Niu M,Hang T,Li S

更新日期：2017-07-01 00:00:00

abstract：:The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...

journal_title：Oncology letters

authors： Li Z,Gu X,Fang Y,Xiang J,Chen Z

更新日期：2012-02-01 00:00:00

abstract：:Maternal embryonic leucine zipper kinase (MELK) is an important regulator in tumorigenesis of human breast cancer, and if silenced leads to programmed cell death in specific breast cancer cell lines, including MDA-MB-231 cells. In the present study, RNA interference, proliferation assay and semi-quantification of cell...

journal_title：Oncology letters

authors： Li G,Yang M,Zuo L,Wang MX

更新日期：2018-06-01 00:00:00

abstract：:Impairment of microRNA (miRNA) biogenesis may be involved in clear cell renal cell carcinoma (ccRCC). The objective of the present study was to investigate the mRNA levels of important miRNA machinery components, DICER1, DROSHA, DiGeroge syndrome critical region gene 8 (DGCR8), and Argonaute 2 (AGO2), and their correl...

journal_title：Oncology letters

authors： Lee SS,Min H,Ha JY,Kim BH,Choi MS,Kim S

更新日期：2019-10-01 00:00:00

abstract：:Differences in inflammatory factors IL-6 and miR-1271 expression levels between elderly and young gastric cancer patients were investigated. A retrospective analysis of 146 cases of gastric cancer tissue and normal fresh tissue specimens diagnosed in The First Hospital of Lanzhou University from January 2013 to Januar...

journal_title：Oncology letters

authors： Liu S,Zhou Y,Zhao L,Wang J,Ji R,Wang Y,Wu J,Yan X

更新日期：2019-06-01 00:00:00

abstract：:Ku80, a subunit of the heterodymeric Ku protein, is clearly implicated in nonhomologous end joining DNA repair, chemoresistance and radioresistance in malignant tumors. In the present study, the clinicopathological significance of Ku80 in esophageal squamous cell carcinoma (ESCC) was investigated. The expression level...

journal_title：Oncology letters

authors： Wang S,Wang Z,Yang YU,Shi MO,Sun Z

更新日期：2015-11-01 00:00:00

abstract：:The present study aimed to investigate the anti-cancer activity of imidazo[1,2-a]pyridine 5-7 in the A375 and WM115 melanoma and HeLa cervical cancer cell lines. The viability of cancer cells was analyzed by the MTT assay. Apoptosis was quantified by flow cytometry following staining of the cells with AnnexinV/propidi...

journal_title：Oncology letters

authors： Aliwaini S,Awadallah AM,Morjan RY,Ghunaim M,Alqaddi H,Abuhamad AY,Awadallah EA,Abughefra YM

更新日期：2019-07-01 00:00:00

abstract：:MicroRNAs (miRs) are often located in genomic breakpoint regions and are hypothesized to be important regulators involved in the regulation of critical cell processes, including cell apoptosis, proliferation and differentiation. miR-299 has been reported to be upregulated in acute promyelocytic leukemia (APL); however...

journal_title：Oncology letters

authors： Wu SQ,Zhang LH,Huang HB,Li YP,Niu WY,Zhan R

更新日期：2016-07-01 00:00:00

abstract：:The present study reports the rare case of a patient with quintuple primary cancer that underwent systematic treatment, including surgical intervention. A 63-year-old male patient was initially diagnosed with primary esophageal cancer and hypopharyngeal cancer. The patient underwent total pharyngolaryngoesophagectomy ...

journal_title：Oncology letters

authors： Otowa Y,Nakamura T,Takiguchi G,Urakawa N,Ishida R,Imanishi T,Suzuki S,Tanaka K,Kuroda D,Kakeji Y

更新日期：2015-06-01 00:00:00

abstract：:Vasculogenic mimicry (VM) formation is important for invasion and metastasis of tumor cells in gastric adenocarcinoma (GAC). The present study aimed to investigate the association between signal transducer and activator of transcription-3 (STAT3), phosphor-STAT3 (p-STAT3), hypoxia-inducible factor-1α (HIF-1α) and VM f...

journal_title：Oncology letters

authors： Song YY,Sun LD,Liu ML,Liu ZL,Chen F,Zhang YZ,Zheng Y,Zhang JP

更新日期：2014-07-01 00:00:00

abstract：:Metastasis negatively affects the prognosis of hepatocellular carcinoma (HCC). In the present study, niclosamide, which is known to suppress the proliferation of HCC cells, was investigated for possible suppressant effects on the migration of HCC cells. HLF and PLC/PRF/5 HCC cells were cultured in the presence of nicl...

journal_title：Oncology letters

authors： Tomizawa M,Shinozaki F,Motoyoshi Y,Sugiyama T,Yamamoto S,Ishige N

更新日期：2015-12-01 00:00:00

abstract：:Studies conducted in our lab have indicated that thalidomide cytotoxicity in the KG-1a human acute myelogenous leukemia (AML) cell line was enhanced by combining it with arsenic trioxide. The current investigation was conducted in order to evaluate the effect of thalidomide either alone or in combination with arsenic ...

journal_title：Oncology letters

authors： Girgis EH,Mahoney JP,Khalil RH,Soliman MR

更新日期：2010-07-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the dynamic intensity-modulated radiation therapy planned γ analysis passing rate and respiratory amplitude (A) and period (T) for different tumor volumes. A total of 30 patients with malignant lung tumors were divided into three groups: A; B; and...

journal_title：Oncology letters

authors： Xie K,Sun H,Lin T,Gao L,Sui J,Ni X

更新日期：2018-07-01 00:00:00

abstract：:The aim of the present study was to evaluate the clinical importance of melanoma-associated antigen D4 (MAGE-D4) expression in glioma, and to identify it as a valuable prognostic biomarker and therapeutic target. To achieve this, the expression of MAGE-D4 protein in 124 tumor tissues from patients with glioma was meas...

journal_title：Oncology letters

authors： Yan J,Wen J,Wei ZD,Li XS,Li P,Xiao SW

更新日期：2018-04-01 00:00:00

abstract：:Transforming growth factor β (TGFβ) ligands, including TGFβ1, are multifunctional cytokines known as key regulators of cell growth, differentiation and inflammation. Dysregulated TGFβ signaling is common in numerous solid tumors, including head and neck squamous cell carcinoma (HNSCC). Previously, TGFβ ligands were al...

journal_title：Oncology letters

authors： Bae WJ,Lee SH,Rho YS,Koo BS,Lim YC

更新日期：2016-12-01 00:00:00