Abstract:
:Survivin, a member of the inhibitor of apoptosis protein family, is a potential prognostic marker and molecular target for anticancer therapies. Chromosomal regional maintenance protein-1 (CRM-1) mediates the nuclear export of proteins such as survivin. The aims of the present study were to compare the expression and subcellular localization of CRM-1 in human gastric and colorectal carcinomas and to assess the association between CRM-1 and survivin expression in these tumor types. The nuclear and cytoplasmic CRM-1 expression rates in gastric carcinoma were 61% (42/69) and 29% (20/69), respectively, while the nuclear and cytoplasmic CRM-1 expression rates in colorectal carcinoma were 55% (43/78) and 37% (29/78), respectively. Nuclear and cytoplasmic CRM-1 expression was found to be significantly correlated with nuclear and cytoplasmic survivin expression in colorectal carcinoma, but not gastric carcinoma. These results indicate that CRM-1 expression patterns differ between gastric and colorectal carcinomas and thus, we hypothesize that CRM-1-mediated nuclear export of survivin may be deregulated in gastric carcinoma. Therefore, CRM-1 may exhibit different functions in gastric and colorectal carcinoma.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Shintani M,Tashiro A,Sangawa A,Yamao N,Kamoshida Sdoi
10.3892/ol.2016.5220subject
Has Abstractpub_date
2016-12-01 00:00:00pages
4630-4634issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-5220journal_volume
12pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The aim of the present study was to establish a prediction index (PI) model for the 5-year survival rate of patients with hepatitis B-related hepatocellular carcinoma (HCC) after radical resection, and to evaluate the effect of prophylactic transcatheter arterial chemoembolization (TACE). A total of 201 patients with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10517
更新日期:2019-08-01 00:00:00
abstract::Oncostatin M (OSM) induces the differentiation of liver cancer stem cells (LCSCs) and increases sensitivity to the chemotherapeutic agent 5-fluorouracil, whereas salinomycin (Sal) induces apoptosis in cancer stem cells and inhibits the proliferation of liver cancer cells. However, there have been no studies investigat...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9796
更新日期:2019-02-01 00:00:00
abstract::This study aimed to determine the relationship between human papillomavirus (HPV) and nuclear factor-κB (NF-κB) in cervical cancer using 62 tissues of cervical cancer, and to compare the findings to penile cancer. HPV-DNA integration is a crucial factor for malignant transformation in cervical cancer and can be identi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2010.207
更新日期:2011-01-01 00:00:00
abstract::Bladder cancer is one of the most common forms of malignancies involving the urinary system and multiple risk factors have been associated with its etiology. The most common of which include cigarette smoking and various occupational or chemical exposures. It is usually diagnosed in older individuals with an average a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4355
更新日期:2016-05-01 00:00:00
abstract::Pituitary tumor transforming gene 1 (PTTG11) is abundantly expressed in glioma. Our previous study demonstrated that the downregulation of PTTG11 gene expression significantly inhibited the proliferation, migration and invasion ability, and increased the apoptosis of SHG44 glioma cells. However, the molecular mechanis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11867
更新日期:2020-10-01 00:00:00
abstract::The recognition of the biological relevance of long non-coding RNA (lncRNA) molecules has only recently been recognized as one of the most significant advances in contemporary molecular biology. A growing body of evidence indicates that lncRNAs act not only as the intermediary between DNA and protein but also as signi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3553
更新日期:2015-10-01 00:00:00
abstract::Correlation between CT features of adrenocortical and adrenal medullary tumors and the expression of miR-96 in serum were investigated. A total of 230 patients with adrenocortical tumors and 194 patients with adrenal medullary tumors were selected in Dongying People's Hospital from August 2013 to August 2017. The two ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8863
更新日期:2018-08-01 00:00:00
abstract::The long non-coding RNA (lncRNA), RP11-480I12.5 is one of the most dysregulated lncRNAs, which is believed to contribute to the progression of cervical carcinoma (CC); however, the exact function of RP11-480I12.5 in human CC remains unknown. The present study aimed to investigate the function and underlying molecular ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11120
更新日期:2020-01-01 00:00:00
abstract::Indocyanine green (ICG) fluorescence imaging represents a promising method for sentinel node (SN) biopsy in laparoscopic gastric surgery due to its signal stability. In the present study, the suitability and optimal settings of ICG fluorescence imaging for SN biopsy in early gastric cancer were determined. Patients wi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4492
更新日期:2016-06-01 00:00:00
abstract::Ovarian metastasis from non-small cell lung cancer (NSCLC) is a rare condition. The current study presents the cases of 2 female patients aged 38 and 47 years old, respectively, who were initially diagnosed with NSCLC adenocarcinoma on histology. Both patients initially presented with chest pain and a cough, and subse...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5292
更新日期:2016-12-01 00:00:00
abstract::In the current era of multi-disciplinary treatment, precise and detailed diagnosis prior to treatment is crucial for clinical practice. For different lesions that fit different indications, the optimum approach for treatment differs significantly. Thus, the recent 8th American Joint Committee on Cancer classification ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9920
更新日期:2019-03-01 00:00:00
abstract::Ameloblastoma is the most common and clinically relevant type of odontogenic tumor. Clear cell odontogenic carcinoma is histologically characterized by solid sheets and nests of clear cells, whereas clear cell ameloblastoma (CCAM) is histologically characterized by an ameloblastomatous component intermixed with an ext...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7116
更新日期:2017-12-01 00:00:00
abstract::Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4563
更新日期:2016-07-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are enzymes for extracellular matrix remodeling that are involved in tumor growth, progression and metastasis. Among them, MMP-9 has been implicated in tumor angiogenesis. Tissue inhibitor of matrix metalloproteinase (TIMP)-2, a member of the family of MMP inhibitors, induces apoptosis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1767
更新日期:2014-03-01 00:00:00
abstract::Fibroadenomas are a type of benign tumor that occur in young women below the age of 35 years old. The tumors are the second most common type of tumor after fibrocystic disease. The chance of carcinoma arising in a fibroadenoma is extremely low. To date, <130 such cases have been reported. Previous studies have reporte...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3420
更新日期:2015-09-01 00:00:00
abstract::Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) is a diterpenoid isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine. It was demonstrated in our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5099
更新日期:2016-11-01 00:00:00
abstract::Glioblastomas are the most common primary and malignant brain tumors. The standard therapy includes surgery and radiotherapy plus chemotherapy, with additional bevacizumab to block the angiogenesis in tumors. However, the ever-growing tolerance of glioblastomas to chemotherapeutic drugs impairs the clinical outputs of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7446
更新日期:2018-02-01 00:00:00
abstract::Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is currently approved in Japan for treatment of breast cancer. However, apart from phase I clinical trials, data regarding Japanese patients are scant. In the present study, the efficacy and safety of nab-paclitaxel therapy were retrospectively analyzed in 22 pati...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2954
更新日期:2015-04-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) has a high incidence and mortality rate, particularly in Southern China. Apogossypolone (ApoG2) is a novel derivative of gossypol with antitumor activity and less toxicity. The human NPC CNE-2 cell line was studied in the in vitro model; whilst 4 week-old male nude mice (BALB/c-nu) were ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6176
更新日期:2017-07-01 00:00:00
abstract::Expression level of miR-181c in neuroblastoma children and its effect on proliferation of neuroblastoma M17 cells were investigated. Fifty-seven neuroblastoma patients admitted to Weifang People's Hospital from January 2013 to December 2017 were selected and their cancer tissues and normal adjacent tissues were obtain...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10602
更新日期:2019-09-01 00:00:00
abstract::Epidemiological data has demonstrated that particulate matter (PM) with an aerodynamic diameter ≤ 2.5 µm (PM2.5) is associated with cancer incidence. However, the precise mechanisms underlying PM2.5-mediated hepatocellular carcinoma cancer (HCC) migration and invasion remain unclear. The aim of the present study was t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5947
更新日期:2017-05-01 00:00:00
abstract::Urothelial cancer is the most frequently diagnosed type of malignant tumor in the bladder, of which primary adenocarcinoma accounts for a small percentage. Secondary malignancies, in particular metastatic adenocarcinoma from the lung, are exceedingly rare, with only six cases previously reported in the literature. The...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3445
更新日期:2015-09-01 00:00:00
abstract::Laryngeal squamous cell carcinoma (LSCC) is a genetically complex tumor type and one of the leading causes of cancer-associated disability and mortality. Genetic instability, such as chromosomal instability, is associated with the tumorigenesis of LSCC. Copy number variations (CNVs) have been demonstrated to contribut...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11653
更新日期:2020-08-01 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC), one of the most common malignant tumors, endangers human health. Recently, the incidence of HNSCC has kept increasing: However, its prognosis has not significantly improved. Understanding the molecular mechanism underlying HNSCC development will therefore provide new stra...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10920
更新日期:2019-12-01 00:00:00
abstract::The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.497
更新日期:2012-02-01 00:00:00
abstract::The present study reports the case of a 20-year-old female who was identified to have a left renal angiomyolipoma (AML) with hemorrhage. Following temporary conservative observation, the patient received continuous ultrasonic follow-up. Due to the rapid growth of the lesion, further examinations were performed. Comput...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3718
更新日期:2015-11-01 00:00:00
abstract::Evidence-based guidelines for the prevention of surgical site infection (SSI) have been published by the U.S. Centers for Disease Control and Prevention (CDC). According to these guidelines, a wound should usually be covered with a sterile dressing for 24 to 48 h when a surgical incision is closed primarily. However, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.687
更新日期:2012-07-01 00:00:00
abstract::Micheliolide (MCL), a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, has been used previously to inhibit the NF-κB signaling pathway. MCL has exerted various therapeutic effects in numerous types of disease, such as inflammatory and cancer. However, to the best of our knowledge, its unde...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11928
更新日期:2020-10-01 00:00:00
abstract::Tumor development is associated with the methylation of cytosine-guanine (CpG) islands. The occurrence of methylation requires several factors, such as DNA methylation systems and polycomb group (PcG) proteins. At present, novel drugs are needed for the treatment of chronic myeloid leukaemia (CML), particularly consid...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6050
更新日期:2017-06-01 00:00:00
abstract::S100A11, a member of S100 calcium-binding protein family, is associated with the numerous processes of tumorigenesis and metastasis. In the present study, the role of S100A11, and its possible underlying mechanisms in cell proliferation, apoptosis and cell cycle distribution in human pancreatic cancer were explored. I...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7295
更新日期:2018-01-01 00:00:00