Long non-coding RNA RP11-480I12.5 promotes cervical carcinoma progression by regulating the Wnt/β-catenin signaling pathway.

abstract：:The association between inflammation and cancer has been established in certain forms of human malignancies; however, its role in prostate cancer remains unclear. The present study investigates a possible association between chronic inflammation and the development of epithelial neoplasia in the prostate. Needle biops...

journal_title：Oncology letters

authors： Glover M,Soni S,Ren Q,Maclennan GT,Fu P,Gupta S

更新日期：2017-10-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) functions as a chromatin-associated nuclear protein and an extracellular signaling molecule. The concentration of HMGB1 protein and the expression of HMGB1 mRNA were analyzed by ELISA and polymerase chain reaction (PCR), respectively. The present study reports high plasma HMGB1 levels...

journal_title：Oncology letters

authors： Kimura R,Mori N

更新日期：2014-04-01 00:00:00

abstract：:There is increasing evidence that microRNAs (miRNAs) play important roles in tumor progression and development by targeting different genes, including gastric cancer (GC). However, the role of miR-16 in GC is so far unclear. Herein, we examined the function and potential mechanism of miR-16 in GC. Reverse transcriptio...

journal_title：Oncology letters

authors： Jiang X,Wang Z

更新日期：2018-09-01 00:00:00

abstract：:Differences in inflammatory factors IL-6 and miR-1271 expression levels between elderly and young gastric cancer patients were investigated. A retrospective analysis of 146 cases of gastric cancer tissue and normal fresh tissue specimens diagnosed in The First Hospital of Lanzhou University from January 2013 to Januar...

journal_title：Oncology letters

authors： Liu S,Zhou Y,Zhao L,Wang J,Ji R,Wang Y,Wu J,Yan X

更新日期：2019-06-01 00:00:00

abstract：:Micheliolide (MCL), a sesquiterpene lactone isolated from Michelia compressa and Michelia champaca, has been used previously to inhibit the NF-κB signaling pathway. MCL has exerted various therapeutic effects in numerous types of disease, such as inflammatory and cancer. However, to the best of our knowledge, its unde...

journal_title：Oncology letters

authors： Feng D,Liu M,Liu Y,Zhao X,Sun H,Zheng X,Zhu J,Shang F

更新日期：2020-10-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is a common tumor in south China. Kinesin family member 2A (KIF2A) belongs to the kinesin-13 family and is associated with the growth and invasion of a number of different types of human cancer, including ovarian, breast and prostate cancer. The aim of the present study was to evaluate t...

journal_title：Oncology letters

authors： Zhang Q,Lu D,Liu W,Ye S,Guo H,Liao T,Chen C

更新日期：2019-09-01 00:00:00

abstract：:Despite improvements in diagnosis and treatment, the survival of patients with advanced stages of esophageal squamous cell carcinoma (ESCC) remains poor. Therefore, novel biomarkers that can assist with early detection of ESCC are required. In the present study, three paired ESCC and normal esophageal tissue samples f...

journal_title：Oncology letters

authors： Cheng L,Shi G,Fang C,Li G,Zheng Y,Chen W

更新日期：2019-03-01 00:00:00

abstract：:Correlation of xeroderma pigmentosum complementation group F (XPF) expression with gastric cancer and prognosis was investigated. We randomly selected 76 gastric cancer patients who were admitted to the Second People's Hospital of Dezhou City and received treatment, and detected XPF expression in gastric cancer tissue...

journal_title：Oncology letters

authors： Li P,Ma Y

更新日期：2018-12-01 00:00:00

abstract：:Abnormalities in proto-oncogene B-Raf (BRAF) are typical in several subgroups of gliomas, including pilocytic astrocytomas, optic nerve gliomas, pleomorphic xanthoastrocytomas (PXA), anaplastic PXAs and gangliogliomas. However, they are rarely reported in adult gliomas. BRAF alterations are frequent in a distinct vari...

journal_title：Oncology letters

authors： Tosuner Z,Geçer MÖ,Hatiboğlu MA,Abdallah A,Turna S

更新日期：2018-08-01 00:00:00

abstract：:Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable p...

journal_title：Oncology letters

authors： Fusco P,Esposito MR,Tonini GP

更新日期：2018-12-01 00:00:00

abstract：:The issue of delayed neurological damage as a result of treatment is becoming increasingly important now that an increased number of children survive treatment for acute lymphoblastic leukemia (ALL). Following modification of the treatment protocols, severe symptomatic late effects are rare, and most adverse effects a...

journal_title：Oncology letters

authors： Badr MA,Hassan TH,El-Gerby KM,Lamey ME

更新日期：2013-02-01 00:00:00

abstract：:Effects of different levels of PM2.5 on invasion and proliferation of HeLa cells and the expression levels of inflammatory cytokines IL-1 and IL-6 under 10 µg/ml PM2.5 were investigated. Different groups of HeLa cells were treated with PM2.5 at 0, 10, 25, 50, 100 and 200 µg/ml for 36 h, respectively. Cell proliferatio...

journal_title：Oncology letters

authors： Huang K,Li W,Chen Y,Zhu J

更新日期：2018-12-01 00:00:00

abstract：:Epithelioid angiosarcoma (EA) is an extremely rare subtype of angiosarcoma, which is characterized by large cells with an epithelioid morphology. EA typically arises in deep soft tissues, including the adrenal gland, skin and thyroid, however, EA rarely arises in the spine. The current study presents a case of osteoly...

journal_title：Oncology letters

authors： Lang J,Chen L,Chen B,Chen K,Liu A,Li J,Wang J

更新日期：2014-06-01 00:00:00

abstract：:The human ether-a-go-go-related potassium channel 1 (hERG1) is a component of the voltage-gated Kv11.1 potassium channel, which has been recently indicated to have a crucial role in the tumorigenesis of multiple tumors, including pancreatic carcinoma. Pancreatic carcinoma is one of the most malignant human cancer type...

journal_title：Oncology letters

authors： Zhi D,Zhao X,Dong M,Yan C

更新日期：2017-12-01 00:00:00

abstract：:Protease-activated receptor 4 (PAR4), a member of the G-protein-coupled receptor family, was previously identified to be involved in the progression of cancer. Previous study revealed that the expression of PAR4 was increased in colorectal cancer tissues compared with the associated normal tissues, particularly in pos...

journal_title：Oncology letters

authors： Zhang H,Jiang P,Zhang C,Lee S,Wang W,Zou H

更新日期：2018-11-01 00:00:00

abstract：:Ubiquitin-like modifier-activating enzyme 7 (UBA7) is a specific E1-like ubiquitin-activating enzyme involved in interferon-stimulated gene 15 (ISG15) conjugation. UBA7 expression has been reported to be notably decreased in lung cancer. The present study aimed to investigate the changes in UBA7 expression in breast c...

journal_title：Oncology letters

authors： Lin M,Li Y,Qin S,Jiao Y,Hua F

更新日期：2020-04-01 00:00:00

abstract：:A significant factor that affects the value of the Ki-67 proliferation index (IK) is the interpretation and implementation approach. This method is based on visual or automated methods to count tumor nuclei labeled with Ki-67 antigen, and is prone to errors. Detection of Ki-67 is a useful tool in breast cancer and con...

journal_title：Oncology letters

authors： Suciu C,Muresan A,Cornea R,Suciu O,Dema A,Raica M

更新日期：2014-01-01 00:00:00

abstract：:Aldo-keto reductases, known as AKR1C1-AKR1C4 enzymes, are pivotal to NADPH-dependent reduction, and their expression is highly associated with the progression of malignant cancers. However, the expression and distinct prognostic value of the AKR1C family members in liver cancer are not well established. In the current...

journal_title：Oncology letters

authors： Zhao SF,Wang SG,Zhao ZY,Li WL

更新日期：2019-11-01 00:00:00

abstract：:As a member of the tripartite motif family, tripartite motif-containing protein 59 (TRIM59) serves as an E3 ubiquitin ligase in various cellular processes, including intracellular signaling, development, apoptosis, protein quality control, innate immunity, autophagy and carcinogenesis. The present study aimed to inves...

journal_title：Oncology letters

authors： Lou M,Gao Z,Zhu T,Mao X,Wang Y,Yuan K,Tong J

更新日期：2020-02-01 00:00:00

abstract：:The present study aimed to examine the effectiveness of immunostaining of cytological specimens in discerning squamous from non-squamous cell carcinoma. Various combinations of six antibodies were examined in order to determine the optimal combination for use in differential diagnosis. Immunostaining was performed usi...

journal_title：Oncology letters

authors： Ikeda S,Naruse K,Nagata C,Kuramochi M,Onuki T,Inagaki M,Suzuki K

更新日期：2015-05-01 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC), one of the most common malignant tumors, endangers human health. Recently, the incidence of HNSCC has kept increasing: However, its prognosis has not significantly improved. Understanding the molecular mechanism underlying HNSCC development will therefore provide new stra...

journal_title：Oncology letters

authors： Zou B,Guan X,Zhang W,Wang D,Xu K,Yuan DY,Meng Z,Zhang B

更新日期：2019-12-01 00:00:00

abstract：:Krüppel-like factor 5 (KLF5) is frequently deleted and inactivated in prostate cancer, and exerts tumor-suppressing function in prostate cancer cells. However, the function of KLF5 in the apoptosis of prostate cancer cells remains unclear. In the present study, the effect of KLF5 on phorbol 12-myristate 13-acetate (PM...

journal_title：Oncology letters

authors： Shi Q,Jia J,Hui K,Gao Y,Xu S,Guan B,Tang X,Wang X,He D,Guo P

更新日期：2017-08-01 00:00:00

abstract：:Segmental ureterectomy (SU) represents a promising alternative for the treatment of upper tract urothelial carcinomas (UTUCs) as it is a less invasive procedure and guarantees the preservation of renal units. The present study evaluated oncological outcomes and renal functions following SU when compared with radical n...

journal_title：Oncology letters

authors： Kato T,Nakayama R,Haba T,Kawaguchi M,Komiya A,Koike H

更新日期：2018-11-01 00:00:00

abstract：:Cardiac toxicity has been the major concern when using doxorubicin (DOX) in cancer therapy. Thrombopoietin (TPO) protects cardiac cells from DOX-induced cell damage; however, its molecular mechanism remains exclusive. The anti-autophagic and anti-apoptotic effects of TPO upon DOX treatment were studied in the cardiac ...

journal_title：Oncology letters

authors： Wang H,Wang H,Liang EY,Zhou LX,Dong ZL,Liang P,Weng QF,Yang M

更新日期：2018-01-01 00:00:00

abstract：:Ascorbic acid (A) has been demonstrated to exhibit anti-cancer activity in association with chemotherapeutic agents. Potassium (K) is a regulator of cellular proliferation. In the present study, the biological effects of A and K bicarbonate, alone or in combination (A+K), on breast cancer cell lines were evaluated. Th...

journal_title：Oncology letters

authors： Frajese GV,Benvenuto M,Fantini M,Ambrosin E,Sacchetti P,Masuelli L,Giganti MG,Modesti A,Bei R

更新日期：2016-06-01 00:00:00

abstract：:Aquaporin 1 (AQP1), which functions as a water transporter, is associated with cancer cell proliferation, invasion, metastasis and angiogenesis in numerous types of solid cancer, including colorectal cancer (CRC). The focus of the present study was to address the potential clinical use of AQP1 expression in CRC as a p...

journal_title：Oncology letters

authors： Imaizumi H,Ishibashi K,Takenoshita S,Ishida H

更新日期：2018-05-01 00:00:00

abstract：:Osteosarcoma is a malignant tumor derived from the skeletal system, often occurring in bone tissues, and it is the most common malignant tumor in the skeletal system, with more than 90% of cases being highly malignant. The present study was designed to explore the regulatory effects of microRNA (miR)-19a on the prolif...

journal_title：Oncology letters

authors： Chen J,Chen Z

更新日期：2020-11-01 00:00:00

abstract：:Previous studies have reported that basic fibroblast growth factor (bFGF) is associated with tumor genesis, growth and prognosis. The present study was conducted to detect the levels of bFGF expression in women with non-small cell lung cancer (NSCLC), colon cancer, breast cancer and melanoma, and analyze its associati...

journal_title：Oncology letters

authors： Liu M,Xing LQ

更新日期：2017-08-01 00:00:00

abstract：:Tricholemmal carcinoma is an extremely rare malignancy of the skin, and its biological behavior and management is controversial. The objective of the present study was to investigate the clinicopathological characteristics and management of tricholemmal carcinoma of the head and neck region. The study analyzed 15 pati...

journal_title：Oncology letters

authors： Feng Z,Zhu HG,Wang LZ,Zheng JW,Chen WT,Zhang Z,Dong W,Qu W,Wang YA

更新日期：2014-02-01 00:00:00

abstract：:Preoperative radiotherapy improves local disease control and disease-free survival in patients with advanced rectal cancer; however, a reliable predictive biomarker for the effectiveness of irradiation has yet to be elucidated. Phosphorylation of H2A histone family member X (H2AX) to γ-H2AX is induced by DNA double-st...

journal_title：Oncology letters

authors： Kawashima S,Kawaguchi N,Taniguchi K,Tashiro K,Komura K,Tanaka T,Inomata Y,Imai Y,Tanaka R,Yamamoto M,Inoue Y,Lee SW,Kawai M,Tanaka K,Okuda J,Uchiyama K

更新日期：2020-09-01 00:00:00