Chromosome instability in neuroblastoma.

Abstract:

:Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable prognosis exhibit several structural copy number variations (CNVs), whereas localized tumors belonging to patients in the low- and intermediate-risk classes, have favorable outcomes and display several numerical CNVs. Taken together these results are indicative of chromosome instability (CIN) in neuroblastoma tumor cells. The present review discusses multiple aspects of CIN including methods of measuring CIN, CIN targeting as a therapeutic strategy in cancer and the effects of CIN in neuroblastoma development and aggressiveness with particular emphasis on the CIN gene signature associated with HR neuroblastoma patients.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Fusco P,Esposito MR,Tonini GP

doi

10.3892/ol.2018.9545

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

6887-6894

issue

6

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-9545

journal_volume

16

pub_type

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