Abstract:
:Neuroblastoma is a neural crest-derived tumor that accounts for 7-10% of all malignancies in children and ~15% of all childhood cancer-associated mortalities. Approximately 50% of patients are characterized as high-risk (HR) and have an overall survival of <40% at 5 years from diagnosis. HR patients with unfavorable prognosis exhibit several structural copy number variations (CNVs), whereas localized tumors belonging to patients in the low- and intermediate-risk classes, have favorable outcomes and display several numerical CNVs. Taken together these results are indicative of chromosome instability (CIN) in neuroblastoma tumor cells. The present review discusses multiple aspects of CIN including methods of measuring CIN, CIN targeting as a therapeutic strategy in cancer and the effects of CIN in neuroblastoma development and aggressiveness with particular emphasis on the CIN gene signature associated with HR neuroblastoma patients.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Fusco P,Esposito MR,Tonini GPdoi
10.3892/ol.2018.9545subject
Has Abstractpub_date
2018-12-01 00:00:00pages
6887-6894issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-9545journal_volume
16pub_type
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