Abstract:
:Correlation of xeroderma pigmentosum complementation group F (XPF) expression with gastric cancer and prognosis was investigated. We randomly selected 76 gastric cancer patients who were admitted to the Second People's Hospital of Dezhou City and received treatment, and detected XPF expression in gastric cancer tissues (observation group) and normal gastric mucosa adjacent to tumor (control group) via immunohistochemistry. Correlation between XPF expression and clinicopathological indicators of gastric cancer was verified via single-factor Chi-square test. Cox's proportional hazard regression model was used in the analysis of influencing factors of patient's prognosis, and Kaplan-Meier was used to analyze the survival rates of XPF-positive and -negative patients. In the observation group, the XPF-positive rate was significantly higher than that in the control group with a statistically significant difference (P<0.05). Single-factor analysis showed that XPF expression was correlated with the family history and Laurén classification (P<0.05). Kaplan-Meier survival analysis revealed that the survival time of XPF-positive patients was shorter than that of XPF-negative patients (P<0.05). Multifactorial analysis using Cox's hazards model suggested that XPF was an independent factor affecting the prognosis of gastric cancer (P<0.05). In conclusion, XPF expression plays an important role in the occurrence and development of gastric cancer, and a high expression of XPF suggests a poor prognosis of gastric cancer patients.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Li P,Ma Ydoi
10.3892/ol.2018.9529subject
Has Abstractpub_date
2018-12-01 00:00:00pages
6971-6976issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-9529journal_volume
16pub_type
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