Berberine sensitizes mutliple human cancer cells to the anticancer effects of doxorubicin in vitro.

abstract：:The Ganoderma lucidum (G. lucidum) mushroom is one of the most extensively studied functional foods, known for its numerous health benefits, including the inhibition of tumor cell growth. The present study assessed the anti-proliferative and pro-apoptotic activity of a novel G. lucidum polysaccharide peptide (GL-PP) i...

journal_title：Oncology letters

authors： Wang C,Lin D,Chen Q,Lin S,Shi S,Chen C

更新日期：2018-04-01 00:00:00

abstract：:The present study reports the rare case of a patient with quintuple primary cancer that underwent systematic treatment, including surgical intervention. A 63-year-old male patient was initially diagnosed with primary esophageal cancer and hypopharyngeal cancer. The patient underwent total pharyngolaryngoesophagectomy ...

journal_title：Oncology letters

authors： Otowa Y,Nakamura T,Takiguchi G,Urakawa N,Ishida R,Imanishi T,Suzuki S,Tanaka K,Kuroda D,Kakeji Y

更新日期：2015-06-01 00:00:00

abstract：:The management of recurrent diffuse low-grade gliomas (LGGs) is controversial. In the present study, the multidisciplinary management of 35 patients with recurrent LGGs was retrospectively analyzed. Tumor progression or recurrence was defined by clinical, radiological and/or metabolic pejorative evolution. All patient...

journal_title：Oncology letters

authors： Spitaels J,Devriendt D,Sadeghi N,Luce S,De Witte O,Goldman S,Mélot C,Lefranc F

更新日期：2017-09-01 00:00:00

abstract：:Radiotherapy, particularly the target delineation of cancer based on scanned images, plays a key role in the planning of cancer treatment. Recently, diffusion-weighted magnetic resonance imaging (DW-MRI) has emerged as a prospective superior procedure compared with intensified computed tomography (CT) and positron emi...

journal_title：Oncology letters

authors： Zhang X,Fu Z,Gong G,Wei H,Duan J,Chen Z,Chen X,Wang R,Yin Y

更新日期：2017-09-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most prevalent malignancies worldwide and remains the third leading cause of cancer-associated mortality. The present study aimed to fully elucidate the pathogenesis of CRC and identify associated genes in tumor development. Microarray GSE44076, GSE41328 and GSE44861 datasets were...

journal_title：Oncology letters

authors： Shen X,Yue M,Meng F,Zhu J,Zhu X,Jiang Y

更新日期：2016-11-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) is a diterpenoid isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine. It was demonstrated in our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (i...

journal_title：Oncology letters

authors： Xie CQ,Zhou P,Zuo J,Li X,Chen Y,Chen JW

更新日期：2016-11-01 00:00:00

abstract：:Malignant gastrointestinal neuroectodermal tumors (GNETs) are rare aggressive malignant neoplasms that exclusively occur within the wall of the gastrointestinal tract. The GNET was first described as an 'osteoclast-rich tumor of the gastrointestinal tract with features resembling clear cell sarcoma (CCS) of soft parts...

journal_title：Oncology letters

authors： Huang GX,Chen QY,Zhong LL,Chen H,Zhang HP,Liu XF,Tang F

更新日期：2019-04-01 00:00:00

abstract：:The present study aimed to evaluate regional liver function impairment following transcatheter arterial chemoembolization (TACE), assessed by magnetic resonance imaging (MRI) enhanced by gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA). Additionally, this study evaluated the associations betwe...

journal_title：Oncology letters

authors： Xiao YD,Paudel R,Liu H,Zhang B,Ma C,Zhou SK

更新日期：2015-03-01 00:00:00

abstract：:Our previous study demonstrated that the 2-benzyloxybenzaldehyde analog CCY-1a-E2 is a potent compound against HL-60 human leukemia cell lines. To investigate the potential therapeutic application of CCY-1a-E2 for leukemia, we analyzed the antileukemic effects and safety of CCY-1a-E2 in the BALB/c mouse WEHI-3 allogra...

journal_title：Oncology letters

authors： Lin C,Yang JS,Tsai SC,Lin CF,Lee MR

更新日期：2013-03-01 00:00:00

abstract：:Lung cancer is one of the most lethal types of cancer, and its poor prognosis is primarily due to drug resistance and cancer recurrence. As it is associated with a low five-year survival rate, lung cancer stem cells (LCSCs) have been the subject of numerous recent studies. For these studies of LCSCs, lung cancer cell ...

journal_title：Oncology letters

authors： Wang Y,Jiang M,Du C,Yu Y,Liu Y,Li M,Luo F

更新日期：2018-05-01 00:00:00

abstract：:Little information from clinical trials is available regarding the efficacy of trastuzumab treatment in subcentimetric breast carcinomas (BCs). The aim of this study was to verify the existence of correlations between HER2 and hormone receptor status, Ki67 values, grade, histotype and node involvement in a cohort of p...

journal_title：Oncology letters

authors： Ieni A,Giuffrè G,Lanzafame S,Nuciforo G,Curduman M,Villari L,Roz E,Certo G,Cabibi D,Salomone E,Labate A,Messina D,Franco V,Adamo V,Tuccari G

更新日期：2012-01-01 00:00:00

abstract：:Gastrinoma is a gastrin-secreting tumor that is associated with Zollinger-Ellison syndrome. The majority of cases occur in the pancreas, followed by the duodenum. Early diagnosis is difficult due to the relative rarity of the tumor and the lack of specific symptoms. In the current study, a 68-year-old female patient p...

journal_title：Oncology letters

authors： Zhang WD,Liu DR,Wang P,Zhao JG,Wang ZF,Chen LI

更新日期：2016-05-01 00:00:00

abstract：:Telomeres are located at the ends of chromosomes and protect them from degradation. Suppressing the activity of telomerase, a telomere-synthesizing enzyme, and maintaining short telomeres is a protective mechanism against cancer in humans. In most human somatic cells, the expression of telomerase reverse transcriptase...

journal_title：Oncology letters

authors： Trybek T,Kowalik A,Góźdź S,Kowalska A

更新日期：2020-08-01 00:00:00

abstract：:Dysregulated expression of long non-coding RNAs has been determined to be important in cancer development; however, their role in tongue squamous cell carcinoma (TSCC) progression and carcinogenesis, to the best of our knowledge, is yet to be elucidated. The present study revealed that long intergenic non-coding RNA 0...

journal_title：Oncology letters

authors： Li X,Rui B,Cao Y,Gong X,Li H

更新日期：2020-03-01 00:00:00

abstract：:Segmental ureterectomy (SU) represents a promising alternative for the treatment of upper tract urothelial carcinomas (UTUCs) as it is a less invasive procedure and guarantees the preservation of renal units. The present study evaluated oncological outcomes and renal functions following SU when compared with radical n...

journal_title：Oncology letters

authors： Kato T,Nakayama R,Haba T,Kawaguchi M,Komiya A,Koike H

更新日期：2018-11-01 00:00:00

abstract：:The Wnt signaling pathway plays a crucial role in human cancer development, and axis inhibition protein 2 (Axin2) is a master scaffold protein involved in Wnt signaling. Axin2 negatively regulates Wnt signaling and acts as a tumor suppressor protein. The present study evaluated the association between the Axin2 single...

journal_title：Oncology letters

authors： Ma C,Liu C,Huang P,Kaku H,Chen J,Guo K,Ueki H,Sakai A,Nasu Y,Kumon H,Shimizu K,Watanabe M

更新日期：2014-08-01 00:00:00

abstract：:The clinical resistance of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has been linked to EGFR T790M resistance mutations or MET amplifications. Additional mechanisms underlying EGFR-TKI drug resistance remain unclear. The present study demonstrated t...

journal_title：Oncology letters

authors： Zhai Y,Zhang Y,Nan K,Liang X

更新日期：2017-05-01 00:00:00

abstract：:Aminoacylase 1 (ACY1) is important for regulating the proliferation of numerous types of cancer. However, the expression and mechanisms underlying the function of ACY1 in colorectal cancer remain unclear. In order to investigate the expression and function of ACY1 in colorectal cancer, tumor tissue and blood samples w...

journal_title：Oncology letters

authors： Yu B,Liu X,Cao X,Zhang M,Chang H

更新日期：2017-04-01 00:00:00

abstract：:The global incidence of prostate cancer (PCa) has been increasing in recent years. Meanwhile, some studies have indicated the association between malignancies, such as lung and gastric cancer and PCa, and microRNAs (miRNAs). The present study was designed to assess the prognostic value of miR-92b-3p in patients with P...

journal_title：Oncology letters

authors： Wang G,Cheng B,Jia R,Tan B,Liu W

更新日期：2021-01-01 00:00:00

abstract：:The present study aimed to examine the associations between the protein and mRNA expression levels of ovarian cancer gene 1 (OVCA1), cyclin D1 and p16 and high-risk human papillomavirus (HR-HPV) infection in cervical lesions. The protein expression levels of OVCA1, cyclin D1 and p16 in 66 cases of cervical cancer, 64 ...

journal_title：Oncology letters

authors： Tong R,Yang Q,Wang C,Bi F,Jiang B

更新日期：2017-05-01 00:00:00

abstract：:The present study reports the clinical data of two patients with renal pelvis carcinoma and one patient with renal carcinoma who developed port-site metastasis following retroperitoneal laparoscopic surgery. The current study aimed to identify the cause and prognosis of the occurrence of port-site metastasis subsequen...

journal_title：Oncology letters

authors： Wang N,Wang K,Zhong D,Liu X,Sun JI,Lin L,Ge L,Yang BO

更新日期：2016-06-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most common cause of cancer-associated mortality worldwide. Prostaglandin E2 (PGE2) regulates various biological processes, including invasion, proliferation and apoptosis. E-prostanoid 3 (Ep3) is a PGE2 receptor, and the functional role of Ep3 in the progression of NSCLC rema...

journal_title：Oncology letters

authors： Li L,Lv Y,Yan D

更新日期：2018-11-01 00:00:00

abstract：:Lymph node metastasis is the primary site of metastasis for patients with gallbladder cancer (GBC). Vascular endothelial growth factor-C (VEGF-C) has been implicated in the control of lymphangiogenesis and lymph node metastasis in various malignant tumors. However, the function of circulating VEGF-C is unclear and it ...

journal_title：Oncology letters

authors： Jiang L,Liu M,Cai X,Xie L,She F,Chen Y

更新日期：2018-11-01 00:00:00

abstract：:Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...

journal_title：Oncology letters

authors： Lu X,Cui J,Fu M,Wang W

更新日期：2016-07-01 00:00:00

abstract：:Solanine is an alkaloid and is the main extract of the traditional Chinese herb, Solanum nigrum Linn. It has been reported that Solanine has anti-inflammatory and antitumor properties. The present study aimed to investigate the antitumor effect of Solanine in Jurkat cells and demonstrate the molecular mechanism of ant...

journal_title：Oncology letters

authors： Yi YJ,Jia XH,Wang JY,Chen JR,Wang H,Li YJ

更新日期：2018-05-01 00:00:00

abstract：:Malignant melanoma can be successfully treated when it is identified in its early stages, but the disease is associated with a poor prognosis when it is detected in an advanced stage. Papillary thyroid carcinoma is a thyroid cancer that has a good prognosis. The present study reports a rare case of malignant melanoma ...

journal_title：Oncology letters

authors： Ozgun A,Tuncel T,Emirzeoglu L,Celik S,Bilgi O,Haholu A,Urhan M,Karagoz B

更新日期：2015-01-01 00:00:00

abstract：:Osteosarcoma is the most common primary bone tumor and predominantly affects children and adolescents. The prognosis for patients with osteosarcoma is poor. Therefore, the development of novel treatments for osteosarcoma is required. Photodynamic therapy (PDT) is a disease site-specific treatment that utilizes a photo...

journal_title：Oncology letters

authors： Zhang F,Zhu Y,Fan G,Hu S

更新日期：2018-10-01 00:00:00

abstract：:Leptomeningeal metastasis (LM) is increasingly common in patients with non-small cell lung cancer (NSCLC) due to improved treatment, and ultimately, prolonged patient survival. The current study is a pooled analysis that evaluated intrathecal chemotherapy (ITC) as a treatment for NSCLC patients with LM. The PUBMED, OV...

journal_title：Oncology letters

authors： Wu YL,Zhou L,Lu Y

更新日期：2016-08-01 00:00:00

abstract：:The outcomes of matched unrelated donor (MUD) hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST) in patients with severe aplastic anemia (SAA) remain controversial. The clinical outcome in patients that undergo transplantation following failed IST is typically poorer when compared with ...

journal_title：Oncology letters

authors： Hsu SN,Chen JH,Kao WY

更新日期：2014-10-01 00:00:00

abstract：:This study aims to comparatively analyze the impact of laparoscopic myomectomy (LM) and transcervical resection of myoma (TCRM) on ovarian function, immune function and quality of sexual life of patients with hysteromyoma. Two hundred and forty patients with hysteromyoma admitted into the Second Affiliated Hospital of...

journal_title：Oncology letters

authors： Zhang Y,Gu X,Meng Y,Guo H,Du J,Xing W

更新日期：2018-03-01 00:00:00