Abstract:
:Nucleobindin 2 (NUCB2) is mainly expressed in the hypothalamic nuclei and has a proven role in energy homeostasis. It has also been recently reported to have a key role in tumor progression. However, the clinical significance of NUCB2 in colorectal cancer (CRC) remains unknown. In the present study, the level of NUCB2 mRNA was quantified by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in 34 paired fresh tissues from patients with CRC. RT-qPCR was followed by immunohistochemical (IHC) staining of NUCB2 protein in tissue microarrays of 251 samples to evaluate the clinical significance of NUCB2 in CRC. The RT-qPCR indicated an upregulation of NUCB2 mRNA in CRC tissues compared with normal tissues (P=0.027). IHC staining indicated a positive association between elevated NUCB2 expression and lymph node metastasis or tumor-node-metastasis (TNM) stage. Patients with CRC and lymph node metastasis demonstrated a higher expression of NUCB2 (49.5%, 50/101) compared with those without lymph node metastasis (36.7%, 55/150; P=0.043). Furthermore, NUCB2 expression was also higher in patients with CRC and TNM stage III-IV compared with those with TNM stage I-II (50.9% vs. 35.0%; P=0.011). However, Kaplan-Meier analysis indicated no significant association between NUCB2 expression and disease-free survival of patients. Additionally, multivariate analysis did not identify the upregulation of NUCB2 as an independent prognostic predictor in patients with CRC (P=0.755). In conclusion, the present study demonstrated that upregulation of NUCB2 is significantly associated with CRC metastasis, indicating that NUCB2 may be a cancer-associated oncogene associated with the aggressive progression of CRC.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Xie J,Chen L,Chen Wdoi
10.3892/ol.2018.8523subject
Has Abstractpub_date
2018-06-01 00:00:00pages
9188-9194issue
6eissn
1792-1074issn
1792-1082pii
OL-0-0-8523journal_volume
15pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Correlation of APOBEC3G expression with liver function indexes of patients with chronic hepatitis B and its expression in chronic hepatitis B, liver cirrhosis and liver cancer were investigated to evaluated the significance of APOBEC3G. Fifty-eight patients with chronic hepatitis B were selected, including 20 cases of...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11257
更新日期:2020-03-01 00:00:00
abstract::Human papilloma virus (HPV) infection has previously been reported to be associated with TP53 and TP16 expression in Japanese and Taiwanese patients with lung cancer, but data for advanced non-small cell lung cancer (NSCLC) patients is limited. The present study examined the association between HPV infection and TP53 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5087
更新日期:2016-11-01 00:00:00
abstract::The aim of the present study was to evaluate the clinical importance of melanoma-associated antigen D4 (MAGE-D4) expression in glioma, and to identify it as a valuable prognostic biomarker and therapeutic target. To achieve this, the expression of MAGE-D4 protein in 124 tumor tissues from patients with glioma was meas...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7884
更新日期:2018-04-01 00:00:00
abstract::Previous studies have revealed the aberrant expression of a number of microRNAs (miRNA/miRs) in the blood circulation of patients with breast cancer (BC). The aim of the present study was to assess the effect of neoadjuvant chemotherapy on the levels of a panel of BC-associated miRNAs, which are at relatively low (let...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2188
更新日期:2014-08-01 00:00:00
abstract::The danger of overexposure to solar ultraviolet radiation has been widely reviewed since the 1980s due to the depletion of the ozone layer. However, the benefits of mild exposure of the skin to ultraviolet (UV) light have not been widely investigated. Numerous reports have demonstrated that an association exists betwe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3519
更新日期:2015-10-01 00:00:00
abstract::In recent years, the use of statins has been reported to be associated with a reduced risk of prostate cancer (PCa), particularly metastatic PCa. The mechanisms underlying these epidemiological observations are poorly understood. Epithelial-mesenchymal transition (EMT) is a critical initial step and a hallmark for can...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4404
更新日期:2016-05-01 00:00:00
abstract::Exophthalmos, myxedema and osteoarthropathy (EMO) comprise the triad known as EMO syndrome, which is rarely observed in patients with autoimmune thyroid disease. The present study reports the case of a patient with EMO, including the response of this rare combination to radiotherapy. A 48-year-old patient with EMO syn...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2990
更新日期:2015-05-01 00:00:00
abstract::Natural dietary components have become the subject of an increasing amount of interest due to the side effects of anticancer treatment. Pterostilbene, an analog of resveratrol, is primarily found in grapes, and has been suggested to exert antioxidant and anticancer effects in different tumor types. The present study a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10499
更新日期:2019-08-01 00:00:00
abstract::A tissue-specific promoter can control downstream gene expression in tissues or organs. The human involucrin (hINV) promoter (pINV) that contains 2474 bp of hINV upstream sequence is able to regulate tissue-specific gene expression. This tissue specificity may be important for the prevention and treatment of human pap...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2736
更新日期:2015-02-01 00:00:00
abstract::The recognition of the biological relevance of long non-coding RNA (lncRNA) molecules has only recently been recognized as one of the most significant advances in contemporary molecular biology. A growing body of evidence indicates that lncRNAs act not only as the intermediary between DNA and protein but also as signi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3553
更新日期:2015-10-01 00:00:00
abstract::Numerous studies have shown that marital status may be a prognostic factor in various malignancies, but little is known about its effect on duodenal adenocarcinoma. The aim of the present study was to determine the association between marital status and survival in patients with duodenal adenocarcinoma. The Surveillan...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10475
更新日期:2019-08-01 00:00:00
abstract::microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decrease...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8609
更新日期:2018-07-01 00:00:00
abstract::Interleukin (IL)-37, a new IL-1 family member, has received increasing attention in recent years. In the past decade, it has been determined that IL-37 is expressed in various normal cells and tissues and is regulated by inflammatory stimuli and pro-cytokines via different signal transduction pathways. Recently, it ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7982
更新日期:2018-04-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a serious threat to human health. Chemotherapy drugs such as cisplatin are widely used in cancer treatment, but can cause severe side effects. Hydroxyl safflower yellow A (HSYA) is a water-soluble chalcone glycoside substance extracted from safflowers (Carthamus tinctorius L.) that ha...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.9946
更新日期:2019-03-01 00:00:00
abstract::Clear cell sarcoma of soft tissues is a very rare, malignant soft tissue tumor that usually arises in the extremities, with a predilection for the lower limbs. This report presents a 45-year-old male with a painless mass in the right lumbar region for one year. Magnetic resonance imaging showed a 3.6×3.2×1.5-cm soft t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2372
更新日期:2014-10-01 00:00:00
abstract::Evidence-based guidelines for the prevention of surgical site infection (SSI) have been published by the U.S. Centers for Disease Control and Prevention (CDC). According to these guidelines, a wound should usually be covered with a sterile dressing for 24 to 48 h when a surgical incision is closed primarily. However, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.687
更新日期:2012-07-01 00:00:00
abstract::The aim of the present study was to determine the usefulness of the positron emission tomography/computed tomography (PET/CT) with 18F-fluorodeoxyglucose (FDG) in the detection of recurrence or metastasization of differentiated thyroid carcinoma (DTC) in patients with abnormal thyroglobulin levels and negative finding...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4229
更新日期:2016-04-01 00:00:00
abstract::The prognosis following surgical treatment of gastric carcinoma (GC) or gastroesophageal junction (GEJ) adenocarcinoma remains poor. Although adjuvant chemo-radiotherapy with 5-fluorouracil has been shown to be beneficial, a high rate of distant failure has been reported. Thus, the toxicity profile and efficacy of an ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.617
更新日期:2012-05-01 00:00:00
abstract::The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks after intervention. P...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1407
更新日期:2013-08-01 00:00:00
abstract::Bladder cancer (BC) is one of the most common urogenital malignancies. However, present studies of its multiple gene interaction and cellular pathways remain unable to accurately verify the genesis and the development of BC. The aim of the present study was to investigate the genetic signatures of BC and identify its ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9002
更新日期:2018-09-01 00:00:00
abstract::Although ring finger protein 2 (RNF2) serves an important role in the occurrence, development and regulation of various types of cancer, RNF2 expression in skin squamous cell carcinoma (SCC) remains unknown. The aim of the present study was to investigate the role of RNF2 expression in SCC and adjacent tissues from pa...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11666
更新日期:2020-08-01 00:00:00
abstract::A common method to distinguish large cell neuroendocrine carcinoma (LCNEC) from non-neuroendocrine large cell carcinoma (non-NE LCC) is from using specific immunohistochemistry markers, such as CgA, Syn, CD56 and Napsin A, however, the results remain controversial using these markers. Secretagogin (SCGN) is a newly di...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11336
更新日期:2020-03-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is generally considered one of the most common gastrointestinal malignant tumors, characterized by high invasiveness and metastatic rate, as well as insidious onset. A relationship between carcinogenicity and aberrant microRNA-139-5p (miR-139-5p) expression has been identified in multipl...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11031
更新日期:2019-12-01 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the most common cause of cancer-associated mortality worldwide. Prostaglandin E2 (PGE2) regulates various biological processes, including invasion, proliferation and apoptosis. E-prostanoid 3 (Ep3) is a PGE2 receptor, and the functional role of Ep3 in the progression of NSCLC rema...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9391
更新日期:2018-11-01 00:00:00
abstract::Lung cancer is one of the most common malignant cancers in the Czech Republic in men, with the highest mortality rate of all the malignant diseases. The development of biological treatment enables study into novel personalized treatment options. This type of treatment is usually of high quality, and is often demanding...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7167
更新日期:2017-12-01 00:00:00
abstract::Numerous genetic alterations have been implicated in the development of prostate cancer (PCa). DNA and protein microarrays have enabled the identification of genes associated with apoptosis, which is important in PCa development. Despite the molecular mechanisms are not entirely understood, inhibition of apoptosis is ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4983
更新日期:2016-10-01 00:00:00
abstract::The aim of the present study was to identify and characterize side population (SP) cells in primary cervical cancer. A primary culture was successfully established, and the SP cells were isolated via fluorescence-activated cell sorting. Subsequently, in vitro analysis of clonogenic capacity by soft agar assay and in v...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6606
更新日期:2017-09-01 00:00:00
abstract::Hypericum ascyron L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. The aim of the present study was to clarify the anticancer a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7812
更新日期:2018-03-01 00:00:00
abstract::A 20-year-old male presented to hospital with blood in the mucus, which had occurred for 6 months, and was diagnosed with nasopharyngeal carcinoma (NPC). Due to passive smoking, the patient developed a constant and violent cough, pain behind the right ear and swelling of the retropharynx. The results of a computed tom...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4473
更新日期:2016-06-01 00:00:00
abstract::An elevated neutrophil to lymphocyte ratio (NLR) has been reported to be associated with the pathological response to neoadjuvant therapies in numerous types of cancer. The aim of the current study was to clarify the association between pre-treatment NLR and the pathological response to preoperative chemoradiotherapy ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4057
更新日期:2016-02-01 00:00:00