Simvastatin blocks TGF-β1-induced epithelial-mesenchymal transition in human prostate cancer cells.

abstract：:The downregulation of farnesoid X receptor (FXR; gene name, nuclear receptor subfamily 1 group h member 4), an enteric nuclear bile acid receptor, has been reported in colorectal carcinoma (CRC), and FXR expression has been inversely correlated with CRC stage and clinical outcome. FXR knockdown in chronic colitis mous...

journal_title：Oncology letters

authors： Mao J,Chen X,Wang C,Li W,Li J

更新日期：2020-07-01 00:00:00

abstract：:In order to assess the metastatic potential of residual hepatocellular carcinoma (HCC) following insufficient radiofrequency ablation (RFA) and to improve the current animal model, an insufficient RFA orthotopic nude mouse model of HCC was developed in the present study. A human HCC orthotopic nude mouse model was est...

journal_title：Oncology letters

authors： Zhang N,Zhu H,Dong YH,Wang L

更新日期：2019-09-01 00:00:00

abstract：:Focal adhesion kinase (FAK) has long been considered to be a key regulator of growth factor receptor- and integrin-mediated signals, with pivotal roles in tumor cells through its kinase activity and scaffolding function. Increased FAK expression and activity has been observed in tumors of various origins and is often ...

journal_title：Oncology letters

authors： Li M,Hou F,Zhao J,Zhang T,Li D,Wu W,Liu X,Xu L

更新日期：2018-03-01 00:00:00

abstract：:Extra-adrenal pheochromocytomas are rare tumors that originate from the chromaffin tissue of the sympathetic nervous system. Ovarian extra-adrenal pheochromocytoma is even more rare. The present study reports a rare case of an extra-adrenal pheochromocytoma that was localized to the right ovary, but was gynecologicall...

journal_title：Oncology letters

authors： Liu H,Li WZ,Wang XY,Pei YG,Long XY,Chen CY,Hu YB

更新日期：2015-02-01 00:00:00

abstract：:Previous studies have demonstrated an association between human papillomavirus (HPV) and mutations in the epidermal growth factor receptor (EGFR) gene in lung cancer patients; however, few studies have investigated this association in advanced lung adenocarcinoma patients undergoing gefitinib treatment. The present st...

journal_title：Oncology letters

authors： Li M,Deng F,Qian LT,Meng SP,Zhang Y,Shan WL,Zhang XL,Wang BL

更新日期：2016-09-01 00:00:00

abstract：:TERT is the main functional unit of telomerase, which maintains telomere length and chromosome structure stability. TERT has been shown to act as a key factor in various biological processes, such as cell proliferation, via uncharacterized mechanisms. We transfected HEp-2 laryngeal carcinoma cells with a TERT overexpr...

journal_title：Oncology letters

authors： Jiang Y,Chen C,Chen SM,Wang YQ,Xu Y,Wang Y,Chen Z,Xiao BK,Tao ZZ

更新日期：2013-07-01 00:00:00

abstract：:Hepatic epithelioid angiomyolipoma (EAML) is a rare type of hepatic tumor. Due to a lack of adequate understanding about this tumor, hepatic EAML is often misdiagnosed as other diseases with similar clinical characteristics such as hepatic cancer. In the present study, 3 cases of hepatic EAML are reported, and the mai...

journal_title：Oncology letters

authors： Liu W,Meng Z,Liu H,Li W,Wu Q,Zhang X,E C

更新日期：2016-06-01 00:00:00

abstract：:Lung cancer, a malignant tumor, is the most frequently fatal cancer, with poor survival rates in the advanced stages. In order to improve the understanding of this disease, and to improve the outcomes of patients, additional studies are required. In the present study, differentially expressed genes (DEGs) in patients ...

journal_title：Oncology letters

authors： Xu X,Cao L,Zhang Y,Yin Y,Hu X,Cui Y

更新日期：2018-01-01 00:00:00

abstract：:A nitroxide radical, Tempol (Tempol, TPL), is usually used as an antioxidative agent clinically, whereas the mechanism underlying its pro-oxidative effect has not been thoroughly investigated. The present study investigated the pro-oxidative effect of TPL on the inhibition of cellular proliferation and its role in enh...

journal_title：Oncology letters

authors： Wang M,Li K,Zou Z,Li L,Zhu L,Wang Q,Gao W,Wang Y,Huang W,Liu R,Yao K,Liu Q

更新日期：2018-10-01 00:00:00

abstract：:The aim of this study was to detect methylation of the RAR-β gene in tissues from non-small cell lung cancer (NSCLC) patients. The methylation of the RAR-β gene in DNA from 80 cases with NSCLC and corresponding non-malignant tissues was tested using methylation-specific polymerase chain reaction (PCR; MSP). The result...

journal_title：Oncology letters

authors： Zhao X,Wang N,Zhang M,Xue S,Shi K,Chen Z

更新日期：2012-03-01 00:00:00

abstract：:Giant cell tumor of bone (GCTB) is a primary benign bone tumor with a locally aggressive character. Definitive descriptions of the site of origin for this type of tumor are not available. The aim of the present study was to evaluate the site of origin of GCTB of long bones with regards to epiphyseal lines by means of ...

journal_title：Oncology letters

authors： Futamura N,Urakawa H,Tsukushi S,Arai E,Kozawa E,Ishiguro N,Nishida Y

更新日期：2016-04-01 00:00:00

abstract：:The danger of overexposure to solar ultraviolet radiation has been widely reviewed since the 1980s due to the depletion of the ozone layer. However, the benefits of mild exposure of the skin to ultraviolet (UV) light have not been widely investigated. Numerous reports have demonstrated that an association exists betwe...

journal_title：Oncology letters

authors： Rivas M,Rojas E,Araya MC,Calaf GM

更新日期：2015-10-01 00:00:00

abstract：:Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein and exhibits an organ-dependent expression pattern in cancer. PSCA is upregulated in prostate cancer and downregulated in gastric cancer. PSCA is expressed in a variety of human organs. Although certain studies prev...

journal_title：Oncology letters

authors： Ono H,Sakamoto H,Yoshida T,Saeki N

更新日期：2018-03-01 00:00:00

abstract：:Hypericum ascyron L. (Great St. Johnswort), which belongs to the Hypericaceae family, has been used for the treatment of hematemesis, metrorrhagia, rheumatism, swelling, stomach ache, abscesses, dysentery and irregular menstruation for >2,000 years in China. The aim of the present study was to clarify the anticancer a...

journal_title：Oncology letters

authors： Li XM,Luo XG,He JF,Wang N,Zhou H,Yang PL,Zhang TC

更新日期：2018-03-01 00:00:00

abstract：:Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...

journal_title：Oncology letters

authors： Lu X,Cui J,Fu M,Wang W

更新日期：2016-07-01 00:00:00

abstract：:The aim of the present study was to develop a procedure for the isolation of circulating tumor cells (CTCs), and to evaluate its application in the detection of epidermal growth factor receptor (EGFR) mutations, and potential heterogeneity in patients with non-small-cell lung cancer (NSCLC). Peripheral blood samples w...

journal_title：Oncology letters

authors： Zhang Q,Nong J,Wang J,Yan Z,Yi L,Gao X,Liu Z,Zhang H,Zhang S

更新日期：2019-04-01 00:00:00

abstract：:Serine/threonine kinase 39 (STK39) is associated with hypertension, autism, Parkinson's disease and various types of cancer in recent years. This study investigated STK39 expression and possible roles in osteosarcoma using qPCR and western blot analysis. Compared to normal bone tissues, the mRNA and protein expression...

journal_title：Oncology letters

authors： Huang T,Zhou Y,Cao Y,Tao J,Zhou ZH,Hang DH

更新日期：2017-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 base pairs that regulate the expression of genes by targeting messenger RNA with complementarity with the miRNA base sequence. Regulation of gene expression by miRNAs is crucial in cellular development and differentiation, and recent studies suggest a re...

journal_title：Oncology letters

authors： Yanokura M,Banno K,Kobayashi Y,Kisu I,Ueki A,Ono A,Masuda K,Nomura H,Hirasawa A,Susumu N,Aoki D

更新日期：2010-11-01 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, and its incidence has been on the increase in recent years. However, the molecular mechanism of PTC is unclear and misdiagnosis remains a major issue. Therefore, the present study aimed to investigate this mechanism, and to identify key pr...

journal_title：Oncology letters

authors： Liu Y,Gao S,Jin Y,Yang Y,Tai J,Wang S,Yang H,Chu P,Han S,Lu J,Ni X,Yu Y,Guo Y

更新日期：2020-01-01 00:00:00

abstract：:LIM domain containing 2 (LIMD2) is a small LIM-only protein that has been demonstrated to promote tumor progression; however, the expression and function of LIMD2 in non-small cell lung cancer (NSCLC) has not previously been reported. In the present study, reverse transcription-quantitative PCR and western blot analys...

journal_title：Oncology letters

authors： Zhang F,Qin S,Xiao X,Tan Y,Hao P,Xu Y

更新日期：2019-08-01 00:00:00

abstract：:Lung adenocarcinoma (LUAD) is a major subtype of non-small cell lung cancer. Despite significant progress in its diagnosis and treatment, the mortality and morbidity rate of LUAD remains high worldwide. The aim of the present study was to perform a systematic investigation of the tumor microenvironment (TME) and ident...

journal_title：Oncology letters

authors： Yuan J,Yuan B,Zeng L,Liu B,Chen Y,Meng X,Sun R,Lv X,Wang W,Yang S

更新日期：2020-08-01 00:00:00

abstract：:Vasculogenic mimicry (VM) formation is important for invasion and metastasis of tumor cells in gastric adenocarcinoma (GAC). The present study aimed to investigate the association between signal transducer and activator of transcription-3 (STAT3), phosphor-STAT3 (p-STAT3), hypoxia-inducible factor-1α (HIF-1α) and VM f...

journal_title：Oncology letters

authors： Song YY,Sun LD,Liu ML,Liu ZL,Chen F,Zhang YZ,Zheng Y,Zhang JP

更新日期：2014-07-01 00:00:00

abstract：:The present study aimed to investigate the association between excision repair cross-complementation group 1 (ERCC1) expression and clinical resistance to platinum-based chemotherapy or clinical characteristics, including survival time, in patients with epithelial ovarian cancer (EOC). ERCC1 expression was determined ...

journal_title：Oncology letters

authors： Du P,Wang Y,Chen L,Gan Y,Wu Q

更新日期：2016-08-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer-associated mortality worldwide. The present study investigated the effects of K9(C4H4FN2O2)2Nd(PW11O39)2·25H2O (FNdPW), a chemically synthesized polyoxometalate that contains rare earth elements, on lung cancer growth, and explored the mechanism underlying its actions. The ef...

journal_title：Oncology letters

authors： Xia RY,Zhang RR,Jiang Z,Sun YJ,Liu J,Chen FH

更新日期：2017-03-01 00:00:00

abstract：:The aim of the present study was to establish a prediction index (PI) model for the 5-year survival rate of patients with hepatitis B-related hepatocellular carcinoma (HCC) after radical resection, and to evaluate the effect of prophylactic transcatheter arterial chemoembolization (TACE). A total of 201 patients with ...

journal_title：Oncology letters

authors： He S,Fan X,Ma H,Xiaerfuhazi H,Rehato A,Feng J,Shi X,He F

更新日期：2019-08-01 00:00:00

abstract：:Activating mutations in the cytosolic serine/threonine kinase, BRAF, have been reported in a variety of neoplasms. BRAF activation may contribute to tumor growth via activation of the MAP/ERK kinase pathway, and BRAF represents a possible therapeutic target. Activating BRAF mutations were recently reported in approxim...

journal_title：Oncology letters

authors： Köllermann J,Albrecht H,Schlomm T,Huland H,Graefen M,Bokemeyer C,Simon R,Sauter G,Wilczak W

更新日期：2010-07-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) promotes invasive and migratory activities by upregulating Forkhead box protein M1 (FoxM1) expression. The present study investigated whether modulation of MnSOD and FoxM1 expression was responsible for the antitumor effects of genistein on cancer stem-like cells (CSLCs) derived ...

journal_title：Oncology letters

authors： Fu Z,Cao X,Liu L,Cao X,Cui Y,Li X,Quan M,Ren K,Chen A,Xu C,Qiu Y,Chen X,Wang Z,Cao J

更新日期：2020-09-01 00:00:00

abstract：:For individualized bevacizumab-based therapy, non-invasive biomarkers are necessary. This study assessed the predictive value of plasma vascular endothelial growth factor (VEGF)-A, soluble VEGF receptor (sVEGFR)-1 and sVEGFR-2 levels as biomarkers for clinical response and survival in advanced colorectal cancer (CRC) ...

journal_title：Oncology letters

authors： Aoyagi Y,Iinuma H,Horiuchi A,Shimada R,Watanabe T

更新日期：2010-03-01 00:00:00

abstract：:Pulmonary inflammatory myofibroblastic tumors (PIMTs) are extremely rare in adults. If occurring in patients >40 years old, PIMT should be rapidly distinguished from lung cancer. The present study aimed to characterize the imaging features of PIMT in patients >40 years old in order to improve the diagnosis of PIMT. Th...

journal_title：Oncology letters

authors： Wu J,Zhu H,Li K,Yuan CY,Wang YF,Lu GM

更新日期：2015-04-01 00:00:00

abstract：:DJ-1 and HSP90α play a significant role in the progression of various types of cancer and are known to be associated with phosphatase and tensin homolog deleted on chromosome 10 (PTEN), PI3K-p110α and pAkt, the signaling molecule proteins from the phosphatidylinositol 3-kinase (PI3K) pathway. However, the expression o...

journal_title：Oncology letters

authors： Lee H,Choi SK,Ro JY

更新日期：2012-03-01 00:00:00