Human wings apart-like gene is specifically overexpressed in cervical cancer.

abstract：:Malignant gastrointestinal neuroectodermal tumor (GNET) is a rare soft tissue sarcoma, previously referred to as clear cell sarcoma-like gastrointestinal tumor (CCSLGT) and also commonly reported in the literature as clear cell sarcoma of the gastrointestinal tract (CCS-GI). The current study reports a case of GNET ar...

journal_title：Oncology letters

authors： Kong J,Li N,Wu S,Guo X,Gu C,Feng Z

更新日期：2014-12-01 00:00:00

abstract：:Hypoxia-inducible factor-1α (HIF-1α) and toll-like receptor 4 (TLR4) are involved in numerous mechanisms of cancer biology, including cell proliferation and survival; however the interaction of the two factors under hypoxic conditions remains unclear. The present study investigated the in vitro mechanism that results ...

journal_title：Oncology letters

authors： Zhang X,Li S,Li M,Huang H,Li J,Zhou C

更新日期：2016-08-01 00:00:00

abstract：:The issue of delayed neurological damage as a result of treatment is becoming increasingly important now that an increased number of children survive treatment for acute lymphoblastic leukemia (ALL). Following modification of the treatment protocols, severe symptomatic late effects are rare, and most adverse effects a...

journal_title：Oncology letters

authors： Badr MA,Hassan TH,El-Gerby KM,Lamey ME

更新日期：2013-02-01 00:00:00

abstract：:The aim of the present study was to investigate the inhibitory effects of dihydroartemisinin (DHA) on the primary tumor growth and metastasis of the human breast cancer cell line, MDA-MB-231, in vitro. The expression levels of urokinase-type plasminogen activator (uPA) were detected by immunocytochemistry in two cell ...

journal_title：Oncology letters

authors： Zhang S,Ma Y,Jiang J,Dai Z,Gao X,Yin X,Xi W,Min W

更新日期：2014-05-01 00:00:00

abstract：:5-lipoxygenase (5-LO) catalyzes the first step of arachidonic acid metabolism to inflammatory mediator leukotrienes. The present study assessed 5-LO expression in esophageal squamous cell carcinoma (ESCC) tissue specimens for associations with clinicopathological and survival data from patients, then explored 5-LO act...

journal_title：Oncology letters

authors： Bai CY,Zhang JY,Shi TW,Bai YQ,Wu BL,Du ZP,Wu ZY,Xu XE,Wang SH,Wu JY,Te RY,Zhang JY,Xu LY,Li EM

更新日期：2018-06-01 00:00:00

abstract：:Wiskott-Aldrich syndrome protein family member 3 (WASF3) is required for invasion and metastasis in different cancer cell types, and has been demonstrated to possess prognostic value in various types of human cancer. However, to the best of our knowledge, the expression profile of WASF3 and its correlations with the c...

journal_title：Oncology letters

authors： Wu J,Wang GC,Chen XJ,Xue ZR

更新日期：2014-09-01 00:00:00

abstract：:Periosteal chondrosarcoma is an extremely rare low-grade malignant cartilaginous tumor arising from the external bone surface. Diagnosis of periosteal chondrosarcomas may be challenging, since this condition closely resembles periosteal chondromas. It has been reported that positron emission tomography (PET) is useful...

journal_title：Oncology letters

authors： Morimoto S,Futani H,Tsuchiyama K,Fukunaga S,Tsukamoto Y,Yoshiya S

更新日期：2014-06-01 00:00:00

abstract：:The CyberKnife® is expected to be a novel local treatment for hepatocellular carcinoma (HCC), however, a long-term follow-up using dynamic computed tomography and magnetic resonance imaging is required to determine the effect of treatment in a number of the affected patients. Therefore, there is a requirement to evalu...

journal_title：Oncology letters

authors： Shiozawa K,Watanabe M,Ikehara T,Kobayashi K,Ochi Y,Suzuki Y,Fuchinoue K,Yoneda M,Kenmochi T,Okubo Y,Mori T,Makino H,Tsukamoto N,Igarashi Y,Sumino Y

更新日期：2016-01-01 00:00:00

abstract：:This study was designed to explore the expression of phosphoinositide-dependent protein kinase 1 (PDK-1), deleted in malignant brain tumors (DMBT1) in the thyroid carcinoma. A total of 87 fresh samples of thyroid carcinoma from surgical resection in The Second People's Hospital of Lianyungang from June 2016 to March 2...

journal_title：Oncology letters

authors： Sun Z,Xu L

更新日期：2019-09-01 00:00:00

abstract：:Aberrant promoter methylation of tumor relevant genes frequently occurs in early steps of carcinogenesis and during tumor progression. Epigenetic alterations could be used as potential biomarkers for early detection and for prediction of prognosis and therapy response in lung cancer. The present study quantitatively a...

journal_title：Oncology letters

authors： Duppel U,Woenckhaus M,Schulz C,Merk J,Dietmaier W

更新日期：2016-10-01 00:00:00

abstract：:The epidermal growth factor receptor (EGF-R) signaling pathway is thought to have an important role in the development and progression of several carcinomas, as it is associated with cell proliferation, differentiation and migration. Activation of EGF-R signaling regulates epithelial-mesenchymal transition (EMT)-assoc...

journal_title：Oncology letters

authors： Cui L,Song J,Wu L,Cheng L,Chen A,Wang Y,Huang Y,Huang L

更新日期：2017-01-01 00:00:00

abstract：:The aim of this study was to investigate the effect of dexmedetomidine (Dex) on the respiratory function during anesthesia induction in pediatric patients undergoing retinoblastoma (RB) resection. A total of 87 pediatric patients who underwent RB resection in Yidu Central Hospital of Weifang were recruited into this s...

journal_title：Oncology letters

authors： Rong X,Sun C,Zhang F,Zheng J

更新日期：2019-03-01 00:00:00

abstract：:S100A11, a member of S100 calcium-binding protein family, is associated with the numerous processes of tumorigenesis and metastasis. In the present study, the role of S100A11, and its possible underlying mechanisms in cell proliferation, apoptosis and cell cycle distribution in human pancreatic cancer were explored. I...

journal_title：Oncology letters

authors： Xiao M,Li T,Ji Y,Jiang F,Ni W,Zhu J,Bao B,Lu C,Ni R

更新日期：2018-01-01 00:00:00

abstract：:The aim of the present study is to investigate if rapamycin is a radiosensitizer of nasopharyngeal carcinoma (NPC), and to identify which pathways are involved in radiation sensitization. In vitro, using untreated cells as the control, NPC cells were treated with rapamycin, ionizing radiation (IR) or both. Differences...

journal_title：Oncology letters

authors： Wang D,Gao L,Liu X,Yuan C,Wang G

更新日期：2017-07-01 00:00:00

abstract：:The present study aimed to identify microRNA (miRNA) expression profiles associated with brain metastases of colorectal cancers. We conducted miRNA expression profiling of 3 primary colorectal cancers and 3 brain-metastatic carcinomas using Agilent Human miRNA Microarrays. Quantitative real-time reverse transcription-...

journal_title：Oncology letters

authors： Li Z,Gu X,Fang Y,Xiang J,Chen Z

更新日期：2012-02-01 00:00:00

abstract：:Inhibition of nuclear factor-κB (NF-κB) results in antitumor activity in leukemia cells, and may be a potential therapeutic strategy for the treatment of leukemia. However, a significant limitation of NF-κB inhibition in the treatment of leukemia is the low efficiency of this technique. NF-κB inhibitor treatment induc...

journal_title：Oncology letters

authors： Dong QM,Ling C,Chen X,Zhao LI

更新日期：2015-12-01 00:00:00

abstract：:The present study aims to investigate the radiosensitization effect of the migration and invasion inhibitory protein (MIIP) gene on nasopharyngeal carcinoma (NPC) cells. The MIIP gene was transfected into NPC 5-8F and CNE2 cells. The level of MIIP was analyzed by quantitative reverse transcription-polymerase chain rea...

journal_title：Oncology letters

authors： Zhou HP,Qian LX,Zhang N,Gu JJ,Ding K,Wu J,Lu ZW,Du MY,Zhu HM,Wu JZ,He X,Yin L

更新日期：2018-06-01 00:00:00

abstract：:The present study aimed to assess the B rapidly accelerated fibrosarcoma (BRAFV600E) status in plasma from Chinese patients with melanoma, and evaluated its prognostic value following treatment with BRAF inhibitors. Mutation-specific 3D digital polymerase chain reaction (dPCR) was used to quantify BRAFV600E in circula...

journal_title：Oncology letters

authors： Tang H,Kong Y,Si L,Cui C,Sheng X,Chi Z,Dai J,Yu S,Ma M,Wu X,Yu J,Xu T,Yu H,Yan J,Guo J

更新日期：2018-02-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microarray analysis was u...

journal_title：Oncology letters

authors： Jiang Y,Luan Y,Chang H,Chen G

更新日期：2018-09-01 00:00:00

abstract：:Cholangiocarcinoma (CCA) is a malignancy with no effective therapy and poor prognosis. Forbesione, a caged xanthone isolated from Garcinia hanburyi, has been reported to inhibit proliferation and to induce apoptosis in human CCA cell lines. The present study aimed to further explore the potential anticancer properties...

journal_title：Oncology letters

authors： Boueroy P,Hahnvajanawong C,Boonmars T,Saensa-Ard S,Anantachoke N,Vaeteewoottacharn K,Reutrakul V

更新日期：2016-12-01 00:00:00

abstract：:The clinicopathological value and exploration of the potential molecular mechanism of microRNA-183-5p (miR-183-5p) have been investigated in various cancers; however, to the best of the author's knowledge, no similar research has been reported for bladder cancer. In the present study, it was revealed that the expressi...

journal_title：Oncology letters

authors： Gao JM,Huang LZ,Huang ZG,He RQ

更新日期：2018-04-01 00:00:00

abstract：:TERT is the main functional unit of telomerase, which maintains telomere length and chromosome structure stability. TERT has been shown to act as a key factor in various biological processes, such as cell proliferation, via uncharacterized mechanisms. We transfected HEp-2 laryngeal carcinoma cells with a TERT overexpr...

journal_title：Oncology letters

authors： Jiang Y,Chen C,Chen SM,Wang YQ,Xu Y,Wang Y,Chen Z,Xiao BK,Tao ZZ

更新日期：2013-07-01 00:00:00

abstract：:Preeclampsia (PE) is characterized by gestational hypertension and proteinuria, and is a leading cause of maternal death and perinatal morbidity globally. Although the exact cause of PE remains unclear, several studies have suggested a role for abnormal expression of multiple genes. The aim of the present study was to...

journal_title：Oncology letters

authors： Xu Z,Wu C,Liu Y,Wang N,Gao S,Qiu S,Wang Z,Ding J,Zhang L,Wang H,Wu W,Wan B,Yu J,Fang J,Yang P,Shao Q

更新日期：2020-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common types of human tumors, which is characterized by high morbidity and mortality rates. AKT1 transcriptional activity is implicated in HCC initiation and development. In the present study, the effects of rs2494752 single nucleotide polymorphism (SNP) on AKT1 transc...

journal_title：Oncology letters

authors： Wang Z,Fu H,Li W

更新日期：2018-09-01 00:00:00

abstract：:Breast cancer is the most prevalent cancer among women, and diagnosis and treatment represent a substantial challenge due to the lack of adequate molecular targets. It has been shown that long noncoding RNAs (lncRNAs) serve pivotal roles in regulating gene expression in tumors. The roles of long intervening noncoding ...

journal_title：Oncology letters

authors： Zhu Q,Li Y,Dong X,Yang Y,Wang H,Guo S

更新日期：2020-01-01 00:00:00

abstract：:Patients with renal medullary carcinoma (RMC) have a poor prognosis, usually due to late diagnosis. Computed tomography (CT) analysis may aid the differentiation between RMC and other types of renal cell carcinoma, in order to establish an accurate early diagnosis. There is a limited number of reports in the literatur...

journal_title：Oncology letters

authors： Shi Z,Zhuang Q,You R,Li Y,Li J,Cao D

更新日期：2016-01-01 00:00:00

abstract：:Esophageal cancer is one of the most common types of malignant tumors located within the digestive system, with >50% of esophageal cancer cases worldwide occurring in China. Recent studies have demonstrated that long non-coding RNAs (lncRNAs) are frequently dysregulated in cancer; however, few lncRNAs have been charac...

journal_title：Oncology letters

authors： Chen R,Xia W,Wang X,Qiu M,Yin R,Wang S,Xi X,Wang J,Xu Y,Dong G,Xu L,De W

更新日期：2018-04-01 00:00:00

abstract：:The present study aimed to address the pharmacogenetic role of BAG1 in platinum-based chemotherapy in advanced non-small-cell lung cancer (NSCLC) and in cultured human lung adenocarcinoma A549 cells. A total of 108 NSCLC patients (stages I-IIIA) were treated with a standard chemotherapy regimen of cisplatin plus vinor...

journal_title：Oncology letters

authors： Wang Y,Ha M,Liu J,Li P,Zhang W,Zhang X

更新日期：2016-02-01 00:00:00

abstract：:Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, ca...

journal_title：Oncology letters

authors： Yang L,Wang Y,Wang H

更新日期：2019-12-01 00:00:00

abstract：:Targeted therapy of non-small cell lung cancer (NSCLC) patients with mutations in the epidermal growth factor receptor (EGFR) gene has been associated with improved prognosis. However, there is a shortage on data from real-world clinical practice in management of EGFR-positive NSCLC patients in Poland. The present stu...

journal_title：Oncology letters

authors： Ramlau R,Krawczyk P,Dziadziuszko R,Chmielewska I,Milanowski J,Olszewski W,Stencel K,Ramlau-Piątek K,Segiet A,Skroński M,Grudny J,Chorostowska-Wynimko J

更新日期：2017-11-01 00:00:00