Overexpression of DJ-1 and HSP90α, and loss of PTEN associated with invasive urothelial carcinoma of urinary bladder: Possible prognostic markers.

abstract：:A growing body of evidence suggests that oncogenesis is associated with systemic inflammation. The present study investigated white blood cell and platelet indices, whose values change during the inflammatory response, in women with invasive ductal breast carcinoma. Preoperatively obtained white blood cell and platele...

journal_title：Oncology letters

authors： Mantas D,Kostakis ID,Machairas N,Markopoulos C

更新日期：2016-08-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of the mammalian target of rapamycin (mTOR) inhibitor, RAD001, on the growth of human endometrial cancer cells. The effects of RAD001 on human endometrial cancer Ishikawa and HEC-1A cell proliferation were determined by MTT assay. Green fluorescent protein mi...

journal_title：Oncology letters

authors： Wang H,Li D,Li X,Ou X,Liu S,Zhang Y,Ding J,Xie B

更新日期：2016-12-01 00:00:00

abstract：:The present study aimed to investigate the effect of microRNA-150 (miRNA/miR-150) in osteosarcoma (OS) cell invasion and metastasis by the regulation of Ezrin. To compare the differences in the expression of miR-150 and Ezrin, cell models of OS metastasis were established by exogenous transfection of miR-150 on the ba...

journal_title：Oncology letters

authors： Zhan C,Li C,Zhang H,Tang H,Ji F,Qiao SC,Xu WD,Wang ZW

更新日期：2016-11-01 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) is the most common type of mesenchymal tumor in the gastrointestinal tract. A large tumor size often means a poor prognosis. This report presents a case of a large exophytic GIST with cyst change, for which the outcome of favourable prognosis was unexpected. A 78-year-old male pre...

journal_title：Oncology letters

authors： Zhu CC,Liu Y,Zhao G

更新日期：2014-05-01 00:00:00

abstract：:Urothelial cancer is the most frequently diagnosed type of malignant tumor in the bladder, of which primary adenocarcinoma accounts for a small percentage. Secondary malignancies, in particular metastatic adenocarcinoma from the lung, are exceedingly rare, with only six cases previously reported in the literature. The...

journal_title：Oncology letters

authors： Ye HJ,Ma J,Liu YJ,Ye XF,Zhang LW,Li JG

更新日期：2015-09-01 00:00:00

abstract：:The present study aimed to explore the diagnostic and prognostic value of lncRNA maternally expressed 3 (MEG3) in cervical cancer. Eighty-four patients with cervical cancer from February 2013 to March 2014 were enrolled in the observation group (OG), and another 58 female subjects who underwent physical examination at...

journal_title：Oncology letters

authors： Wan S,Zhao H

更新日期：2020-11-01 00:00:00

abstract：:Previous studies have revealed that fibrosis may affect the biological behavior of tumors, however associated research on papillary thyroid microcarcinoma (PTMC) is rare. The aim of the present study was to explore the association between interstitial fibrosis (IF) and the biological behavior of PTMC. In the present s...

journal_title：Oncology letters

authors： Liu X,Zhang S,Gang Q,Shen S,Zhang J,Lun Y,Xu D,Duan Z,Xin S

更新日期：2018-04-01 00:00:00

abstract：:The aim of the present study was to identify monitoring and prevention measures as well as predictive factors for early detection of renal toxicity associated with long-term administration of adefovir dipivoxil in order to avoid progression to Fanconi syndrome. Clinical data of 28 patients with Fanconi syndrome caused...

journal_title：Oncology letters

authors： Lin Y,Pan F,Wang Y,Chen Z,Lin C,Yao L,Zhang X,Zhou R,Pan C

更新日期：2017-01-01 00:00:00

abstract：:Numerous genetic alterations have been implicated in the development of prostate cancer (PCa). DNA and protein microarrays have enabled the identification of genes associated with apoptosis, which is important in PCa development. Despite the molecular mechanisms are not entirely understood, inhibition of apoptosis is ...

journal_title：Oncology letters

authors： Salemi M,Barone N,La Vignera S,Condorelli RA,Recupero D,Galia A,Fraggetta F,Aiello AM,Pepe P,Castiglione R,Vicari E,Calogero AE

更新日期：2016-10-01 00:00:00

abstract：:Abnormal glucose metabolism is critical in colorectal cancer (CRC) development. Expression of the pyruvate kinase (PK) M2 isoform, rather than the PKM1 isoform, serves important functions in reprogramming the glucose metabolism of cancer cells. Preferential expression of PKM2 is primarily driven by alternative splicin...

journal_title：Oncology letters

authors： Sun Y,Luo M,Chang G,Ren W,Wu K,Li X,Shen J,Zhao X,Hu Y

更新日期：2017-12-01 00:00:00

abstract：:Salivary gland carcinomas are rare tumors, representing ~0.5% of all malignancies. Myoepithelioma is also uncommon, representing ~1% of all salivary gland tumors. Myoepithelial carcinoma (MC) is even rarer, representing 0.2 to 0.6% of all salivary gland tumors. We herein report a case of MC with multiple metastases ar...

journal_title：Oncology letters

authors： Panelli Santos KCP,Matsuzaki H,Unetsubo T,Tsuyoshi S,Nagatsuka H,Asaumi JI

更新日期：2017-04-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are an approved first-line therapy against unresectable or advanced non-small cell lung cancer (NSCLC) harboring EGFR gene activating mutations. However, the majority of tumors develop acquired resistance against EGFR-TKIs and some tumors exhibi...

journal_title：Oncology letters

authors： Yamaura T,Muto S,Mine H,Takagi H,Watanabe M,Ozaki Y,Inoue T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

更新日期：2020-06-01 00:00:00

abstract：:The expression level and roles of microRNA-497 (miR-497) have been frequently reported in previous studies on cancer. However, its expression, function and associated molecular mechanisms in retinoblastoma remain unknown. In the present study, miR-497 expression levels in human retinoblastoma tissues, normal retinal t...

journal_title：Oncology letters

authors： Li J,Zhang Y,Wang X,Zhao R

更新日期：2017-06-01 00:00:00

abstract：:The correlation between the expression levels of p65 and TNF-α in patients with acute myelocytic leukemia (AML) and AML cell lines were investigated. The bone marrow samples of 30 AML patients and 10 non-leukemia controls were studied. The mRNA expression levels of p65 and TNF-α were detected by reverse transcription-...

journal_title：Oncology letters

authors： Dong QM,Ling C,Zhu JF,Chen X,Tang Y,Zhao LI

更新日期：2015-11-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in different types of cancer, including gastric cancer. Although altered lncRNAs profiles have been observed in or around gastric cancer tissues, the diagnostic value of circulating lncRNAs in gastric cancer remains unclear. In the present study, a n...

journal_title：Oncology letters

authors： Xian HP,Zhuo ZL,Sun YJ,Liang B,Zhao XT

更新日期：2018-10-01 00:00:00

abstract：:[This corrects the article DOI: 10.3892/ol.2017.6254.]. ...

journal_title：Oncology letters

authors： Sato S,Kato T,Abe K,Hanaoka T,Yano Y,Kurosaki A,Yasuda M,Sekino T,Fujiwara K,Hasegawa K

更新日期：2017-10-01 00:00:00

abstract：:Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microarray analysis was u...

journal_title：Oncology letters

authors： Jiang Y,Luan Y,Chang H,Chen G

更新日期：2018-09-01 00:00:00

abstract：:Osteosarcoma (OS) is the most common tumor of the musculoskeletal system. Recently, cold atmospheric plasma (CAP) has been regarded as a promising anti-oncogenic therapy. Previous experimental studies have demonstrated that CAP treatment results in significant growth inhibition of human sarcoma and is able to induce a...

journal_title：Oncology letters

authors： Haralambiev L,Wien L,Gelbrich N,Lange J,Bakir S,Kramer A,Burchardt M,Ekkernkamp A,Gümbel D,Stope MB

更新日期：2020-01-01 00:00:00

abstract：:Cervical cancer is the third most common malignancy worldwide, accounting for 250,000 mortalities annually. Notch1, an important regulator of cell-fate decisions and differentiation, has been found to be overexpressed in certain types of cancer. However, the role of Notch1 in cervical carcinogenesis remains unclear. I...

journal_title：Oncology letters

authors： Sun Y,Zhang R,Zhou S,Ji Y

更新日期：2015-06-01 00:00:00

abstract：:Effect of crizotinib on apoptosis of lung cancer cells was investigated. Human non-small cell lung adenocarcinoma H2228 cells were cultured in the presence of 0, 20, 40, 80, 160 and 320 nmol/l of crizotinib for 3 days, respectively. The inhibition rate of cell proliferation was measured by MTT assay, and half maximal ...

journal_title：Oncology letters

authors： Lu H,Wu S,Chen H,Huang Y,Qiu G,Liu L,Li Y

更新日期：2018-11-01 00:00:00

abstract：:The present study reports a case of pancreatic vasoactive intestinal peptide-secreting tumor (VIPoma), of 2.2 cm in diameter, arising from the region of the uncus of the pancreas with liver metastases in a 50-year-old patient, which demonstrated unusual multiple-phase spiral computed tomography (MPSCT) results. The pa...

journal_title：Oncology letters

authors： Chen Y,Shi D,Dong F,Han SG,Qian ZH,Yang LI,Wang Y,Yu RS,Li QH,Fu YB

更新日期：2015-10-01 00:00:00

abstract：:To aim of the present study was to investigate the association between special AT-rich DNA-binding protein-1 (SATB1) expression and liver cancer metastasis. SATB1 mRNA and protein expression in hepatocellular carcinoma tissues was analyzed by immunohistochemistry, and in two hepatocellular cancer cell lines, MHCC-97H ...

journal_title：Oncology letters

authors： Wu D,Zeng L,Liu F,Zhong Q,Zhang D,Cai C,Zhang W,Wu L,Chen H

更新日期：2016-12-01 00:00:00

abstract：:The clinical effect of interventional therapy on gastric cancer after chemotherapy and effect on inflammatory factors in peripheral blood serum of patients were investigated. A retrospective analysis of 429 patients with gastric cancer treated in Xiangyang No. 1 People's Hospital, Hubei University of Medicine from Jul...

journal_title：Oncology letters

authors： Wu P,Wang J

更新日期：2019-08-01 00:00:00

abstract：:Chemotherapy drugs, including 5-fluorouracil (5-FU), oxaliplatin and docetaxel, are commonly used in the treatment of gastric cancer (GC). Apoptosis-relevant genes may be associated with drug resistance. In the present study, the messenger RNA (mRNA) expression levels of B-cell lymphoma 2 interacting mediator of cell ...

journal_title：Oncology letters

authors： Wu N,Huang Y,Zou Z,Gimenez-Capitan A,Yu L,Hu W,Zhu L,Sun X,Sanchez JJ,Guan W,Liu B,Rosell R,Wei J

更新日期：2017-03-01 00:00:00

abstract：:Breast lumpectomy is usually performed under general or local anesthesia. To the best of our knowledge, whether conscious sedation with intranasal dexmedetomidine and local anesthesia is an effective anesthetic technique has not been studied. Thus, the present study aimed to investigate the effectiveness of conscious ...

journal_title：Oncology letters

authors： Yuan YJ,Zhou P,Xia F,Zhang XB,He SS,Guo DY,Xing YH,Zhao HW

更新日期：2020-10-01 00:00:00

abstract：:Dopamine receptor 2 (DR2) may be a biomarker for various types of cancer. Ovarian cancer cells overexpress DR2; therefore, blocking DR2 may be a novel treatment strategy for ovarian cancer. Thioridazine, a DR2 blocker, has antineoplastic activity in a variety of cancer cells. In view of the requirement for novel thera...

journal_title：Oncology letters

authors： Yong M,Yu T,Tian S,Liu S,Xu J,Hu J,Hu L

更新日期：2017-12-01 00:00:00

abstract：:The aim of the present study was to examine the interrelations between MEG-A3 gene and incidence of breast cancer. The expression of MEG-A3 gene in the tissue samples of patients with breast cancer and normal controls at RNA and protein levels was determined. Subsequently, the relative expression of RNA for the same p...

journal_title：Oncology letters

authors： Hou X,Guo F,Sun Q

更新日期：2016-12-01 00:00:00

abstract：:Despite the efficacy of combination chemotherapy with arsenic trioxide (ATO), interferon α (IFN) and zidovudine (AZT) for adult T cell leukemia/lymphoma (ATL), the precise mechanism underlying this combination treatment effect is unknown. In the present study, ATO/IFN/AZT was examined in an ATL leukemic cell line (S1T...

journal_title：Oncology letters

authors： Hachiman M,Yoshimitsu M,Ezinne C,Kuroki A,Kozako T,Arima N

更新日期：2018-07-01 00:00:00

abstract：:Knowledge of potential tumor markers may improve chemotherapeutic efficacy. Interleukin-6 (IL-6) expression in local tumor tissues is associated with cancer progression and poor prognosis in variety of cancer types. The aim of the present study was to investigate the role and potential application of IL-6 in determini...

journal_title：Oncology letters

authors： Zhao ZF,Li JX,Ye R,Wu X,Gao LL,Niu BL

更新日期：2016-02-01 00:00:00

abstract：:Segmental ureterectomy (SU) represents a promising alternative for the treatment of upper tract urothelial carcinomas (UTUCs) as it is a less invasive procedure and guarantees the preservation of renal units. The present study evaluated oncological outcomes and renal functions following SU when compared with radical n...

journal_title：Oncology letters

authors： Kato T,Nakayama R,Haba T,Kawaguchi M,Komiya A,Koike H

更新日期：2018-11-01 00:00:00