Abstract:
:Serine/threonine kinase 39 (STK39) is associated with hypertension, autism, Parkinson's disease and various types of cancer in recent years. This study investigated STK39 expression and possible roles in osteosarcoma using qPCR and western blot analysis. Compared to normal bone tissues, the mRNA and protein expression of STK39 was found to be upregulated in osteosarcoma. Using small interfering RNA transfection, STK39 was knocked down into two cell lines of osteosarcoma, U2OS and MG63, and the effects exerted on cell functioning were examined. The results showed that STK39 downregulation inhibited ostesarcoma cell proliferation and invasion. Moreover, STK39 knockdown in osteosarcoma cells significantly affected the expression of proteins connected to cell proliferation (proliferating cell nuclear antigen and p21) and invasion [Twist1, matrix metalloproteinase (MMP)2 and MMP9]. Phosphorylation of Smad2/3 was reduced by STK39 knock down. In conclusion, our data provide evidence that STK39 was overexpressed in osteosarcoma. STK39 may serve as an oncogene by adjusting the proliferation and invasion of osteosarcoma cells.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Huang T,Zhou Y,Cao Y,Tao J,Zhou ZH,Hang DHdoi
10.3892/ol.2017.6728subject
Has Abstractpub_date
2017-10-01 00:00:00pages
4599-4604issue
4eissn
1792-1074issn
1792-1082pii
OL-0-0-6728journal_volume
14pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Pro-angiogenic factors [vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)] and anti-angiogenic factors (endostatin) play important roles in the progression of pancreatic cancer. The purpose of the present study was to investigate the knockdown effect by either VEGF or bFGF siRNA on th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1102
更新日期:2013-03-01 00:00:00
abstract::The recent successful use of the immune checkpoint inhibitors (CPIs) anti-programmed death receptor-1 (PD-1)/PD-1 ligand 1 in clinical trials indicates their crucial role in obtaining an effective cancer immune therapy. These CPIs have been identified to have an effective therapeutic response, particularly in tumors w...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2019.10166
更新日期:2019-06-01 00:00:00
abstract::Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathol...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1454
更新日期:2013-09-01 00:00:00
abstract::Virosecurinine, a primary alkaloid from Securinega suffruticosa plant is known as a potent differentiation-inducing agent in acute leukemia cells. The present study aimed to investigate the effects and underlying mechanisms of virosecurinine on human leukemia THP-1 cells in vitro. The effects of virosecurinine on cell...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7437
更新日期:2018-01-01 00:00:00
abstract::Severe hemorrhage following a prostatectomy is a rare and serious complication. A 63-year-old male with severe hemorrhage following radical prostatectomy which led to hypovolemic shock presented at our department and was treated with superselective internal iliac arterial embolization. At 6 months follow-up, the patie...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.749
更新日期:2012-09-01 00:00:00
abstract::Evaluation of carcinogenic substances from the environment is a challenge for scientists. Recently, a novel approach based on 10 key characteristics of human carcinogens classified by the International Agency for Research on Cancer (IARC) has emerged. Carcinogenesis depends on different mechanisms and factors, includi...
journal_title:Oncology letters
pub_type: 杂志文章,评审
doi:10.3892/ol.2020.11566
更新日期:2020-07-01 00:00:00
abstract::Liver cancer is the sixth most commonly occurring cancer globally, and the main histological type is hepatocellular carcinoma. This type of neoplasia has a poor prognosis due to a high rate of recurrence and intrahepatic metastasis, which are closely are closely associated with the angiogenic process. Vascular endothe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4605
更新日期:2016-07-01 00:00:00
abstract::The molecular mechanisms underlying the dysregulation of microRNAs (miRs) have been previously documented in breast cancer. miR-198 has been reported to be deregulated in several human cancers. However, the detailed effects of miR-198 on breast cancer progression remain unclear. Using quantitative polymerase chain rea...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5673
更新日期:2017-03-01 00:00:00
abstract::Point mutation of the BRAF gene is a genetic event that occurs in a subset of lung adenocarcinoma cases. For example, BRAF V600E is a driver mutation that can be effectively targeted using selective BRAF and/or MEK inhibitors. The present study hypothesized that an increase in BRAF copy number may be correlated with c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2719
更新日期:2015-02-01 00:00:00
abstract::Primary mediastinal seminoma is a rare extragonadal germ cell tumour that mainly occurs in males. The present study reports the case of a 27-year-old woman that presented with superior vena cava syndrome and a large mass in the mediastinum, which was diagnosed as primary female mediastinal seminoma. The patient receiv...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5555
更新日期:2017-03-01 00:00:00
abstract::K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation, as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras mutation status can be used to predict the therapeutic efficacy of targeted drugs such as cetuximab. The aim of this study was to co...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2205
更新日期:2014-08-01 00:00:00
abstract::Evidence-based guidelines for the prevention of surgical site infection (SSI) have been published by the U.S. Centers for Disease Control and Prevention (CDC). According to these guidelines, a wound should usually be covered with a sterile dressing for 24 to 48 h when a surgical incision is closed primarily. However, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.687
更新日期:2012-07-01 00:00:00
abstract::Pituitary tumor transforming gene 1 (PTTG11) is abundantly expressed in glioma. Our previous study demonstrated that the downregulation of PTTG11 gene expression significantly inhibited the proliferation, migration and invasion ability, and increased the apoptosis of SHG44 glioma cells. However, the molecular mechanis...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11867
更新日期:2020-10-01 00:00:00
abstract::Oncological and functional prognostic factors for patients with foot sarcomas have yet to be clarified. This study was undertaken to identify the prognostic factors for oncological and functional outcomes and the significance of adjuvant radiotherapy in achieving local control in patients with foot sarcomas. We review...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2011.427
更新日期:2012-01-01 00:00:00
abstract::The present study reported three rare cases of multicystic vestibular schwannoma with fluid-fluid levels. These three tumors exhibited apparent fluid-fluid levels that demonstrated a radiological appearance of two fluid levels in the cystic area. Two cases had an acute history, whereas one case presented with a chroni...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3211
更新日期:2015-07-01 00:00:00
abstract::The purpose of the present study was to investigate the clinical significance of BRCA1/BRCA2 DNA repair associated (BRCA1/BRCA2) gene expression in patients with sporadic gastric cancer (GC) who had received postoperative adjuvant chemotherapy. Breast cancer type 1 and 2 susceptibility protein (BRCA1 and BRCA2) expres...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10132
更新日期:2019-05-01 00:00:00
abstract::Integrin signaling may modulate several different functions involved in cell migration, invasion, proliferation and motility, and is a potential candidate biomarker for oral cancer. In the present study, a total of four integrin genes were evaluated as potential biomarkers of oral squamous cell carcinoma (OSCC). Gene ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9168
更新日期:2018-10-01 00:00:00
abstract::The aim of the present study was to examine the interrelations between MEG-A3 gene and incidence of breast cancer. The expression of MEG-A3 gene in the tissue samples of patients with breast cancer and normal controls at RNA and protein levels was determined. Subsequently, the relative expression of RNA for the same p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5325
更新日期:2016-12-01 00:00:00
abstract::The aim of the present study was to evaluate the clinical utility of plasma chromogranin A (CgA) in patients diagnosed with early-stage pancreatic neuroendocrine tumors (PNETs) in terms of diagnostic value and treatment response. A total of 35 patients with PNETs were prospectively enrolled from August 2010 to April 2...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8472
更新日期:2018-06-01 00:00:00
abstract::[This corrects the article DOI: 10.3892/ol.2017.6254.]. ...
journal_title:Oncology letters
pub_type: 杂志文章,已发布勘误
doi:10.3892/ol.2017.6794
更新日期:2017-10-01 00:00:00
abstract::Research on the immunosuppression of cancer cells has attracted much attention in recent years. The present study sought to provide a new strategy for tumor immunotherapy targeting mast cells by studying the mechanisms underlying mast cell function in cancer immunosuppression. Between January 2015 and December 2017, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.12224
更新日期:2020-12-01 00:00:00
abstract::The present study examined the association between squamous cell carcinoma antigen (SCCA) expression and the response of patients with cervical cancer to docetaxel-carboplatin (DC) combination chemotherapy, in order to determine the prognostic potential of SCCA expression. A total of 21 patients were enrolled with sta...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.5560
更新日期:2017-03-01 00:00:00
abstract::Lung adenocarcinoma (LUAD) is a major subtype of non-small cell lung cancer. Despite significant progress in its diagnosis and treatment, the mortality and morbidity rate of LUAD remains high worldwide. The aim of the present study was to perform a systematic investigation of the tumor microenvironment (TME) and ident...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11735
更新日期:2020-08-01 00:00:00
abstract::The aim of the present study was to compare intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in irradiation of lung cancer. Plans of 14 patients were compared. The results demonstrated that in peripheral lung cancer, V5 (%) of the lung in partial-arc (PA)-VMAT was decreased comp...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7732
更新日期:2018-03-01 00:00:00
abstract::The tumor suppressor protein retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) is downregulated in several types of cancer, including esophageal squamous cell carcinoma (ESCC). The present study used two in vitro methods to re-express RIZ1 in the human ESCC TE13 cell line in order to induce apoptosis. RIZ1 ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1608
更新日期:2013-12-01 00:00:00
abstract::Numerous genetic alterations have been implicated in the development of prostate cancer (PCa). DNA and protein microarrays have enabled the identification of genes associated with apoptosis, which is important in PCa development. Despite the molecular mechanisms are not entirely understood, inhibition of apoptosis is ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4983
更新日期:2016-10-01 00:00:00
abstract::MicroRNA-181 (miR-181) has been recently demonstrated to participate in the differentiation and development of immune cells, including natural killer cells and B and T lymphocytes, and myeloid linages, including erythroid and megakaryocytic cells. The aberrant expression of miR-181, particularly low expression levels,...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3663
更新日期:2015-11-01 00:00:00
abstract::Interferon (IFN)-α is generated in response to viral infections and is used clinically in the therapy of a variety of viral infections and cancers. The present study investigated whether IFN-α could inhibit the invasive ability of osteosarcoma cells using a Matrigel invasion assay. In addition, the osteosarcoma cells ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1762
更新日期:2014-03-01 00:00:00
abstract::The aim of the present study was to use imaging to retrospectively analyze the recurrent sites and patterns of spread of early cervical cancer following radical surgery. A total of 86 patients with cervical cancer (stage IB or IIA) showed postoperative pelvic recurrences and distant metastases. Based on positron emiss...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9070
更新日期:2018-09-01 00:00:00
abstract::The aim of the present study was to investigate the feasibility and value of serum microRNAs (miRNAs/miRs) as biological markers for the prediction of the behavior and prognosis of esophageal squamous cell cancer (ESCC). The differential expression of serum miRNA was detected by an miRNA microarray of 9 patients with ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3642
更新日期:2015-11-01 00:00:00