Abstract:
:Oncological and functional prognostic factors for patients with foot sarcomas have yet to be clarified. This study was undertaken to identify the prognostic factors for oncological and functional outcomes and the significance of adjuvant radiotherapy in achieving local control in patients with foot sarcomas. We reviewed 31 consecutive patients with soft tissue (24), and bone (7) sarcomas arising in the foot and analyzed the impact of patient characteristics on the functional and oncological outcomes. There were seven cases with clear cell or epithelioid sarcomas. Two of the 31 cases experienced local recurrence despite the fact that only two cases received adjuvant radiotherapy. Sixteen out of 18 cases of soft tissue sarcomas with limb salvage surgery underwent reconstructive procedures for soft tissue defects. Amputation required as a surgical treatment (p=0.002) was a poor prognostic factor. Larger size (p=0.029) and bone reconstruction (p=0.018) were poor prognostic factors for local recurrence-free survival, and amputation (p=0.001) and bone reconstruction (p=0.008) for metastasis-free survival in patients with soft tissue sarcomas. No significant factors were derived in patients with bone sarcomas. Larger size (p=0.021), amputation (p=0.016) and bone reconstruction (p=0.03) were poor prognostic factors affecting function in patients with soft tissue sarcomas, and hindfoot site (p=0.028) and amputation (p=0.028) were poor prognostic factors affecting function in patients with bone sarcomas. Surgery with a negative operative margin and reconstructive procedures achieved good local control and function. Patients that had tumors with larger size, necessitating amputation or bone reconstruction, required novel multimodal treatment in order to improve their outcomes.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Kozawa E,Nishida Y,Nakashima H,Tsukushi S,Toriyama K,Kamei Y,Ishiguro Ndoi
10.3892/ol.2011.427subject
Has Abstractpub_date
2012-01-01 00:00:00pages
82-88issue
1eissn
1792-1074issn
1792-1082pii
ol-03-01-0082journal_volume
3pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::Gastrinoma is a gastrin-secreting tumor that is associated with Zollinger-Ellison syndrome. The majority of cases occur in the pancreas, followed by the duodenum. Early diagnosis is difficult due to the relative rarity of the tumor and the lack of specific symptoms. In the current study, a 68-year-old female patient p...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4397
更新日期:2016-05-01 00:00:00
abstract::Acute promyelocytic leukemia (APL) is a rare leukemia characterized by the balanced reciprocal translocation between the promyelocytic leukemia gene on chromosome 15 and the retinoic acid receptor α (RARα) gene on chromosome 17, and accounts for 10-15% of newly diagnosed acute myeloid leukemia each year. The combined ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7854
更新日期:2018-04-01 00:00:00
abstract::Although it is established as a marker of cancer-associated fibroblasts, the expression of fibroblast activation protein (FAP) is not restricted to stromal cells; its expression in multiple types of tumor cell and its pro-tumor functions have been reported. However, the role of FAP in angiogenesis in osteosarcoma rema...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8027
更新日期:2018-04-01 00:00:00
abstract::The present study aimed to analyze the imaging features and pathological basis of primary hepatic neuroendocrine carcinoma (PHNEC). A retrospective analysis of the imaging and pathological features of nine PHNEC cases was carried out at The Second Xiangya Hospital of Central South University (Changsha, China). The nin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1844
更新日期:2014-04-01 00:00:00
abstract::Forkhead box M1 (FOXM1) and hedgehog (Hh) signaling pathway are implicated in the formation and development of human tumors, including cervical cancer. Previous studies have indicated that FOXM1 may be a downstream target gene of the Hh signaling pathway, but their association in cervical cancer is largely unknown. In...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4932
更新日期:2016-10-01 00:00:00
abstract::Metastasis remains a notable issue in patients with newly diagnosed colorectal carcinomas (CRC). Although anti-angiogenic therapies target metastatic diseases, hypoxia-inducible factor-1 α (HIF-1α) and vascular endothelial growth factor (VEGF) status are routinely evaluated in primary tumors as metastatic sites are in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11450
更新日期:2020-05-01 00:00:00
abstract::Mitotically-associated long non-coding RNA (MANCR) is involved in malignant breast cancer. The present study analyzed the role of MANCR in hepatocellular carcinoma (HCC). MANCR was found to be upregulated in HCC and high expression level of MANCR in cancer tissues predicted poor survival of HCC patients. MicroRNA (miR...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10947
更新日期:2019-12-01 00:00:00
abstract::Diffusion weighted imaging (DWI) has been found to increase the sensitivity in the diagnosis of small hepatocellular carcinoma (HCC), although additional studies are required to confirm its value. The aim of the present study was to explore the diagnostic performance of DWI combined with contrast-enhanced magnetic res...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11805
更新日期:2020-09-01 00:00:00
abstract::A total of 76 blood samples from patients without malignant disease and 107 blood samples from patients with malignant disease were investigated for the presence of circulating tumor cells (CTCs). To detect CTCs, hematopoietic cells were removed from the blood samples and different RNA extraction methods were used to ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6226
更新日期:2017-07-01 00:00:00
abstract::The Mantle Cell Lymphoma International Prognostic Index (MIPI) combines four factors to differentiate low-, intermediate- and high-risk prognostic groups in advanced mantle cell lymphoma using data from patients treated in clinical trials. To evaluate its use in routine practice, we applied the simplified index retros...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_00000034
更新日期:2010-01-01 00:00:00
abstract::Aberrant expression of microRNAs (miRNAs) contributes to the progression and outcomes of several types of tumor, while circulating miRNAs have been reported to act as biomarkers for several types of cancer. To identify specific circulating miRNAs associated with multiple myeloma (MM), a miRNA microarray analysis was u...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9128
更新日期:2018-09-01 00:00:00
abstract::The present study aimed to assess the B rapidly accelerated fibrosarcoma (BRAFV600E) status in plasma from Chinese patients with melanoma, and evaluated its prognostic value following treatment with BRAF inhibitors. Mutation-specific 3D digital polymerase chain reaction (dPCR) was used to quantify BRAFV600E in circula...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7529
更新日期:2018-02-01 00:00:00
abstract::Application of dexmedetomidine combined with sufentanil in colon cancer resection and its effect on immune and coagulation function of patients was studied. Colon cancer cases (n=176) admitted to Xiangya Hospital Central South University were selected into the study. They were divided into group A (n=92) and group B (...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11643
更新日期:2020-08-01 00:00:00
abstract::Malignant melanoma can be successfully treated when it is identified in its early stages, but the disease is associated with a poor prognosis when it is detected in an advanced stage. Papillary thyroid carcinoma is a thyroid cancer that has a good prognosis. The present study reports a rare case of malignant melanoma ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2642
更新日期:2015-01-01 00:00:00
abstract::Overexpression of apoptosis-stimulating of p53 protein 2 (ASPP2) can induce apoptotic cell death in hepatoma cells, which contributes to a killing effect of ASPP2 on treating hepatocellular carcinoma (HCC). In the present study, ASPP2 overexpression failed to induce apoptotic cell death in the HCC Huh7.5 cell line, bu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8453
更新日期:2018-06-01 00:00:00
abstract::Multiple myeloma is a type of malignancy, which affects the plasma cells of the bone marrow. Recent studies have found that malignant plasma cells may express urokinase plasminogen activator (uPA) and uPA receptor (uPAR), and that initiation of proteolytic events by this system contributes to the process of invasion a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3613
更新日期:2015-10-01 00:00:00
abstract::Cervical cancer is the third most commonly diagnosed cancer in women. The human wings apart-like (hWAPL) gene, which is 30,793 bp long and located on 10q23.2., is a human homologue of the WAPL gene in Drosophila melanogaster. hWAPL has the characteristics of an oncogene in uterine cervical cancer. The present study in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4563
更新日期:2016-07-01 00:00:00
abstract::The seven-amino acid truncated (7ND) protein is an N-terminal deletion mutant of monocyte chemoattractant protein-1 (MCP-1) and it functions as a dominant-negative inhibitor. 7ND and wild-type MCP-1 form a heterodimer, which binds to MCP-1 receptors and inhibits monocyte chemotaxis. In the present study, the 7ND prote...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8308
更新日期:2018-05-01 00:00:00
abstract::Controversy exists regarding a possible association between prostatitis and prostate cancer. To further evaluate the incidence of prostate cancer following prostatitis, a study of prostate cancer incidence in a cohort of Finnish men was performed. The original survey evaluating self-reported prostatitis was conducted ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4702
更新日期:2016-08-01 00:00:00
abstract::Evidence-based guidelines for the prevention of surgical site infection (SSI) have been published by the U.S. Centers for Disease Control and Prevention (CDC). According to these guidelines, a wound should usually be covered with a sterile dressing for 24 to 48 h when a surgical incision is closed primarily. However, ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.687
更新日期:2012-07-01 00:00:00
abstract::Cancer metastasis, particularly multiple metastatic cancer, is a significant event that affects patient prognosis. However, single metastasis can be treated by partial resection, although the clinicopathological and molecular profile of single lung metastasis has not been thoroughly elucidated. The present study exami...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11627
更新日期:2020-07-01 00:00:00
abstract::KRAS mutation is frequently identified in advanced colorectal carcinoma (CRC); however, its prognostic significance and the associated histological features have remained to be clarified. In the present study, the precise histological results and prognostic value of KRAS-mutated CRCs were investigated in patients from...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11606
更新日期:2020-07-01 00:00:00
abstract::Canonical WNT signaling promotes breast cancer progression. Although APC downregulated 1 (APCDD1) may inhibit canonical WNT signaling, its role in breast cancer remains to be fully understood. The present study demonstrated that APCDD1 suppressed in vitro breast cancer growth and metastasis by inhibiting canonical WNT...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6801
更新日期:2017-10-01 00:00:00
abstract::The molecular profile of low-grade mucoepidermoid carcinomas remains to be clarified. In the present study, matrix metalloproteinase (MMP) expression was compared in low-grade mucoepidermoid carcinoma (MEC) and typical lung cancer. The expression of MMP-2, MMP-7 and MMP-9 was detected by immunohistochemistry in a coho...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol_2011.387
更新日期:2011-11-01 00:00:00
abstract::Metastasis-associated in colon cancer-1 (MACC1) is a gene that has been newly identified by a genome-wide search for differentially expressed genes in human colon cancer tissues, metastases and normal tissues. MACC1 exerts an important role in colon cancer metastasis through upregulation of the c-Met proto-oncogene. T...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2984
更新日期:2015-05-01 00:00:00
abstract::The present study investigated the value of combinations of five specific tumor biomarkers for the diagnosis of colorectal cancer (CRC): Neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), cancer antigen (CA)19-9, CA125 and CA242. Associations between these markers and clinicopathological characteristics (i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11633
更新日期:2020-07-01 00:00:00
abstract::Lung cancer is one of the most common cancers, which is the leading cause of cancer-related death among various cancers worldwide. Flavokawain A (FKA), a chalcone found in the kava plant, exerts potent anticancer activity. However, the activity and mechanisms of FKA in inhibiting the viability of paclitaxel (PTX)-resi...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11069
更新日期:2020-01-01 00:00:00
abstract::Osteosarcoma (OS) is the most common tumor of the musculoskeletal system. Recently, cold atmospheric plasma (CAP) has been regarded as a promising anti-oncogenic therapy. Previous experimental studies have demonstrated that CAP treatment results in significant growth inhibition of human sarcoma and is able to induce a...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11115
更新日期:2020-01-01 00:00:00
abstract::Malignant pleural mesothelioma (MPM) is associated with a history of heavy, long-term exposure to asbestos. However, MPM may also be associated with simian virus 40 (SV40), a polyomavirus. The association between SV40 and MPM remains unclear. The present study was conducted in order to investigate the proportion of SV...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4174
更新日期:2016-03-01 00:00:00
abstract::Synovial sarcoma (SS) is a soft tissue sarcoma of unknown histogenesis that rarely occurs in the female genital tract. We report a case of SS occurring in the right vulva of a young Japanese female. The tumor was composed of poorly differentiated rounded cell areas, surrounded by fibroblastic spindle-shaped cell areas...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.857
更新日期:2012-11-01 00:00:00