Malignant melanoma and papillary thyroid carcinoma that were diagnosed concurrently and treated simultaneously: A case report.

abstract：:Breast cancer affects ~10% of women worldwide and is responsible for ~12% of all cancer-associated mortalities. Breast cancer is more prone to metastasis compared with other types of cancer. Up to 5% of patients with breast cancer present with incurable metastasis and an additional 10-15% of patients develop metastase...

journal_title：Oncology letters

authors： Gao S,Cao C,Dai Q,Chen J,Tu J

更新日期：2018-07-01 00:00:00

abstract：:Although bulk high-throughput genomic profiling studies have led to a significant increase in the understanding of cancer biology, there is increasing awareness that bulk profiling approaches do not completely elucidate tumor heterogeneity. Single-cell genomic profiling enables the distinction of tumor heterogeneity, ...

journal_title：Oncology letters

authors： Yan B,Hu Y,Ban KHK,Tiang Z,Ng C,Lee J,Tan W,Chiu L,Tan TW,Seah E,Ng CH,Chng WJ,Foo R

更新日期：2017-03-01 00:00:00

abstract：:The elbow is an uncommon site for malignant bone tumors. Surgical options for the reconstruction of the elbow joint are limited and technically challenging. In this study, we describe a patient with osteosarcoma of the proximal ulna treated by wide resection and reconstruction with a combined use of free vascularised ...

journal_title：Oncology letters

authors： Ogose A,Hotta T,Shibata M,Kawashima H,Endo N

更新日期：2010-01-01 00:00:00

abstract：:Polymorphisms of the vitamin D receptor (VDR) gene may be a risk factor for pancreatic cancer (PC). We investigated the association of two single-nucleotide polymorphisms (SNPs) of the VDR gene with PC in age- and gender-matched patients and controls. PC (n=91) and healthy control (n=80) samples were genotyped for the...

journal_title：Oncology letters

authors： Li L,Wu B,Yang L,Yin G,Wei W,Sui S,Liu J

更新日期：2013-05-01 00:00:00

abstract：:Carbohydrate antigen 19-9 (CA19-9) is not generally considered to be a biomarker in pancreatic neuroendocrine tumors (pNETs), as the majority of pNETs present with a normal range of CA19-9. The present study aimed to evaluate the role of serum CA19-9 levels as a prognostic factor in a relatively large number of patien...

journal_title：Oncology letters

authors： Luo G,Jin K,Cheng H,Liu C,Guo M,Lu Y,Yang C,Xu J,Wang W,Gao H,Zhang S,Long J,Xu J,Ni Q,Chen J,Yu X

更新日期：2017-12-01 00:00:00

abstract：:Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising therapeutic options for patients with advanced cancer. The aim of the present study was to investigate the prognostic value of somatic mutations in mismatch repair (MMR) genes in metastatic cancers after ICI treatment, as well as their assoc...

journal_title：Oncology letters

authors： Liu Y,Chen L,Zhang S,Shu Y,Qi Q,Zhu M,Peng Y,Ling Y

更新日期：2020-10-01 00:00:00

abstract：:Patients with the luminal B subtype of breast cancer exhibit a poor prognosis, high metastatic risk and high incidence of chemotherapy resistance. Luminal B breast cancer is sub-classified into B1 and B2. The pathophysiological mechanism of luminal B2 breast cancer (LB2BC) progression has yet to be characterized. Ther...

journal_title：Oncology letters

authors： Wang J,Du Q,Li C

更新日期：2017-12-01 00:00:00

abstract：:A standard treatment for patients with early-stage non-small cell lung cancer (NSCLC) who undergo surgery, and subsequently develop local failure or intrathoracic oligo-recurrence, has not yet been established. The present study aimed to assess the feasibility of stereotactic body radiotherapy (SBRT) for this subgroup...

journal_title：Oncology letters

authors： Aoki S,Yamashita H,Takahashi W,Nawa K,Ota T,Imae T,Ozaki S,Nozawa Y,Nakajima J,Sato M,Anraku M,Nitadori J,Karasaki T,Abe O,Nakagawa K

更新日期：2020-04-01 00:00:00

abstract：:MicroRNAs (miRs) can function as tumor suppressors or oncogenes in different types of human malignancy, and may provide an effective therapy for cancer. The expression and functions of miR-592 have previously been studied in relation to cancer. However, the expression and potential functions of miR-592 in hepatocellul...

journal_title：Oncology letters

authors： Wang W,Zhang H,Tang M,Liu L,Zhou Z,Zhang S,Wang L

更新日期：2017-05-01 00:00:00

abstract：:Notch-regulated ankyrin-repeat protein (NRARP) has recently been reported to be involved in a number of malignant cancers; however, its role in non-small lung cancer (NSCLC) remains unclear. The present study aimed to identify whether NRARP could be applied as a novel prognostic marker for NSCLC. A total of 108 NSCLC ...

journal_title：Oncology letters

authors： Liao Y,Chen J,Ma J,Mao Q,Wei R,Zheng J

更新日期：2018-08-01 00:00:00

abstract：:The role of mitogen-activated protein kinase (MAPK) signaling pathways in cell growth and differentiation has been well established. The present study aimed to investigate the anti-proliferative effect of stevioside on human colon cancer HT-29 cells. Additionally, the effect of stevioside on cell cycle arrest and MAPK...

journal_title：Oncology letters

authors： Ren HP,Yin XY,Yu HY,Xiao HF

更新日期：2017-04-01 00:00:00

abstract：:The incidence of gastric cancer is high, especially in China. The present study aims to provide a novel therapeutic target for gastric cancer. Peripheral blood, cancerous and paracancerous tissues were collected from patients with gastric cancer. T-cell immunoglobulin mucin domain-3 (Tim-3) expression in T-cells was m...

journal_title：Oncology letters

authors： Yu J,Zhang H,Sun S,Sun S,Li L

更新日期：2019-02-01 00:00:00

abstract：:Microcystic adnexal carcinoma (MAC) is extremely rare among Asians, with the majority of cases presenting in Caucasian individuals. The current study describes the case of a 38-year-old Chinese woman who presented with a 10 year history of a mass in the upper lip. A biopsy resulted in a diagnosis of MAC. The patient u...

journal_title：Oncology letters

authors： Chen J,Yang S,Chen J,Liao T,Deng W,Li W

更新日期：2016-04-01 00:00:00

abstract：:Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferat...

journal_title：Oncology letters

authors： Li Z,Wu J,Wu C,Jiang J,Zheng X,Xu B,Li M

更新日期：2012-10-01 00:00:00

abstract：:In order to estimate the effects of small interfering RNA (siRNA) targeting retinoblastoma binding protein 2 (RBP2) on the proliferation, expression, invasion, migration and tumorigenicity abilities of papillary thyroid carcinoma K1 cells, siRNA targeting RBP2 (RBP2-siRNA) and negative control siRNA were transfected i...

journal_title：Oncology letters

authors： Kong LL,Man DM,Wang T,Zhang GA,Cui W

更新日期：2015-12-01 00:00:00

abstract：:Aquaporin 1 (AQP1), which functions as a water transporter, is associated with cancer cell proliferation, invasion, metastasis and angiogenesis in numerous types of solid cancer, including colorectal cancer (CRC). The focus of the present study was to address the potential clinical use of AQP1 expression in CRC as a p...

journal_title：Oncology letters

authors： Imaizumi H,Ishibashi K,Takenoshita S,Ishida H

更新日期：2018-05-01 00:00:00

abstract：:The primary goal of radiotherapy in oncology is to enhance the efficacy of tumor cell death while decreasing damage to surrounding normal cells. Positive therapeutic outcomes may be accomplished by improved targeting, precisely targeting tumor cells or protecting normal cells against radiation-induced damage. The pote...

journal_title：Oncology letters

authors： Kim W,Kang J,Lee S,Youn B

更新日期：2017-06-01 00:00:00

abstract：:In the present study, we analyzed the supra-additive effect of oxaliplatin in combination with gemcitabine on terminal colorectal cancer and its influence on high-mobility group box 1 (HMGB1) expression. A total of 86 patients with terminal colorectal cancer were enrolled in this study. Patients received oxaliplatin i...

journal_title：Oncology letters

authors： Wen S,Du X,Gou Y,Jiang L

更新日期：2016-11-01 00:00:00

abstract：:The aim of this study was to clarify the association between expression of human leukocyte antigen (HLA) class I in non-small-cell lung cancer (NSCLC) cells and patient survival. To address this, immunohistochemical staining for HLA class I was performed on specimens from 111 patients with NSCLC, and overall survival ...

journal_title：Oncology letters

authors： Ichinokawa K,Nakanishi Y,Hida Y,Tsuchikawa T,Kato T,Itoh T,Kaji M,Kaga K,Hirano S

更新日期：2019-07-01 00:00:00

abstract：:Osteosarcoma (OS) is the most common tumor of the musculoskeletal system. Recently, cold atmospheric plasma (CAP) has been regarded as a promising anti-oncogenic therapy. Previous experimental studies have demonstrated that CAP treatment results in significant growth inhibition of human sarcoma and is able to induce a...

journal_title：Oncology letters

authors： Haralambiev L,Wien L,Gelbrich N,Lange J,Bakir S,Kramer A,Burchardt M,Ekkernkamp A,Gümbel D,Stope MB

更新日期：2020-01-01 00:00:00

abstract：:The present case study reported of amelanotic malignant melanoma of the esophagus. A 68-year-old man underwent laparoscopic distal gastrectomy for early gastric cancer diagnosis. After gastrectomy, endoscopic examination revealed a protruded lesion lying adjacent to the melanosis area of the esophagus. Histology of th...

journal_title：Oncology letters

authors： Kobayashi J,Fujimoto D,Murakami M,Hirono Y,Goi T

更新日期：2018-06-01 00:00:00

abstract：:Low-grade cribriform cystadenocarcinoma (LGCCC) is a malignant salivary gland tumor. LGCCC occurs rarely, with the parotid gland being the most commonly afflicted site. Few cases arise in other sites. The present study reports a case of LGCCC that occurred at the palatal gland of the hard palate. A 56-year-old female ...

journal_title：Oncology letters

authors： Kokabu S,Nojima J,Kayano H,Yoda T

更新日期：2015-10-01 00:00:00

abstract：:In the present study, we investigated the correlation between the presence of occult neoplastic cells (ONCs) in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer in 164 patients who underwent radical curative resection. We calculated the five-year relapse-free survival rate (5Y-RFS) and five-...

journal_title：Oncology letters

authors： Sekido Y,Mukai M,Yamazaki M,Tajima T,Yamamoto S,Hasegawa S,Kishima K,Tajiri T,Nakamura N

更新日期：2014-01-01 00:00:00

abstract：:The transcription factor AP-2 β (TFAP2B) serves an important role in kidney development. MicroRNAs (miRNAs) regulate carcinogenic pathways and have gained increasing attention owing to their association with human clear cell renal cell carcinoma (ccRCC) tumorigenesis. However, whether miRNAs could affect renal cell tu...

journal_title：Oncology letters

authors： Zhu M,Zou L,Lu F,Ye L,Su B,Yang K,Lin M,Fu J,Li Y

更新日期：2020-12-01 00:00:00

abstract：:The aim of the current study was to investigate the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) expression and cell proliferation in the human osteosarcoma cell line U20S. U20S cells were treated with Res at various concentrations (0, 10, 20 and 40 μmol/l) for various times (24, 48 and 72...

journal_title：Oncology letters

authors： Liu Z,Li Y,Yang R

更新日期：2012-10-01 00:00:00

abstract：:The present study reports a case of low-grade fibromyxoid sarcoma that occurred in a 62-year-old woman 9 years subsequent to whole breast irradiation for a carcinoma of the left breast, and 18 years following chemotherapy and radiotherapy (RT) for non-Hodgkin's lymphoma (NHL; diagnosed at the age of 43). The patient w...

journal_title：Oncology letters

authors： Shibata S,Shiraishi K,Yamashita H,Kobayashi R,Nakagawa K

更新日期：2016-04-01 00:00:00

abstract：:Lung cancer is one of the most common malignancies worldwide; however, its detailed molecular mechanism remains largely unknown. Long non-coding RNAs (lncRNAs) have been identified to serve critical roles in tumorigenesis. The aim of the present study was to investigate the role of a newly identified lncRNA, overexpre...

journal_title：Oncology letters

authors： Zou Y,Zhang B,Mao Y,Zhang H,Hong W

更新日期：2019-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) metastases in the mediastinum are rare, particularly under the arch of the aorta. The present study describes the case of a 30-year-old male patient who presented with back pain and hoarseness for 2 months due to lymph node metastasis of HCC. The patient had undergone right hepatic lobec...

journal_title：Oncology letters

authors： Xu L,Xue F,Wang B,Yan D,Ding W,Yin J,Yi C,Wang W

更新日期：2016-08-01 00:00:00

abstract：:The study aim was to evaluate the association of the expression of serum microribonucleic acid-590 (miR-590) with the risk of lung squamous cell carcinoma (LUSC), clinicopathological staging and prognosis. A total of 237 patients with LUSC and 100 healthy volunteers (control group) were included in the study. Total RN...

journal_title：Oncology letters

authors： Ma Z,Wang Y,He B,Cui J,Zhang C,Wang H,Feng W,Wang B,Wei D,Wu Y,Zeng Y,Yu G

更新日期：2018-02-01 00:00:00

abstract：:The underlying molecular mechanisms of pancreatic neuroendocrine tumor (pNET) development have not yet been clearly identified. The present study revealed that thrombospondin 2 (THBS2) was downregulated in pNET tissues and cells. Forced expression of THBS2 inhibited the proliferation and migration of pNET cells in vit...

journal_title：Oncology letters

authors： Jiao H,Zeng L,Zhang J,Yang S,Lou W

更新日期：2020-03-01 00:00:00