Abstract:
:Deguelin is a naturally occurring rotenoid with strong cancer chemopreventive and antitumor activities. In the present study, we investigated the antitumor activity of deguelin against MPC-11 murine myeloma cells and the possible mechanism of action in vitro. Our results revealed that deguelin inhibited the proliferation of MPC-11 cells in a concentration- and time-dependent manner and caused the apoptotic death of MPC-11 cells. Following exposure to deguelin, the phosphorylation of Akt was decreased. The inhibition of cell growth may be associated with decreased levels of phosphorylated Akt. Deguelin-induced apoptosis was characterized by the upregulation of Bax, downregulation of Bcl-2 and activation of caspase-3. In conclusion, deguelin inhibits murine myeloma cell proliferation by inducing apoptosis via regulation of the Bax/Bcl-2 ratio and by inhibition of the activation of Akt. Its potential as an anticancer agent against multiple myeloma warrants further investigation.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Li Z,Wu J,Wu C,Jiang J,Zheng X,Xu B,Li Mdoi
10.3892/ol.2012.790subject
Has Abstractpub_date
2012-10-01 00:00:00pages
677-681issue
4eissn
1792-1074issn
1792-1082pii
ol-04-04-0677journal_volume
4pub_type
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