Effects of resveratrol on vascular endothelial growth factor expression in osteosarcoma cells and cell proliferation.

Abstract:

:The aim of the current study was to investigate the effects of resveratrol (Res) on vascular endothelial growth factor (VEGF) expression and cell proliferation in the human osteosarcoma cell line U20S. U20S cells were treated with Res at various concentrations (0, 10, 20 and 40 μmol/l) for various times (24, 48 and 72 h). The inhibitory effect of Res on U20S proliferation was observed using methyl thiazolyl tetrazolium (MTT) colorimetry. VEGF expression was determined using real-time polymerase chain reaction (RT-PCR) and western blot analysis. The inhibitory effect of Res on U20S proliferation increased as the concentration of Res increased. The inhibitory effect also increased with time. Res had an inhibitory effect on VEGF expression and significantly inhibited U20S cell proliferation. Res may exert an anti-osteosarcoma effect by inhibiting VEGF expression in tumor cells.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Liu Z,Li Y,Yang R

doi

10.3892/ol.2012.824

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

837-839

issue

4

eissn

1792-1074

issn

1792-1082

pii

ol-04-04-0837

journal_volume

4

pub_type

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