Abstract:
:The underlying molecular mechanisms of pancreatic neuroendocrine tumor (pNET) development have not yet been clearly identified. The present study revealed that thrombospondin 2 (THBS2) was downregulated in pNET tissues and cells. Forced expression of THBS2 inhibited the proliferation and migration of pNET cells in vitro. MicroRNA(miR)-744-5p was indicated to be a direct regulator of THBS2. Upregulation of miR-744-5p potentially caused THBS2 repression. Furthermore, THBS2 inhibited the production of matrix metalloproteinase (MMP) MMP9 through suppressing the transcriptional activity of CUT-like homeobox 1 (CUX1). CUX1 and MMP9 mediated the effect of THBS2 on pNET proliferation and migration, respectively. The results of the present study revealed a mechanistic role for THBS2 in pNET proliferation and migration, indicating that THBS2 was downregulated by miR-744-5p and further affected the CUX1/MMP9 cascade, which promoted the development of pNET.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Jiao H,Zeng L,Zhang J,Yang S,Lou Wdoi
10.3892/ol.2020.11273subject
Has Abstractpub_date
2020-03-01 00:00:00pages
1683-1692issue
3eissn
1792-1074issn
1792-1082pii
OL-0-0-11273journal_volume
19pub_type
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