Long non-coding RNA OECC promotes cell proliferation and metastasis through the PI3K/Akt/mTOR signaling pathway in human lung cancer.

abstract：:Hypoxia-inducible factor-1α (HIF-1α) and toll-like receptor 4 (TLR4) are involved in numerous mechanisms of cancer biology, including cell proliferation and survival; however the interaction of the two factors under hypoxic conditions remains unclear. The present study investigated the in vitro mechanism that results ...

journal_title：Oncology letters

authors： Zhang X,Li S,Li M,Huang H,Li J,Zhou C

更新日期：2016-08-01 00:00:00

abstract：:Golgi protein 73 (GP73) is a resident Golgi type II transmembrane protein that has been reported to markedly increase in chronic liver disease, particularly in hepatocellular carcinoma (HCC). However, it remains unclear as to whether serum GP73 represents a reliable serum marker for the diagnosis of HCC. The aim of th...

journal_title：Oncology letters

authors： Hou SC,Xiao MB,Ni RZ,Ni WK,Jiang F,Li XY,Lu CH,Chen BY

更新日期：2013-10-01 00:00:00

abstract：:The aim of the present study was to develop a procedure for the isolation of circulating tumor cells (CTCs), and to evaluate its application in the detection of epidermal growth factor receptor (EGFR) mutations, and potential heterogeneity in patients with non-small-cell lung cancer (NSCLC). Peripheral blood samples w...

journal_title：Oncology letters

authors： Zhang Q,Nong J,Wang J,Yan Z,Yi L,Gao X,Liu Z,Zhang H,Zhang S

更新日期：2019-04-01 00:00:00

abstract：:Cutaneous melanoma (CM) is the most aggressive form of skin cancer, exhibits an increasing incidence worldwide and has a high potential to develop metastasis. The current study aimed to identify a set of parameters that may aid in predicting the probability and timing of the onset of CM metastasis. A retrospective ana...

journal_title：Oncology letters

authors： Pjanova D,Ruklisa D,Kregere E,Azarjana K,Ozola A,Cema I

更新日期：2020-10-01 00:00:00

abstract：:The aim of the study was to determine whether interleukin-8 (IL-8) affects human SKOV3 ovarian cancer cell migration and invasion by targeting silencing of IL-8 expression. Silencing small-interfering RNA (siRNA) targeting IL-8 gene was constructed to infect SKOV3 cells by lentiviral vector. The expression of IL-8 and...

journal_title：Oncology letters

authors： Li Y,Liu L,Yin Z,Xu H,Li S,Tao W,Cheng H,Du L,Zhou X,Zhang B

更新日期：2017-02-01 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the most common types of cancer worldwide. However, operative diagnostic and prognostic systems for ESCC remain to be established. To improve assessment of the prognosis for patients with ESCC, the present study developed an online consensus survival tool for ESCC, t...

journal_title：Oncology letters

authors： Wang Q,Wang F,Lv J,Xin J,Xie L,Zhu W,Tang Y,Li Y,Zhao X,Wang Y,Li X,Guo X

更新日期：2019-08-01 00:00:00

abstract：:The present study aimed to conduct a prognosis analysis of Taiwanese patients with metastatic gastrointestinal stromal tumors (GISTs), who are resistant to or were unable to tolerate imatinib or sunitinib, and were subsequently treated with regorafenib. The study considered the survival, potential prognostic factors a...

journal_title：Oncology letters

authors： Hu CH,Yeh CN,Chen JS,Tsai CY,Wang SY,Cheng CT,Yeh TS

更新日期：2020-09-01 00:00:00

abstract：:The present study reports a case of pancreatic vasoactive intestinal peptide-secreting tumor (VIPoma), of 2.2 cm in diameter, arising from the region of the uncus of the pancreas with liver metastases in a 50-year-old patient, which demonstrated unusual multiple-phase spiral computed tomography (MPSCT) results. The pa...

journal_title：Oncology letters

authors： Chen Y,Shi D,Dong F,Han SG,Qian ZH,Yang LI,Wang Y,Yu RS,Li QH,Fu YB

更新日期：2015-10-01 00:00:00

abstract：:Aquaporin 1 (AQP1), which functions as a water transporter, is associated with cancer cell proliferation, invasion, metastasis and angiogenesis in numerous types of solid cancer, including colorectal cancer (CRC). The focus of the present study was to address the potential clinical use of AQP1 expression in CRC as a p...

journal_title：Oncology letters

authors： Imaizumi H,Ishibashi K,Takenoshita S,Ishida H

更新日期：2018-05-01 00:00:00

abstract：:Previous studies have revealed that fibrosis may affect the biological behavior of tumors, however associated research on papillary thyroid microcarcinoma (PTMC) is rare. The aim of the present study was to explore the association between interstitial fibrosis (IF) and the biological behavior of PTMC. In the present s...

journal_title：Oncology letters

authors： Liu X,Zhang S,Gang Q,Shen S,Zhang J,Lun Y,Xu D,Duan Z,Xin S

更新日期：2018-04-01 00:00:00

abstract：:Hypoxia occurs in a wide range of solid tumors, and is strongly associated with radio-resistance of malignant tumors. The aim of the present study was to investigate the effect of endostatin combined with ionizing radiation (IR) on hypoxic conditions. A total of 24 mice bearing SKOV3 ovarian carcinoma were divided int...

journal_title：Oncology letters

authors： Zhang YC,Li XM,Yu Z,Shi XL,Li Y,Wang WL

更新日期：2017-03-01 00:00:00

abstract：:The high mobility group A1 (HMGA1) protein is associated with poor prognosis in patients with a wide range of cancers. However, the affect of HMGA1 on the risk of mortality from breast cancer (BC) has not been fully characterized. In the present retrospective multiple center study, the HMGA1 expression level was deter...

journal_title：Oncology letters

authors： Zhang S,Lei R,Wu J,Shan J,Hu Z,Chen L,Ren X,Yao L,Wang J,Wang X

更新日期：2017-11-01 00:00:00

abstract：:Aberrant expression of Ras homolog enriched in brain (RHEB) has been observed in a variety of cancer tissues and is closely associated with clinicopathological features. However, the expression profile of RHEB in patients with hepatocellular carcinoma (HCC) and its clinical signature with underlying mechanisms have no...

journal_title：Oncology letters

authors： Liu F,Pan Z,Zhang J,Ni J,Wang C,Wang Z,Gu F,Dong W,Zhou W,Liu H

更新日期：2018-03-01 00:00:00

abstract：:The present study investigated enhancement of apoptosis induction and the mechanisms underlying calcium overload on C6 glioma cells in vitro, stimulated by low-level ultrasound in combination with hematoporphyrin monomethyl ether (HMME). The optimum frequency of ultrasound was determined by 3-(4,5-dimethythiazol-2-yl)...

journal_title：Oncology letters

authors： Dai S,Xu C,Tian Y,Cheng W,Li B

更新日期：2014-10-01 00:00:00

abstract：:Brain-specific metastasis is one of the primary causes of recurrence following complete resection of non-small cell lung cancer (NSCLC) and the underlying mechanism remains unclear. The present study was designed to investigate the correlation between C-X-C chemokine receptor type 4 (CXCR4) expression and brain-specif...

journal_title：Oncology letters

authors： Wang L,Wang Z,Liu X,Liu F

更新日期：2014-06-01 00:00:00

abstract：:The Ganoderma lucidum (G. lucidum) mushroom is one of the most extensively studied functional foods, known for its numerous health benefits, including the inhibition of tumor cell growth. The present study assessed the anti-proliferative and pro-apoptotic activity of a novel G. lucidum polysaccharide peptide (GL-PP) i...

journal_title：Oncology letters

authors： Wang C,Lin D,Chen Q,Lin S,Shi S,Chen C

更新日期：2018-04-01 00:00:00

abstract：:In this study, we report the cytogenetic analysis of a 31-year-old male with a rare translocation between chromosomes 1 and 16 and inversion of chromosome 5 in CD99-positive soft tissue sarcoma of the thigh, which metastasized to the lung. Histologically, the tumor showed ovoid or short-spindle atypical cells with pos...

journal_title：Oncology letters

authors： Kanamori M,Suzuki K,Yasuda T,Hori T

更新日期：2012-06-01 00:00:00

abstract：:Multidrug resistance (MDR) is a major obstacle in the effective chemotherapeutic treatment of cancers. Triptolide (TPL) is a diterpenoid isolated from Tripterygium wilfordii Hook. f., a traditional Chinese medicine. It was demonstrated in our previous study that TPL exerts anti-MDR cancers on various MDR cell lines (i...

journal_title：Oncology letters

authors： Xie CQ,Zhou P,Zuo J,Li X,Chen Y,Chen JW

更新日期：2016-11-01 00:00:00

abstract：:Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and r...

journal_title：Oncology letters

authors： Dong G,Mao Q,Xia W,Xu Y,Wang J,Xu L,Jiang F

更新日期：2016-03-01 00:00:00

abstract：:The present study sought to characterize the role of macrophage inflammatory protein-3α (MIP-3α) in non-small cell lung cancer (NSCLC) patients with early recurrence or metastasis after primary pulmonary resection. Follow-up examinations were conducted for 203 NSCLC patients with primary pulmonary resection for two ye...

journal_title：Oncology letters

authors： Zhang X,Meng A,Wang H,Yan X

更新日期：2014-08-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death. Due to rapid progression and metastasis, the long-term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that chond...

journal_title：Oncology letters

authors： Huang Z,Zhang N,Li W,Cao J,Zhang L,Chen Y

更新日期：2017-02-01 00:00:00

abstract：:Multiple myeloma (MM) is a hematological malignancy that lacks a cure. However, novel combination therapy is a current anti-MM strategy. Doxorubicin (DOX) is a type of anthracycline which is a first-line chemotherapeutic for treating MM and induces senescence in many types of cancer. Dinaciclib is a potent, small mole...

journal_title：Oncology letters

authors： Tang H,Xu L,Liang X,Gao G

更新日期：2018-11-01 00:00:00

abstract：:[This retracts the article DOI: 10.3892/ol.2016.4607.]. ...

journal_title：Oncology letters

authors： Li L,Mao X,Qin X,Zhou M,Xing H,Dong F,Jiang X,Zhuang W

更新日期：2019-05-01 00:00:00

abstract：:In order to study the influence and mechanism of miR-544a on the self-renewal ability of lung cancer stem cells, TargetScan was used to predict the target gene of miR-544a. A luciferase reporter system and western blotting were used to validate the target genes identified by TargetScan. 95C and 95D low and high metast...

journal_title：Oncology letters

authors： Mo XM,Li HH,Liu M,Li YT

更新日期：2014-10-01 00:00:00

abstract：:Previous studies have demonstrated that members of the brain-expressed X-linked (BEX) family participate in a wide range of biological functions in normal and tumor tissues. However, their role and clinical significance in lung adenocarcinoma (LUAD) remains unclear. The present study investigated The Cancer Genome Atl...

journal_title：Oncology letters

authors： Zhang ZH,Luan ZY,Han F,Chen HQ,Liu WB,Liu JY,Cao J

更新日期：2019-11-01 00:00:00

abstract：:The present study aimed to investigate the effect of fisetin on proliferation and apoptosis of gastric cancer cells, as well as the underlying mechanism. Proliferation in SGC7901 cancer and GES-1 normal cells was analyzed using a CCK-8 assay. Apoptosis was analyzed using an Annexin V/Propidium Iodide apoptosis kit and...

journal_title：Oncology letters

authors： Yan W,Chen S,Zhao Y,Ye X

更新日期：2018-06-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) functions as a chromatin-associated nuclear protein and an extracellular signaling molecule. The concentration of HMGB1 protein and the expression of HMGB1 mRNA were analyzed by ELISA and polymerase chain reaction (PCR), respectively. The present study reports high plasma HMGB1 levels...

journal_title：Oncology letters

authors： Kimura R,Mori N

更新日期：2014-04-01 00:00:00

abstract：:Intrahepatic cholangiocarcinoma (ICC) is an aggressive type of cancer, and its incidence and mortality rates are increasing worldwide. Mortalin is a highly conserved chaperone protein involved in multiple pathological and physiological processes, including anti-apoptosis, carcinogenesis and metastasis. The Bcl-2 famil...

journal_title：Oncology letters

authors： Kang Q,Zou H,Yang X,Cai JB,Liu LX,Xie N,Wang LM,Li YH,Zhang XW

更新日期：2018-02-01 00:00:00

abstract：:Colonic schwannomas are rare gastrointestinal mesenchymal tumors, and only a limited number of cases has been reported. The occurrence of these tumors is less common in the large intestine than in the stomach. The present study reports a case of colonic schwannoma in a 62-year-old female patient with no specific sympt...

journal_title：Oncology letters

authors： Wang WB,Chen WB,Lin JJ,Xu JH,Wang JH,Sheng QS

更新日期：2016-04-01 00:00:00

abstract：:The aberrant expression of microRNAs (miRs) has a significant impact on the biological characteristics of lymphocytes, and is important in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). It has been demonstrated, using miR profiling and detecting distinct miR signatures, that certain miRs may accurately dis...

journal_title：Oncology letters

authors： Ni H,Tong R,Zou L,Song G,Cho WC

更新日期：2016-02-01 00:00:00