Abstract:
:MicroRNAs (miRs) can function as tumor suppressors or oncogenes in different types of human malignancy, and may provide an effective therapy for cancer. The expression and functions of miR-592 have previously been studied in relation to cancer. However, the expression and potential functions of miR-592 in hepatocellular carcinoma (HCC) are still unknown. Using quantitative polymerase chain reaction, MTT assays, cellular migration and invasion assays, bioinformatics software, western blot analysis and dual-luciferase report assays, the present study explored the expression and roles of miR-592 in HCC. It was identified that miR-592 was significantly downregulated in HCC tissues and cell lines. The statistical analysis revealed that low expression of miR-592 was evidently associated with tumor node metastasis stage and lymph node metastasis. Additionally, the present study provided the first evidence that miR-592 was likely to directly target the insulin-like growth factor 1 receptor in vitro. The present results indicated that miR-592 could be investigated as an efficacious therapeutic target for HCC in the future.
journal_name
Oncol Lettjournal_title
Oncology lettersauthors
Wang W,Zhang H,Tang M,Liu L,Zhou Z,Zhang S,Wang Ldoi
10.3892/ol.2017.5902subject
Has Abstractpub_date
2017-05-01 00:00:00pages
3522-3528issue
5eissn
1792-1074issn
1792-1082pii
OL-0-0-5902journal_volume
13pub_type
杂志文章相关文献
Oncology Letters文献大全abstract::The present study sought to characterize the role of macrophage inflammatory protein-3α (MIP-3α) in non-small cell lung cancer (NSCLC) patients with early recurrence or metastasis after primary pulmonary resection. Follow-up examinations were conducted for 203 NSCLC patients with primary pulmonary resection for two ye...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2229
更新日期:2014-08-01 00:00:00
abstract::Clear cell myoepithelial carcinoma is a very rare disease which develops primarily in the parotid gland. To date, only 17 cases of clear cell myoepithelial carcinoma have been reported worldwide. Among them, only three cases developed in the minor salivary gland in the oral cavity. No cases developed in the base of th...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.900
更新日期:2012-12-01 00:00:00
abstract::Osteosarcoma (OS) is identified as the most commonly diagnosed malignant cancer of bone, and has approximately three million new cases annually. miR-26a plays an important role in the development of various types of cancer. We investigated whether miR-26a can regulate the migration and invasion of OS by targeting high...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.8359
更新日期:2018-06-01 00:00:00
abstract::Carbohydrate antigen 19-9 (CA19-9) is not generally considered to be a biomarker in pancreatic neuroendocrine tumors (pNETs), as the majority of pNETs present with a normal range of CA19-9. The present study aimed to evaluate the role of serum CA19-9 levels as a prognostic factor in a relatively large number of patien...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.7071
更新日期:2017-12-01 00:00:00
abstract::The present study aimed to evaluate the expression of p53, Ki-67, epidermal growth factor receptor (EGFR) and O6-methylguanine-DNA methyltransferase (MGMT), and to analyze the correlation between their expression and the histological grade of the tumors in 152 patients with gliomas. The tumors were classified accordin...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1317
更新日期:2013-07-01 00:00:00
abstract::MicroRNAs (miRs) have been demonstrated to serve important roles in the development and progression of human cancer, primarily through the direct targeting of oncogenes or tumor suppressors. It has been previously suggested that miR-126 may be associated with endometrial cancer (EC). However, the exact role of miR-126...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4001
更新日期:2016-02-01 00:00:00
abstract::Metastasis remains a notable issue in patients with newly diagnosed colorectal carcinomas (CRC). Although anti-angiogenic therapies target metastatic diseases, hypoxia-inducible factor-1 α (HIF-1α) and vascular endothelial growth factor (VEGF) status are routinely evaluated in primary tumors as metastatic sites are in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11450
更新日期:2020-05-01 00:00:00
abstract::Glioma is one of the most prevalent types of malignancy in the central nervous system worldwide, and the prognosis of patients with late stage glioma remains poor. Thus, the development of promising therapeutic strategies against glioma is essential. Long non-coding RNAs (lncRNAs) are functional RNA molecules involved...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11847
更新日期:2020-09-01 00:00:00
abstract::The present study aimed to investigate the clinical significance of paired-box 8 (PAX8) in primary epithelial ovarian cancer (PEOC). Using immunohistochemical (IHC) staining, the expression of PAX8 in 60 patients with PEOC, 20 patients with ovarian benign lesions and 10 patients with metastatic ovarian cancer (MOC), w...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2017.6949
更新日期:2017-11-01 00:00:00
abstract::Previous studies have revealed that fibrosis may affect the biological behavior of tumors, however associated research on papillary thyroid microcarcinoma (PTMC) is rare. The aim of the present study was to explore the association between interstitial fibrosis (IF) and the biological behavior of PTMC. In the present s...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7928
更新日期:2018-04-01 00:00:00
abstract::The Ganoderma lucidum (G. lucidum) mushroom is one of the most extensively studied functional foods, known for its numerous health benefits, including the inhibition of tumor cell growth. The present study assessed the anti-proliferative and pro-apoptotic activity of a novel G. lucidum polysaccharide peptide (GL-PP) i...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7823
更新日期:2018-04-01 00:00:00
abstract::Transforming growth factor β (TGFβ) ligands, including TGFβ1, are multifunctional cytokines known as key regulators of cell growth, differentiation and inflammation. Dysregulated TGFβ signaling is common in numerous solid tumors, including head and neck squamous cell carcinoma (HNSCC). Previously, TGFβ ligands were al...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.5336
更新日期:2016-12-01 00:00:00
abstract::Voltage-dependent anion channels (VDACs) are situated in the outer membrane of the mitochondria and serve as gatekeepers that control metabolite and ion exchange between the cytosol and mitochondria. VDAC1 is one of the most studied members of the VDAC protein family and is overexpressed in multiple types of cancer. H...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.10534
更新日期:2019-09-01 00:00:00
abstract::Effective therapies are limited for pancreatic cancer, particularly for those with distant tumour metastases. Therefore, more individualised drug screening is urgently required. Next-generation sequencing (NGS) is a powerful tool to investigate the genomic landscape of patients and the mechanism of drug response, whic...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9876
更新日期:2019-02-01 00:00:00
abstract::The aim of the present study was to investigate the association between the expression of chemokine receptors CCR7 and CXCR4 and vascular endothelial growth factor (VEGF)-C and the lymph node metastasis of pancreatic ductal adenocarcinoma (PDAC). The mRNA transcription levels of CCR7, CXCR4 and VEGF-C were measured in...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2013.1261
更新日期:2013-05-01 00:00:00
abstract::HRas proto-oncogene (HRAS) is one of the most commonly mutated genes in thyroid cancer, with mutations frequently occurring in the follicular and Hurthle cell subtypes. However, the contribution of mutations in HRAS to papillary thyroid carcinoma (PTC) progression and the tall-cell variant (TCV) is poorly understood. ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.7818
更新日期:2018-04-01 00:00:00
abstract::The danger of overexposure to solar ultraviolet radiation has been widely reviewed since the 1980s due to the depletion of the ozone layer. However, the benefits of mild exposure of the skin to ultraviolet (UV) light have not been widely investigated. Numerous reports have demonstrated that an association exists betwe...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.3519
更新日期:2015-10-01 00:00:00
abstract::Lung cancer is one of the leading causes of cancer-associated mortality. C-reactive protein (CRP), albumin (ALB), globulin (GLB), lactate dehydrogenase (LDH), neutrophil-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified as general parameters for systemic inflammatory response (SIR). Fu...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2018.9858
更新日期:2019-02-01 00:00:00
abstract::Numerous genetic alterations have been implicated in the development of prostate cancer (PCa). DNA and protein microarrays have enabled the identification of genes associated with apoptosis, which is important in PCa development. Despite the molecular mechanisms are not entirely understood, inhibition of apoptosis is ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4983
更新日期:2016-10-01 00:00:00
abstract::The present study aimed to investigate the effects of silencing RIP1 by small interfering RNA (siRNA) on the biological behavior of the LoVo human colorectal carcinoma cell line and to provide evidence for the feasibility of colorectal cancer gene therapy. LoVo cells were divided into the RIP1 siRNA group, the blank c...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2040
更新日期:2014-06-01 00:00:00
abstract::The aim of the present study was to investigate the association between the clinicopathological and demographic factors, and the survival time of patients with triple-negative breast cancer (TNBC) in China. The patients had received adjuvant chemotherapy consisting of 5-fluorouracil, epirubicin and cyclophosphamide (F...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4176
更新日期:2016-03-01 00:00:00
abstract::Connexins (Cxs), a conserved family of trans-membrane proteins, function in the organization of cell-cell communicatin via gap junctions in multicellular organisms. However, the role of Cxs in acute myeloid leukemia (AML) is poorly understood. In this study, we investigated the relationship between cell proliferation ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.884
更新日期:2012-11-01 00:00:00
abstract::Extragastrointestinal stromal tumors (EGISTs) are relatively rare soft tissue neoplasms arising from the extra gastrointestinal tract. The current study presents a case of primary EGIST of the prostate observed in a 55-year-old male. Imaging studies showed a 10×10.5×9.5-cm prostate mass. On histological observation, t...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.1968
更新日期:2014-06-01 00:00:00
abstract::Papillary thyroid carcinoma (PTC) is the most common type of thyroid carcinoma, and its incidence has been on the increase in recent years. However, the molecular mechanism of PTC is unclear and misdiagnosis remains a major issue. Therefore, the present study aimed to investigate this mechanism, and to identify key pr...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2019.11100
更新日期:2020-01-01 00:00:00
abstract::In colorectal cancer (CRC), KRAS and BRAF mutations in primary tumors are associated with resistance to anti-epidermal growth factor receptor (anti-EGFR)-based therapies. However, the correlation between KRAS/BRAF mutation in primary tumors and serum has not been well studied. To evaluate the degree of concordance of ...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2012.963
更新日期:2013-01-01 00:00:00
abstract::Cholangiocarcinoma (CCA) is a primary malignancy, which is often diagnosed as locally advanced or metastatic. Previous studies have revealed genomic characteristics of CCA in Western patients, however comprehensive genomic features of CCA in Chinese patients have not been well understood. To explore the specific genom...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2020.11429
更新日期:2020-04-01 00:00:00
abstract::The predominant characteristic of malignant glioma is the presence of invading tumor cells in the peritumoral zone. Distinguishing between tumor cells and normal cells in a peritumoral lesion is challenging. Therefore, the aim of the present study was to investigate the cell-cycle phase measurements of fixed paraffin-...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2016.4205
更新日期:2016-03-01 00:00:00
abstract::Few reports have explored laparoscopic adnexal tumorectomy as a treatment for large and symptomatic ovarian leiomyomas during pregnancy. The current study presents the case of a patient with a large and symptomatic ovarian leiomyoma at 14 weeks of pregnancy. A laparoscopic adnexal tumorectomy was performed without com...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2014.2596
更新日期:2014-12-01 00:00:00
abstract::Radical cystectomy, as the most common surgical treatment for patients with invasive bladder cancer (IBC) complicated by peritoneal metastasis, is usually accompanied by a urinary diversion procedure. In this study, we evaluated the improved tubeless cutaneous ureterostomy technique by comparing the resulting clinical...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.4045
更新日期:2016-02-01 00:00:00
abstract::Exophthalmos, myxedema and osteoarthropathy (EMO) comprise the triad known as EMO syndrome, which is rarely observed in patients with autoimmune thyroid disease. The present study reports the case of a patient with EMO, including the response of this rare combination to radiotherapy. A 48-year-old patient with EMO syn...
journal_title:Oncology letters
pub_type: 杂志文章
doi:10.3892/ol.2015.2990
更新日期:2015-05-01 00:00:00