Identification of a novel HRAS variant and its association with papillary thyroid carcinoma.

Abstract:

:HRas proto-oncogene (HRAS) is one of the most commonly mutated genes in thyroid cancer, with mutations frequently occurring in the follicular and Hurthle cell subtypes. However, the contribution of mutations in HRAS to papillary thyroid carcinoma (PTC) progression and the tall-cell variant (TCV) is poorly understood. The aim of the present study was to investigate the somatic genetic variants present in HRAS in patients with PTC, and to investigate the association of these mutations with PTC. The present study is a retrospective case-control study using tumor samples collected from 139 patients with PTC and blood samples from 195 healthy individuals. All patient samples were screened for mutations in 'hotspot' regions of HRAS and B-raf proto-oncogene (BRAF) by single-stranded conformational polymorphism analysis, followed by direct sequencing. A novel variant (IVS1-82del gctgggcctggg) in the HRAS 5'-untranslated region was identified. There was no difference in age or sex of patients with PTC and the healthy controls; however, the HRAS variant was more frequently detected in PTC tissue than in the healthy control samples (37 vs. 26%, P=0.04). There was no association between the HRAS variant and age, sex, tumor size, encapsulation, multifocality/intra-thyroidal spread, Tumor-Node-Metastasis stage, history of Hashimoto's disease, BRAF V600E mutation or PTC subtype (all P>0.05). There were differences of BRAF V600E distribution among different subtypes (χ2=6.390, P=0.041). HRAS variant co-occurring with the BRAF V600E mutation accounted for 31.6% of the total number (P=0.196). Therefore, this novel variant of HRAS (IVS1-82del gctgggcctggg) may be associated with PTC; however, larger scale studies are required to assess the contribution of this novel HRAS variant to PTC progression.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Dou R,Zhang L,Lu T,Liu D,Mei F,Huang J,Qian L

doi

10.3892/ol.2018.7818

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

4511-4516

issue

4

eissn

1792-1074

issn

1792-1082

pii

OL-0-0-7818

journal_volume

15

pub_type

杂志文章
  • Leptomeningeal carcinomatosis as the primary presentation of relapse in breast cancer.

    abstract::Leptomeningeal metastasis (LM) is an uncommon presentation of relapse in breast cancer, which is associated with poor clinical outcomes and poor prognosis. Notably, LM most commonly occurs in breast cancer. The aim of the present review was to investigate the occurrence of LM as the primary presentation of relapse fol...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4745

    authors: Sacco K,Muhammad A,Saleem W,Alshaker H,Monzon L,Islam MR,Pchejetski D

    更新日期:2016-08-01 00:00:00

  • Comparative evaluation of surgical stress of laparoscopically assisted vaginal radical hysterectomy and lymphadenectomy and laparotomy for early-stage cervical cancer.

    abstract::The aim of this study was to objectively evaluate the benefits of laparoscopically assisted vaginal radical hysterectomy and lymphadenectomy for early-stage cervical cancer. Clinical data were prospectively collected from patients with IA-IIB cervical cancer who underwent laparoscopically assisted vaginal radical hyst...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.311

    authors: Hou CY,Li XL,Jiang F,Gong RJ,Guo XY,Yao YQ

    更新日期:2011-07-01 00:00:00

  • Single nucleotide polymorphisms in the HIF-1α gene and chemoradiotherapy of locally advanced rectal cancer.

    abstract::The aim of this study was to investigate the predictive impact of polymorphisms in the HIF-1α gene on the response to chemoradiotherapy (CRT) in rectal cancer. This study included two cohorts of patients with locally advanced rectal cancer receiving long-course CRT. The HIF-1α C1772T (rs11549465), G1790A (rs11549467) ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.837

    authors: Havelund BM,Spindler KL,Ploen J,Andersen RF,Jakobsen A

    更新日期:2012-11-01 00:00:00

  • Pyridine analogues of curcumin exhibit high activity for inhibiting CWR-22Rv1 human prostate cancer cell growth and androgen receptor activation.

    abstract::The concentrations required for curcumin to exert its anticancer activity (IC50, 20 µM) are difficult to achieve in the blood plasma of patients, due to the low bioavailability of the compound. Therefore, much effort has been devoted to the development of curcumin analogues that exhibit stronger anticancer activity an...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4536

    authors: Zhou DY,Zhao SQ,DU ZY,Zheng XI,Zhang K

    更新日期:2016-06-01 00:00:00

  • Definitive chemoradiotherapy of limited-disease small cell lung cancer: Retrospective analysis of new predictive factors affecting treatment results.

    abstract::The aim of this study was to evaluate potential predictive factors in the treatment of limited-disease small cell lung cancer (LD-SCLC). A total of 33 patients with LD-SCLC who underwent definitive chemoradiotherapy at our institute between April 1996 and May 2007 were enrolled in our retrospective study. The relation...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.361

    authors: Komatsu T,Oizumi Y,Kunieda E,Tamai Y,Akiba T,Kogawa A

    更新日期:2011-09-01 00:00:00

  • Cluster of differentiation 19 chimeric antigen receptor T-cell therapy in pediatric acute lymphoblastic leukemia.

    abstract::Chimeric antigen receptor (CAR) T cells have an unprecedented positive curative effect for hematological malignances. Most notably, cluster of differentiation 19 (CD19) CAR T-cell therapy for pediatric acute lymphoblastic leukemia is associated with a high complete remission rate and has aroused considerable attention...

    journal_title:Oncology letters

    pub_type: 杂志文章,评审

    doi:10.3892/ol.2020.11897

    authors: Fu Z,Zhou J,Chen R,Jin Y,Ni T,Qian L,Xiao C

    更新日期:2020-10-01 00:00:00

  • Cancer and embryo expression protein 65 promotes cancer cell growth and metastasis.

    abstract::Cancer and embryo expression protein 65 (CEP65) is a centrosomal protein that is expressed at relatively high levels in embryonic tissue and different cancerous tissues, but its role in tumorigenesis remains unknown. In the present study, CEP65 was stably expressed in AGS gastric cancer cells. CEP65 was found to promo...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.2958

    authors: Jin G,Peng L,Zhang J,Qu L,Shou C

    更新日期:2015-04-01 00:00:00

  • Use of immunotherapy in the treatment of gastric cancer.

    abstract::Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. Despite the development of combination chemotherapy, only a modest survival advantage is gained in patients with GC treated by this method. Recently, ca...

    journal_title:Oncology letters

    pub_type: 杂志文章,评审

    doi:10.3892/ol.2019.10935

    authors: Yang L,Wang Y,Wang H

    更新日期:2019-12-01 00:00:00

  • Jinfukang induces cellular apoptosis through activation of Fas and DR4 in A549 cells.

    abstract::The traditional Chinese medicine Jinfukang (JFK) has been shown as a valuable drug to treat non-small cell lung cancer (NSCLC). Previously, it was reported that JFK-induced epigenetic alteration is involved in anti-lung cancer activity. In the present study, the effect of JFK on lung cancer cell lines was examined wit...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9149

    authors: Lu J,Chen J,Kang Y,Wu J,Shi H,Fu Y,Jiao L,Dong C,Li X,Jin Y,Zhao W,Xu L,Zhao X

    更新日期:2018-10-01 00:00:00

  • Downregulation of miR-1266-5P, miR-185-5P and miR-30c-2 in prostatic cancer tissue and cell lines.

    abstract::Over the latest decade, the role of microRNAs (miRNAs/miRs) has received more attention. miRNAs are small non-coding RNAs that may serve a role as oncogenes or tumor suppressor genes. Certain miRNAs regulate the apoptosis pathway by influencing pro- or anti-apoptotic genes. We hypothesized that increases in the expres...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8336

    authors: Ostadrahimi S,Fayaz S,Parvizhamidi M,Abedi-Valugerdi M,Hassan M,Kadivar M,Teimoori-Toolabi L,Asgari M,Shahrokh H,Abolhasani M,Mahdian R,Fard-Esfahani P

    更新日期:2018-05-01 00:00:00

  • Hyperthermia and radiation reduce the toxic side-effects of bufadienolides for cancer therapy.

    abstract::Bufadienolides are constituents of the traditional Chinese medicine Chan Su and are found in toad venom. Cardiovascular side-effects are one of the limiting factors towards developing bufadienolides as chemotherapeutic agents. Thus, in the present study, low doses of bufalin and cinobufotalin, prominent members of the...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6256

    authors: Emam H,Refaat A,Jawaid P,Ur Rehman M,Li P,Zhao QL,Kondo T

    更新日期:2017-07-01 00:00:00

  • Schwannoma of the colon: A case report and review of the literature.

    abstract::Colonic schwannomas are rare gastrointestinal mesenchymal tumors, and only a limited number of cases has been reported. The occurrence of these tumors is less common in the large intestine than in the stomach. The present study reports a case of colonic schwannoma in a 62-year-old female patient with no specific sympt...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4271

    authors: Wang WB,Chen WB,Lin JJ,Xu JH,Wang JH,Sheng QS

    更新日期:2016-04-01 00:00:00

  • Terrein performs antitumor functions on esophageal cancer cells by inhibiting cell proliferation and synergistic interaction with cisplatin.

    abstract::Terrein is a bioactive fungal metabolite isolated from Aspergillus terreus. Besides being a melanogenesis inhibitor, previous studies have revealed that terrein has antiproliferative effects on a number of types of cancer tumors. In the present study, the inhibitory effect of terrein on esophageal cancer was evaluated...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.5758

    authors: Wu Y,Zhu Y,Li S,Zeng M,Chu J,Hu P,Li J,Guo Q,Lv XB,Huang G

    更新日期:2017-04-01 00:00:00

  • Expression of WNT1 in ameloblastoma and its significance.

    abstract::The present study aimed to measure the expression of WNT1 in ameloblastoma (AB). Immunohistochemistry was used to observe changes in WNT1 expression in 80 AB samples, 10 keratocystic odontogenic tumor (KCOT) samples and 10 normal oral mucosa (NOM) samples. Western blotting and reverse transcription-quantitative polyme...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8820

    authors: Wang GN,Zhong M,Chen Y,Ji J,Gao XQ,Wang TF

    更新日期:2018-08-01 00:00:00

  • Simian virus 40 may be associated with developing malignant pleural mesothelioma.

    abstract::Malignant pleural mesothelioma (MPM) is associated with a history of heavy, long-term exposure to asbestos. However, MPM may also be associated with simian virus 40 (SV40), a polyomavirus. The association between SV40 and MPM remains unclear. The present study was conducted in order to investigate the proportion of SV...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4174

    authors: Thanh TD,Tho NV,Lam NS,Dung NH,Tabata C,Nakano Y

    更新日期:2016-03-01 00:00:00

  • Long non-coding RNA OECC promotes cell proliferation and metastasis through the PI3K/Akt/mTOR signaling pathway in human lung cancer.

    abstract::Lung cancer is one of the most common malignancies worldwide; however, its detailed molecular mechanism remains largely unknown. Long non-coding RNAs (lncRNAs) have been identified to serve critical roles in tumorigenesis. The aim of the present study was to investigate the role of a newly identified lncRNA, overexpre...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10644

    authors: Zou Y,Zhang B,Mao Y,Zhang H,Hong W

    更新日期:2019-09-01 00:00:00

  • Application of the chemokine-chemokine receptor axis increases the tumor-targeted migration ability of cytokine-induced killer cells in patients with colorectal cancer.

    abstract::Cytokine-induced killer (CIK) cells are a group of heterogeneous immune cells which can be isolated from human peripheral blood mononuclear cells and have demonstrated therapeutic benefit both in hematologic malignancies and solid tumors, including colorectal cancer. However, poor tumor-targeted migration has limited ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11539

    authors: Zou Y,Liang J,Li D,Fang J,Wang L,Wang J,Zhang J,Guo Q,Yan X,Tang H

    更新日期:2020-07-01 00:00:00

  • Suppression of tumor cell proliferation and migration by human umbilical cord mesenchymal stem cells: A possible role for apoptosis and Wnt signaling.

    abstract::Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent potential therapeutic tools for solid tumors. However, there are numerous inconsistent results regarding the effects of hUCMSCs on tumors, and the mechanisms underlying this remain poorly understood. The present study further examined this controv...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8368

    authors: Yuan Y,Zhou C,Chen X,Tao C,Cheng H,Lu X

    更新日期:2018-06-01 00:00:00

  • Classical intracranial chondrosarcoma: A case report.

    abstract::Intracranial chondrosarcoma is a rare malignant cartilage-forming tumor, with only a small number of cases in the posterior cranial fossa reported previously. The present study reports the case of a 40-year-old male patient who was admitted to Tianjin Huanhu Hospital with a progressive headache and dizziness that had ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5154

    authors: Chi J,Zhang M,Kang J

    更新日期:2016-11-01 00:00:00

  • Expression of cyclooxygenase-2, peroxiredoxin I, peroxiredoxin 6 and nuclear factor-κB in oral squamous cell carcinoma.

    abstract::Tumor development and progression are multistep processes that involve local tumor growth and invasion, followed by metastasis. The aggressiveness of the tumor is the major determinant of the mortality of oral cancer patients. The present study investigates whether the expression levels of cyclooxygenase-2 (COX-2), nu...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3705

    authors: Lee EY,Kang JY,Kim KW

    更新日期:2015-11-01 00:00:00

  • Isoliquiritigenin induces apoptosis of human bladder cancer T24 cells via a cyclin-dependent kinase-independent mechanism.

    abstract::The aim of the present study was to investigate whether an increase in cyclin-dependent kinase 2 (CDK2) activity is involved in apoptosis of human bladder cancer T24 cells induced by isoliquiritigenin (ISL). The viability of T24 cells was estimated using a sulforhodamine B assay. Cell morphological changes were examin...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6159

    authors: Si L,Yang X,Yan X,Wang Y,Zheng Q

    更新日期:2017-07-01 00:00:00

  • Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies.

    abstract::Activating mutations of the epidermal growth factor receptor (EGFR) gene are characteristic of non-small cell lung cancer (NSCLC). EGFR mutations were previously detected in histologically normal lung tissue around NSCLC tumors. Computed tomography-guided lung needle biopsy (CTNB) is an accurate and useful technique f...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.471

    authors: Ueno T,Soh J,Hiraki T,Asano H,Ichimura K,Shibamoto K,Gobara H,Kanazawa S,Toyooka S,Miyoshi S

    更新日期:2012-02-01 00:00:00

  • Effect of integrin receptor-targeted liposomal paclitaxel for hepatocellular carcinoma targeting and therapy.

    abstract::The major aim of the present study was to develop an integrin receptor-targeted liposomal paclitaxel (PTX) to enhance the targeting specificity and therapeutic effect of PTX on hepatocellular carcinoma (HCC) cells. The specific Arg-Gly-Asp (RGD) ligand was conjugated to 1,2-distearoylphosphatidylethanolamine-polyethyl...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3242

    authors: Chen L,Liu Y,Wang W,Liu K

    更新日期:2015-07-01 00:00:00

  • Multicenter, phase II clinical trial of peptide vaccination with oral chemotherapy following curative resection for stage III colorectal cancer.

    abstract::The safety and immunological responsiveness of a peptide vaccine of ring finger protein 43 and 34-kDa translocase of the outer mitochondrial membrane combined with uracil-tegafur/leucovorin (UFT/LV) was previously demonstrated in metastatic colorectal cancer (CRC) in a phase I clinical trial. To clarify the survival b...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.7905

    authors: Kawamura J,Sugiura F,Sukegawa Y,Yoshioka Y,Hida JI,Hazama S,Okuno K

    更新日期:2018-04-01 00:00:00

  • Giant cell tumor of bone arising in long bones possibly originates from the metaphyseal region.

    abstract::Giant cell tumor of bone (GCTB) is a primary benign bone tumor with a locally aggressive character. Definitive descriptions of the site of origin for this type of tumor are not available. The aim of the present study was to evaluate the site of origin of GCTB of long bones with regards to epiphyseal lines by means of ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4264

    authors: Futamura N,Urakawa H,Tsukushi S,Arai E,Kozawa E,Ishiguro N,Nishida Y

    更新日期:2016-04-01 00:00:00

  • Expression of Toll-like receptor-9 is associated with poor progression-free survival in prostate cancer.

    abstract::Toll-like receptor-9 (TLR9) is a member of the innate immune system and recognizes bacterial and vertebrate DNA in cells. In addition to being expressed in cells of the immune system, it is widely expressed in various types of human cancer, including prostate cancer. We have previously demonstrated that synthetic TLR9...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1204

    authors: Väisänen MR,Jukkola-Vuorinen A,Vuopala KS,Selander KS,Vaarala MH

    更新日期:2013-05-01 00:00:00

  • Expression of CD24 and B7-H3 in breast cancer and the clinical significance.

    abstract::This study aimed to investigate the correlation between the expression of CD24 and B7-H3 in breast cancer tissues and the clinical significance. Expression of CD24 and B7-H3 in breast cancer and adjacent tissues were detected by immunohistochemistry. Quantitative PCR was used to detect the expression of CD24 and B7-H3...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.7142

    authors: Cong F,Yu H,Gao X

    更新日期:2017-12-01 00:00:00

  • Low-grade cribriform cystadenocarcinoma of the palatal gland: A case report.

    abstract::Low-grade cribriform cystadenocarcinoma (LGCCC) is a malignant salivary gland tumor. LGCCC occurs rarely, with the parotid gland being the most commonly afflicted site. Few cases arise in other sites. The present study reports a case of LGCCC that occurred at the palatal gland of the hard palate. A 56-year-old female ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3528

    authors: Kokabu S,Nojima J,Kayano H,Yoda T

    更新日期:2015-10-01 00:00:00

  • Mutation analysis of key genes in RAS/RAF and PI3K/PTEN pathways in Chinese patients with hepatocellular carcinoma.

    abstract::The RAS/RAF and PI3K/PTEN signaling pathways play central roles in hepatocarcinogenesis. KRAS, NRAS, HRAS, BRAF, PIK3CA, PIK3R1 and PTEN are key cancer-related genes in the RAS/RAF and PI3K/PTEN signaling pathways. Genetic alterations in these genes often lead to the dysregulation of the two cascades. Little is known ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2253

    authors: Hou W,Liu J,Chen P,Wang H,Ye BC,Qiang F

    更新日期:2014-09-01 00:00:00

  • Piperidine nitroxide Tempol enhances cisplatin-induced apoptosis in ovarian cancer cells.

    abstract::A nitroxide radical, Tempol (Tempol, TPL), is usually used as an antioxidative agent clinically, whereas the mechanism underlying its pro-oxidative effect has not been thoroughly investigated. The present study investigated the pro-oxidative effect of TPL on the inhibition of cellular proliferation and its role in enh...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9289

    authors: Wang M,Li K,Zou Z,Li L,Zhu L,Wang Q,Gao W,Wang Y,Huang W,Liu R,Yao K,Liu Q

    更新日期:2018-10-01 00:00:00